FlyBase Gene Report: Dmel\RhoGEF64C

General Information

Symbol

Dmel\RhoGEF64C

Species

D. melanogaster

Name

Rho guanine nucleotide exchange factor at 64C

Annotation Symbol

CG32239

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035574

Gene Model Status

Current

Stock Availability

18 publicly available

Gene Summary

Rho guanine nucleotide exchange factor at 64C (RhoGEF64C) encodes a guanine nucleotide exchange factor with apical protein localization. In some ectodermal cells localization is controlled at the level of RNA. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Gef64C, RhoGEF, Guanine nucleotide exchange factor GEF64C

Key Links

Genomic Location

Cytogenetic map

64B13-64B17

Sequence location

3L:4,692,783..4,796,253 [+]

Recombination map

3-12

RefSeq locus

NT_037436 REGION:4692783..4796253

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from genetic interaction with FLYBASE:Rho1; FB:FBgn0014020

(Simões et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from electronic annotation with InterPro:IPR000219

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Bashaw et al., 2001)

involved_in imaginal disc-derived leg morphogenesis

inferred from mutant phenotype

(Greenberg and Hatini, 2011)

involved_in positive regulation of Rho protein signal transduction

inferred from genetic interaction with FLYBASE:Rho1; FB:FBgn0014020

(Simões et al., 2006)

involved_in spiracle morphogenesis, open tracheal system

inferred from genetic interaction with FLYBASE:Rho1; FB:FBgn0014020

(Simões et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in positive regulation of Rho protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000517811

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Simões et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RhoGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Rho family GTPases. They include Dbl-homology domain-containing proteins (the largest family of RhoGEFs) and CZH2 domain/Dock family GEFs. (Adapted from FBrf0190957).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RhoGEF64C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VZ85)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RhoGEF64C-RA

FBtr0073345

NM_168102

7297

1984

RhoGEF64C-RB

FBtr0332738

NM_001274496

7166

1984

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RhoGEF64C-PA

FBpp0073201

214.9

1984

6.78

FBpp0304983

214.9

1984

6.78

Q9VZ85

NP_001261425

AGB94120

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1984 aa isoforms: RhoGEF64C-PA, RhoGEF64C-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RhoGEF64C using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RhoGEF64C_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.59

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

hindgut proper primordium

(Fisher et al., 2012)

large intestine primordium

Comment: reported as large intestine specific anlage

(Fisher et al., 2012)

Malpighian tubule tip cell primordium

(Fisher et al., 2012)

posterior spiracle primordium

Comment: reported as posterior spiracle specific anlage

(Fisher et al., 2012)

small intestine primordium

Comment: reported as small intestine specific anlage

(Fisher et al., 2012)

prepupal stage P3

leg joint

(Greenberg and Hatini, 2011)

oogenesis

centripetal follicle cell

(Wang et al., 2006)

Additional Descriptive Data

Expression in stage P3 pupal leg discs is restricted to presumptive leg joints.

(Greenberg and Hatini, 2011)

RhoGEF64C expression is enriched in centripetal cells relative to other cells in the egg chamber.

(Wang et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

presumptive embryonic/larval central nervous system

(Bashaw et al., 2001)

organism | ubiquitous

(Bashaw et al., 2001)

embryonic stage 15 -- 17

embryonic/larval tracheal section

(Massarwa et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

RhoGEF64C protein shows apical localization in trachea.

(Massarwa et al., 2009)

Broad, low levelexpression of RhoGEF64C is observed in embryos with enrichment in the nervous system.

(Bashaw et al., 2001)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Simões et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RhoGEF64C in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RhoGEF64C

View exonic expression by tissue for Dmel\RhoGEF64C

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035574

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38578/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035574

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035574

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035574

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32239

Flygut - An atlas of the Drosophila adult midgut

FBgn0035574

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\RhoGEF64C

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 30 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RhoGEF64C

