FlyBase Gene Report: Dmel\TppII

General Information

Symbol

Dmel\TppII

Species

D. melanogaster

Name

Tripeptidyl-peptidase II

Annotation Symbol

CG3991

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020370

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

tripeptidyl-peptidase II (3.4.14.10)

Gene Summary

tripeptidyl-peptidase II (TppII) encodes an exopeptidase that removes tripeptides from the free N-terminus of longer peptides. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

TPP II, dTPPII, dTPP II

Key Links

Genomic Location

Cytogenetic map

49F4-49F4

Sequence location

2R:13,152,885..13,159,141 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13152885..13159141

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables identical protein binding

inferred from physical interaction with UniProtKB:Q9V6K1

(Rockel et al., 2005)

enables serine hydrolase activity

inferred from high throughput direct assay

(Kumar et al., 2021)

enables tripeptidyl-peptidase activity

inferred from direct assay

(Renn et al., 1998)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR036852

(InterPro Project Members, 2004-)

enables serine-type peptidase activity

inferred from electronic annotation with InterPro:IPR000209

(InterPro Project Members, 2004-)

enables tripeptidyl-peptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000083315

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR034051

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from direct assay

(Renn et al., 1998)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000209, InterPro:IPR036852

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000209, InterPro:IPR034051, InterPro:IPR036852

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Renn et al., 1998)

part_of protein-containing complex

inferred from direct assay

(Rockel et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000083315

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TRIPEPTIDYL PEPTIDASES

Protein Family (UniProt)

Belongs to the peptidase S8 family. (Q9V6K1)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

tripeptidyl-peptidase activity

Release of an N-terminal tripeptide from a polypeptide (3.4.14.10)

serine-type endopeptidase activity

Summaries

Gene Snapshot

tripeptidyl-peptidase II (TppII) encodes an exopeptidase that removes tripeptides from the free N-terminus of longer peptides. [Date last reviewed: 2018-10-04]

Gene Group (FlyBase)

TRIPEPTIDYL PEPTIDASES -: The huge exopeptidase, tripeptidyl-peptidase II, is a large homooligomeric complex involved in a large number of important biological processes. It is present in the cytosol of most eukaryotic cells, where it removes tripeptides from free amino termini of longer peptides with a broad specificity. Its main role appears to be general protein degradation, together with the proteasome. (Adapted from PMID:31108122.)

Protein Function (UniProtKB)

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide.

(UniProt, Q9V6K1)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\TppII for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V6K1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

3LXU

Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

TppII-RA

FBtr0087775

NM_057899

4287

1354

TppII-RD

FBtr0087774

NM_165966

4641

1441

TppII-RE

FBtr0339755

NM_001299448

4350

1375

TppII-RF

FBtr0344199

NM_001299447

4375

1354

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

TppII-PA

FBpp0086888

148.9

1354

6.98

FBpp0086887

158.7

1441

7.64

FBpp0308802

151.1

1375

7.18

FBpp0310608

148.9

1354

6.98

A0A0B4LGC0

NP_001286376

AHN56174

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1354 aa isoforms: TppII-PA, TppII-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homooligomer; forms a complex of 6 MDa probably composed of 40 subunits. Forms a structure consisting of 2 segmented and twisted strands that form a spindle-shaped structure. Each strand is composed of 10 segments (a segment being a homodimer oriented head to head), stacking of these segments leads to the formation of a twisted single strand. 2 strands compose the fully assembled spindle.

(UniProt, Q9V6K1)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

3LXU

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TppII using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TppII_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.06

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Renn et al., 1998)

part_of protein-containing complex

inferred from direct assay

(Rockel et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\TppII in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\TppII

View exonic expression by tissue for Dmel\TppII

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020370

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36444/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020370

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020370

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020370

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3991

Flygut - An atlas of the Drosophila adult midgut

FBgn0020370

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\TppII

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of TppII

Transgenic constructs containing regulatory region of TppII

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel8057

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

TppII^k14301

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

TppII^GD11183

viable, with Scer\GAL4^Mef2.PR

TppII^GD11183

viable, with Scer\GAL4^pnr-MD237

TppII^GD11183

viable, with Scer\GAL4^tin.CΔ4

TppII^GD11183

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

TppII^GD11183

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

TppII^GD11183

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\TPP2

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (14)

Rnor\Tpp2

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Tpp2

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\tpp2

11 of 13

Yes

Xtro\htr6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (12)

