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Citation
Kaur, R., Surala, M., Hoger, S., Grössmann, N., Grimm, A., Timaeus, L., Kallina, W., Hummel, T. (2019). Pioneer interneurons instruct bilaterality in the Drosophila olfactory sensory map.  Sci. Adv. 5(10): eaaw5537.
FlyBase ID
FBrf0243918
Publication Type
Research paper
Abstract

Interhemispheric synaptic connections, a prominent feature in animal nervous systems for the rapid exchange and integration of neuronal information, can appear quite suddenly during brain evolution, raising the question about the underlying developmental mechanism. Here, we show in the Drosophila olfactory system that the induction of a bilateral sensory map, an evolutionary novelty in dipteran flies, is mediated by a unique type of commissural pioneer interneurons (cPINs) via the localized activity of the cell adhesion molecule Neuroglian. Differential Neuroglian signaling in cPINs not only prepatterns the olfactory contralateral tracts but also prevents the targeting of ingrowing sensory axons to their ipsilateral synaptic partners. These results identified a sensitive cellular interaction to switch the sequential assembly of diverse neuron types from a unilateral to a bilateral brain circuit organization.

PubMed ID
PubMed Central ID
PMC6810332 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Adv.
    Title
    Science advances
    ISBN/ISSN
    2375-2548
    Data From Reference