T-cp1, Tcp1-like, Tcp1, TCP1α, T-cpl
Gene model reviewed during 5.47
Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCT1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\CCT1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: CCT1 T-cp1
RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Area matching Drosophila Tcp-1 gene, Acc. No. M21159.
Identified with: GH05123 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.
EST GH05123 is chimeric; the 3' portion (BG632209) corresponds to part of T-cp1 on 3R, the 5' portion (AI107438) maps to 3L.
Codes for a cDNA from D.melanogaster that shares 66% sequence identity with the mouse Tcp-1 gene encoding TCP1 (t-complex polypeptide 1).