Drer\tpp2

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\tpp-2

14 of 14

Yes

Cele\aex-5

1 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP004870

12 of 12

Yes

Agam\AgaP_AGAP002176

1 of 12

Agam\AgaP_AGAP002915

1 of 12

Agam\AgaP_AGAP012203

1 of 12

Arabidopsis thaliana (thale-cress) (58)

Atha\TPP2

13 of 13

Yes

Atha\AIR3

2 of 13

Yes

Atha\AT1G20150

2 of 13

Yes

Atha\AT1G30600

2 of 13

Yes

Atha\AT1G32950

2 of 13

Yes

Atha\AT1G32970

2 of 13

Yes

Atha\AT1G32980

2 of 13

Yes

Atha\AT1G66210

2 of 13

Yes

Atha\AT1G66220

2 of 13

Yes

Atha\AT2G39850

2 of 13

Yes

Atha\AT3G46840

2 of 13

Yes

Atha\AT3G46850

2 of 13

Yes

Atha\AT4G10510

2 of 13

Yes

Atha\AT4G10520

2 of 13

Yes

Atha\AT4G10530

2 of 13

Yes

Atha\AT4G10540

2 of 13

Yes

Atha\AT4G10550

2 of 13

Yes

Atha\AT4G15040

2 of 13

Yes

Atha\AT4G20430

2 of 13

Yes

Atha\AT4G21323

2 of 13

Yes

Atha\AT4G21630

2 of 13

Yes

Atha\AT4G21640

2 of 13

Yes

Atha\AT4G21650

2 of 13

Yes

Atha\AT4G30020

2 of 13

Yes

Atha\AT5G03620

2 of 13

Yes

Atha\AT5G11940

2 of 13

Yes

Atha\AT5G44530

2 of 13

Yes

Atha\AT5G45640

2 of 13

Yes

Atha\AT5G45650

2 of 13

Yes

Atha\AT5G58820

2 of 13

Yes

Atha\AT5G58830

2 of 13

Yes

Atha\AT5G58840

2 of 13

Yes

Atha\AT5G59100

2 of 13

Yes

Atha\AT5G59110

2 of 13

Yes

Atha\AT5G59130

2 of 13

Yes

Atha\AT5G59190

2 of 13

Yes

Atha\ATSBT5.2

2 of 13

Yes

Atha\SBT3.3

2 of 13

Yes

Atha\SBT3.5

2 of 13

Yes

Atha\SBT3.12

2 of 13

Yes

Atha\SBT4.12

2 of 13

Yes

Atha\SBT4.13

2 of 13

Yes

Atha\SBT5.4

2 of 13

Yes

Atha\SLP3

2 of 13

Yes

Atha\UNE17

2 of 13

Yes

Atha\XSP1

2 of 13

Yes

Atha\ALE1

1 of 13

Yes

Atha\ARA12

1 of 13

Yes

Atha\AT2G05920

1 of 13

Yes

Atha\AT3G14067

1 of 13

Yes

Atha\AT3G14240

1 of 13

Atha\AT5G58810

1 of 13

Yes

Atha\AT5G67090

1 of 13

Yes

Atha\S1P

1 of 13

Atha\SBT1.3

1 of 13

Yes

Atha\SBTI1.1

1 of 13

Yes

Atha\SDD1

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\PRB1

2 of 13

Yes

Scer\YSP3

2 of 13

Yes

Scer\KEX2

1 of 13

Scer\RRT12

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\tpp2

11 of 12

Yes

Spom\isp6

1 of 12

Spom\krp1

1 of 12

Spom\psp3

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:TppII. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

S1P

3 of 13

amon

2 of 13

Fur2

2 of 13

Fur1

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TPP2; tripeptidyl peptidase 2

14 of 14

190470

IMMUNODEFICIENCY 78 WITH AUTOIMMUNITY AND DEVELOPMENTAL DELAY; IMD78

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

TppII

x-ray crystallography, electron microscopy

(Chuang et al., 2010)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9V6K1 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62211

DroID - A comprehensive database of gene and protein interactions.

