FlyBase Gene Report: Hsap\RUNX1::Hsap\RUNX1T1

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Gene: Hsap\RUNX1::HsapRUNX1T1

General Information

Symbol

Hsap\RUNX1::Hsap\RUNX1T1

Species

H. sapiens

Name

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0084482

Gene Model Status

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

AML1-ETO, AML-ETO

Key Links

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hsap\RUNX1::Hsap\RUNX1T1

Transgenic constructs containing regulatory region of Hsap\RUNX1::Hsap\RUNX1T1

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

Other Phenotypes

Allele

hyperplasia | third instar larval stage, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

increased cell number | third instar larval stage, with Scer\GAL4^Hml.Δ

melanotic mass phenotype | third instar larval stage, with Scer\GAL4^Hml.Δ

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

some die during pupal stage, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

Phenotype manifest in

Allele

cone cell, with Scer\GAL4^GMR.PF

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

embryonic/larval crystal cell, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

embryonic/larval crystal cell, with Scer\GAL4^srp.D.cCa

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

embryonic/larval crystal cell | larval stage, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

embryonic/larval crystal cell | third instar larval stage, with Scer\GAL4^Hml.Δ

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

embryonic/larval hemocyte | larval stage | increased number, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

eye, with Scer\GAL4^GMR.PF

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

eye, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

lamellocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

ommatidial precursor cluster, with Scer\GAL4^GMR.PF

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

ommatidium, with Scer\GAL4^GMR.PF

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

ommatidium, with Scer\GAL4^lz-gal4

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

acute myeloid leukemia, RUNX1-RUNX1T1 fusion

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

model of acute myeloid leukemia

CEA

(Osman et al., 2009)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

model of acute myeloid leukemia

CEA

(Sinenko et al., 2010)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

model of acute myeloid leukemia

is ameliorated by CalpB^NIG.cUa

(Osman et al., 2009)

is ameliorated by CalpB^e04062

(Osman et al., 2009)

is ameliorated by pont^NIG.4003R

(Breig et al., 2014)

is ameliorated by pont^KK101103

(Breig et al., 2014)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

model of acute myeloid leukemia

is ameliorated by sls^KG00981

(Sinenko et al., 2010)

is ameliorated by msl-3^d01070

(Sinenko et al., 2010)

is ameliorated by cpo^BG02810

(Sinenko et al., 2010)

is exacerbated by S042938^S042938

(Sinenko et al., 2010)

is ameliorated by Cat^UAS.cAa

(Sinenko et al., 2010)

is exacerbated by S1364-03^S1364-03

(Sinenko et al., 2010)

is exacerbated by Wnt4^C1

(Sinenko et al., 2010)

is ameliorated by Sin3A^GD4387

(Sinenko et al., 2010)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Sinenko et al., 2010)

is ameliorated by E2f1⁰⁷¹⁷²

(Sinenko et al., 2010)

is ameliorated by S0279-04^S0279-04

(Sinenko et al., 2010)

is ameliorated by CG5033^EY04217

(Sinenko et al., 2010)

is ameliorated by Nurf-38^k16102

(Sinenko et al., 2010)

is exacerbated by Pkc53E^EY14093

(Sinenko et al., 2010)

is ameliorated by Sin3A^KK100700

(Sinenko et al., 2010)

is ameliorated by msl-3¹

(Sinenko et al., 2010)

is exacerbated by DCTN3-p24^k14618

(Sinenko et al., 2010)

is ameliorated by Akt^KK100495

(Sinenko et al., 2010)

is exacerbated by Atu^s1938

(Sinenko et al., 2010)

is exacerbated by EcR^RNAi.A.UAS

(Sinenko et al., 2010)

is exacerbated by fz^JB

(Sinenko et al., 2010)

is exacerbated by Wnt4^EMS23

(Sinenko et al., 2010)

is ameliorated by EcR^KG04522

(Sinenko et al., 2010)

is ameliorated by Sod2^UAS.cMa

(Sinenko et al., 2010)

is exacerbated by RyR^EY12439

(Sinenko et al., 2010)

is ameliorated by EcR^NIG.1765R

(Sinenko et al., 2010)

is ameliorated by Nurf-38^NIG.4634R

(Sinenko et al., 2010)

is ameliorated by Akt^GD1361

(Sinenko et al., 2010)

is exacerbated by fz2^UAS.N

(Sinenko et al., 2010)

is exacerbated by dsf^MB03062

(Sinenko et al., 2010)

is ameliorated by Kr²

(Sinenko et al., 2010)

is ameliorated by foxo^UAS.cPa

(Sinenko et al., 2010)

is ameliorated by EcR^Q50st

(Sinenko et al., 2010)

is exacerbated by Bgb^D

(Sinenko et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

(Wildonger and Mann, 2005)

engineered_fusion_gene

(Wildonger and Mann, 2005)

Stocks and Reagents

Stocks (0)

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

AML-ETO

(Skayneh et al., 2019, Wildonger and Mann, 2005)

AML1-ETO

(Sinenko et al., 2021, Al Outa et al., 2020, Reitman et al., 2015, Sinenko et al., 2010, Osman et al., 2009)

Hsap\RUNX1::Hsap\RUNX1T1

RUNX1-ETO

(Bras et al., 2012)

RUNX1::Hsap\RUNX1T1

Name Synonyms

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (10)