FB2026_02 , released June 18, 2026
Gene: Dmel\Hex-C
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General Information
Symbol
Dmel\Hex-C
Species
D. melanogaster
Name
Hexokinase C
Annotation Symbol
CG8094
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001187
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
hexokinase (2.7.1.1)
glucokinase (2.7.1.2)
fructokinase (2.7.1.4)
mannokinase (2.7.1.7)
glucosamine kinase (2.7.1.8)
Gene Summary
Hexokinase C (Hex-C) encodes an enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexoses D-glucose, D-fructose and D-mannose to D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively. It mediates the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate. [Date last reviewed: 2024-09-19] (FlyBase Gene Snapshot)
All Summaries
Also Known As

HEX, HexC, hexokinase, HK, HK-C

Key Links
Genomic Location
Cytogenetic map
51E7-51E7
Sequence location
Recombination map
2-74
RefSeq locus
NT_033778 REGION:15218837..15220329
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables fructokinase activity
inferred from direct assay
(Moser et al., 1980)
enables glucokinase activity
inferred from direct assay
(Moser et al., 1980)
enables glucosamine kinase activity
inferred from direct assay
(Moser et al., 1980)
enables hexokinase activity
inferred from mutant phenotype
(Talbert et al., 2015)
enables mannokinase activity
inferred from direct assay
(Moser et al., 1980)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR001312, InterPro:IPR022672, InterPro:IPR022673
(InterPro Project Members, 2004-)
enables D-glucose binding
inferred from electronic annotation with InterPro:IPR001312
(InterPro Project Members, 2004-)
enables hexokinase activity
inferred from electronic annotation with InterPro:IPR001312
(InterPro Project Members, 2004-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in glucose 6-phosphate metabolic process
inferred from direct assay
(Moser et al., 1980)
involved_in glucose catabolic process
inferred from mutant phenotype
(Mascolo et al., 2021, Barry and Thummel, 2016)
involved_in glucose homeostasis
inferred from mutant phenotype
(Ugrankar et al., 2015)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in canonical glycolysis
inferred from sequence or structural similarity with UniProtKB:Q9W330
(Gene Ontology Curators, 2002-)
involved_in carbohydrate metabolic process
inferred from electronic annotation with InterPro:IPR001312, InterPro:IPR022672, InterPro:IPR022673
(InterPro Project Members, 2004-)
involved_in glucose 6-phosphate metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(GO Reference Genome Project, 2011-)
involved_in glucose metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN004516717
(GO Reference Genome Project, 2011-)
involved_in glycolytic process
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(GO Reference Genome Project, 2011-)
involved_in intracellular glucose homeostasis
inferred from electronic annotation with InterPro:IPR001312
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(GO Reference Genome Project, 2011-)
located_in cytosol
inferred from sequence or structural similarity with UniProtKB:P04807
(Gene Ontology Curators, 2002-)
located_in mitochondrial outer membrane
inferred from sequence or structural similarity with UniProtKB:P52789
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
hexokinase activity
a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+) (2.7.1.1)
RHEA 22740: mannokinase activity
D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+) (2.7.1.7)
RHEA 11028: glucosamine kinase activity
D-glucosamine + ATP = D-glucosamine 6-phosphate + ADP + H(+) (2.7.1.8)
