FlyBase Allele Report: Dmel\Itpr[05616]

General Information

Symbol

Dmel\Itpr⁰⁵⁶¹⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0009542

Feature type

allele

Associated gene

Dmel\Itpr

Associated Insertion(s)

P{PZ}Itpr⁰⁵⁶¹⁶

Carried in Construct

Also Known As

itpr¹⁶⁶⁴

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Deshpande et al., 2000, Venkatesh and Hasan, 1997)

Mutagen

P-element activity

(Venkatesh et al., 2001, Sinha and Hasan, 1999, Spradling et al., 1999, Venkatesh and Hasan, 1997, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}Itpr⁰⁵⁶¹⁶

Cytology

Description

Insertion of a P{PZ} element in the 5' UTR of the embryonic Itp-r83A transcript at nucleotide position 364.

(Sinha and Hasan, 1999)

P{PZ} element insertion approximately 200bp upstream of the 5' end of the first exon.

(Venkatesh and Hasan, 1997)

The P{PZ}Itp-r83A⁰⁵⁶¹⁶ insertion maps within both Itp-r83A and Nmdar1 (overlapping genes on opposite strands).

(FlyBase, 1996-)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:5,517,510..5,517,510 [+]

(Joshi et al., 2004, Venkatesh et al., 2001, Sinha and Hasan, 1999, Spradling et al., 1999, Venkatesh and Hasan, 1997, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes can molt to the third instar and eventually die primarily as pupae. A few adult survivors do survive.

(Venkatesh et al., 2001)

The response of homozygous Itp-r83A⁰⁵⁶¹⁶ and Itp-r83A⁰⁵⁶¹⁶/Itp-r83A^XR12 survivors to all concentrations of ethyl acetate is normal.

(Deshpande et al., 2000)

Almost 50% of homozygotes moult into third instar larvae and pupae. Both moults are delayed compared to heterozygotes. The remaining 50% of homozygotes survive at the second larval stage for an extended time period and then appear to moult directly into pupae. Very few homozygous adults eclose, those that do have no obvious morphological defects. The larval moulting delay in homozygotes is rescued by 20-hydroxyecdysone.

(Venkatesh and Hasan, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Itpr⁰⁵⁶¹⁶ has abnormal developmental rate | recessive phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-178

(Venkatesh et al., 2001)

Itpr⁰⁵⁶¹⁶ has abnormal developmental rate | recessive phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-2080

(Venkatesh et al., 2001)

Itpr⁰⁵⁶¹⁶ has lethal | pupal stage | recessive phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-2080

(Venkatesh et al., 2001)

Itpr⁰⁵⁶¹⁶ has lethal | larval stage | recessive phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-178

(Venkatesh et al., 2001)

Itpr⁰⁵⁶¹⁶ has lethal | pupal stage | recessive phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-178

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has abnormal developmental rate phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-178

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has lethal | larval stage phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-178

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has lethal | pupal stage phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-178

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has abnormal developmental rate phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-2080

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has lethal | larval stage phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-2080

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has lethal | pupal stage phenotype, enhanceable by Adcy1^rut-2080/Adcy1^rut-2080

(Venkatesh et al., 2001)

Enhancer of

Statement

Reference

Itpr^1664GAL4/Itpr⁰⁵⁶¹⁶ is an enhancer of abnormal developmental rate phenotype of Pka-R1^BDK.UAS, Scer\GAL4^{Itpr-1664GAL4}

(Venkatesh et al., 2001)

Suppressor of

Statement

Reference

Itpr⁰⁵⁶¹⁶ is a suppressor of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Other

Statement

Reference

Adcy1^rut-2080, Itpr⁰⁵⁶¹⁶ has lethal | recessive | larval stage phenotype

(Venkatesh et al., 2001)

Phenotype Manifest In

Suppressor of

Statement

Reference

Itpr⁰⁵⁶¹⁶ is a suppressor of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Other

Statement

Reference

Adcy1^rut-2080/Adcy1^rut-178, Itpr⁰⁵⁶¹⁶ has larval tracheal system phenotype

(Venkatesh et al., 2001)

Adcy1^rut-2080, Itpr⁰⁵⁶¹⁶ has larval tracheal system phenotype

(Venkatesh et al., 2001)

Adcy1^rut-2080, Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has larval tracheal system phenotype

(Venkatesh et al., 2001)

Adcy1^rut-2080/Adcy1^rut-178, Itpr^90B.0/Itpr⁰⁵⁶¹⁶ has larval tracheal system phenotype

(Venkatesh et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

rut²⁰⁸⁰, Itp-r83A⁰⁵⁶¹⁶ double mutants fail to moult from the second to the third larval instar and perish in the second larval instar. Several of the double mutant larvae have tracheal endings characteristic of the first instar larva.

(Venkatesh et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements