FlyBase Gene Report: Dmel\Cdc23

General Information

Symbol

Dmel\Cdc23

Species

D. melanogaster

Name

Cell division cycle 23

Annotation Symbol

CG2508

Feature Type

protein_coding_gene

FlyBase ID

FBgn0032863

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Cell division cycle 23 (Cdc23) encodes a subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

APC8, 38C.54

Key Links

Genomic Location

Cytogenetic map

38C7-38C8

Sequence location

2L:20,459,342..20,461,729 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:20459342..20461729

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables enzyme-substrate adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002649387

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in endomitotic cell cycle

inferred from mutant phenotype

(Narbonne-Reveau et al., 2008)

involved_in positive regulation of mitotic metaphase/anaphase transition

inferred from mutant phenotype

(Pal et al., 2007)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in anaphase-promoting complex-dependent catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000285356

(GO Reference Genome Project, 2011-)

involved_in cell division

inferred from biological aspect of ancestor with PANTHER:PTN001757014

(GO Reference Genome Project, 2011-)

involved_in positive regulation of mitotic metaphase/anaphase transition

inferred from biological aspect of ancestor with PANTHER:PTN000285356

(GO Reference Genome Project, 2011-)

involved_in protein ubiquitination

inferred from biological aspect of ancestor with PANTHER:PTN000285356

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of anaphase-promoting complex

inferred from physical interaction with FLYBASE:APC7; FB:FBgn0029879

(Pal et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of anaphase-promoting complex

inferred from biological aspect of ancestor with PANTHER:PTN000285356

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR007192

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

ANAPHASE-PROMOTING COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ANAPHASE-PROMOTING COMPLEX -: Anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase. Active during mitosis and G1 phases of the cell cycle, it mediates the degradation of cyclins and other key cell cycle regulators triggering the metaphase to anaphase transition and the exit from mitosis. (Adapted from PMID:12208841).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cdc23 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9I7L8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cdc23-RA

FBtr0081362

NM_136192

2270

678

Cdc23-RB

FBtr0332969

NM_001273700

2184

678

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cdc23-PA

FBpp0080894

77.6

678

6.47

FBpp0305185

77.6

678

6.47

Q9I7L8

NP_001260629

AGB93164

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

678 aa isoforms: Cdc23-PA, Cdc23-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9I7L8

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc23 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.38

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of anaphase-promoting complex

inferred from physical interaction with FLYBASE:APC7; FB:FBgn0029879

(Pal et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc23 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cdc23

View exonic expression by tissue for Dmel\Cdc23

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032863

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35315/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032863

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032863

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032863

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2508

Flygut - An atlas of the Drosophila adult midgut

FBgn0032863

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cdc23

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cdc23

Transgenic constructs containing regulatory region of Cdc23

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel7078

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Cdc23^GD17046

lethal | prepupal stage P4(ii), with Scer\GAL4^Act5C.PU

Cdc23^RNAi.WIZ.UAS

lethal | third instar larval stage, with Scer\GAL4^Act5C.PU

Cdc23^RNAi.WIZ.UAS

viable

Cdc23^c06630

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cdc23^GD17046

viable, with Scer\GAL4^tin.CΔ4

Cdc23^GD17046

Sterility

Allele

fertile

Cdc23^c06630

Other Phenotypes

Allele

abnormal endomitotic cell cycle | somatic clone, with Scer\GAL4^Act5C.PP

Cdc23^RNAi.WIZ.UAS

abnormal mitotic cell cycle, with Scer\GAL4^Act5C.PU

Cdc23^RNAi.WIZ.UAS

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Cdc23^GD17046

abnormal size | adult stage, with Scer\GAL4^ey.PU

Cdc23^KK108295

increased cell death, with Scer\GAL4^Act5C.PU

Cdc23^RNAi.WIZ.UAS

melanotic mass phenotype | third instar larval stage, with Scer\GAL4^Act5C.PU

Cdc23^RNAi.WIZ.UAS

visible | adult stage, with Scer\GAL4^ey.PU

Cdc23^KK108295

Phenotype manifest in

Allele

eye, with Scer\GAL4^ey.PU

Cdc23^KK108295

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Cdc23^GD17046

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

Cdc23^GD17046

nucleus | somatic clone, with Scer\GAL4^Act5C.PP

Cdc23^RNAi.WIZ.UAS

retina, with Scer\GAL4^ey.PU

Cdc23^KK108295

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (22)

Hsap\CDC23

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Cdc23

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (16)

Mmus\Cdc23

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\cdc23

8 of 13

Yes

Xtro\txnip

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ttc27

1 of 13

Xtro\ttc28

1 of 13

Xtro\ttc37

1 of 13

Danio rerio (Zebrafish) (17)

Drer\cdc23

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\mat-3

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP009880

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (17)

Atha\APC8

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\CDC23

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\cut23

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (3)

