FlyBase Allele Report: Dmel\Ubx[130]

General Information

Symbol

Dmel\Ubx¹³⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0017400

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Kauffman, 1981)

Mutagen

X ray

(Lindsley and Zimm, 1992)

Progenitor genotype

Caused by aberration

In(3LR)Ubx¹³⁰

Cytology

Description

Breakpoint in Ubx.

(Castelli-Gair and Garcia-Bellido, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity

(Puro, 1982)

lethal | recessive

(Lindsley and Zimm, 1992)

visible | dominant

(Kauffman, 1981)

Phenotype Manifest In

haltere

(Shimojima et al., 2003, Laney and Biggin, 1996, Kauffman, 1981)

haltere disc anterior compartment (with Ubx^bx-3)

(de Navas et al., 2006)

haltere disc posterior compartment (with Ubx^pbx-1)

(de Navas et al., 2006)

Detailed Description

Statement

Reference

The anterior compartment is increased in size in Ubx¹³⁰/Ubx^bx-3 haltere discs.

The posterior compartment is increased in size in Ubx¹³⁰/Ubx^pbx-1 haltere discs.

(de Navas et al., 2006)

Ubx¹³⁰ heterozygotes display slightly enlarged halteres compared to wild-type.

(Faucheux et al., 2003)

In Ubx¹³⁰ mutant adults, halters are homogeneous in size and shape, being slightly larger than those in wild-type.

(Shimojima et al., 2003)

Ubx¹³⁰ heterozygotes have normal halteres and nota.

(Schwendemann and Lehmann, 2002)

Like Ubx¹ as a dominant. RK1A.

(Lindsley and Zimm, 1992)

Increases the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

(Castelli-Gair and Garcia-Bellido, 1990)

Flies carrying both RpII215^Ubl and Ubx¹³⁰ show a greater transformation of haltere to wing than flies carrying RpII215^Ubl alone.

(Mortin et al., 1985)

Transheterozygotes with Ubx^S1, Ubx^S2 and Ubx^S3 are viable.

(Tiong et al., 1985)

T(2;3)T1-19/Ubx¹³⁰ flies show reduced viability and fecundity.

(Puro, 1982)

The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is increased in flies also containing a copy of Ubx¹³⁰.

(Capdevila and Garcia-Bellido, 1981)

Heterozygotes have a slight transformation of haltere to wing at 29^oC and 17^oC. Ubx¹³⁰/Ubx^Cbx-1 flies show a temperature sensitive phenotype; flies grown at 29^oC have a slight conversion of haltere to wing and strong transformation of wing to haltere, while those grown at 17^oC have a strong haltere to wing transformation and a slight transformation of wing to haltere. The Ubx^Cbx-1 transformation in the wing is generally reduced and the Ubx¹³⁰ transformation in the haltere is generally enhanced in the transheterozygote, compared to heterozygous or homozygous Ubx^Cbx-1 or Ubx¹³⁰ flies respectively.

(Kauffman, 1981)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Trl^R85, Ubx¹³⁰/Ubx[+] has homeotic phenotype, enhanceable by Taf3^Fa4a

(Chopra et al., 2008)

Trl^R85, Ubx¹³⁰ has visible phenotype, enhanceable by pho¹

(Bejarano and Busturia, 2004)

Trl[+]/Trl^R85, Ubx¹³⁰ has visible | dominant phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰/Ubx[+] has visible | dominant phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Suppressor of

Statement

Reference

Ubx¹³⁰/Ubx[+] is a suppressor | partially of visible phenotype of dpp^d5/dpp^d12

(de Navas et al., 2006)

Other

Statement

Reference

Ino80[+]/Ino80^Δ4, Ubx¹³⁰ has visible | dominant phenotype

(Bhatia et al., 2010)

Trl^R85, Ubx¹³⁰/Ubx[+] has homeotic phenotype

(Chopra et al., 2008)

Trl^R85, Ubx¹³⁰ has visible phenotype

(Bejarano and Busturia, 2004)

Trl[+]/Trl^R85, Ubx¹³⁰ has visible | dominant phenotype

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰ has visible | dominant phenotype

(Schwendemann and Lehmann, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Trl^R85, Ubx¹³⁰/Ubx[+] has haltere phenotype, enhanceable by Taf3^Fa4a

(Chopra et al., 2008)

Trl^R85, Ubx¹³⁰/Ubx[+] has wing | ectopic phenotype, enhanceable by Taf3^Fa4a

(Chopra et al., 2008)

Ubx¹³⁰ has haltere phenotype, enhanceable by Df(3L)Aprt-21

(Shimojima et al., 2003)

Trl^13C, Ubx¹³⁰ has haltere phenotype, enhanceable by Df(3L)Aprt-21

(Shimojima et al., 2003)

Ubx¹³⁰ has haltere phenotype, enhanceable by Trl^13C

(Shimojima et al., 2003)

Trl[+]/Trl^R85, Ubx¹³⁰ has haltere phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰/Ubx[+] has haltere phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰/Ubx[+] has mesonotum phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰/Ubx[+] has wing | ectopic phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Trl[+]/Trl^R85, Ubx¹³⁰ has mesonotum phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Trl[+]/Trl^R85, Ubx¹³⁰ has wing | ectopic phenotype, enhanceable by +/Df(2R)Δ18

(Schwendemann and Lehmann, 2002)