FBgn0020370

MIST (protein-protein) - An integrated Molecular Interaction Database

36444

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Antigen processing: Ubiquitination & Proteasome degradation

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V6K1

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

49F4-49F4

Sequence location

2R:13,152,885..13,159,141 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F4-49F4

Limits computationally determined from genome sequence between P{lacW}Psc^k07834&P{lacW}Su(z)2^k06344 and P{EP}EP873^EP873

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

49F7-49F8

(Renn, 1997.11.19)

49F-49F

(determined by in situ hybridisation)

(Renn et al., 1998)

49F7-49F8

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

13339

y¹; P{SUPor-P}TppII^KG03294/CyO; ry⁵⁰⁶

65178

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06052}attP40

80595

y¹ w^*; TI{CRIMIC.TG4.0}ND-MWFE^{CR00565-TG4.0} TppII^{CR00565-TG4.0-X}

11122

y¹ w^67c23; P{lacW}Nrk^k14301 ND-MWFE^k14301 TppII^k14301/CyO

Kyoto

113048

w^*; P{GawB}TppII^NP2796 / CyO

103914

y^* w^*; P{GawB}TppII^NP1170 / CyO, P{UAS-lacZ.UW14}UW14

111339

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Nrk^k14301 /CyO y⁺

111498

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{GT1}ND-MWFE^BG01873 /CyO y⁺

NIG-Fly

2RG-0902

y² VhaAC39-1^cho-1 v¹; P{U6-TppII.NIG.sgRNA}attP40/CyO

VDRC

v108589

P{KK101556}VIE-260B

v26348

w¹¹¹⁸; P{GD11183}v26348

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (208)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI06467

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020370

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020370

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

TppII proteins assemble into a giant proteolytic copmplex of 6 MDa, with a remarkable architecture consisting of two segmented and twisted strands that form a spindle-shaped structure. The building blocks of this complex are dimers, within which the 150kDa monomers are oriented head to head. Stacking of these dimers leads to the formation of twisted single strands, two of which comprise the fully assembled spindle. Reciprocal interactions of the N-terminal part of subunits from neighboring strands are probably involved in the formation of the native quaternary structure, lending the TppII spindle a stability higher than that of single strands.

(Rockel et al., 2005)

Area matching Drosophila EST AA978904.

(Davies, 2001.3.15)

TppII has been cloned and characterised.

(Renn et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: TppII anon-WO0118547.127

(FlyBase, 1996-)

Additional comments

Source for merge of TppII anon-WO0118547.127 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG3991

(National Institute of Genetics Fly Stocks, 2022-, Christis and Munro, 2012, Cammarato et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Lee et al., 2003)

TPP II

(Eklund et al., 2012, Eklund et al., 2012, Chuang et al., 2010, Seyit et al., 2006, Rockel et al., 2002)

TPP2

(Jager et al., 2005)

TPPII

(Kurshakova et al., 2019, Peters et al., 2011, Rockel et al., 2005, Wojcik and DeMartino, 2002)

TppII

(Candia et al., 2023, Li et al., 2022, Kumar et al., 2021, Lindsey et al., 2021, Gene Disruption Project members, 2018-, Levis, 2018.8.30, Japanese National Institute of Genetics, 2012.5.21, Tan et al., 2009, Zahedi et al., 2008, Liebl and Featherstone, 2005)

anon-WO0118547.127

dTPP II

(Renn et al., 1998, Renn, 1997.11.19)

dTPPII

(Renn et al., 1998, Renn et al., 1997)

l(2)k14301

Name Synonyms

Tripeptidyl-peptidase II

(Eklund et al., 2012, Carpenter et al., 2009)

Tripeptidylpeptidase II

(Seyit et al., 2006)

tripeptidyl peptidase II

(Chuang et al., 2010, Renn, 1997.11.19)

tripeptidyl-peptidase II

(Cammarato et al., 2011, Renn et al., 1997)

Secondary FlyBase IDs

FBgn0021861
FBgn0062227

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 69 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36444

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V6K1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V6K1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V6K1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020370

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36444/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020370

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020370

FlyMine - An integrated database for Drosophila genomics

FBgn0020370

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3991

MARRVEL_MODEL - MARRVEL (model organism gene)

36444

PDB - An information portal to biological macromolecular structures

3LXU

Linkouts

BioGRID - A database of protein and genetic interactions.

62211

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020370

DroID - A comprehensive database of gene and protein interactions.

FBgn0020370

DRSC - Results frm RNAi screens

FBgn0020370

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TppII_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020370

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020370

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3991

Flygut - An atlas of the Drosophila adult midgut

FBgn0020370

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0020370

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034512

MIST (protein-protein) - An integrated Molecular Interaction Database

36444

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Antigen processing: Ubiquitination & Proteasome degradation

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V6K1

References (77)

The following external sites may use different assemblies or annotations than FlyBase.

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