FB2020_06, released Dec 22, 2020

Gene: Dmel\Hsc70-2

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General Information
Symbol
Dmel\Hsc70-2
Species
D. melanogaster
Name
Heat shock protein cognate 2
Annotation Symbol
CG7756
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001217
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Heat shock protein cognate 2 (Hsc70-2) encodes a member of the heat shock protein 70 family. It functions as chaperone protein in facilitating the proper folding of proteins. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Hsc70, hsc2

Key Links
Genomic Location
Cytogenetic map
87D10-87D10
Sequence location
3R:13,044,759..13,047,388 [+]
Recombination map

3-53

RefSeq locus
NT_033777 REGION:13044759..13047388
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
enables ATP binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables ATPase activity
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables heat shock protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables misfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein folding chaperone
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables unfolded protein binding
inferred from sequence or structural similarity with UniProtKB:P38646
(Sardiello et al., 2003.6.11)
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in cellular response to unfolded protein
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in chaperone cofactor-dependent protein refolding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein folding
inferred from sequence or structural similarity with UniProtKB:P38646
(Sardiello et al., 2003.6.11)
involved_in protein refolding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in mitochondrion
inferred from sequence or structural similarity with UniProtKB:P38646
(Sardiello et al., 2003.6.11)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the heat shock protein 70 family. (P11146)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
HEAT SHOCK PROTEIN 70 CHAPERONES -
The Heat Shock Protein 70 (Hsp70) superfamily of chaperones assist in numerous folding processes and are upregulated by heat stress and toxic chemicals. Hsp70 chaperones share a highly conserved bipartite domain structure composed of an ATPase domain and a substrate-binding domain. (Adapted from PMID:17441502, FBrf0232269 and FBrf0174945).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Hsc70-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hsc70-2-RA
FBtr0082707
NM_079615
2174
633
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hsc70-2-PA
FBpp0082175
69.7
633
7.20
NP_524339
AAF54899
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsc70-2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hsc70-2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsc70-2
Transgenic constructs containing regulatory region of Hsc70-2
Deletions and Duplications ( 4 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HSPA1B
6 of 15
Yes
No
Hsap\HSPA1A
5 of 15
No
No
3  
Hsap\HSPA1L
5 of 15
No
No
9  
Hsap\HSPA2
5 of 15
No
No
Hsap\HSPA6
5 of 15
No
No
Hsap\HSPA8
5 of 15
No
No
1  
Hsap\HSPA5
4 of 15
No
No
Hsap\HSPA9
3 of 15
No
No
Hsap\HSPA12A
2 of 15
No
Yes
Hsap\HSPA12B
2 of 15
No
Yes
Hsap\HSPA13
2 of 15
No
Yes
Hsap\HSPA14
2 of 15
No
No
Hsap\ANKRD45
1 of 15
No
Yes
Hsap\HSPA4
1 of 15
No
No
1  
Hsap\HSPA4L
1 of 15
No
No
1  
Hsap\HSPA7
1 of 15
No
No
Hsap\HSPH1
1 of 15
No
No
1  
Hsap\HYOU1
1 of 15
No
No
1  
Hsap\NKX2-6
1 of 15
No
No
Hsap\SLC9C2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hspa1a
6 of 15
Yes
No
Mmus\Hspa1b
5 of 15
No
No
Mmus\Hspa1l
5 of 15
No
No
Mmus\Hspa2
5 of 15
No
No
Mmus\Hspa8
5 of 15
No
No
Mmus\Hspa5
3 of 15
No
No
Mmus\Hspa9
3 of 15
No
No
Mmus\Hspa12a
2 of 15
No
Yes
Mmus\Hspa12b
2 of 15
No
Yes
Mmus\Hspa13
2 of 15
No
Yes
Mmus\Hspa14
2 of 15
No
No
Mmus\Ankrd45
1 of 15
No
Yes
Mmus\Hspa4l
1 of 15
No
No
Mmus\Hspa4
1 of 15
No
No
Mmus\Hsph1
1 of 15
No
No
Mmus\Hyou1
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Hspa2
5 of 13
Yes
No
Rnor\Hspa8
5 of 13
Yes
No
Rnor\Hspa1a
4 of 13
No
Yes
Rnor\Hspa1l
4 of 13
No
No
Rnor\Hspa5
4 of 13
No
No
Rnor\Hspa1b
3 of 13
No
No
Rnor\Hspa9
3 of 13
No
No
Rnor\Hspa12a
2 of 13
No
Yes
Rnor\Hspa12b
2 of 13
No
Yes
Rnor\LOC689955
2 of 13
No
Yes
Rnor\LOC108348108
2 of 13
No
No
Rnor\Hspa4l
1 of 13
No
No
Rnor\Hspa4
1 of 13
No
No
Rnor\Hspa13
1 of 13
No
Yes
Rnor\Hspa14
1 of 13
No
No
Rnor\Hsph1
1 of 13
No
No
Rnor\Hyou1
1 of 13
No
No
Rnor\LOC680121
1 of 13
No
No
Rnor\LOC100912578
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (16)
Xtro\hsp70
5 of 12
Yes
No
Xtro\hspa1b
5 of 12
Yes
No
Xtro\hspa1l
5 of 12
Yes
No
Xtro\hspa1a
4 of 12
No
No
Xtro\hspa2
4 of 12
No
No
Xtro\hspa8
4 of 12
No
No
Xtro\hspa5
3 of 12
No
No
Xtro\hspa9
3 of 12
No
No
Xtro\hspa12b
2 of 12
No
Yes
Xtro\hspa13
2 of 12
No
Yes
Xtro\ankrd45
1 of 12
No
Yes
Xtro\hspa4
1 of 12
No
No
Xtro\hspa12a
1 of 12
No
Yes
Xtro\hspa14
1 of 12
No
No
Xtro\hsph1
1 of 12
No
No
Xtro\hyou1
1 of 12
No
No
Danio rerio (Zebrafish) (22)
Drer\hsc70
6 of 15
Yes
No
Drer\hsp70.3
5 of 15
No
No
Drer\hsp70l
5 of 15
No
No
0  
Drer\hspa8
5 of 15
No
No
Drer\si:ch211-199o1.2
5 of 15
No
No
Drer\si:dkey-4p15.3
5 of 15
No
No
Drer\hsp70.2
4 of 15
No
No
Drer\hspa5
4 of 15
No
No
Drer\hsp70.1
3 of 15
No
No
Drer\hspa9
3 of 15
No
No
Drer\hspa12a
2 of 15
No
Yes
Drer\hspa13
2 of 15
No
Yes
Drer\ankrd45
1 of 15
No
Yes
Drer\hspa4a
1 of 15
No
No
Drer\hspa4b
1 of 15
No
No
Drer\hspa4l
1 of 15
No
No
Drer\hspa12b
1 of 15
No
Yes
Drer\hspa14
1 of 15
No
No
Drer\hsph1
1 of 15
No
No
Drer\hyou1
1 of 15
No
No
Drer\si:ch211-250m6.2
1 of 15
No
Yes
Drer\si:dkey-61p9.6
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\F44E5.5
5 of 15
Yes
Yes
Cele\hsp-70
5 of 15
Yes
Yes
Cele\hsp-1
4 of 15
No
No
Cele\F44E5.4
3 of 15
No
No
Cele\hsp-3
3 of 15
No
No
Cele\hsp-4
3 of 15
No
No
Cele\hsp-6
3 of 15
No
No
Cele\stc-1
2 of 15
No
Yes
Cele\F11F1.1
1 of 15
No
No
Cele\T14G8.3
1 of 15
No
No
Cele\T24H7.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\Hsp70-2
5 of 9
Yes
No
Atha\AT3G09440
4 of 9
No
No
Atha\ERD2
4 of 9
No
No
Atha\HSC70-1
4 of 9
No
No
Atha\HSP70
4 of 9
No
No
Atha\Hsp70b
4 of 9
No
No
Atha\BIP1
2 of 9
No
No
Atha\BIP2
2 of 9
No
No
Atha\BIP3
2 of 9
No
No
Atha\HSP70T-2
2 of 9
No
Yes
Atha\cpHsc70-1
1 of 9
No
No
Atha\cpHsc70-2
1 of 9
No
No
Atha\mtHsc70-1
1 of 9
No
No
Atha\MTHSC70-2
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (14)
Scer\SSA3
7 of 15
Yes
No
Scer\SSA4
7 of 15
Yes
No
Scer\SSA1
6 of 15
No
No
Scer\SSA2
6 of 15
No
No
Scer\SSB1
5 of 15
No
No
Scer\SSB2
5 of 15
No
No
Scer\KAR2
3 of 15
No
No
Scer\ECM10
2 of 15
No
No
Scer\LHS1
2 of 15
No
No
Scer\SSC1
2 of 15
No
No
Scer\SSQ1
2 of 15
No
No
Scer\SSE1
1 of 15
No
No
Scer\SSE2
1 of 15
No
No
Scer\SSZ1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\ssa1
4 of 12
Yes
No
Spom\ssa2
4 of 12
Yes
No
Spom\sks2
3 of 12
No
No
Spom\bip1
2 of 12
No
No
Spom\lsh1
1 of 12
No
No
Spom\ssc1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904E8 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009454
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012807
Drosophila simulans
Dsim\GD18878
Drosophila sechellia
Dsec\GM24082
Drosophila erecta
Dere\GG19412
Drosophila yakuba
Dyak\GE26242
Drosophila ananassae
Dana\GF17572
Drosophila pseudoobscura pseudoobscura
Dpse\GA20564
Drosophila willistoni
Dwil\GK12230
Drosophila virilis
Dvir\GJ10355
Drosophila mojavensis
Dmoj\GI23362
Drosophila grimshawi
Dgri\GH18372
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502IF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008612
Musca domestica
House fly
Mdoa\17013981
Musca domestica
House fly
Mdoa\17005774
Musca domestica
House fly
Mdoa\17008614
Musca domestica
House fly
Mdoa\17006254
Musca domestica
House fly
Mdoa\17008613
Glossina morsitans
Tsetse fly
Gmor\GMOY009493
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03660
Mayetiola destructor
Hessian fly
Mdes\Mdes000202
Mayetiola destructor
Hessian fly
Mdes\Mdes011175
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Ba
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Ab
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Ab_prime_
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Aa
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Cb
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Aa_prime_
Aedes aegypti
Yellow fever mosquito
Aaeg\HSP70Bb
Anopheles darlingi
American malaria mosquito
Adar\ADAC003118
Anopheles darlingi
American malaria mosquito
Adar\ADAC005660
Anopheles darlingi
American malaria mosquito
Adar\ADAC004661
Anopheles darlingi
American malaria mosquito
Adar\ADAC002898
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014283
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011082
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011083
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011081
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02J2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002428
Bombyx mori
Silkmoth
Bmor\BGIBMGA014536
Bombyx mori
Silkmoth
Bmor\BmHSC70-4
Danaus plexippus
Monarch butterfly
Dple\DPOGS208954-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210048-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213900-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212775-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213925-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210250-PA
Heliconius melpomene
Postman butterfly
Hmel\Hem
Heliconius melpomene
Postman butterfly
Hmel\HMEL010425
Heliconius melpomene
Postman butterfly
Hmel\HMEL014657
Heliconius melpomene
Postman butterfly
Hmel\HMEL014163
Heliconius melpomene
Postman butterfly
Hmel\HMEL006064
Apis florea
Little honeybee
Aflo\2484227444
Apis florea
Little honeybee
Aflo\2994796276
Apis florea
Little honeybee
Aflo\2354233092
Apis mellifera
Western honey bee
Amel\LOC410620
Apis mellifera
Western honey bee
Amel\GB50246
Apis mellifera
Western honey bee
Amel\Hsc70-4
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16151
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14904
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25428
Bombus terrestris
Buff-tailed bumblebee
Bter\15203980
Bombus terrestris
Buff-tailed bumblebee
Bter\15207411
Bombus terrestris
Buff-tailed bumblebee
Bter\15209666
Linepithema humile
Argentine ant
Lhum\LH12354
Linepithema humile
Argentine ant
Lhum\LH21302
Linepithema humile
Argentine ant
Lhum\LH21803
