FlyBase Gene Report: Dmel\Cpr

General Information

Symbol

Dmel\Cpr

Species

D. melanogaster

Name

Cytochrome P450 reductase

Annotation Symbol

CG11567

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015623

Gene Model Status

Current

Stock Availability

20 publicly available

Enzyme Name (EC)

NADPH--hemoprotein reductase (1.6.2.4)

Gene Summary

This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. (UniProt, Q27597)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

P450, P450 reductase

Key Links

Genomic Location

Cytogenetic map

26C3-26C3

Sequence location

2L:6,338,836..6,346,280 [+]

Recombination map

2-19

RefSeq locus

NT_033779 REGION:6338836..6346280

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:E1JHB6,UniProtKB:Q7JRC3,UniProtKB:Q7KB18,UniProtKB:Q9VAY2,UniProtKB:Q9VB46,UniProtKB:Q9W0H3

(Werthebach et al., 2019)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables flavin adenine dinucleotide binding

inferred from biological aspect of ancestor with PANTHER:PTN000453956

(GO Reference Genome Project, 2011-)

enables FMN binding

inferred from biological aspect of ancestor with PANTHER:PTN000453956

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001094, InterPro:IPR008254

(InterPro Project Members, 2004-)

enables NADPH-hemoprotein reductase activity

inferred from biological aspect of ancestor with PANTHER:PTN000453765

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P16435

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR023208

(InterPro Project Members, 2004-)

enables oxidoreductase activity

inferred from electronic annotation with InterPro:IPR001433, InterPro:IPR001709, InterPro:IPR003097, InterPro:IPR017927, InterPro:IPR023173

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in cuticle hydrocarbon biosynthetic process

inferred from mutant phenotype

(Qiu et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in nitric oxide biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN002322100

(GO Reference Genome Project, 2011-)

involved_in response to hormone

inferred from biological aspect of ancestor with PANTHER:PTN002322100

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000453956

(GO Reference Genome Project, 2011-)

located_in mitochondrial outer membrane

inferred from sequence or structural similarity with UniProtKB:P16603

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

NAD(P)H OXIDOREDUCTASES, HEME PROTEIN AS ACCEPTOR

Protein Family (UniProt)

Belongs to the NADPH--cytochrome P450 reductase family. (Q27597)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

NADPH-hemoprotein reductase activity

2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+) (1.6.2.4)

RHEA 24040:

Summaries

Gene Group (FlyBase)

NAD(P)H OXIDOREDUCTASES, HEME PROTEIN AS ACCEPTOR -: NAD(P)H oxidoreductases with heme protein as acceptor, include dehydrogenases that oxidize NADH or NADPH with the reduction of heme protein.

Protein Function (UniProtKB)

(UniProt, Q27597)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cpr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q27597)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cpr-RA

FBtr0079250

NM_057810

2739

679

Cpr-RB

FBtr0079251

NM_164689

2157

550

Cpr-RC

FBtr0331223

NM_001273199

2581

679

Cpr-RD

FBtr0331224

NM_001273200

2679

679

Additional Transcript Data and Comments

Reported size (kB)

2.7 (northern blot)

(Hovemann et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cpr-PA

FBpp0078880

76.3

679

5.70

FBpp0078881

62.9

550

8.38

FBpp0303665

76.3

679

5.70

FBpp0303666

76.3

679

5.70

Q27597

NP_001260129

AGB92665

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

679 aa isoforms: Cpr-PA, Cpr-PC, Cpr-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

679 (aa); 76 (kD predicted)

(Hovemann et al., 1997)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with sturkopf.

(UniProt, Q27597)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cpr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

inclusive hindgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

amnioserosa

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval oenocyte

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Hovemann et al., 1997)

adult stage

antenna

(Hovemann et al., 1997)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

organism

Comment: induced after emergence

(Storelli et al., 2019)

Additional Descriptive Data

Cpr expression is induced after emergence and peaks at day 2.

(Storelli et al., 2019)

High levels of Cpr transcripts are detected in adult antennae and in embryos.

(Hovemann et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cpr in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cpr

View exonic expression by tissue for Dmel\Cpr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015623

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33883/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015623

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015623

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015623

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11567

Flygut - An atlas of the Drosophila adult midgut

FBgn0015623

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cpr

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cpr

Transgenic constructs containing regulatory region of Cpr

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel6016

(Ryder, 2004.4.26)

Inferred from location ( 17 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Cpr^GD945

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Cpr^GD945

lethal | recessive

Cpr^e5

lethal - all die before end of larval stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cpr^GD945

viable, with Scer\GAL4^Mef2.PR

Cpr^GD945

viable, with Scer\GAL4^tin.CΔ4

Cpr^GD945

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^Mef2.PR

Cpr^GD945

abnormal starvation stress response | larval stage, with Scer\GAL4^Desat1.PB

Cpr^GD945

some die during larval stage | recessive

Phenotype manifest in

Allele

embryonic/larval oenocyte | larval stage | nutrition conditional, with Scer\GAL4^Desat1.PB

Cpr^GD945

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (6)

Hsap\POR

13 of 14

Yes

5 of 14

4 of 14

2 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Por

14 of 14

Yes

5 of 14

4 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (6)

Mmus\Por

14 of 14

Yes

5 of 14

3 of 14

2 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (9)

Xtro\por

11 of 13

Yes

4 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\mrpl48

1 of 13

Xtro\ndor1

1 of 13

Danio rerio (Zebrafish) (7)

