FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Nup44A
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General Information
Symbol
Dmel\Nup44A
Species
D. melanogaster
Name
Nucleoporin at 44A
Annotation Symbol
CG8722
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033247
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Nucleoporin at 44A (Nup44A) encodes a nuclear pore protein involved in TORC1 signaling, autophagy and oogenesis. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

seh1

Key Links
Genomic Location
Cytogenetic map
44A2-44A2
Sequence location
Recombination map
2-58
RefSeq locus
NT_033778 REGION:7988462..7991283
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables structural molecule activity
inferred from electronic annotation with InterPro:IPR037363
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from mutant phenotype
(Bar-Peled et al., 2013)
involved_in germarium-derived egg chamber formation
inferred from mutant phenotype
(Wei et al., 2014)
involved_in negative regulation of autophagy
inferred from mutant phenotype
(Wei et al., 2014)
involved_in oogenesis
inferred from mutant phenotype
(Senger et al., 2011)
involved_in positive regulation of autophagy
inferred from mutant phenotype
(Cai et al., 2016)
involved_in positive regulation of cell size
inferred from mutant phenotype
(Bar-Peled et al., 2013)
involved_in positive regulation of TOR signaling
inferred from mutant phenotype
(Bar-Peled et al., 2013)
involved_in positive regulation of TORC1 signaling
inferred from mutant phenotype
(Wei et al., 2014)
involved_in regulation of meiotic cell cycle
inferred from mutant phenotype
(Senger et al., 2011)
involved_in regulation of mitotic cell cycle
inferred from mutant phenotype
(Senger et al., 2011)
NOT involved_in protein import into nucleus
inferred from mutant phenotype
(Chen and Xu, 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from biological aspect of ancestor with PANTHER:PTN000111887
(GO Reference Genome Project, 2011-)
involved_in positive regulation of TORC1 signaling
inferred from biological aspect of ancestor with PANTHER:PTN000111887
(GO Reference Genome Project, 2011-)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Wei et al., 2014)
located_in lysosome
inferred from direct assay
(Wei et al., 2014)
located_in nuclear envelope
inferred from direct assay
(Senger et al., 2011)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:mio; FB:FBgn0031399
(Senger et al., 2011)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of GATOR2 complex
traceable author statement
(Cai et al., 2016)
part_of nuclear pore outer ring
inferred from biological aspect of ancestor with PANTHER:PTN000111811
(GO Reference Genome Project, 2011-)
part_of Seh1-associated complex
inferred from sequence or structural similarity with SGD:S000003068
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000111887
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the WD repeat SEC13 family. (Q7K2X8)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Nucleoporin at 44A (Nup44A) encodes a nuclear pore protein involved in TORC1 signaling, autophagy and oogenesis. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
NUCLEAR PORE COMPLEX -
The Nuclear Pore Complex (NPC) is a large protein complex embedded in the nuclear membrane that facilitates nucleocytoplasmic traffic. The NPC is composed of approximately 30 different proteins: the nucleoporins. The NPC displays 8-fold symmetry and each nucleoporin is present in multiple copies. From the central ring that forms the pore, filaments protrude into the cytoplasm (cytoplasmic filaments) and the nucleoplasm (nuclear basket). Many nucleoporins contain FG repeats which are thought to act as a diffusion barrier and docking sight for transport receptors (karyopherins). Export and import is controlled by the interaction of the karyopherins with localization and export sequences. (Adapted from FBrf0220062 and PMID:21495847).
GATOR2 COMPLEX -
GATOR2 is a subcomplex of the GATOR or SEA complex. It suppresses the Rag GTPase activating protein activity of the GATOR1 subcomplex, promoting TORC1 activity. (Adapted from FBrf0232362 and PMID:25934700).
Protein Function (UniProtKB)
Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mgtor to the nuclear envelope of early meiotic female germline cells (PubMed:21521741). It is not involved in recruiting the nucleoporins Mgtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC (PubMed:21521741). An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:25512509, PubMed:27166823). GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation growth under nutrient replete conditions and growth during female oocyte development (PubMed:21521741, PubMed:23723238, PubMed:25512509, PubMed:27166823). This component is required for activating mTORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate, probably influences the organization and/or function of microtubules within ovarian cysts, and promotes accumulation of another GATOR2 complex member mio in germline and somatic tissues (PubMed:21521741, PubMed:23723238, PubMed:25512509, PubMed:27166823). GATOR1 and GATOR2 act at different stages of oogenesis to regulate mTORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate mTORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate mTORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509). In addition to its role in the regulation of the mTORC1 complex, functions independently of mTORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823).
(UniProt, Q7K2X8)
Summary (Interactive Fly)

component of a nucleoporin subcomplex - a binding parter of Missing oocyte; regulates nuclear architecture and meiotic progression in early ovarian cysts