RHEA 10948: fructokinase activity
D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+) (2.7.1.4)
RHEA 16125: glucokinase activity
D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+) (2.7.1.2)
RHEA 17825:
Summaries
Gene Snapshot
Hexokinase C (Hex-C) encodes an enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexoses D-glucose, D-fructose and D-mannose to D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively. It mediates the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate. [Date last reviewed: 2024-09-19]
Gene Group (FlyBase)
CARBOHYDRATE KINASES -
Carbohydrate kinases catalyze the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule.
Pathway (FlyBase)
GLYCOLYSIS -
Glycolysis converts glucose into ATP and pyruvate in the cytosol. The overall reaction is glucose + 2 ADP + 2Pi + 2 NAD+ -> 2 pyruvate + 2 ATP + 2 NADH 2H+ + 2 H2O and involves 10 enzymatic steps. In the presence of oxygen, pyruvate is transported into the mitochondrion where, after oxidation into acetyl-CoA, it enters the tricarboxylic acid cycle (TCA cycle). In anaerobic conditions, pyruvate is reduced to lactate in the cytosol. Although glucose, trehalose and glycogen are the main entry points for glycolysis in D. melanogaster, fructose, galactose, mannose and glycerol can also enter the glycolytic pathway to be converted into pyruvate. (Adapted from PMID:33941515 and FBrf0144936.)
GDP-MANNOSE BIOSYNTHESIS -
The nucleotide-sugar GDP-D-mannose is primarily synthesized in the cytosol from D-glucose (though it can also be produced from D-mannose). GDP-D-mannose is a precursor for GDP-L-fucose biosynthesis and dolichyl β-D-mannosyl phosphate and it is directly involved in protein glycosylation. (Adapted from PMID:24931670.)
UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS -
The synthesis of the nucleotide-sugar UDP-N-acetylglucosamine (UDP-GlcNAc) can occur via de novo or salvage pathways in the cytosol. In the de novo pathway, which is the main one, D-glucose, L-glutamine, acetyl-CoA and UTP are used to produce UDP-GlcNAc. In the salvage pathway glucosamine and N-acetylglucosamine acquired from environmental sources or from the degradation of glycoconjugates can be used to produce UDP-GlcNAc. UDP-GlcNAc is a precursor for protein glycosylation and the biosynthesis of chitin, peptidoglycans and GPI-anchors. (Adapted from PMID:37107691.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Hex-C
The structural gene for hexokinase-C [HEX-C (EC 2.7.1.1)]. The enzyme is a monomer of estimated molecular weight 42,000 _ 3,000 (Moser et al.) or 35,000 (Leigh Brown in Racine, Langley, and Voelker, 1980, Environ. Mutagen. 2: 167-77). Activity present in all developmental stages except freshly laid eggs; restricted to fat body in larvae, but present in many organs in adult. Weakly active or inactive in cell line (Deber, 1974, Wilhelm Roux's Arch. Entwicklungsmech. Org. 174: 1-9). HEX-C activity not necessary for survival; null mutants viable (Burkhart, Montgomery, Langley and Voelker, 1984, Genetics 107: 295-306). Purification and biochemical characterization of enzyme described by Moser et al..
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Hex-C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7JYW9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hex-C-RA
FBtr0087399
NM_079935
1493
454
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Hex-C-PA
FBpp0086530
50.7
454
6.51
Q7JYW9
NP_524674
AAF58160
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hex-C using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
border follicle cell
(Borghese et al., 2006)
Additional Descriptive Data