Transgenic constructs containing regulatory region of RhoGEF64C

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6102

(Ryder, 2004.4.26)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

RhoGEF64C^GD16275

partially lethal - majority die, with Scer\GAL4^pnr-MD237

viable

RhoGEF64C^PL00309

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

RhoGEF64C^GD16275

viable, with Scer\GAL4^sca-4512

Sterility

Allele

fertile

RhoGEF64C^PL00309

Other Phenotypes

Allele

abnormal behavior | recessive

RhoGEF64C^BG00336

abnormal locomotor behavior | adult stage | male limited

RhoGEF64C^BG00336

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

abnormal starvation stress response

RhoGEF64C^BG00336

abnormal temperature response

RhoGEF64C^BG00336

long lived

RhoGEF64C^BG00336

short lived, with Scer\GAL4^Mef2.PR

RhoGEF64C^GD10829

some die during pupal stage, with Scer\GAL4^pnr-MD237

visible, with Scer\GAL4^GMR.PU

RhoGEF64C^EP3322

visible, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

actin filament & embryonic/larval tracheal system, with Scer\GAL4^btl.PS

RhoGEF64C^GD16275

eye, with Scer\GAL4^GMR.PU

RhoGEF64C^EP3322

larval longitudinal connective, with Scer\GAL4^elav.PLu

larval ventral nerve cord commissure, with Scer\GAL4^sca-4512

mesonotum, with Scer\GAL4^pnr-MD237

ovariole, with Scer\GAL4^bab1-Pgal4-2

RhoGEF64C^KK103071

ovariole, with Scer\GAL4^tj.PU

RhoGEF64C^KK103071

symmetrical commissure, with Scer\GAL4^elav.PLu

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (47)

Hsap\ITSN1

3 of 14

Yes

Hsap\ITSN2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (35)

Rnor\Akap13

2 of 14

Yes

Rnor\Arhgef3

2 of 14

Yes

Rnor\Arhgef11

2 of 14

Yes

Rnor\Arhgef12

2 of 14

Yes

Rnor\Arhgef16

2 of 14

Yes

Rnor\Arhgef18

2 of 14

Yes

Rnor\Arhgef26

2 of 14

Yes

Rnor\Fgd2

2 of 14

Yes

Rnor\Itsn1

2 of 14

Yes

Rnor\Itsn2

2 of 14

Yes

Rnor\Net1

2 of 14

Yes

Rnor\Plekhg5

2 of 14

Yes

Rnor\Plekhg6

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (38)

Mmus\Itsn1

3 of 14

Yes

Mmus\Itsn2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (23)

Xtro\LOC100490228

5 of 13

Yes

Xtro\asb13

2 of 13

Yes

Xtro\abr

1 of 13

Xtro\arhgef3.1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\arhgef38

1 of 13

Yes

Xtro\arhgef39

1 of 13

Xtro\c16orf87

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ngef

1 of 13

Xtro\plekhg5

1 of 13

Xtro\plekhg7

1 of 13

Yes

Xtro\prex1

1 of 13

Yes

Xtro\prex2

1 of 13

Xtro\rps6ka1

1 of 13

Danio rerio (Zebrafish) (48)

Drer\si:dkey-91i10.2

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-172h23.2

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\rhgf-1

2 of 14

Yes

Cele\tag-52

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP006514

10 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\ROM1

2 of 13

Yes

Scer\ROM2

2 of 13

Yes

Scer\TUS1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\rgf1

2 of 12

Yes

Spom\rgf2

2 of 12

Yes

Spom\rgf3

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RhoGEF64C. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

CG42674

2 of 13

cyst

2 of 13

Exn

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

sif

1 of 13

Vav

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

3 of 14

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

RhoGEF64C

suppressible

Rho1

(Bashaw et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

fra

enhanceable

RhoGEF64C

(Bashaw et al., 2001)

pnr

enhanceable

RhoGEF64C

(Pena-Rangel et al., 2002)

RacGAP84C

enhanceable

RhoGEF64C

(Raymond et al., 2004)

Rho1

suppressible

RhoGEF64C

(Simões et al., 2006)

robo1

suppressible

RhoGEF64C

(Bashaw et al., 2001)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64047

DroID - A comprehensive database of gene and protein interactions.

FBgn0035574

MIST (genetic) - An integrated Molecular Interaction Database

38578

MIST (protein-protein) - An integrated Molecular Interaction Database

38578

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-12

Cytogenetic map

64B13-64B17

Sequence location

3L:4,692,783..4,796,253 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

64B13-64B17

Limits computationally determined from genome sequence between P{PZ}l(3)rG166^rG166 and P{PZ}sinu⁰⁶⁵²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-12

(FlyBase, 2016)

3-10.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31130

y¹ v¹; P{TRiP.JF01604}attP2

13235

y¹; P{SUPor-P}RhoGEF64C^KG02832

24220

w¹¹¹⁸; Mi{ET1}RhoGEF64C^MB04730

26054

w¹¹¹⁸; Mi{ET1}RhoGEF64C^MB06529

85351

w¹¹¹⁸; PBac{PB}RhoGEF64C^c01959

20985

w¹¹¹⁸; P{GT1}RhoGEF64C^GT-000502

44204

y¹ w^*; Mi{MIC}RhoGEF64C^MI07648

44295

y¹ w^*; Mi{MIC}RhoGEF64C^MI05884

44861

y¹ w^*; Mi{MIC}RhoGEF64C^MI05417

13283

y¹ w^67c23; P{SUPor-P}RhoGEF64C^KG04233

VDRC

v105252

P{KK103071}VIE-260B

v47121

w¹¹¹⁸; P{GD16275}v47121

More stocks available...