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Nup44A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7K2X8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Nup44A-RA
FBtr0088862
NM_136499
1208
354
Nup44A-RB
FBtr0088860
NM_165582
1283
354
Nup44A-RC
FBtr0088861
NM_165583
1331
354
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Nup44A-PA
FBpp0087938
39.5
354
6.70
Q7K2X8
NP_610343
AAF59154
Nup44A-PB
FBpp0087936
39.5
354
6.70
Q7K2X8
NP_724637
AAM68880
Nup44A-PC
FBpp0087937
39.5
354
6.70
Q7K2X8
NP_724638
AAM68881
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

354 aa isoforms: Nup44A-PA, Nup44A-PB, Nup44A-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Probable component of the nuclear pore complex (NPC) (By similarity). Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with mio (PubMed:21521741). Interacts with Wdr24 (PubMed:27166823). The GATOR2 complex associates with unmet in the absence of S-adenosyl-L-methionine; the mio-Wdr24-Nup44A subcomplex is essential and sufficient for this interaction while Wdr59 and Sec13 are dispensable (PubMed:38514639). This association acts as a nutrient sensor to inhibit mTORC1 signaling in the absence of methionine (PubMed:38514639).

(UniProt, Q7K2X8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nup44A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.46

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
nurse cell
(Senger et al., 2011)
oocyte
(Senger et al., 2011)
ovariole
(Senger et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Wei et al., 2014)
located_in lysosome
inferred from direct assay
(Wei et al., 2014)
located_in nuclear envelope
inferred from direct assay
(Senger et al., 2011)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:mio; FB:FBgn0031399
(Senger et al., 2011)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nup44A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Nup44A
Transgenic constructs containing regulatory region of Nup44A
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6055
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (15)
Hsap\SEH1L
14 of 14
Yes
Yes
Hsap\SEC13
2 of 14
No
No
Hsap\APAF1
1 of 14
No
No
Hsap\CIAO1
1 of 14
No
No
Hsap\DAW1
1 of 14
No
No
Hsap\DCAF7
1 of 14
No
No
1  
Hsap\GRWD1
1 of 14
No
No
Hsap\PAFAH1B1
1 of 14
No
No
1  
Hsap\POC1A
1 of 14
No
No
1  
Hsap\POC1B
1 of 14
No
No
1  
Hsap\RBBP4
1 of 14
No
No
2  
Hsap\RBBP7
1 of 14
No
No
4  
Hsap\SPAG16
1 of 14
No
Yes
Hsap\WDR17
1 of 14
No
No
Hsap\WDR59
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
Rnor\Cep192
4 of 14
Yes
Yes
Rnor\Sec13
2 of 14
No
No
Rnor\Seh1l
2 of 14
No
Yes
Rnor\Apaf1
1 of 14
No
No
Rnor\Ciao1
1 of 14
No
No
Rnor\Dcaf7
1 of 14
No
No
Rnor\Grwd1
1 of 14
No
No
Rnor\Pafah1b1
1 of 14
No
No
Rnor\Rbbp4
1 of 14
No
No
Rnor\Rbbp7
1 of 14
No
No
Rnor\RGD1563620
1 of 14
No
No
Rnor\Spag16
1 of 14
No
Yes
Mus musculus (laboratory mouse) (10)
Mmus\Seh1l
14 of 14
Yes
Yes
Mmus\Apaf1
1 of 14
No
No
Mmus\Ciao1
1 of 14
No
No
Mmus\Dcaf7
1 of 14
No
No
Mmus\Grwd1
1 of 14
No
No
Mmus\Pafah1b1
1 of 14
No
No
Mmus\Rbbp4
1 of 14
No
No
Mmus\Rbbp7
1 of 14
No
No
Mmus\Sec13
1 of 14
No
No
Mmus\Spag16
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (14)
Xtro\seh1l
11 of 13
Yes
Yes
Xtro\ciao1
1 of 13
No
No
Xtro\dcaf7
1 of 13
No
No
Xtro\gnb5
1 of 13
No
No
Xtro\grwd1
1 of 13
No
No
Xtro\pafah1b1
1 of 13
No
No
Xtro\poc1b
1 of 13
No
No
Xtro\pwp1
1 of 13
No
No
Xtro\rbbp4
1 of 13
No
No
Xtro\rbbp7
1 of 13
No
No
Xtro\sec13
1 of 13
No
No
Xtro\slc39a2
1 of 13
No
No
Xtro\spag16
1 of 13
No
Yes
Xtro\taf5
1 of 13
No
No
Danio rerio (Zebrafish) (11)
Drer\seh1l
14 of 14
Yes
Yes
Drer\sec13
2 of 14
No
No
Drer\ciao1
1 of 14
No
No
Drer\dcaf7
1 of 14
No
No
Drer\grwd1
1 of 14
No
No
Drer\pafah1b1a
1 of 14
No
No
Drer\pafah1b1b
1 of 14
No
No
Drer\rbb4l
1 of 14
No
No
Drer\rbbp4
1 of 14
No
No
Drer\sec31a
1 of 14
No
No
Drer\sec31b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\npp-18
14 of 14
Yes
Yes
Cele\npp-20
2 of 14
No
No
Cele\ciao-1
1 of 14
No
No
Cele\lin-53
1 of 14
No
No
Cele\lis-1
1 of 14
No
No
Cele\rba-1
1 of 14
No
No
Cele\swan-1
1 of 14
No
No
Cele\swan-2
1 of 14
No
No
Cele\wdr-5.3
1 of 14
No
No
Cele\Y32H12A.8
1 of 14
No
No