Hex-C is enriched in border follicle cells relative to follicle cells.

(Borghese et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Hex-C in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hex-C
Transgenic constructs containing regulatory region of Hex-C
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel7135
(Ryder, 2004.4.26)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\GCK
12 of 14
Yes
Yes
Hsap\HK1
11 of 14
No
Yes
1  
Hsap\HK2
10 of 14
No
Yes
Hsap\HK3
10 of 14
No
Yes
1  
Hsap\HKDC1
10 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Gck
11 of 14
Yes
Yes
Rnor\Hk2
10 of 14
No
Yes
Rnor\Hk1
9 of 14
No
Yes
Rnor\Hk3
9 of 14
No
Yes
Rnor\Hkdc1
7 of 14
No
Yes
Mus musculus (laboratory mouse) (5)
Mmus\Gck
12 of 14
Yes
Yes
Mmus\Hk1
11 of 14
No
Yes
Mmus\Hkdc1
10 of 14
No
Yes
Mmus\Hk2
9 of 14
No
Yes
Mmus\Hk3
9 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (12)
Xtro\hk1
7 of 13
Yes
Yes
Xtro\gck
6 of 13
No
Yes
Xtro\hk2
6 of 13
No
Yes
Xtro\hkdc1
6 of 13
No
Yes
Xtro\drd2
5 of 13
No
Yes
Xtro\LOC100493823
5 of 13
No
Yes
Xtro\LOC100492955
4 of 13
No
Yes
Xtro\LOC105946413
2 of 13
No
Yes
Xtro\gsx2
1 of 13
No
No
Xtro\LOC100486739
1 of 13
No
Yes
Xtro\psmb5
1 of 13
No
No
Xtro\smpd3
1 of 13
No
Yes
Danio rerio (Zebrafish) (4)
Drer\gck
12 of 14
Yes
Yes
Drer\hk1
11 of 14
No
Yes
Drer\hkdc1
10 of 14
No
Yes
Drer\hk2
9 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\hxk-1
11 of 14
Yes
No
Cele\hxk-2
8 of 14
No
Yes
Cele\hxk-3
5 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP011208
6 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (7)
Atha\HXK1
13 of 13
Yes
Yes
Atha\HXK2
13 of 13
Yes
Yes
Atha\HXK3
12 of 13
No
Yes
Atha\HKL3
11 of 13
No
Yes
Atha\ATHXK4
10 of 13
No
Yes
Atha\HKL1
10 of 13
No
Yes
Atha\AT1G47845
4 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\HXK1
12 of 13
Yes
No
Scer\HXK2
12 of 13
Yes
No
Scer\EMI2
7 of 13
No
No
Scer\GLK1
7 of 13
No
No
Scer\YLR446W
4 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\hxk1
12 of 12
Yes
Yes
Spom\hxk2
7 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Hex-C. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
Hex-A
12 of 13
Hex-T
12 of 13
Hexl
10 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Hex-CGD12378
model of  glucose metabolism disease
CEA
(Mascolo et al., 2021)
Potential Models Based on Orthology ( 8 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
GCK; glucokinase
12 of 14
138079
HK1; hexokinase 1
11 of 14
142600
 
HK2; hexokinase 2
10 of 14
601125
      HK3; hexokinase 3
      10 of 14
      142570
           
          HKDC1; hexokinase domain containing 1
          10 of 14
          617221
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          IA-2
          suppressible
          Hex-C
          (Kim et al., 2008)
          ND-20L|ND-20
          suppressible
          Hex-A|Hex-C
          (Mallik et al., 2025)
          ND-20L|ND-20
          suppressible
          Hex-C
          (Mallik et al., 2025)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-74
          Cytogenetic map
          51E7-51E7
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          51E7-51E7
          Limits computationally determined from genome sequence between P{PZ}chn02064 and P{PZ}scb01288
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          51B-52E
          (Lee, 2000.2.18, Burkhart et al., 1984)
          Experimentally Determined Recombination Data
          Location

          2-74

          (FlyBase, 2016)

          2-77.8

          (Comeron et al., 2012)

          2-75.0

          (Clark et al., 1995)

          2-75.4

          (Harada et al., 1993)

          1-

          (Choudhary et al., 1992)

          2-74.5 +/- 0.003

          (Mukai and Voelker, 1977)
          Left of (cM)
          Right of (cM)
          (Mukai and Voelker, 1977)
          Notes
          Stocks and Reagents
          Stocks (11)
          Genomic Clones (14)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (53)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Kim et al., 2008)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              The effects of a high sucrose diet on live weight, total protein, stored lipid and glycogen and crude activities of 12 enzymes involved in energy metabolism are quantified. The activities of many enzymes are reduced by the sucrose treatment.

              (Wang and Clark, 1995)

              The isoacceptor pattern of tRNA:E4 is altered in l(2)me1 mutant flies, supporting the hypothesis that the l(2)me1 mutation may be a deletion of part of the tRNA:E4 cistrons (and Hex-C) located at 2-72.

              (Kubli, 1978)

              No linkage disequilibrium has been detected between Gpdh, Mdh1, Adh, Hex-C, Est-C or Fdh. Significant linkage disequilibrium has been detected between In(2L)NS and Hex-C.

              (Mukai and Voelker, 1977)

              The structural gene for hexokinase-C (HEX-C). The enzyme is a monomer of estimated molecular weight 42,000 +/- 3,000 (Moser et al.) or 35,000 (Leigh Brown in Racine, Langley and Voelker, 1980). Activity present in all developmental stages except freshly laid eggs; restricted to fat body in larvae, but present in many organs in adult. Weakly active or inactive in cell line (Debec, 1974). HEX-C activity not necessary for survival; null mutants viable (Burkhart et al., 1984). Purification and biochemical characterization of enzyme described by Moser et al., 1980.

