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General Information
Symbol
Dmel\Itpr05616
Species
D. melanogaster
Name
FlyBase ID
FBal0009542
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
itpr1664
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a P{PZ} element in the 5' UTR of the embryonic Itp-r83A transcript at nucleotide position 364.

P{PZ} element insertion approximately 200bp upstream of the 5' end of the first exon.

The P{PZ}Itp-r83A05616 insertion maps within both Itp-r83A and Nmdar1 (overlapping genes on opposite strands).

Insertion components
P{PZ}Itpr05616
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes can molt to the third instar and eventually die primarily as pupae. A few adult survivors do survive.

The response of homozygous Itp-r83A05616 and Itp-r83A05616/Itp-r83AXR12 survivors to all concentrations of ethyl acetate is normal.

Almost 50% of homozygotes moult into third instar larvae and pupae. Both moults are delayed compared to heterozygotes. The remaining 50% of homozygotes survive at the second larval stage for an extended time period and then appear to moult directly into pupae. Very few homozygous adults eclose, those that do have no obvious morphological defects. The larval moulting delay in homozygotes is rescued by 20-hydroxyecdysone.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Enhancer of
Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

rut2080, Itp-r83A05616 double mutants fail to moult from the second to the third larval instar and perish in the second larval instar. Several of the double mutant larvae have tracheal endings characteristic of the first instar larva.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Complements: Snr101319. Complements: l(3)0364403644. Complements: ksrj5E2.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (8)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)