FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\fab1
Open Close
General Information
Symbol
Dmel\fab1
Species
D. melanogaster
Name
fab1 kinase
Annotation Symbol
CG6355
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028741
Gene Model Status
Current
Stock Availability
13 publicly available
Enzyme Name (EC)
1-phosphatidylinositol-3-phosphate 5-kinase (2.7.1.150)
Gene Summary
fab1 kinase (fab1) encodes a phosphatidylinositol-3-phosphate 5-kinase. It phosphorylates phosphatidylinositol-3-phosphate lipid head groups on the cytosolic leaflet of endosomal compartments. The product of fab1 functions in late endosome-to lysosome trafficking, retrograde trafficking, and autophagy. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

PtdIns(3)P 5-kinase, EG:52C10.5

Key Links
Genomic Location
Cytogenetic map
54E9-54E9
Sequence location
Recombination map
2-84
RefSeq locus
NT_033778 REGION:17773964..17781930
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity
inferred from mutant phenotype
(Rusten et al., 2006)
inferred from direct assay
(Ghosh et al., 2023)
enables 1-phosphatidylinositol-5-kinase activity
inferred from direct assay
(Ghosh et al., 2023)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity
inferred from electronic annotation with InterPro:IPR044769
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000144086
(GO Reference Genome Project, 2011-)
enables ATP binding
inferred from electronic annotation with InterPro:IPR002423
(InterPro Project Members, 2004-)
enables metal ion binding
inferred from electronic annotation with InterPro:IPR000306
(InterPro Project Members, 2004-)
enables phosphatidylinositol kinase activity
inferred from electronic annotation with InterPro:IPR002498
(InterPro Project Members, 2004-)
enables zinc ion binding
inferred from sequence or structural similarity with UniProtKB:Q9Z1T6
(Gene Ontology Curators, 2002-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in autophagosome maturation
inferred from mutant phenotype
(Rusten et al., 2007)
involved_in endosome to lysosome transport
inferred from mutant phenotype
(Rusten et al., 2006)
involved_in phosphatidylinositol phosphate biosynthetic process
inferred from mutant phenotype
(Rusten et al., 2006)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in intracellular signal transduction
inferred from electronic annotation with InterPro:IPR000591
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:Q9Z1T6
(Gene Ontology Curators, 2002-)
involved_in phosphatidylinositol metabolic process
inferred from electronic annotation with InterPro:IPR002498
(InterPro Project Members, 2004-)
involved_in phosphatidylinositol phosphate biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000144086
(GO Reference Genome Project, 2011-)
involved_in vacuole organization
inferred from biological aspect of ancestor with PANTHER:PTN000144086
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endosome
inferred from direct assay
(Rusten et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in endosome membrane
inferred from biological aspect of ancestor with PANTHER:PTN000144086
(GO Reference Genome Project, 2011-)
part_of PAS complex
inferred from sequence or structural similarity with UniProtKB:P34756
(Gene Ontology Curators, 2002-)
located_in vesicle membrane
inferred from sequence or structural similarity with UniProtKB:Q9Z1T6
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
1-phosphatidylinositol-5-kinase activity
RHEA 44680: 1-phosphatidylinositol-3-phosphate 5-kinase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) (2.7.1.150)
RHEA 13609:
Summaries
Gene Snapshot
fab1 kinase (fab1) encodes a phosphatidylinositol-3-phosphate 5-kinase. It phosphorylates phosphatidylinositol-3-phosphate lipid head groups on the cytosolic leaflet of endosomal compartments. The product of fab1 functions in late endosome-to lysosome trafficking, retrograde trafficking, and autophagy. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
PHOSPHATIDYLINOSITOL 5 KINASES -
D :Phosphatidylinositol 5 kinases catalyze the phosphorylation of phosphatidylinositol (PI), or specific mono or bisphosphate derivatives of PI, at position 5 on the inositol ring to generate PI5P, PI(3,5)P[[2]], PI(4,5)P[[2]] or PI(3,4,5)P[[3]]. The resulting phosphoinositides can then act as signalling molecules to mediate/regulate a range of cellular and physiological processes, including cell polarity, cell migration, autophagy, growth, development, and ageing. (Adapted from FBrf0227909.)
Protein Function (UniProtKB)
Regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) or PtdIns(3,5)P2) (PubMed:16837550). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)) on the fifth hydroxyl of the myo-inositol ring, to form PtdIns(3,5)P2 (PubMed:16837550). Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing.
(UniProt, O96838)
Summary (Interactive Fly)

phosphatidylinositol phosphate kinase - controls vesicular trafficking but not silencing of endocytosed receptors, including Wingless and Notch - functions in negative regulation of cell volume - regulates autophagy by being required for the maturation of autolysosomes

