FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: cancer, tracheal model of angiogenesis
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General Information
Name
cancer, tracheal model of angiogenesis
FlyBase ID
FBhh0000745
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes a tracheal model of angiogenesis in Drsoophila. Analysis of the tracheal changes occurring during tumorigenesis in Drosophila larval epithelia (see FBhh0000588) has shown that they are closely related to the vascular modifications seen in mammalian cancers, including sprouting angiogenesis, intussusceptive angiogenesis, vascular co-option, and vascular mimicry.

Many of the same molecular mechanisms known to respond to hypoxic stress in mammalian cancers are observed, including translocation of sima, the Drosophila ortholog of HIFA (hypoxia inducible factor), into the nucleus. Increased expression of bnl, which encodes a fibroblast growth factor analogous to vascular endothelial growth factors in human, results; cancer cells expressing trh, a transcription factor and tracheal determinant, are observed.

[updated Feb. 2018 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cancer, tracheal model of angiogenesis
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (3)
        Dmel\sima
        Gene Snapshot
        Contributions welcome
        Molecular function (GO)
        Cellular component (GO)
        Gene Groups / Pathways
        Comments on ortholog(s)

        Moderate- to high-scoring ortholog of human HIF1A, EPAS1, and HIF3A (1 Drosophila to 3 human).

        Orthologs and Alignments from DRSC
        DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
        H. sapiens (Human)
        Dmel\bnl
        Gene Snapshot
        branchless (bnl) encodes a fibroblast growth factor (FGF) ligand for the transmembrane tyrosine kinase receptor encoded by btl that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic tracheal migration. [Date last reviewed: 2021-03-11]
        Molecular function (GO)
        Cellular component (GO)
        Gene Groups / Pathways
        Comments on ortholog(s)

        Low-scoring ortholog of multiple fibroblast growth factors in human (1 Drosophila to many human). There are several other fibroblast growth factors in Drosophila, but they do not exhibit similarity to known human genes.

        Orthologs and Alignments from DRSC
        DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
        H. sapiens (Human)
        Dmel\trh
        Gene Snapshot
        trachealess (trh) encodes a bHLH-PAS nuclear transcription factor required for the formation of the tube of the salivary duct, trachea and filzkorper. It is also required for expression of all tracheal genes. [Date last reviewed: 2019-03-14]
        Molecular function (GO)
        Cellular component (GO)
        Gene Groups / Pathways
        Comments on ortholog(s)

        High-scoring ortholog of human NPAS1 and NPAS3 (1 Drosophila to 2 human).

