FlyBase Allele Report: Dmel\ninaE[G69D.UAS]

General Information

Symbol

Dmel\ninaE^G69D.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0230353

Feature type

allele

Associated gene

Dmel\ninaE

Associated Insertion(s)

Carried in Construct

P{UAS-ninaE.G69D}

Also Known As

uas-Rh1^G69D, UAS-Rh-1^G69D, UAS-Rh1G69D

Key Links

Transgenic product class

missense_variant

(Ryoo et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Ryoo et al., 2007)

Mutagen

in vitro construct

(Ryoo et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-ninaE.G69D}

Cytology

Description

Amino acid replacement: G69D.

(Ryoo et al., 2007)

UASt regulatory sequences drive expression of the ninaE product with a transmembrane glycine substituted to an aspartic acid residue (G69D).

(Ryoo et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ninaE

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of retinitis pigmentosa

CEA

(Kang et al., 2017, Chow et al., 2016)

model of retinal disease

CEA

(Kang et al., 2012)

model of retinitis pigmentosa 4

CEA

(Guo et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of retinitis pigmentosa

is exacerbated by Gcn2^KK103566

(Kang et al., 2017)

is exacerbated by Prosap^KK101537

(Chow et al., 2016)

is exacerbated by Vajk2^KK112024

(Chow et al., 2016)

is exacerbated by hppy^KK101460

(Chow et al., 2016)

is ameliorated by Cdk5^KK109344

(Chow et al., 2016)

is ameliorated by Adgf-D^KK104007

(Chow et al., 2016)

is ameliorated by CG31468^KK110989

(Chow et al., 2016)

is exacerbated by fred^KK103938

(Chow et al., 2016)

is exacerbated by lola^KK110256

(Chow et al., 2016)

is exacerbated by BBS9^KK102315

(Chow et al., 2016)

is exacerbated by CG2004^GD9700

(Chow et al., 2016)

model of retinal disease

is ameliorated by Cdk5^GD13840

(Kang et al., 2012)

is ameliorated by Diap1^EY00710

(Kang et al., 2012)

is exacerbated by Mekk1^EY02276

(Kang et al., 2012)

is ameliorated by Mekk1^Ur36

(Kang et al., 2012)

is ameliorated by sip3^EY11980

(Kang et al., 2012)

model of retinitis pigmentosa 4

is ameliorated by Catsup^UAS.Tag:V5

(Guo et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PF

(Chow et al., 2016)

abnormal size | adult stage, with Scer\GAL4^GMR.PF

(Chow et al., 2016)

decreased size | adult stage, with Scer\GAL4^Bx-MS1096-KE

(Palu et al., 2020)

decreased size | adult stage, with Scer\GAL4^GMR.PF

(Palu et al., 2020)

increased cell death, with Scer\GAL4^GMR.PF

(Kang et al., 2012)

increased cell death | larval stage, with Scer\GAL4^GMR.PF

(Palu et al., 2020)

visible, with Scer\GAL4^GMR.PF

(Kang et al., 2012)

visible | adult stage, with Scer\GAL4^Bx-MS1096-KE

(Palu et al., 2020)

visible | adult stage, with Scer\GAL4^GMR.PF

(Palu et al., 2020, Chow et al., 2016)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Palu et al., 2020, Chow et al., 2016, Kang et al., 2012)

eye disc, with Scer\GAL4^GMR.PF

(Palu et al., 2020, Kang et al., 2012)

ommatidium, with Scer\GAL4^GMR.PF

(Kang et al., 2012)

retina | adult stage | progressive, with Scer\GAL4^GMR.PU, Scer\GAL4^ninaE.PU

(Kang et al., 2017)

wing, with Scer\GAL4^Bx-MS1096-KE

(Palu et al., 2020)

Detailed Description

Statement

Reference

Expression of ninaE^G69D.UAS under the control of Scer\GAL4^GMR.PF leads to retinal degeneration (monitored using eye size) and ER stress in the eye. It also leads to increased apoptosis in eye discs.

Expression of ninaE^G69D.UAS under the control of Scer\GAL4^Bx-MS1096-KE leads to ER stress and apoptosis, resulting in a small, degenerate wing that fails to unfold upon eclosion.

(Palu et al., 2020)

Expression of ninaE^{G69D.Scer\UAS} under the combined control of Scer\GAL4^ninaE.PU and Scer\GAL4^GMR.PU leads to age-progressive retinal degeneration in adult flies, the phenotype is milder in flies kept on a low-protein diet.

(Kang et al., 2017)

Expression of ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in significantly reduced adult eye size and decreased eye pigmentation.

(Chow et al., 2016)

Projection neurons expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GH146 do not show defects in targeting.

(Sekine et al., 2013)

Flies expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF have small eyes, and the surviving eye tissue has a glassy surface which is devoid of ommatidial structures. Larval eye discs show a massive amount of apoptosis in these animals.