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001e42
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002430
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c83
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ed9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008319
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002344
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002830
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007999
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003712
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002346
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11145
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06831
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06803
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01683
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06804
Tribolium castaneum
Red flour beetle
Tcas\TC033493
Tribolium castaneum
Red flour beetle
Tcas\TC010172
Tribolium castaneum
Red flour beetle
Tcas\TC031639
Tribolium castaneum
Red flour beetle
Tcas\hsp68b
Tribolium castaneum
Red flour beetle
Tcas\Hem
Tribolium castaneum
Red flour beetle
Tcas\TC000188
Pediculus humanus
Human body louse
Phum\PHUM126800
Pediculus humanus
Human body louse
Phum\PHUM333930
Pediculus humanus
Human body louse
Phum\PHUM588610
Pediculus humanus
Human body louse
Phum\PHUM018540
Rhodnius prolixus
Kissing bug
Rpro\RPRC004310
Rhodnius prolixus
Kissing bug
Rpro\RPRC009759
Rhodnius prolixus
Kissing bug
Rpro\RPRC012193
Cimex lectularius
Bed bug
Clec\CLEC002869
Cimex lectularius
Bed bug
Clec\CLEC002762
Cimex lectularius
Bed bug
Clec\CLEC010952
Cimex lectularius
Bed bug
Clec\CLEC025196
Cimex lectularius
Bed bug
Clec\CLEC010950
Cimex lectularius
Bed bug
Clec\CLEC005841
Cimex lectularius
Bed bug
Clec\CLEC025196-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007961
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000474
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000903
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001597
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080190
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008763
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004809
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI067751
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI073873
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080139
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05273
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04366
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06862
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02GG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004960
Strigamia maritima
European centipede
Smar\SMAR013707
Strigamia maritima
European centipede
Smar\SMAR004796
Ixodes scapularis
Black-legged tick
Isca\ISCW009279
Ixodes scapularis
Black-legged tick
Isca\ISCW024910
Ixodes scapularis
Black-legged tick
Isca\ISCW017456
Ixodes scapularis
Black-legged tick
Isca\ISCW011425
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80380.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78034.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83474.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76829.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83484.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78035.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69762.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83486.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57777.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69761.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03320
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g01700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_227800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302856
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303127
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_256736
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03SF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701E
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701C
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701D
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp703A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nckap1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nckap1
Ciona intestinalis
Vase tunicate
Cint\LOC100187210
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003184
Ciona intestinalis
Vase tunicate
Cint\hsp70
Gallus gallus
Domestic chicken
Ggal\NCKAP1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027417
Gallus gallus
Domestic chicken
Ggal\HSP70
Gallus gallus
Domestic chicken
Ggal\HSPA8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Hsp68
7 of 10
Hsp70Aa
7 of 10
Hsp70Ba
7 of 10
Hsp70Bbb
7 of 10
Hsc70-1
6 of 10
Hsc70-3
6 of 10
Hsc70-4
6 of 10
Hsp70Ab
6 of 10
Hsp70Bb
6 of 10
Hsp70Bc
6 of 10
Hsc70-5
5 of 10
CG7182
3 of 10
CG2918
2 of 10
Hsc70Cb
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HSPA1B; heat shock protein family A (Hsp70) member 1B
    6 of 15
    603012
        HSPA1A; heat shock protein family A (Hsp70) member 1A
        5 of 15
        140550
             