        Orthologs and Alignments from DRSC
        DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
        H. sapiens (Human)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (206 groups)
          sima
          protein-protein
          Interacting group
          Assay
          References
          sima - 14-3-3ζ
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ago
          anti bait coimmunoprecipitation, western blot
          (Mortimer and Moberg, 2013)
          sima - αCOP
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - α-Spec
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - AsnRS
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - AspRS
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ATPsynβ
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Bap111
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - β'COP
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - βTub60D
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - βTub97EF
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - blanks
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - blw
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - brm
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Brr2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - bsf
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Bug22
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - c12.1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Caf1-55
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Cand1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - cathD
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CCT1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CCT2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CCT6
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CCT7
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Cdc5
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG1416
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG3817
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG5516
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG6686
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG6695
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG8478
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG9281
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG9915
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG11583
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG12391
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG13097
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG13185
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG15784
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG32176
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CG32409
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Chc
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - cindr
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - cora
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - cpa
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ctp
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CtsF
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - CtsK1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Dis3l2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Dlic
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Dp1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Dref
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Droj2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eEF2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eIF3a
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eIF3b
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eIF3i
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eIF3m
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eIF4A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eIF4G1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - eIF5
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ERR
          two hybrid, pull down, autoradiography
          (Li et al., 2013)
          sima - FASN1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Fib
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - fliI
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - fmt
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Gale
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - GckIII
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Gfat2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - GluProRS
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Glys
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Gmppb
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Gnf1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Gp93
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Gtpbp1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - hang
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Hel25E
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - hfp
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Hmr
          two hybrid array
          (Shokri et al., 2019)
          sima - Hsc70-3
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Imp
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - indra
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Ipo9
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Iswi
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Kap-α3
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - kst
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - kuk
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - l(1)G0320
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ldbr
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Ldh
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - lds
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - lic
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - lola
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - mahj
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Map205
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Mcad
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Mkk4
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Mlf
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - mod
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - mor
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Mybbp1A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Nap1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ncd
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Nfs1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Nsun2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Nup50
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Ogdh1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Osbp
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - P32
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - p53
          pull down, autoradiography
          (Lunardi et al., 2010)
          sima - Past1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Patronin
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - pav
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - peng
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - poe
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Prp19
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Psa
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Pyk
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - pzg
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rack1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RAF2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rbcn-3A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Ref1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RfC4
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RFeSP
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rop
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL7A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL9
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL10
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL13
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL13A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL14
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL15
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL17
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL18
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL18A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL23
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL23A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL27
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL27A
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL30
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpL31
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpLP1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpLP2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rpn11
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS5a
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS6
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS7
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS10b
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS11
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS14a
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS15
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS15Aa
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS16
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS17
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS23
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - RpS27
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rpt1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rpt2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rpt3
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rpt4
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rpt5
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Rtf1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - rump
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - rush
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ScsβA
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ScsβG
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Sec63
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - SERCA
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Sf3b2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Shmt
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - shrb
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - shv
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - smid
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - SPARC
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - spd-2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Spx
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - sqh
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - SsRβ
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Strica
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - TfIIFα
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - tgo
          anti tag coimmunoprecipitation, western blot, two hybrid
          (Romero et al., 2008, Sonnenfeld et al., 1997)
          sima - Tkt
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - tum
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Txl
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - UQCR-C2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Usp10
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Vha68-2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - Vhl
          affinity technology, fluorescence technology, predetermined participant
          (Shmueli et al., 2014)
          sima - vig2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - wal
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - whd
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - yps
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - ZC3H18
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - zda
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          sima - zip
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          RNA-protein
          Interacting group
          Assay
          References
          sima - msi
          anti tag coimmunoprecipitation, quantitative reverse transcription pcr
          (Bertolin et al., 2016)
          bnl
          RNA-protein
          Interacting group
          Assay
          References
          bnl - orb2
          pull down, western blot
          (Mastushita-Sakai et al., 2010)
          bnl - Tis11
          anti tag coimmunoprecipitation, quantitative reverse transcription pcr
          (de Toeuf et al., 2018)
          trh
          protein-protein
          Interacting group
          Assay
          References
          trh - ago
          anti tag coimmunoprecipitation, anti tag western blot
          (Mortimer and Moberg, 2007)
          trh - Bdp1
          two hybrid array
          (Shokri et al., 2019)
          trh - D
          two hybrid
          (Ma et al., 2000)
          trh - drm
          two hybrid array
          (Shokri et al., 2019)
          trh - Hinfp
          two hybrid array
          (Shokri et al., 2019)
          trh - tgo
          anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, two hybrid, two hybrid array
          (Shokri et al., 2019, Sonnenfeld et al., 2010, Sonnenfeld et al., 1997)
          trh - vvl
          pull down, autoradiography
          (Zelzer and Shilo, 2000)
          Alleles Reported to Model Human Disease (Disease Ontology) (7 alleles)
          sima
          Models Based on Experimental Evidence ( 0 )
          Allele
          Disease
          Evidence
          References
          Modifiers Based on Experimental Evidence ( 4 )
          bnl
          Models Based on Experimental Evidence ( 1 )
          Modifiers Based on Experimental Evidence ( 2 )
          Allele
          Disease
          Interaction
          References
          bnl00857
          exacerbates  tauopathy
          modeled by Hsap\MAPTUAS.cWa
          (Feuillette et al., 2020)
          bnl06916
          exacerbates  tauopathy
          modeled by Hsap\MAPTUAS.cWa
          (Feuillette et al., 2020)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          bnlE324K.UAS.cOa
          P{UAS-bnl.E324K}
          simaUAS.cBa
          P{UAS-sima.B}
          w*; P{UAS-sima.B}2
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          bnlGD3070
          P{GD3070}
          w1118; P{GD3070}v5730
          bnlKK109317
          P{KK109317}
          P{KK109317}VIE-260B
          bnlHMS01046
          P{TRiP.HMS01046}
          y1 sc* v1 sev21; P{TRiP.HMS01046}attP2
          bnlNIG.4608R
          P{NIG.4608R}
          P{NIG.4608R}1
          trhGD12826
          P{GD12826}
          trhKK108906
          P{KK108906}
          P{KK108906}VIE-260B
          trhKK108968
          P{KK108968}
          P{KK108968}VIE-260B
          trhJF02188
          P{TRiP.JF02188}
          y1 v1; P{TRiP.JF02188}attP2
          trhHMS00002
          P{TRiP.HMS00002}
          y1 v1; P{TRiP.HMS00002}attP2
          trhKK115660
          P{KK115660}
          trhNIG.6883R
          P{NIG.6883R}
          P{NIG.6883R}1
          trhRNAi.UAS
          P{UAS-trh.RNAi}
          simaRNAi.UAS.cUa
          P{UAS-sima.RNAi.U}
          simaGD10139
          P{GD10139}
          simaJF02105
          P{TRiP.JF02105}
          y1 v1; P{TRiP.JF02105}attP2
          simaKK102226
          P{KK102226}
          P{KK102226}VIE-260B
          simaKK110834
          P{KK110834}
          P{KK110834}VIE-260B
          simaHMS00832
          P{TRiP.HMS00832}
          y1 sc* v1 sev21; P{TRiP.HMS00832}attP2
          simaHMS00833
          P{TRiP.HMS00833}
          y1 sc* v1 sev21; P{TRiP.HMS00833}attP2
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          bnl06916
          P-element activity
          ry506 P{PZ}bnl06916/TM3, ryRK Sb1 Ser1
          bnl00857
          amorphic allele - genetic evidence
          P-element activity
          ry506 P{PZ}bnl00857/TM3, Sb1
          bnlMI00874-TG4.1
          loss of function allele
          phiC31 integrase
          trh10512
          amorphic allele - genetic evidence
          P-element activity
          P{PZ}trh10512 ry506/TM3, ryRK Sb1 Ser1
          trh8
          amorphic allele - molecular evidence
          P-element activity
          simaKG07607
          loss of function allele
          P-element activity
          y1; ry506 P{SUPor-P}simaKG07607/TM3, Sb1 Ser+
          simaΔ1
          loss of function allele
          CRISPR/Cas9
          w1118; simaΔ1/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb1 Ser1
          simaΔ20
          loss of function allele
          CRISPR/Cas9
          w1118; simaΔ20/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb1 Ser1
          References (16)