FlyBase Allele Report: Hsap\RUNX1::Hsap\RUNX1T1[UAS.cSa]

General Information

Symbol

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

Species

H. sapiens

Name

FlyBase ID

FBal0276915

Feature type

allele

Associated gene

Hsap\RUNX1::Hsap\RUNX1T1

Associated Insertion(s)

Carried in Construct

P{UAS-RUNX1::RUNX1T1.S}

Also Known As

AML1-ETO, UAS-AML1-ETO

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Sinenko et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-RUNX1::RUNX1T1.S}

Cytology

Description

UAS regulatory sequences drive expression of a Hsap\RUNX1 Hsap\RUNX1T1 fusion gene.

(Sinenko et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\RUNX1::Hsap\RUNX1T1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of acute myeloid leukemia

CEA

(Sinenko et al., 2010)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of acute myeloid leukemia

is ameliorated by sls^KG00981

(Sinenko et al., 2010)

is ameliorated by msl-3^d01070

(Sinenko et al., 2010)

is ameliorated by cpo^BG02810

(Sinenko et al., 2010)

is exacerbated by S042938^S042938

(Sinenko et al., 2010)

is ameliorated by Cat^UAS.cAa

(Sinenko et al., 2010)

is exacerbated by S1364-03^S1364-03

(Sinenko et al., 2010)

is exacerbated by Wnt4^C1

(Sinenko et al., 2010)

is ameliorated by Sin3A^GD4387

(Sinenko et al., 2010)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Sinenko et al., 2010)

is ameliorated by E2f1⁰⁷¹⁷²

(Sinenko et al., 2010)

is ameliorated by S0279-04^S0279-04

(Sinenko et al., 2010)

is ameliorated by CG5033^EY04217

(Sinenko et al., 2010)

is ameliorated by Nurf-38^k16102

(Sinenko et al., 2010)

is exacerbated by Pkc53E^EY14093

(Sinenko et al., 2010)

is ameliorated by Sin3A^KK100700

(Sinenko et al., 2010)

is ameliorated by msl-3¹

(Sinenko et al., 2010)

is exacerbated by DCTN3-p24^k14618

(Sinenko et al., 2010)

is ameliorated by Akt^KK100495

(Sinenko et al., 2010)

is exacerbated by Atu^s1938

(Sinenko et al., 2010)

is exacerbated by EcR^RNAi.A.UAS

(Sinenko et al., 2010)

is exacerbated by fz^JB

(Sinenko et al., 2010)

is exacerbated by Wnt4^EMS23

(Sinenko et al., 2010)

is ameliorated by EcR^KG04522

(Sinenko et al., 2010)

is ameliorated by Sod2^UAS.cMa

(Sinenko et al., 2010)

is exacerbated by RyR^EY12439

(Sinenko et al., 2010)

is ameliorated by EcR^NIG.1765R

(Sinenko et al., 2010)

is ameliorated by Nurf-38^NIG.4634R

(Sinenko et al., 2010)

is ameliorated by Akt^GD1361

(Sinenko et al., 2010)

is exacerbated by fz2^UAS.N

(Sinenko et al., 2010)

is exacerbated by dsf^MB03062

(Sinenko et al., 2010)

is ameliorated by Kr²

(Sinenko et al., 2010)

is ameliorated by foxo^UAS.cPa

(Sinenko et al., 2010)

is ameliorated by EcR^Q50st

(Sinenko et al., 2010)

is exacerbated by Bgb^D

(Sinenko et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Sinenko et al., 2010)

RUNX1/RUNX1T1_fusion

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

acute myeloid leukemia, RUNX1-RUNX1T1 fusion

External database links

COSMIC_fusion: RUNX1-RUNX1T1

Comments concerning this variant

Phenotypic Data

Phenotypic Class

increased cell number | third instar larval stage, with Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

melanotic mass phenotype | third instar larval stage, with Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Phenotype Manifest In

embryonic/larval crystal cell | third instar larval stage, with Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

lamellocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Detailed Description

Statement

Reference

Expression of Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa under the control of Scer\GAL4^Hml.Δ increases proliferation of circulating hemocytes, raising their numbers to 10 times the wild type level. These hemocytes are relatively small and round in shape. The number of hemocyte precursors is also increased compared to wild type. The number of lamellocytes and crystal cells is greater than in wild type and 30-40% of larvae display melanotic tumours. Hemocytes develop with a normal time cycle, indicating that ecdysone pulses in these larvae are intact.

(Sinenko et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by Wnt4[+]/Wnt4^EMS23

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by RyR^EY12439/Rya-r44F[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by Atu^s1938/Atu[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by Pkc53E[+]/Pkc53E^EY14093

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by Bgb^D/Bgb[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by dsf[+]/dsf^MB03062

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by S042938^S042938/S042938[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by S1364-03[+]/S1364-03^S1364-03

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by EcR^RNAi.A.UAS, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by EcR^{A-ΔC655.F645A.UAS}, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by Wnt4^C1/Wnt4[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has melanotic mass phenotype | third instar larval stage phenotype, enhanceable by Df(3L)ZN47

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has melanotic mass phenotype | third instar larval stage phenotype, enhanceable by Df(3L)pbl-X1

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by DCTN3-p24^k14618/l(2)06496[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by fz^JB/fz[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by Df(3L)fz2/+

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, enhanceable by fz2[+]/fz2^UAS.N