Drer\pora

14 of 14

Yes

Drer\porb

13 of 14

Yes

5 of 14

3 of 14

2 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\emb-8

14 of 14

Yes

Cele\mtrr-1

4 of 14

Cele\fre-1

3 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP000500

10 of 12

Yes

5 of 12

5 of 12

5 of 12

3 of 12

2 of 12

2 of 12

1 of 12

Yes

Agam\AgaP_AGAP011300

1 of 12

Arabidopsis thaliana (thale-cress) (11)

Atha\ATR2

13 of 13

Yes

Atha\ATR1

12 of 13

Yes

Atha\AT3G02280

4 of 13

Atha\AT3G24710

2 of 13

Atha\FNR1

2 of 13

Yes

Atha\FNR2

2 of 13

Yes

Atha\RFNR1

2 of 13

Yes

Atha\RFNR2

2 of 13

Yes

Atha\AT1G15140

1 of 13

Atha\AT1G30515

1 of 13

Yes

Atha\AT5G20080

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\NCP1

13 of 13

Yes

Scer\MET10

3 of 13

Yes

Scer\TAH18

3 of 13

Scer\CBR1

1 of 13

Scer\PGA3

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\ccr1

12 of 12

Yes

4 of 12

4 of 12

3 of 12

2 of 12

Yes

Escherichia coli (enterobacterium) (2)

Ecol\cysJ

10 of 11

Yes

Ecol\hcp

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cpr. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

CG13667

7 of 13

CG14882

6 of 13

Nos

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

POR; cytochrome p450 oxidoreductase

model of Antley-Bixler syndrome with disordered steroidogenesis

IEA

(FlyBase, 2019-)

model of cytochrome P450 oxidoreductase deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

POR; cytochrome p450 oxidoreductase

13 of 14

124015

MTRR; 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

5 of 14

602568

NDOR1; NADPH dependent diflavin oxidoreductase 1

4 of 14

606073

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cpr - sturkopf

split luciferase complementation, luminiscence technology, anti tag coimmunoprecipitation, Identification by mass spectrometry

(Kolkhof et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with sturkopf.

(UniProt, Q27597 )

Linkouts

BioGRID - A database of protein and genetic interactions.

60040

DroID - A comprehensive database of gene and protein interactions.

FBgn0015623

MIST (protein-protein) - An integrated Molecular Interaction Database

33883

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-19

Cytogenetic map

26C3-26C3

Sequence location

2L:6,338,836..6,346,280 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

26C3-26C3

Limits computationally determined from genome sequence between P{lacW}Gef26^k13720 and P{lacW}l(2)k09923^k09923&P{lacW}CG9523^k07502b

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

26C-26C

(Hovemann, 1995.11.16)

26C-26C

(determined by in situ hybridisation)

(Hovemann et al., 1997)

Experimentally Determined Recombination Data

Location

2-19

(FlyBase, 2016)

2-20.4

(Comeron et al., 2012)

(Hovemann, 1995.11.16)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (190)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015623

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015623

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Pez mutants that lack detectable Pez protein and flies carrying overlapping deletions for Pez are viable. The putative lethal Pez mutants reported in FBrf0146134 were subsequently found to map to Cpr, the adjacent gene, and do not affect Pez.

(Edwards, 2008.7.1)

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

(McDonald and Rosbash, 2001)

Cpr gene structure and expression patterns are studied. The putative amino acid sequence shows strong homology to the reductase of the housefly and to a lesser extent to that of yeast and vertebrates. High levels of expression in adult antenna may reflect an involvement in clearing functions in the process of olfaction.

(Hovemann et al., 1997)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CCR

(Khanna et al., 2010)

CG11567

(National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

CPR

(Hamada et al., 2020, Bass et al., 2013, Qiu et al., 2012, Hovemann et al., 1997)

Cpr

(National Institute of Genetics Fly Stocks, 2022-, Zhang and Zhang, 2020, Pardy et al., 2019, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Cinnamon et al., 2016, Van Bortle et al., 2015, Antao et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Lattao et al., 2011, Gan et al., 2010, Tan et al., 2009, Edwards, 2008.7.1, Xun et al., 2008, Beller et al., 2006, Lee et al., 2002)

DMR

(Helvig et al., 2004)

DmCPR

(Zhang et al., 2004)

NCPR

(Mushegian et al., 1998)

P450

(Ahrens et al., 2007, Morton, 1993)

cpr

(Zhang et al., 2025, Frat et al., 2023, Hovemann, 1995.11.16)

Name Synonyms

Cytochrome P450 reductase

(Cammarato et al., 2011, Lattao et al., 2011)

Cytochrome c reductase (NADPH)

(Khanna et al., 2010)

NADPH--ferrihemoprotein reductase; NADPH-cytochrome P450 reductase

(Jaspers et al., 2012)

NADPH-cytochrome P450 oxidoreductase

NADPH-cytochrome P450 reductase

(Qiu et al., 2012)

P450 reductase

(Helvig et al., 2004, Scott, 1999)

cytochrome P450 reductase

(Bass et al., 2013)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33883

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q27597

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q27597

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q27597

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015623

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33883/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015623

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015623

FlyMine - An integrated database for Drosophila genomics

FBgn0015623

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11567

MARRVEL_MODEL - MARRVEL (model organism gene)

33883

Linkouts

BioGRID - A database of protein and genetic interactions.

60040

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015623

DroID - A comprehensive database of gene and protein interactions.

FBgn0015623

DRSC - Results frm RNAi screens

FBgn0015623

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015623

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015623

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11567

Flygut - An atlas of the Drosophila adult midgut

FBgn0015623

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012437

MIST (protein-protein) - An integrated Molecular Interaction Database

33883

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

-0.49

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