(Kang et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, enhanceable by lola^KK110256/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, enhanceable by lola^KK110256/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, enhanceable by BBS9^KK102315, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, enhanceable by BBS9^KK102315, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, enhanceable by Prosap^KK101537, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, enhanceable by Prosap^KK101537, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, enhanceable by Vajk2^KK112024/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, enhanceable by Vajk2^KK112024/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, enhanceable by hppy^KK101460/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, enhanceable by CG2004^GD9700, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, enhanceable by CG2004^GD9700, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, enhanceable by fred^KK103938/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, enhanceable by fred^KK103938/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has increased cell death phenotype, enhanceable by Ire1^f02170

(Kang et al., 2012)

NOT Enhanced by

Statement

Reference

Cdk5^KK109344, Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-enhanceable by superdeath^HMS02640, Scer\GAL4^GMR.PF

(Palu et al., 2020)

Cdk5^KK109344, Scer\GAL4^GMR.PF, ninaE^G69D.UAS has decreased size | adult stage phenotype, non-enhanceable by superdeath^HMS02640, Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-enhanceable by hppy^KK101460/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-enhanceable by hppy^KK101460/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-enhanceable by Pde1c^KK107045, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-enhanceable by Pde1c^KK107045, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-enhanceable by CG43795^KK115544, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-enhanceable by CG43795^KK115544, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-enhanceable by Nop53^KK102592, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-enhanceable by Nop53^KK102592, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096-KE, ninaE^G69D.UAS has visible | adult stage phenotype, suppressible | partially by superdeath^HMS02640/Scer\GAL4^Bx-MS1096-KE

(Palu et al., 2020)

Scer\GAL4^Bx-MS1096-KE, ninaE^G69D.UAS has decreased size | adult stage phenotype, suppressible | partially by superdeath^HMS02640/Scer\GAL4^Bx-MS1096-KE

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, suppressible by superdeath^HMS02640/Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, suppressible by superdeath^GL00424/Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, suppressible by Scer\GAL4^GMR.PF/superdeath^KK101798

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has increased cell death | larval stage phenotype, suppressible by superdeath^HMS02640/Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has decreased size | adult stage phenotype, suppressible by superdeath^HMS02640/Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, suppressible by Adgf-D^KK104007, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, suppressible by Adgf-D^KK104007, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, suppressible by CG31468^KK110989, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, suppressible by CG31468^KK110989, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible phenotype, suppressible by Cdk5^GD13840, Scer\GAL4^GMR.PF

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has increased cell death phenotype, suppressible by Cdk5^GD13840, Scer\GAL4^GMR.PF

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has increased cell death phenotype, suppressible by Cdk5α^20C/Df(2L)p35-C2

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has increased cell death phenotype, suppressible by Mekk1^Ur36/Mekk1^Ur36

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible phenotype, suppressible by Mekk1^Ur36/Mekk1^Ur36

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has increased cell death phenotype, suppressible by Df(2L)flp170B/Df(2L)flp170B

(Kang et al., 2012)

NOT suppressed by

Statement

Reference

Cdk5^KK109344, Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-suppressible by superdeath^HMS02640, Scer\GAL4^GMR.PF

(Palu et al., 2020)

Cdk5^KK109344, Scer\GAL4^GMR.PF, ninaE^G69D.UAS has decreased size | adult stage phenotype, non-suppressible by superdeath^HMS02640, Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-suppressible by CG43795^KK115544, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-suppressible by Nop53^KK102592, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-suppressible by Nop53^KK102592, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-suppressible by hppy^KK101460/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-suppressible by hppy^KK101460/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-suppressible by Pde1c^KK107045, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has abnormal size | adult stage phenotype, non-suppressible by Pde1c^KK107045, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has visible | adult stage phenotype, non-suppressible by CG43795^KK115544, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has increased cell death phenotype, non-suppressible by crc¹/crc^R6

(Kang et al., 2012)

Enhancer of

Statement

Reference

ninaE^G69D.UAS/Scer\GAL4^GH146 is an enhancer of abnormal neuroanatomy | adult stage | somatic clone phenotype of meigo¹

(Sekine et al., 2013)

Other

Statement

Reference

Scer\GAL4^GMR.PF, hppy^KK101460, ninaE^G69D.UAS has melanotic necrosis | adult stage phenotype

(Chow et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Scer\GAL4^ninaE.PU, ninaE^G69D.UAS has retina | adult stage | progressive phenotype, enhanceable by Gcn2^KK103566, Scer\GAL4^GMR.PU, Scer\GAL4^ninaE.PU

(Kang et al., 2017)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, enhanceable by lola^KK110256/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, enhanceable by BBS9^KK102315, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, enhanceable by Prosap^KK101537, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, enhanceable by Vajk2^KK112024/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, enhanceable by CG2004^GD9700, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, enhanceable by fred^KK103938/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye disc phenotype, enhanceable by Ire1^f02170

