FlyBase Allele Report: Dmel\Dsor1[LH110]

General Information

Symbol

Dmel\Dsor1^LH110

Species

D. melanogaster

Name

FlyBase ID

FBal0039032

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

Also Known As

dSor^LH110

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Hsu and Perrimon, 1994)

loss of function allele

(Lu et al., 1994)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

ameliorates pancreatic ductal adenocarcinoma

modeled by CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Helman et al., 2011)

lethal

(Hsu and Perrimon, 1994, Lu et al., 1994)

lethal - all die during embryonic stage | recessive

(Hou et al., 1997)

some die during embryonic stage | recessive

(Hou et al., 1997)

Phenotype Manifest In

embryonic dorsal epidermis

(Hou et al., 1997)

ventral neurectoderm intermediate zone

(Helman et al., 2011)

Detailed Description

Statement

Reference

Mutant embryos show complete loss of the intermediate neuroblast column of the neuroectoderm.

(Helman et al., 2011)

Dsor1^LH110/+ flies show a wild-type number of rhabdomeres in their eyes.

(Kim et al., 2006)

The mesoderm is able to make contact with and flatten against the ectoderm in a symmetric fashion in homozygous embryos derived from homozygous female germline clones.

(Wilson et al., 2005)

Embryos exhibit a dorsal open phenotype.

(Hou et al., 1997)

Embryos derived from homozygous germ line clones fall into two phenotypic classes depending on paternal contribution. One class is completely rescued embryos and the second class of embryos differentiate cuticle but exhibit deletion of structures posterior to abdominal segment 7 and deletion of the acron.

(Hsu and Perrimon, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dsor1^LH110 has lethal phenotype, suppressible by Src42A^Su(Raf)1-1

(Lu et al., 1994)

Dsor1^LH110 has lethal phenotype, suppressible by Su(phl)43B¹

(Lu et al., 1994)

Dsor1^LH110 has lethal phenotype, suppressible by Su(phl)4¹

(Lu et al., 1994)

Dsor1^LH110 has lethal phenotype, suppressible by Su(phl)6¹

(Lu et al., 1994)

Dsor1^LH110 has lethal phenotype, suppressible by Su(phl)7¹

(Lu et al., 1994)

Dsor1^LH110 has lethal phenotype, suppressible by Su(phl)9¹

(Lu et al., 1994)

Enhancer of

Statement

Reference

Dsor1[+]/Dsor1^LH110 is an enhancer of visible phenotype of S6kII^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Kim et al., 2006)

NOT Enhancer of

Statement

Reference

Dsor1^LH110 is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

Dsor1^LH110 is a suppressor | partially of increased mortality during development phenotype of CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, Ras85D^{G12D.UAS.p53sh}, Scer\GAL4^Ser.PU, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Dsor1^LH110 is a suppressor | partially of increased size | larval stage phenotype of CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, Ras85D^{G12D.UAS.p53sh}, Scer\GAL4^ptc.PU, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Dsor1[+]/Dsor1^LH110 is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

Dsor1[+]/Dsor1^LH110 is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

NOT Suppressor of

Statement

Reference

Dsor1^LH110 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Dsor1^LH110 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, Tak1^UAS.cTa

(Takatsu et al., 2000)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Dsor1^LH110 has embryonic epidermis | dorsal phenotype, non-suppressible by Jra^Asp.hs.sev

(Hou et al., 1997)

Enhancer of

Statement

Reference

Dsor1[+]/Dsor1^LH110 is an enhancer of ommatidium phenotype of S6kII^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Kim et al., 2006)

Dsor1[+]/Dsor1^LH110 is an enhancer of interommatidial bristle phenotype of S6kII^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Kim et al., 2006)

Dsor1[+]/Dsor1^LH110 is an enhancer of rhabdomere phenotype of S6kII^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Kim et al., 2006)

NOT Enhancer of

Statement

Reference

Dsor1^LH110 is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Dsor1^LH110 is a non-enhancer of mesonotum phenotype of Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

