FlyBase Allele Report: Dmel\ph-d[401]

General Information

Symbol

Dmel\ph-d⁴⁰¹

Species

D. melanogaster

Name

FlyBase ID

FBal0013751

Feature type

allele

Associated gene

Dmel\ph-d

Associated Insertion(s)

Carried in Construct

Also Known As

ph⁴⁰¹

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Cheng et al., 1994)

loss of function allele

(O'Dor et al., 2006)

Mutagen

X ray

(Saget and Randsholt, 1994, Dura et al., 1987)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Dura et al., 1987)

Description

Mutation in ph-d.

(Santamaria, 1993.6)

Small deletion within the ph-d locus.

(Dura et al., 1987)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Hodgson et al., 1997, Fauvarque et al., 1995)

visible | recessive

(Saget and Randsholt, 1994)

Phenotype Manifest In

abdominal segment 1

(Saget and Randsholt, 1994)

abdominal segment 4

(Saget and Randsholt, 1994)

abdominal segment | adult stage

(Schaaf et al., 2013)

mesothoracic leg

(Saget and Randsholt, 1994)

sex comb | ectopic

(Schaaf et al., 2013)

Detailed Description

Statement

Reference

ph-d⁴⁰¹ mutants exhibit an A4 to A5 abdominal segment transformation phenotype.

(Schaaf et al., 2013)

The rate of mitotic segregation defects seen in ph-d⁴⁰¹ embryos is not significantly higher than those seen in wild type.

(O'Dor et al., 2006)

ph-d⁴⁰¹/Df(3R)ry27 mutant flies exhibit the same number of legs with sex combs (2.0) as in wild-type or ph-d⁴⁰¹/+ heterozygotes.

ph-d⁴⁰¹/Df(3R)ry619 mutant flies exhibit the same number of legs with sex combs (2.0) as in wild-type or ph-d⁴⁰¹/Tp(3;3)MRS heterozygotes.

(Wang and Brock, 2003)

0% of ph-d⁴⁰¹/Y; en⁵⁴/+ double heterozygotes do not have a gap in the fourth wing vein at 25 or 29^oC.

(Maschat et al., 1998)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is darker.

(Fauvarque et al., 1995)

Viable.

(Cheng et al., 1994)

Hemizygous males occasionally have sex combs on the second legs and often show a partial transformation of abdominal segment A4 towards A5, at both 25 and 29^oC. Hemizygous males occasionally show a partial transformation of abdominal segment A1 to A2 at 25^oC. The penetrance of this phenotype increases at 29^oC.

(Saget and Randsholt, 1994)

Adults viable.

(Dura et al., 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ph-d[+]/ph-d⁴⁰¹ is an enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ph-d[+]/ph-d⁴⁰¹ is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Other

Statement

Reference

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁴ has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰³ has visible | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰² has visible | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁰ has visible | homeotic phenotype

(Boivin et al., 1999)

Df(1)ph-601, Pc⁵, ph-d⁴⁰¹ has visible | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰³ has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰² has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁰ has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁴ has visible | homeotic phenotype

(Boivin et al., 1999)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

ph-d⁴⁰¹ has sex comb | ectopic phenotype, non-enhanceable by pds5^e3

(Schaaf et al., 2013)

ph-d⁴⁰¹ has abdominal segment | adult stage phenotype, non-enhanceable by pds5^e3

(Schaaf et al., 2013)

ph-d⁴⁰¹ has sex comb | ectopic phenotype, non-enhanceable by pds5^e6

(Schaaf et al., 2013)

ph-d⁴⁰¹ has abdominal segment | adult stage phenotype, non-enhanceable by pds5^e6

(Schaaf et al., 2013)

Suppressed by

Statement

Reference

ph-d⁴⁰¹ has sex comb | ectopic phenotype, suppressible by vtd⁶

(Schaaf et al., 2013)

ph-d⁴⁰¹ has sex comb | ectopic phenotype, suppressible by vtd^80Fh-36

(Schaaf et al., 2013)

ph-d⁴⁰¹ has abdominal segment | adult stage phenotype, suppressible by vtd⁶

(Schaaf et al., 2013)

ph-d⁴⁰¹ has abdominal segment | adult stage phenotype, suppressible by vtd^80Fh-36

(Schaaf et al., 2013)

NOT suppressed by

Statement

Reference

ph-d⁴⁰¹ has sex comb | ectopic phenotype, non-suppressible by SMC1^exc46

(Schaaf et al., 2013)

ph-d⁴⁰¹ has sex comb | ectopic phenotype, non-suppressible by Nipped-B⁴⁰⁷

(Schaaf et al., 2013)

ph-d⁴⁰¹ has abdominal segment | adult stage phenotype, non-suppressible by SMC1^exc46

(Schaaf et al., 2013)

ph-d⁴⁰¹ has abdominal segment | adult stage phenotype, non-suppressible by Nipped-B⁴⁰⁷

(Schaaf et al., 2013)

Enhancer of

Statement

Reference

ph-d[+]/ph-d⁴⁰¹ is an enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ph-d[+]/ph-d⁴⁰¹ is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

ph-d[+]/ph-d⁴⁰¹ is an enhancer of leg | ectopic phenotype of hh^Mrt

(Randsholt et al., 2000)

ph-d[+]/ph-d⁴⁰¹ is an enhancer of wing | anterior phenotype of hh^Mrt

(Randsholt et al., 2000)

Other

Statement

Reference

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁴ has wing | posterior phenotype

(Boivin et al., 1999)

Df(1)ph-601, Pc⁵, ph-d⁴⁰¹ has wing | posterior phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰³ has wing | posterior phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰² has wing | posterior phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁰ has wing | posterior phenotype

(Boivin et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is exacerbated by combination with a single copy of ph-d⁴⁰¹.

(Morimoto et al., 2016)

ph-p⁶⁰² ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation. ph-p⁶⁰⁴ ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation. ph-p⁶⁰⁰ ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation. ph-p⁶⁰³ ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation. Df(1)ph-601; Pc⁵/+ flies show a weak wing to haltere transformation.

(Boivin et al., 1999)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is exacerbated by combination with a single copy of ph-d⁴⁰¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

5392

ph-d⁴⁰¹ w¹

5444

ph-d⁴⁰¹ ph-p⁶⁰² w¹/FM7c, sn⁺

Kyoto

108202

ph-d⁴⁰¹ w¹

108238

ph-d⁴⁰¹ ph-p⁶⁰² w¹/FM7c

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ph-d⁴⁰¹

(Vasanthi et al., 2013)

ph-d⁴⁰¹

(Vaziri et al., 2020, Dardalhon-Cuménal et al., 2018, Abed et al., 2013, Bengani et al., 2013, DeVido et al., 2008)

ph⁴⁰¹

(Schaaf et al., 2013, O'Dor et al., 2006, Wang and Brock, 2003, Randsholt et al., 2000, Boivin et al., 1999, Maschat et al., 1998, Netter et al., 1998, Hodgson et al., 1997, Fauvarque et al., 1995, de Camillis and Brock, 1994, Saget and Randsholt, 1994, Dura et al., 1987)

Name Synonyms

Secondary FlyBase IDs

References (21)

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