              Relationship to Other Genes
              Source for database merge of

              Source for merge of: Hex-C CG8094

              (FlyBase, 1996-)
              Additional comments

              Source for merge of Hex-C CG8094 was sequence comparison ( date:000915 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (25)
              Reported As
              Symbol Synonym
              CG8094
              (Yurgel et al., 2019, Çiçek et al., 2016, Vartiainen et al., 2014, Ni et al., 2010.12.1, Mummery-Widmer et al., 2009, Coulier et al., 2000)
              CT22069
              (Ceriani et al., 2002)
              DM2
              (Jayakumar et al., 2001)
              Fk
              HEX
              (Harshman et al., 1999, Clark and Fucito, 1998, Clark and Wang, 1997, Wang and Clark, 1995, Clark, 1994, Clark and Wang, 1994, Clark, 1990, Clark et al., 1990)
              HEX-3
              (Choudhary et al., 1992)
              HEX-C
              (Yi et al., 2025, Gubina et al., 2019, Flowers et al., 2007, Eanes, 1994)
              HK
              (Léger et al., 2024, Montooth et al., 2003, Burnell et al., 1991)
              HK-C
              (de la Cova et al., 2014, Parisi et al., 2013)
              Hex
              (Ugrankar et al., 2018, Ugrankar et al., 2015, Kim et al., 2008, Kasinskaya et al., 1992, Marinkovic et al., 1992)
              Hex-3
              Hex-C
              (Bevinakoppamath et al., 2026, He et al., 2025, Yang et al., 2025, Zaru and Marygold, 2025, Bamgbose and Tulin, 2024, Huang et al., 2024, Li et al., 2024, Liu et al., 2023, Deshpande et al., 2022, Ding et al., 2022, Hunt and Demontis, 2022, Karki et al., 2022, Zhu et al., 2022, Blatt et al., 2021, Liguori et al., 2021, Mascolo et al., 2021, Zarubin et al., 2021, Zhang et al., 2021, Parkhitko et al., 2020, Oh et al., 2019, Wong et al., 2019, Yurgel et al., 2019, Gene Disruption Project members, 2018-, Troha et al., 2018, Ugrankar et al., 2018, Bussmann and Storkebaum, 2017, Matsuoka et al., 2017, Transgenic RNAi Project members, 2017-, Cogni et al., 2015, Dus et al., 2015, Kwon et al., 2015, Talbert et al., 2015, Barrio et al., 2014, Lavington et al., 2014, Vartiainen et al., 2014, Clark et al., 2013, Wilson et al., 2013, Eanes, 2011, Shieh and Bonini, 2011, Wasbrough et al., 2010, Ayroles et al., 2009, Turner et al., 2008, Borghese et al., 2006, Gronke et al., 2005, Duvernell and Eanes, 2000, Kovac and Marinkovic, 1999)
              Hex-c
              (Hastings, 1992)
              HexC
              (Nozawa et al., 2023, Francis et al., 2019, Park et al., 2018, Barry and Thummel, 2016, Nirala et al., 2013, Kim et al., 2010)
              Hk
              (Matthews and Munstermann, 1994)
              Name Synonyms
              Fructokinase
              Hexokinase
              (Ugrankar et al., 2018, Kim et al., 2008, Arking et al., 2000, Arking et al., 2000)
              Hexokinase C
              (Mattila and Hietakangas, 2017, Vartiainen et al., 2014, Parisi et al., 2013, Felix et al., 2012, Mosqueira et al., 2010)
              Hexokinase-3
              (Kubli, 1978)
              Hexokinase-C
              (Feng et al., 2015)
              HexokinaseC
              (Chopra et al., 2008)
              hexokinase
              (Léger et al., 2024, Ugrankar et al., 2015, Gronke et al., 2005, Montooth et al., 2003, Berrigan and Hoang, 1999)
              hexokinase C
              (Musselman et al., 2011)
              hexokinase-C
              (Talbert et al., 2015, Kovac and Marinkovic, 1999)
              hexose kinase
              (Clark et al., 2013)
              Secondary FlyBase IDs
              • FBgn0034003
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 175 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
              References (150)