(Sinenko et al., 2010)

Suppressed by

Statement

Reference

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Bro^UAS.cLa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Bgb^UAS.cLa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by EcR[+]/EcR^KG04522

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by EcR[+]/EcR^Q50st

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by msl-3[+]/msl-3^d01070

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by msl-3[+]/msl-3¹

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by cpo[+]/cpo^BG02810

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Kr²/Kr[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by E2f[+]/E2f1⁰⁷¹⁷²

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by CG5033^EY04217/CG5033[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by sls^KG00981/sls[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Sin3A^KK100700, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Sin3A^GD4387, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Nurf-38^k16102/Nurf-38[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Nurf-38^NIG.4634R, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by S0279-04^S0279-04/S0279-04[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by EcR^NIG.1765R, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by EcR^{B2-ΔC655.F645A.UAS}, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Sod2^UAS.cMa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Cat^UAS.cAa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by foxo^UAS.cPa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Akt^KK100495, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, suppressible | partially by Akt^GD1361, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

NOT suppressed by

Statement

Reference

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, non-suppressible by Pten^{RNAi.Exel.UAS}, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has increased cell number | third instar larval stage phenotype, non-suppressible by Sod2^RNAi.UAS.cKa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Wnt4[+]/Wnt4^EMS23

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by RyR^EY12439/Rya-r44F[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Atu^s1938/Atu[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Pkc53E[+]/Pkc53E^EY14093

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Bgb^D/Bgb[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by dsf[+]/dsf^MB03062

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Wnt4^C1/Wnt4[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by S042938^S042938/S042938[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by S1364-03[+]/S1364-03^S1364-03

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Df(3L)ZN47/+

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Df(3L)pbl-X1/+

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by EcR^RNAi.A.UAS, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by EcR^{A-ΔC655.F645A.UAS}, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by DCTN3-p24^k14618/l(2)06496[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by fz^JB/fz[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by Df(3L)fz2/+

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, enhanceable by fz2[+]/fz2^UAS.N

(Sinenko et al., 2010)

Suppressed by

Statement

Reference

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by msl-3[+]/msl-3^d01070

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by msl-3[+]/msl-3¹

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by cpo[+]/cpo^BG02810

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Kr²/Kr[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by E2f[+]/E2f1⁰⁷¹⁷²

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by CG5033^EY04217/CG5033[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by sls^KG00981/sls[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Sin3A^KK100700, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Sin3A^GD4387, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Nurf-38^k16102/Nurf-38[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Nurf-38^NIG.4634R, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by S0279-04^S0279-04/S0279-04[+]

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by EcR^NIG.1765R, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by EcR^{B2-ΔC655.F645A.UAS}, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Sod2^UAS.cMa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Cat^UAS.cAa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by foxo^UAS.cPa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Akt^KK100495, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Akt^GD1361, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Bro^UAS.cLa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by Bgb^UAS.cLa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by EcR[+]/EcR^KG04522

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, suppressible | partially by EcR[+]/EcR^Q50st

(Sinenko et al., 2010)

NOT suppressed by

Statement

Reference

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, non-suppressible by Akt^UAS.Exel, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, non-suppressible by Pten^{RNAi.Exel.UAS}, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | third instar larval stage phenotype, non-suppressible by Sod2^RNAi.UAS.cKa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Bro^Scer\UAS.cLa partially suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Bgb^Scer\UAS.cLa partially suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of EcR^KG04522 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of EcR^Q50st strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of msl-3^d01070 moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of msl-3¹ moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of cpo^BG02810 moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Kr² strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of E2f⁰⁷¹⁷² moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of CG5033^EY04217 moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of sls^KG00981 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Sin3A⁰⁸²⁶⁹ moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Sin3A^KK100700 moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Sin3A^GD4387 moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Nurf-38^k16102 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Nurf-38^NIG.4634R strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of S0279-04^S0279-04 moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Wnt4^EMS23 strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Wnt4^C1 strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of fz^JB strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Df(3L)fz2 strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of fz2^Scer\UAS.N moderately enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Rya-r44F^EY12439 moderately enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Atu^s1938 strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Pkc53E^EY14093 moderately enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Bgb^D moderately enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of dsf^MB03062 moderately enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of l(2)06496^k14618 strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of S042938^S042938 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of S1364-03^S1364-03 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Df(3L)ZN47 strongly enhances the hemocyte overproliferation and melanotic tumor production seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

One copy of Df(3L)pbl-X1 strongly suppresses the hemocyte overproliferation and melanotic tumor production seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of EcR^NIG.1765R strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of EcR^{dsRNA.A.Scer\UAS} slightly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of EcR^{A-ΔC655.F645A.Scer\UAS} slightly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of EcR^{B2-ΔC655.F645A.Scer\UAS} strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Sod2^Scer\UAS.cMa strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Cat^Scer\UAS.cAa moderately suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of foxo^Scer\UAS.cPa strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Akt1^KK100495 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Akt1^GD1361 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Akt1^{Scer\UAS.Exel} does not suppress the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Pten^{dsRNA.Exel.Scer\UAS} does not suppress the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

Expression of Sod2^{dsRNA.Scer\UAS.cKa} does not suppress the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

(Sinenko et al., 2010)

Complementation and Rescue Data

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Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

AML1-ETO

(Reitman et al., 2015)

Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa

Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

Name Synonyms

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