Ecol\alaS

1 of 11

Yes

Ecol\lapB

1 of 11

Yes

Ecol\yphG

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cdc23. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

11 of 13

3 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sxc

1 of 13

Tmtc4

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDC23; cell division cycle 23

14 of 14

603462

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cdc23 - APC7

affinity chromatography technology, western blot

(Pal et al., 2007)

Cdc23 - CG12702

experimental knowledge based

(Guruharsha et al., 2011)

Cdc23 - Cdk1

anti bait coimmunoprecipitation, western blot

(Mohd-Sarip et al., 2012)

Cdc23 - CycB

anti bait coimmunoprecipitation, western blot

(Mohd-Sarip et al., 2012)

Cdc23 - Psc

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Mohd-Sarip et al., 2012)

Cdc23 - cort

anti tag coimmunoprecipitation, peptide massfingerprinting

(Whitfield et al., 2013)

Cdc23 - fzr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Meghini et al., 2016)

Cdc23 - lmgA

anti bait coimmunoprecipitation, western blot

(Mohd-Sarip et al., 2012)

Cdc23 - mr

anti bait coimmunoprecipitation, western blot

(Mohd-Sarip et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cdc23

enhanceable

APC10

(Narbonne-Reveau et al., 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0032863

MIST (genetic) - An integrated Molecular Interaction Database

35315

MIST (protein-protein) - An integrated Molecular Interaction Database

35315

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

38C7-38C8

Sequence location

2L:20,459,342..20,461,729 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

38C7-38C8

Limits computationally determined from genome sequence between P{EP}CG16798^EP401&P{lacW}k07219 and P{lacW}k02501&P{lacW}k14810

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-54.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17775

w¹¹¹⁸; PBac{PB}Cdc23^c06630

31735

y¹ v¹; P{TRiP.HM04044}attP2

61982

y¹ v¹; P{TRiP.HMJ23608}attP40

FlyORF

F001423

M{UAS-Cdc23.ORF}ZH-86Fb

NIG-Fly

2508R-1

P{NIG.2508R}1

HMJ23608

y¹ v¹; P{TRiP.HMJ23608}attP40/CyO

VDRC

v107306

P{KK108295}VIE-260B

v52279

w¹¹¹⁸; P{GD17046}v52279

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD09850

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0032863

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0032863

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca²⁺ release.

(Zhang et al., 2006)

Relationship to Other Genes

Source for database merge of

Additional comments

CG31687 appears to be a chimeric gene, with the 5' part of the gene derived from cdc23 and the 3' part of the gene derived from CG31688.

(Rogers and Hartl, 2012)

"CG31687" is a putative chimeric gene derived from the "cdc23" and "CG31688" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene).

(Rogers et al., 2009)

Nomenclature History

Source for database identify of

Source for identity of: cdc23 CG2508

(Deak, 2005.9.6)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

38C.54

(Butler, 2001, Butler et al., 2001, McGill Drosophila Genome Project, 2001.9.25)

APC8

(Martins et al., 2017, Weber and Mlodzik, 2017, Weber et al., 2012, Buttitta et al., 2010)

APC8 (cdc23)

(Weber and Mlodzik, 2017)

Apc8

(Narbonne-Reveau et al., 2008, Pal et al., 2007)

CDC23

(Mohd-Sarip et al., 2012)

CG2508

(Weber and Mlodzik, 2017, Schertel et al., 2013, Rogers and Hartl, 2012, Weber et al., 2012, Zhan et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Acquaviva and Pines, 2006, Stroschein-Stevenson et al., 2006, Harper et al., 2002)

CG2508-PA

(Rogers et al., 2009)

Cdc23

(Heigwer et al., 2023, Martins et al., 2017, Solis et al., 2017, Meghini et al., 2016, Fischer et al., 2015, Whitfield et al., 2013, Pal et al., 2007)

cdc23

(Silva et al., 2018, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Weber et al., 2012, Neumüller et al., 2011, Buttitta et al., 2010, Rogers et al., 2009, Zhang et al., 2006)

Name Synonyms

Cell division cycle 23

Cell division cycle 23 ortholog

cdc23

(Pal et al., 2005)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35315

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9I7L8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9I7L8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9I7L8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032863

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35315/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032863

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032863

FlyMine - An integrated database for Drosophila genomics

FBgn0032863

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2508

MARRVEL_MODEL - MARRVEL (model organism gene)

35315

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0032863

DroID - A comprehensive database of gene and protein interactions.

FBgn0032863

DRSC - Results frm RNAi screens

FBgn0032863

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032863

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0032863

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2508

Flygut - An atlas of the Drosophila adult midgut

FBgn0032863

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0032863

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014483

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

MIST (genetic) - An integrated Molecular Interaction Database

35315

MIST (protein-protein) - An integrated Molecular Interaction Database

35315

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (56)

The following external sites may use different assemblies or annotations than FlyBase.

3.38

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