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\fab1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O96838)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fab1-RA
FBtr0089554
NM_137425
7194
1809
fab1-RB
FBtr0089555
NM_206158
6035
1809
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
fab1-PA
FBpp0088523
204.6
1809
7.63
O96838
NP_611269
AAF57789
fab1-PB
FBpp0088952
204.6
1809
7.63
O96838
NP_995880
AAS64818
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1809 aa isoforms: fab1-PA, fab1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fab1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.42

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endosome
inferred from direct assay
(Rusten et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fab1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fab1
Transgenic constructs containing regulatory region of fab1
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)14H10W-30
(Rusten et al., 2006)
Df(2R)Pcl7B
(Rusten et al., 2006)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\PIKFYVE
12 of 14
Yes
Yes
1  
Hsap\PIP4K2A
2 of 14
No
No
1  
Hsap\PIP4K2B
2 of 14
No
No
2  
Hsap\PIP4K2C
2 of 14
No
No
2  
Hsap\PIP5K1A
2 of 14
No
No
1  
Hsap\PIP5K1B
2 of 14
No
No
1  
Hsap\PIP5K1C
2 of 14
No
No
1  
Hsap\PIP5KL1
2 of 14
No
No
Hsap\FARP1
1 of 14
No
No
Hsap\FARP2
1 of 14
No
No
Hsap\FGD1
1 of 14
No
No
Hsap\FGD2
1 of 14
No
No
Hsap\FGD3
1 of 14
No
No
Hsap\FGD4
1 of 14
No
No
Hsap\FGD5
1 of 14
No
No
Hsap\FGD6
1 of 14
No
No
Hsap\MTMR4
1 of 14
No
No
2  
Hsap\PIPSL
1 of 14
No
No
Hsap\PLEKHF1
1 of 14
No
No
Hsap\PLEKHF2
1 of 14
No
No
Hsap\ZFYVE9
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
Rnor\Pikfyve
12 of 14
Yes
Yes
Rnor\Pip4k2b
2 of 14
No
No
Rnor\Pip4k2c
2 of 14
No
No
Rnor\Pip5k1a
2 of 14
No
No
Rnor\Pip5k1b
2 of 14
No
No
Rnor\Pip5k1c
2 of 14
No
No
Rnor\Farp1
1 of 14
No
No
Rnor\Farp2
1 of 14
No
No
Rnor\Fgd1
1 of 14
No
No
Rnor\Fgd2
1 of 14
No
No
Rnor\Fgd4
1 of 14
No
No
Rnor\Fgd5
1 of 14
No
No
Rnor\Fgd6
1 of 14
No
No
Rnor\Mtmr4
1 of 14
No
No
Rnor\Pip4k2a
1 of 14
No
No
Rnor\Pip5kl1
1 of 14
No
No
Rnor\Plekhf1
1 of 14
No
No
Rnor\Plekhf2
1 of 14
No
No
Rnor\Zfyve9
1 of 14
No
No
Mus musculus (laboratory mouse) (19)
Mmus\Pikfyve
12 of 14
Yes
Yes
Mmus\Pip4k2a
2 of 14
No
No
Mmus\Pip4k2b
2 of 14
No
No
Mmus\Pip4k2c
2 of 14
No
No
Mmus\Pip5k1a
2 of 14
No
No
Mmus\Pip5k1b
2 of 14
No
No
Mmus\Pip5k1c
2 of 14
No
No
Mmus\Pip5kl1
2 of 14
No
No
Mmus\Farp1
1 of 14
No
No
Mmus\Farp2
1 of 14
No
No
Mmus\Fgd1
1 of 14
No
No
Mmus\Fgd2
1 of 14
No
No
Mmus\Fgd4
1 of 14
No
No
Mmus\Fgd5
1 of 14
No
No
Mmus\Fgd6
1 of 14
No
No
Mmus\Mtmr4
1 of 14
No
No
Mmus\Plekhf1
1 of 14
No
No
Mmus\Plekhf2
1 of 14
No
No
Mmus\Zfyve9
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\pikfyve
8 of 13
Yes
Yes
Xtro\akap12
1 of 13
No
Yes
Xtro\farp1
1 of 13
No
No
Xtro\fgd1
1 of 13
No
No
Xtro\leprot
1 of 13
No
No
Xtro\mtmr4
1 of 13
No
No
Xtro\pip4k2c
1 of 13
No
No
Xtro\pip5kl1
1 of 13
No
No
Xtro\plekhf1
1 of 13
No
No
Xtro\plekhf2
1 of 13
No
No
Xtro\zfyve16
1 of 13
No
No
Xtro\zfyve26
1 of 13
No
No
Danio rerio (Zebrafish) (23)
Drer\pikfyve
12 of 14
Yes
Yes
Drer\pip4k2aa
2 of 14
No
No
Drer\pip4k2cb
2 of 14
No
No
Drer\pip5k1ab
2 of 14
No
No
Drer\pip5k1ba
2 of 14
No
No
Drer\pip5k1bb
2 of 14
No
No
Drer\pip5k1ca
2 of 14
No
No
Drer\pip5kl1
2 of 14
No
No
Drer\farp2
1 of 14
No
No
Drer\fgd1
1 of 14
No
No
Drer\fgd4a
1 of 14
No
No
