ade2, adenosine 2
Gene model reviewed during 5.55
Gene model reviewed during 5.51
Gene model reviewed during 5.56
4.8 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pfas using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pfas in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Pfas ade2
Renamed from 'ade2' to 'Pfas' (in FB2018_01) to provide more informative nomenclature, consistent with the clear vertebrate ortholog (and replace existing nomenclature suggesting incorrect relationships to yeast orthologs).
ade2 has been cloned and its primary product may be a formylglycineamide ribotide amidotransferase (FGARAT: EC 184.108.40.206).
Structural gene for phosphoribosylformylglycinamidine synthase, an enzyme in the pathway of purine biosynthesis.
Purine nucleoside auxotroph supplementable with adenine, adenosine and inosine. Eye color reddish-brown similar to rosy. Lacks detectable levels of the fourth purine de novo synthetic-pathway enzyme, formylglycineamide ribotide amidotransferase (FGARAT: EC 220.127.116.11). Homozygotes and heteroallelic combinations of many alleles have defective wings; the defects include reduced wing size, deranged posterior wing margins and extra wing veins. Macrochaetae are somewhat thinner than normal and reduced in length. ade25, ade26 and ade27 are sterile, perhaps owing to general debility, when homozygous or in heteroallelic combination with one another. Only ade27 was not tested owing to a linked lethal. Most homozygotes and heteroallelic heterozygotes display reduced viability, with the appearance of pharate adults unable to eclose.