Cele\Y54H5A.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (10)
Agam\AgaP_AGAP005174
12 of 12
Yes
Yes
Agam\AgaP_AGAP003183
2 of 12
No
No
Agam\AgaP_AGAP000678
1 of 12
No
No
Agam\AgaP_AGAP003228
1 of 12
No
No
Agam\AgaP_AGAP007125
1 of 12
No
No
Agam\AgaP_AGAP007739
1 of 12
No
No
Agam\AgaP_AGAP009574
1 of 12
No
No
Agam\AgaP_AGAP011849
1 of 12
No
No
Agam\AgaP_AGAP012029
1 of 12
No
No
Agam\CIAO1_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\SEH1H
7 of 13
Yes
Yes
Atha\AT2G30050
2 of 13
No
No
Atha\AT3G01340
2 of 13
No
No
Atha\AT1G64355
1 of 13
No
Yes
Atha\AT4G32990
1 of 13
No
No
Atha\ATAN11
1 of 13
No
No
Atha\emb1345
1 of 13
No
No
Atha\HOS15
1 of 13
No
No
Atha\LWD2
1 of 13
No
No
Atha\MSI1
1 of 13
No
No
Atha\MSI2
1 of 13
No
No
Atha\MSI3
1 of 13
No
No
Atha\SMU1
1 of 13
No
No
Atha\TTG1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\SEH1
12 of 13
Yes
Yes
Scer\CIA1
1 of 13
No
No
Scer\HAT2
1 of 13
No
No
Scer\LST8
1 of 13
No
No
Scer\RRB1
1 of 13
No
No
Scer\RSA4
1 of 13
No
No
Scer\SEC13
1 of 13
No
No
Scer\UTP13
1 of 13
No
No
Scer\YPL247C
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\seh1
12 of 12
Yes
Yes
Spom\mis16
1 of 12
No
No
Spom\prw1
1 of 12
No
No
Spom\sec13
1 of 12
No
No
Spom\SPAC806.02c
1 of 12
No
No
Spom\SPBC17D11.08
1 of 12
No
No
Spom\SPBC1711.07
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Nup44A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
Sec13
4 of 13
Caf1-55
1 of 13
CG7568
1 of 13
Ciao1
1 of 13
ebi
1 of 13
l(2)09851
1 of 13
Lis-1
1 of 13
wap
1 of 13
Wdr24
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SEH1L; SEH1 like nucleoporin
    14 of 14
    609263
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Nup44A
        enhanceable
        mio
        (Senger et al., 2011)
        Nup44A
        suppressible
        Nprl2
        (Wei et al., 2014)
        Nup44A
        suppressible
        Nprl3
        (Wei et al., 2014)
        Nup44A
        suppressible
        RagA-B
        (Yang et al., 2020)
        Nup44A
        suppressible
        RagC-D
        (Yang et al., 2020)
        Nup44A
        suppressible
        Tsc1
        (Wei et al., 2014)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        mio
        suppressible
        Nup44A
        (Senger et al., 2011)
        Wdr59
        suppressible
        Nup44A
        (Zhang et al., 2023)
        External Data
        Subunit Structure (UniProtKB)
        Probable component of the nuclear pore complex (NPC) (By similarity). Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with mio (PubMed:21521741). Interacts with Wdr24 (PubMed:27166823). The GATOR2 complex associates with unmet in the absence of S-adenosyl-L-methionine; the mio-Wdr24-Nup44A subcomplex is essential and sufficient for this interaction while Wdr59 and Sec13 are dispensable (PubMed:38514639). This association acts as a nutrient sensor to inhibit mTORC1 signaling in the absence of methionine (PubMed:38514639).
        (UniProt, Q7K2X8 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-58
        Cytogenetic map
        44A2-44A2
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        44A2-44A2
        Limits computationally determined from genome sequence between P{lacW}CSN4k08018&P{lacW}l(2)k08504k08504 and P{lacW}Vps28k16503
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-58

        (FlyBase, 2016)

        2-57.2

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (13)
        Genomic Clones (10)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (29)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments
              Relationship to Other Genes
              Source for database merge of
              Additional comments

              FlyBase Curator comment: Correspondence with author Lan Xu revealed that 'seh1' = CG8722.

              (Chen and Xu, 2010)
              Nomenclature History
              Source for database identify of

              Source for identity of: nup44A CG8722

              (Fernandez-Funez et al., 2000)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (14)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 60 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              References (82)