Drer\fgd4b
1 of 14
No
No
Drer\fgd5a
1 of 14
No
No
Drer\fgd5b
1 of 14
No
No
Drer\fgd6
1 of 14
No
No
Drer\morn2
1 of 14
No
Yes
Drer\pip4k2ab
1 of 14
No
No
Drer\pip4k2ca
1 of 14
No
No
Drer\pip5k1aa
1 of 14
No
No
Drer\pip5k1cb
1 of 14
No
No
Drer\plekhf1
1 of 14
No
No
Drer\plekhf2
1 of 14
No
No
Drer\zfyve9a
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\ppk-3
12 of 14
Yes
Yes
Cele\ppk-1
2 of 14
No
No
Cele\ppk-2
2 of 14
No
No
Cele\lst-2
1 of 14
No
No
Cele\tag-77
1 of 14
No
No
Cele\ZK632.12
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP005216
11 of 12
Yes
Yes
Agam\AgaP_AGAP008932
1 of 12
No
No
Agam\AgaP_AGAP009170
1 of 12
No
No
Agam\AgaP_AGAP010307
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\FAB1A
11 of 13
Yes
Yes
Atha\FAB1B
11 of 13
Yes
Yes
Atha\FAB1C
11 of 13
Yes
Yes
Atha\FAB1D
10 of 13
No
Yes
Atha\AT1G10900
2 of 13
No
No
Atha\AT1G60890
2 of 13
No
No
Atha\PIP5K1
2 of 13
No
No
Atha\PIP5K2
2 of 13
No
No
Atha\PIP5K3
2 of 13
No
No
Atha\PIP5K4
2 of 13
No
No
Atha\PIP5K5
2 of 13
No
No
Atha\PIP5K6
2 of 13
No
No
Atha\PIP5K9
2 of 13
No
No
Atha\PIPK10
2 of 13
No
No
Atha\PIPK11
2 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\FAB1
12 of 13
Yes
Yes
Scer\MSS4
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\fab1
10 of 12
Yes
Yes
Spom\its3
2 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:fab1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (20)
PIP4K
2 of 13
PIP5K59B
2 of 13
sktl
2 of 13
CCT1
1 of 13
CCT2
1 of 13
CCT3
1 of 13
CCT4
1 of 13
CCT5
1 of 13
CCT6
1 of 13
CCT7
1 of 13
CCT8
1 of 13
CG6051
1 of 13
CG41099
1 of 13
Exo84
1 of 13
Hrs
1 of 13
Hsp60A
1 of 13
Hsp60B
1 of 13
Hsp60C
1 of 13
Hsp60D
1 of 13
rush
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing
    12 of 14
    609414
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-84
    Cytogenetic map
    54E9-54E9
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    54E9-54E9
    Limits computationally determined from genome sequence between P{EP}subEP616 and P{PZ}grh06850&P{lacW}olf186-Fk11505
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-84

    (FlyBase, 2016)

    2-86.8

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (13)
    Genomic Clones (22)
    cDNA Clones (28)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Rusten et al., 2006)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          fab1 levels respond to the nutritional status of the fly, rather than to insulin signaling.

          (Powis and Macdougall, 2011)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)
          Relationship to Other Genes
          Source for database merge of
          Additional comments

          FlyBase curator comment: Correspondence with author Rusten revealed that 'Fab1' = 'CG6355'.

          (Rusten et al., 2007)

          One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG33981 and fab1.

          (FlyBase Genome Annotators, 2005)

          CG33981 and fab1 appear to be encoded by a dicistronic transcript; CG33981 is encoded within the 5' UTR of fab1.

          (Heriche, 2005.7.14)
          Nomenclature History
          Source for database identify of

          Source for identity of: fab1 CG6355

          (Rusten et al., 2006)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (11)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 61 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (65)