Genomic Clones (70)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (40)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH26207

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035574

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035574

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Bashaw et al., 2001)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

In sensitized genetic backgrounds, loss of Gef64C function causes a phenotype where too few axons cross the midline. In contrast, ectopic expression of Gef64C throughout the nervous system results in a phenotype in which far too many axons cross the midline. Genetic analysis indicates that Gef64C over-expression can in fact overcome robo repulsion.

(Bashaw et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: Gef64C EP3035

(Bashaw et al., 2001)

Source for merge of: CG13709 CG13710

(Bashaw, 2002.3.8)

Additional comments

FlyBase curator comment: the insertion in the "d04957" Exelixis line (P{XP}d04957) was originally assigned to the Gef64C gene in FBrf0179797, resulting in the "Gef64C^d04957" (FBal0160428) allele. However, FBrf0184340 shows that this was incorrect, and the P{XP}d04957 insertion is not within a transcription unit.

(Bloomington Drosophila Stock Center, 2004.11.6)

Annotations CG13709, CG13710 merged as CG32239 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: GEF64C CG13709 CG13710

(Bashaw, 2002.3.8)

Source for identity of: RhoGEF64C Gef64C

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG13709

CG13710

CG32239

(Hosono et al., 2015, Greenberg and Hatini, 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Simões et al., 2006, Ryder, 2004.9.23)

EP(3)3035

(Pena-Rangel et al., 2002)

EP3035

GEF

(Harris and Tepass, 2008)

GEF(64C)

(Raymond et al., 2004)

GEF64C

(Bakal et al., 2007, McGovern et al., 2003, Ghose and Van Vactor, 2002, Bashaw, 2001.11.28, Bashaw et al., 2001)

Gef64C

(Glassford et al., 2015, Ashwal-Fluss et al., 2014, Napoletano et al., 2011, Wasbrough et al., 2010, Massarwa et al., 2009, Bakal et al., 2007, Lovegrove et al., 2006, Lovegrove et al., 2006, Wang et al., 2006, Mok et al., 2005)

RhoGEF

(Sailem et al., 2014, Hickson and O'Farrell, 2008)

RhoGEF64

(Denholm, 2013)

RhoGEF64C

(Bischoff et al., 2025, Kamiyama et al., 2025, Ko et al., 2024, Fabre et al., 2022, Tarikere et al., 2022, Guzman et al., 2021, McLaughlin et al., 2021, Lecheta et al., 2020, Ray et al., 2019, Rech et al., 2019, Gene Disruption Project members, 2018-, Lobell et al., 2017, Transgenic RNAi Project members, 2017-, Greenberg and Hatini, 2011, Vlachos and Harden, 2011, Simões et al., 2006)

RhoGef64C

(Sotillos et al., 2013)

gef64c

(Marcogliese et al., 2017)

Name Synonyms

Guanine nucleotide exchange factor

(Burnette et al., 2005)

Guanine nucleotide exchange factor 64C

(Magwire et al., 2010)

Guanine nucleotide exchange factor GEF64C

(Edwards et al., 2009)

Rho guanine nucleotide exchange factor

(Hickson and O'Farrell, 2008)

Rho guanine nucleotide exchange factor at 64C

guanine nucleotide exchange factor

(Harris and Tepass, 2008)

Secondary FlyBase IDs

FBgn0035573
FBgn0052239
FBgn0062671

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38578

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VZ85

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VZ85

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035574

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38578/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035574

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035574

FlyMine - An integrated database for Drosophila genomics

FBgn0035574

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32239

MARRVEL_MODEL - MARRVEL (model organism gene)

38578

Linkouts

BioGRID - A database of protein and genetic interactions.

64047

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035574

DroID - A comprehensive database of gene and protein interactions.

FBgn0035574

DRSC - Results frm RNAi screens

FBgn0035574

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RhoGEF64C_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035574

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035574

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32239

Flygut - An atlas of the Drosophila adult midgut

FBgn0035574

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003783

MIST (genetic) - An integrated Molecular Interaction Database

38578

MIST (protein-protein) - An integrated Molecular Interaction Database

38578

References (97)

The following external sites may use different assemblies or annotations than FlyBase.

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