FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\egrRNAi.UAS
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General Information
Symbol
Dmel\egrRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0147162
Feature type
allele
Associated gene
Dmel\egr
Associated Insertion(s)
Carried in Construct
P{UAS-eiger.RNAi}
Also Known As
UAS-eiger-RNAi, UAS-Eiger-IR, UAS-eigerRNAi, UAS-egrRNAi, UAS-eigerIR
Key Links
Transgenic product class
RNAi_reagent
(Igaki et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Igaki et al., 2002)
Mutagen
in vitro construct
(Igaki et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-eiger.RNAi}
Cytology
Description

UASt sequences drive expression of a head to head inverted repeat of the egr coding sequence.

(Igaki et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
egr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  carcinoma
      modeled by ph-d505, ph-p505
      (Beira et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of egrdsRNA.UAS under the control of Scer\GAL4sv.PJ leads to accumulation of lipid droplets in retinas of 1-day-old flies when compared to controls.

      (Muliyil et al., 2020)

      Knocking down egr through expression of egrdsRNA.Scer\UAS under the control of Scer\GAL4GMR.PF rescues the cell death found after H[[2]]O[[2]] application on larval eye discs.

      (Yang et al., 2013)

      Knockdown of egr in the fat body (through expression of egrdsRNA.Scer\UAS under the control of Scer\GAL4Lsp2.PH) significantly increases survival time during an Salmonella typhimurium infection. However, bacterial loads over this time remain unchanged, indicating that the extended survival is due to tolerance rather than resistance.

      Knockdown of egr in hemocytes (through expression of egrdsRNA.Scer\UAS under the control of Scer\GAL4Hml.PG) does not affect fly survival when infected by Salmonella typhimurium.

      Knockdown of egr in the fat body or hemocytes (through expression of egrdsRNA.Scer\UAS under the control of Scer\GAL4Lsp2.PH or Scer\GAL4Hml.PG) reduces melanization after Salmonella typhimurium infection.

      Knockdown of egr in the fat body or hemocytes of Salmonella typhimurium infected flies(through expression of egrdsRNA.Scer\UAS under the control of Scer\GAL4Lsp2.PH or Scer\GAL4Hml.PG) reduces feeding rates compared to infected wild-type flies. This change in feeding rate may be responsible for some aspects of the egr phenotype, although it must be noted that even in the absence of infection, egr knockdown flies consume less food.

      (Mabery and Schneider, 2010)

      Expression of egrGS9830 under the control of Scer\GAL4GMR.PF results in ablation of the adult eye. Co-expression of egrIR.Scer\UAS under the control of Scer\GAL4GMR.PF suppresses this phenotype.

      (Polaski et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of egrdsRNA.Scer\UAS suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

      (Chabu and Xu, 2014)

      Expression of egrdsRNA.Scer\UAS under the control of Scer\GAL4egr-GAL4 partially suppresses the NMJ degeneration seen in Ank2f02001 mutant third instar larvae.

      (Keller et al., 2011)

      Expression of egrIR.Scer\UAS under the control of Scer\GAL4Act.PU only within scrib1 clones in the eye-antennal disc results in 30.7% pupal lethality, while expression of egrIR.Scer\UAS under the control of Scer\GAL4Act.PU both within scrib1 clones in the eye-imaginal disc and in the surrounding wild-type cells results in 51.3% pupal lethality.

      (Ohsawa et al., 2011)

      The eye phenotype in Ras85DKP mutant flies is partially suppressed by ectopic expression of egrIR.Scer\UAS in the eye under the control of Scer\GAL4GMR.PF.

      (Wu et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference

      Knocking down egr in necrotic neurons in Scer\GAL4hs.2sev->Mmus\Gria1Lc.Scer\UAS/egrdsRNA.Scer\UAS flies rescues the eye size defect in Mmus\Gria1Lc.Scer\UAS-expressing flies without affecting the primary necrosis.

      (Yang et al., 2013)

      Co-expression of egrdsRNA.Scer\UAS does not suppress the wing defects caused by expression of HIV-1\VpuScer\UAS.cLa under the control of Scer\GAL4dpp.blk1.

      (Marchal et al., 2012)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      egrIR.Scer\UAS
      egrRNAi.UAS
      egrdsRNA.Scer\UAS
      egrdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (24)