Ubx¹³⁰ has phenotype, enhanceable by Trl^13C

(Farkas et al., 1994)

Suppressed by

Statement

Reference

Ubx¹³⁰/Ubx^bx-3 has haltere disc anterior compartment phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/tkv^UAS.cLa

(de Navas et al., 2006)

Suppressor of

Statement

Reference

Ubx¹³⁰/Ubx[+] is a suppressor | partially of capitellum phenotype of dpp^d5/dpp^d12

(de Navas et al., 2006)

Other

Statement

Reference

Ino80[+]/Ino80^Δ4, Ubx¹³⁰ has haltere phenotype

(Bhatia et al., 2010)

Trl^R85, Ubx¹³⁰/Ubx[+] has haltere phenotype

(Chopra et al., 2008, Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰/Ubx[+] has wing | ectopic phenotype

(Chopra et al., 2008, Schwendemann and Lehmann, 2002)

Df(3L)Aprt-21, Trl^13C, Ubx¹³⁰ has wing | ectopic phenotype

(Shimojima et al., 2003)

Trl^R85, Ubx¹³⁰/Ubx[+] has mesonotum phenotype

(Schwendemann and Lehmann, 2002)

Trl[+]/Trl^R85, Ubx¹³⁰ has haltere phenotype

(Schwendemann and Lehmann, 2002)

Trl[+]/Trl^R85, Ubx¹³⁰ has wing | ectopic phenotype

(Schwendemann and Lehmann, 2002)

Trl[+]/Trl^R85, Ubx¹³⁰ has mesonotum phenotype

(Schwendemann and Lehmann, 2002)

+/Df(2R)Δ18, Ubx¹³⁰ has haltere phenotype

(Schwendemann and Lehmann, 2002)

+/Df(2R)Δ18, Ubx¹³⁰ has wing | ectopic phenotype

(Schwendemann and Lehmann, 2002)

+/Df(2R)Δ18, Ubx¹³⁰ has mesonotum phenotype

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰ has haltere phenotype

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰ has wing | ectopic phenotype

(Schwendemann and Lehmann, 2002)

Trl^R85, Ubx¹³⁰ has mesonotum phenotype

(Schwendemann and Lehmann, 2002)

Trl^13C, Ubx¹³⁰ has haltere phenotype

(Laney and Biggin, 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Ubx¹³⁰ Ino80^Δ4 double heterozygotes have a haltere to wing transformation with 100% penetrance.

(Bhatia et al., 2010)

2.48% of flies carrying one copy of Trl^R85 and one copy of Ubx¹³⁰ show a mild haltere to wing transformation.

Homozygous bip2^Fa4a does not enhance the frequency of haltere to wing transformation seen in Trl^R85/TM2, Ubx¹³⁰ flies (2.73% of flies show transformations, compared to 2.48%), but it does enhance the severity of the transformation.

(Chopra et al., 2008)

The reduced size of the capitellum seen in dpp^d5/dpp^d12 adults is partially suppressed by Ubx¹³⁰/+.

(de Navas et al., 2006)

Trl^R85/Ubx¹³⁰; pho¹ flies show an enhancement of the Ubx¹³⁰ phenotype in 18% of flies.

(Bejarano and Busturia, 2004)

Double heterozygous lolal^k02512 Ubx¹³⁰ flies do not show significant increase in the expressivity of the Ubx phenotype. lolal^k02512/+; Trl^13C/Ubx¹³⁰ flies display a higher frequency (18%) of strong haltere-to-wing transformations compared to Trl^13C/Ubx¹³⁰ siblings (6.3%). This increased transformation is often accompanied by a notal transformation.

(Faucheux et al., 2003)

56% of Ubx¹³⁰, Trl^13C double heterozygotes have halteres that quite heterogeneous in size and larger than Ubx¹³⁰ alone. 63% of Ubx¹³⁰, Df(3L)Aprt-21 double heterozygotes have halteres that quite heterogeneous in size and larger than Ubx¹³⁰ alone. 78% of Ubx¹³⁰, Df(3L)Aprt-21, Trl^13C triple heterozygotes have halteres that quite heterogeneous in size and larger than Ubx¹³⁰ alone, also exhibiting a stronger phenotype than any two of the alleles used. The haltere becomes a wing -like structure with wing veins and hairs on the wing margin.

(Shimojima et al., 2003)

Ubx¹³⁰/Trl^R85 flies have a low penetrance of haltere to wing transformations and notal transformations. The penetrance of these phenotypes is significantly enhanced by heterozygosity for Df(2R)Δ18, even though the phenotypes are present at a very low penetrance (<0.5%) in Ubx¹³⁰, Df(2R)Δ18 double heterozygotes.

(Schwendemann and Lehmann, 2002)

Flies doubly heterozygous for Ubx¹³⁰ and Trl^13C show larger halteres than Ubx¹³⁰ heterozygotes alone, and with variable penetrance and expressivity show homeotic transformations of the haltere and postnotum. When z^ae(bx) is added to the doubly heterozygous combination the Ubx phenotype is enhanced.

(Laney and Biggin, 1996)

Heterozygotes have slightly enlarged halteres compared to wild type. Trl^13C+/+Ubx¹³⁰ double heterozygous flies have larger halteres than Ubx¹³⁰ heterozygotes. Homeotic transformations include a low frequency of patches on the haltere and postnotum that develop like wing and notum tissues respectively.

(Farkas et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (16)

Bloomington

3461