Dsor1^LH110 is a non-enhancer of thorax phenotype of Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

Suppressor of

Statement

Reference

Dsor1^LH110 is a suppressor of wing disc phenotype of CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, Ras85D^{G12D.UAS.p53sh}, Scer\GAL4^ptc.PU, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Dsor1[+]/Dsor1^LH110 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Dsor1[+]/Dsor1^LH110 is a suppressor of ommatidium phenotype of PDZ-GEF^EP388, Scer\GAL4^GMR.PF

(Lee et al., 2002)

Dsor1[+]/Dsor1^LH110 is a suppressor of eye photoreceptor cell | ectopic phenotype of PDZ-GEF^EP388, Scer\GAL4^GMR.PF

(Lee et al., 2002)

Dsor1[+]/Dsor1^LH110 is a suppressor of eye phenotype of PDZ-GEF^EP388, Scer\GAL4^GMR.PF

(Lee et al., 2002)

NOT Suppressor of

Statement

Reference

Dsor1^LH110 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Dsor1^LH110 is a non-suppressor of mesonotum phenotype of Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

Dsor1^LH110 is a non-suppressor of thorax phenotype of Pvr^RNAi.UAS, Scer\GAL4^pnr-MD237

(Ishimaru et al., 2004)

Dsor1^LH110 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, Tak1^UAS.cTa

(Takatsu et al., 2000)

Other

Statement

Reference

Dsor1^LH110, sl¹ has border follicle cell | somatic clone phenotype

(Bianco et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Dsor1^LH110 sl¹ double mutant border cell clusters (induced as clones) initiate migration, but are delayed later in posterior migration and do not show dorsal migration.

(Bianco et al., 2007)

Expression of S6kII^{Scer\UAS.T:Hsap\MYC}, under the control of Scer\GAL4^GMR.PF, causes a more severe roughened-eye phenotype and a greater loss of rhabdomeres when expressed in a Dsor1^LH110/+ background than when expressed in a wild-type background.

(Kim et al., 2006)

When Dsor1^LH110 is added to slik^Scer\UAS.cHa, Scer\GAL4^ptc-559.1 animals the overgrowth phenotype is partially suppressed.

(Hipfner and Cohen, 2003)

The rough eye phenotype, irregular ommatidial array and increased photoreceptor cell number caused by expression of Gef26^EP388 under the control of Scer\GAL4^GMR.PF are strongly suppressed by Dsor1^LH110/+.

(Lee et al., 2002)

The Dsor1^LH110 dorsal open phenotype cannot be rescued by heat induced expression of Jra^Asp.hs.sev.

(Hou et al., 1997)

Su(phl)6, Su(phl)43B, Su(phl)9, Src42A, Su(phl)7 and Su(phl)4 and Dsor1^Su34B are able to rescue the lethality at the restrictive temperature.

(Lu et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dsor1^LH110 is rescued by Dsor1^+t9

(Hsu and Perrimon, 1994)

Comments

Lethality can be rescued by the presence of Dsor1^+t9.

(Hsu and Perrimon, 1994)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5545

y¹ w^* Dsor1^LH110 P{FRT(w^hs)}101/FM7a

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

D-mek^LH110

(Hsu and Perrimon, 1994)

DSor1^LH110

(Wilson et al., 2005)

Dmek^LH10

(Mantrova and Hsu, 1998)

Dsor1^LH110

(Sekiya et al., 2023, Li et al., 2015, Walker et al., 2013, Guichard et al., 2006, Oishi et al., 2006)

Dsor1^lh110

(Gomez et al., 2012)

Dsor^LH110

(Helman et al., 2011, Cinnamon et al., 2008, Bianco et al., 2007)

Sor^LH110

(Kim et al., 2006)

dSor^LH110

(Lee et al., 2002)

dsor^LH110

(Datta et al., 2023)

mek^LH110

(Yang et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (23)

Report Sections

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