FlyBase Allele Report: Dmel\Uvrag[KG04163]

General Information

Symbol

Dmel\Uvrag^KG04163

Species

D. melanogaster

Name

FlyBase ID

FBal0131449

Feature type

allele

Associated gene

Dmel\Uvrag

Associated Insertion(s)

P{SUPor-P}Uvrag^KG04163

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lee et al., 2011)

hypomorphic allele - molecular evidence

(Lee et al., 2011)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Uvrag^KG04163

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:13,286,886..13,286,886 [+]

(Lee et al., 2011, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Lee et al., 2011)

Phenotype Manifest In

male genitalia

(Lee et al., 2011)

male genitalia (with Uvrag^B7)

(Lee et al., 2011)

male genitalia (with Uvrag^B21)

(Lee et al., 2011)

Detailed Description

Statement

Reference

~50% of homozygous males show incomplete genitalia rotation, though the direction of rotation is wild type. The spermiduct does not coil around the gut in these mutants, as it does in wild type.

~75% of Uvrag^KG04163/Uvrag^B7 or Uvrag^KG04163/Uvrag^B21 males show incomplete genitalia rotation, though the direction of rotation is wild type.

(Lee et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Uvrag^KG04163/Uvrag^B21 has male genitalia phenotype, enhanceable by Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

Suppressed by

Statement

Reference

Uvrag^KG04163/Uvrag^B21 has male genitalia phenotype, suppressible | partially by Scer\GAL4^Abd-B-LDN/N^RNAi.P.UAS

(Lee et al., 2011)

Uvrag^KG04163/Uvrag^B21 has male genitalia phenotype, suppressible | partially by mam^N.UAS/Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

NOT suppressed by

Statement

Reference

Uvrag^KG04163/Uvrag^B21 has male genitalia phenotype, non-suppressible by Egfr^GD1654/Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

Uvrag^KG04163/Uvrag^B21 has male genitalia phenotype, non-suppressible by Pvr^RNAi.UAS.cRa/Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

Uvrag^KG04163/Uvrag^B21 has male genitalia phenotype, non-suppressible by ptc^NIG.2411R/Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

Uvrag^KG04163/Uvrag^B21 has male genitalia phenotype, non-suppressible by N^ECN.UAS/Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of Scer\GAL4^Abd-B-LDN enhances the Uvrag^KG04163/Uvrag^B21 male genital rotation phenotype, though the reason for this is unknown.

Expression of N^{dsRNA.P.Scer\UAS} or mam^N.Scer\UAS using Scer\GAL4^Abd-B-LDN partially rescues the genital rotation defect in Uvrag^KG04163/Uvrag^B21 males.

(Lee et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Uvrag^KG04163/Uvrag^B21 is rescued by Uvrag^UAS.Tag:FLAG/Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

Uvrag^KG04163/Uvrag^B21 is rescued by Scer\GAL4^hs.PU/Uvrag^UAS.Tag:FLAG

(Lee et al., 2011)

Not rescued by

Uvrag^KG04163/Uvrag^B21 is not rescued by Scer\GAL4^elav.PU/Uvrag^UAS.Tag:FLAG

(Lee et al., 2011)

Uvrag^KG04163/Uvrag^B21 is not rescued by Scer\GAL4^Lsp2.PH/Uvrag^UAS.Tag:FLAG

(Lee et al., 2011)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

13360

y¹ w^67c23; P{SUPor-P}Uvrag^KG04163

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG6116^KG04163

KG04163

(Lee et al., 2011)

UVRAG^KG

(Lee et al., 2011)

Uvrag^KG04163

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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