FlyBase Allele Report: Dmel\Rac1[V12.hs.sev]

General Information

Symbol

Dmel\Rac1^V12.hs.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0105125

Feature type

allele

Associated gene

Dmel\Rac1

Associated Insertion(s)

Carried in Construct

P{sE-Rac1.V12}

Also Known As

sev-Rac^V12

Key Links

Transgenic product class

missense_variant

(Fanto, 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Fanto, 2000)

Mutagen

in vitro construct

(Fanto, 2000)

Progenitor genotype

Carried in construct

P{sE-Rac1.V12}

Cytology

Description

Construct: Three copies of the sev enhancer and the sev promoter drive expression of activated Rac1.

(Fanto, 2000)

Allele components

Component

Use(s)

Encoded product / tool

Rac1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Fanto et al., 2000)

visible

(Fanto et al., 2000)

Phenotype Manifest In

eye

(Fanto et al., 2000)

ommatidium

(Muñoz-Descalzo et al., 2007, Fanto et al., 2000)

photoreceptor neuron

(Fanto et al., 2000)

Detailed Description

Statement

Reference

Only 34.1% of ommatidia are correctly oriented in flies expressing Rac1^V12.hs.sev.

(Muñoz-Descalzo et al., 2007)

Expression of Rac1^V12.hs.sev results in the misorientation of many ommatidia, with some displaying effects in chirality, such as the adoption of the wrong chiral form or remaining symmetrical. The symmetrical clusters are always of the R3/R3 type. The transgene also interferes with photoreceptor recruitment or differentiation. These phenotypes appear early in development, suggesting they are primary defects.

(Fanto et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Rac1^V12.hs.sev has phenotype, non-enhanceable by ex^e1

(Blaumueller and Mlodzik, 2000)

Suppressed by

Statement

Reference

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Mtl[+]/Mtl^Δ

(Muñoz-Descalzo et al., 2007)

Rac1^V12.hs.sev has eye phenotype, suppressible by Rho1^k07903

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Df(2R)E73

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Jra¹

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Jra³

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Jra^IA109

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Rho1^72R

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Vang^X

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by bsk¹

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by bsk²

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by hep¹

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by hep^r75

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by nmo^E33

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by pk^pk-sple-9

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by aos^rlt

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, suppressible by Rho1^k07903

(Fanto et al., 2000)

NOT suppressed by

Statement

Reference

Rac1^V12.hs.sev has phenotype, non-suppressible by ex^e1

(Blaumueller and Mlodzik, 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by Cdc42³

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by pnt^Δ88

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by rl¹⁰

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by wg^l-17

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by Df(3L)Ar14-8

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by Ras85D^e2F

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by aop^yan-1

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by arm²

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by dsh³

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by fz¹

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by pan¹³

(Fanto et al., 2000)

Rac1^V12.hs.sev has ommatidium phenotype, non-suppressible by Raf⁷

(Fanto et al., 2000)

NOT Enhancer of

Statement

Reference

Rac1^V12.hs.sev is a non-enhancer of phenotype of ex^e1

(Blaumueller and Mlodzik, 2000)

NOT Suppressor of

Statement

Reference

Rac1^V12.hs.sev is a non-suppressor of phenotype of ex^e1

(Blaumueller and Mlodzik, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Rho1^k07903 to Rac1^N17.Scer\UAS,Scer\GAL4^hs.2sev flies significantly suppresses the eye phenotype.

(Fanto et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rac1^V12.hs.sev

Rac^V14

(Kockel et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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