(Kang et al., 2012)

NOT Enhanced by

Statement

Reference

Cdk5^KK109344, Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-enhanceable by superdeath^HMS02640, Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-enhanceable by hppy^KK101460/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-enhanceable by Pde1c^KK107045, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-enhanceable by CG43795^KK115544, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-enhanceable by Nop53^KK102592, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096-KE, ninaE^G69D.UAS has wing phenotype, suppressible | partially by superdeath^HMS02640/Scer\GAL4^Bx-MS1096-KE

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, suppressible by superdeath^HMS02640/Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, suppressible by Scer\GAL4^GMR.PF/superdeath^KK101798

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, suppressible by superdeath^GL00424/Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye disc phenotype, suppressible by superdeath^HMS02640/Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, suppressible by Adgf-D^KK104007, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, suppressible by CG31468^KK110989, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, suppressible by Cdk5^GD13840, Scer\GAL4^GMR.PF

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye disc phenotype, suppressible by Cdk5^GD13840, Scer\GAL4^GMR.PF

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye disc phenotype, suppressible by Cdk5α^20C/Df(2L)p35-C2

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, suppressible by Mekk1^Ur36/Mekk1^Ur36

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye disc phenotype, suppressible by Mekk1^Ur36/Mekk1^Ur36

(Kang et al., 2012)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye disc phenotype, suppressible by Df(2L)flp170B/Df(2L)flp170B

(Kang et al., 2012)

NOT suppressed by

Statement

Reference

Cdk5^KK109344, Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-suppressible by superdeath^HMS02640, Scer\GAL4^GMR.PF

(Palu et al., 2020)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-suppressible by hppy^KK101460/Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-suppressible by Pde1c^KK107045, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-suppressible by CG43795^KK115544, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye phenotype, non-suppressible by Nop53^KK102592, Scer\GAL4^GMR.PF

(Chow et al., 2016)

Scer\GAL4^GMR.PF, ninaE^G69D.UAS has eye disc phenotype, non-suppressible by crc¹/crc^R6

(Kang et al., 2012)

Enhancer of

Statement

Reference

ninaE^G69D.UAS/Scer\GAL4^GH146 is an enhancer of adult antennal lobe projection neuron | somatic clone phenotype of meigo¹

(Sekine et al., 2013)

Other

Statement

Reference

Scer\GAL4^GMR.PF, hppy^KK101460, ninaE^G69D.UAS has eye phenotype

(Chow et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The age-progressive retinal degeneration characteristic for adult flies expressing ninaE^{G69D.Scer\UAS} under the combined control of Scer\GAL4^ninaE.PU and Scer\GAL4^GMR.PU is further worsened by co-expression of Gcn2^KK103566 and unlike in the flies expressing only ninaE^{G69D.Scer\UAS}, the phenotype cannot be ameliorated by keeping the flies on a low-protein diet.

(Kang et al., 2017)

The small eye phenotype characteristic for adult flies expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced further by co-expression of any of the following: CG2004^GD9700, fred^KK103938, lola^KK110256, CG15666^KK102315, Prosap^KK101537, CG16885^KK112024; not changed by co-expression of any one of these: hppy^KK101460, Pde1c^KK107045, CG43795^KK115544, CG1785^KK102592, Cdk5^KK109344 and partially suppressed by co-expression of either Adgf-D^KK104007 or CG31468^KK110989. Co-expression of either Cdk5^KK109344 or hppy^KK101460 however have a reproducible qualitative effect on the ninaE^{G69D.Scer\UAS} RNAi-induced eye phenotype: co-expression of Cdk5^KK109344 improves the pigmentation defect, while hppy^KK101460 expression results in the appearance of black necrotic spots.

(Chow et al., 2016)

Expression of ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GH146 enhances the targeting defects seen in homozygous meigo¹ projection neuron clones.

(Sekine et al., 2013)

The eye defects caused by expression of ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF are strongly suppressed by co-expression of Cdk5^GD13840. The massive apoptosis seen in the larval eye discs of animals expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of Cdk5^GD13840.

The massive apoptosis seen in the larval eye discs of animals expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by Cdk5α^20C/Df(2L)p35-C2 but is not suppressed by crc^R6/crc¹.

The apoptosis seen in the larval eye discs of animals expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by Ire1^f02170.

Mekk1^Ur36/Mekk1^Ur36 partially suppresses the eye defects caused by expression of ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF. The massive apoptosis seen in the larval eye discs of animals expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by Mekk1^Ur36/Mekk1^Ur36.

The number of apoptotic cells is reduced in homozygous Df(2L)flp170B clones in eye discs expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Kang et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

605379

w^*; P{UAS-ninaE.G69D}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rh-1^G69D

(Sekine et al., 2013)

ninaE^{G69D.Scer\UAS}

ninaE^G69D.UAS

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

Open Close