            HSPA1L; heat shock protein family A (Hsp70) member 1 like
            5 of 15
            140559
                 
                HSPA2; heat shock protein family A (Hsp70) member 2
                5 of 15
                140560
                    HSPA6; heat shock protein family A (Hsp70) member 6
                    5 of 15
                    140555
                        HSPA8; heat shock protein family A (Hsp70) member 8
                        5 of 15
                        600816
                             
                            HSPA5; heat shock protein family A (Hsp70) member 5
                            4 of 15
                            138120
                                HSPA9; heat shock protein family A (Hsp70) member 9
                                3 of 15
                                600548
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                Summary of Genetic Interactions
                                esyN Network Diagram
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                External Data
                                Linkouts
                                DroID - A comprehensive database of gene and protein interactions.
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Signaling Pathways (FlyBase)
                                Metabolic Pathways
                                External Data
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3R
                                Recombination map

                                3-53

                                Cytogenetic map
                                87D10-87D10
                                Sequence location
                                3R:13,044,759..13,047,388 [+]
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                87D10-87D10
                                Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                Experimentally Determined Recombination Data
                                Location

                                3-53

                                (FlyBase, 2016)

                                3-50.4

                                (Comeron et al., 2012)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (6)
                                Genomic Clones (17)
                                 

                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                cDNA Clones (29)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                  Drosophila Genomics Resource Center cDNA clones

                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                  cDNA Clones, End Sequenced (ESTs)
                                  BDGP DGC clones
                                  Other clones
                                  RNAi and Array Information
                                  Linkouts
                                  DRSC - Results frm RNAi screens
                                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                  Antibody Information
                                  Laboratory Generated Antibodies
                                   
                                  Commercially Available Antibodies
                                   
                                  Other Information
                                  Relationship to Other Genes
                                  Source for database identify of
                                  Source for database merge of
                                  Additional comments
                                  Other Comments

                                  Members of the hsc70 gene family (heat shock cognate genes) that reside within the same intracellular compartment in different organisms share greater amino acid identity than hsc70 proteins from the same organism but different organelles. This pattern of conservation indicates specialisation of hsc70 function.

                                  (Rubin et al., 1993)

                                  transcript abundance embryo: \- transcript abundance larva: \- transcript abundance adult: \+ the codon specifying amino acid 55 is also interrupted by an insertion (Craig et al., 1983).

                                  First recognised by sequence similarity to Hsp70. Transcription is developmentally regulated, but is temperature independent.

                                  Origin and Etymology
                                  Discoverer
                                  Etymology
                                  Identification
                                  External Crossreferences and Linkouts ( 41 )
                                  Sequence Crossreferences
                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                  Other crossreferences
                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                  Flygut - An atlas of the Drosophila adult midgut
                                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                  InterPro - A database of protein families, domains and functional sites
                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                  modMine - A data warehouse for the modENCODE project
                                  Linkouts
                                  DroID - A comprehensive database of gene and protein interactions.
                                  DRSC - Results frm RNAi screens
                                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                  FlyMine - An integrated database for Drosophila genomics
                                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Synonyms and Secondary IDs (18)
                                  Datasets (0)
                                  Study focus (0)
                                  Experimental Role
                                  Project
                                  Project Type
                                  Title
                                  References (80)