FlyBase Gene Report: Dmel\KLHL18

General Information

Symbol

Dmel\KLHL18

Species

D. melanogaster

Name

Kelch like family member 18

Annotation Symbol

CG3571

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037978

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

dKLHL18

Key Links

Genomic Location

Cytogenetic map

87A4-87A5

Sequence location

3R:12,007,476..12,010,434 [-]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:12007476..12010434

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables ubiquitin-like ligase-substrate adaptor activity

inferred from direct assay

(Zhou et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ubiquitin-like ligase-substrate adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001561260

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in imaginal disc fusion, thorax closure

inferred from mutant phenotype

(Fujiyama-Nakamura et al., 2009)

involved_in proteasome-mediated ubiquitin-dependent protein catabolic process

inferred from direct assay

(Zhou et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteasome-mediated ubiquitin-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN001561260

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of Cul3-RING ubiquitin ligase complex

inferred from direct assay

(Zhou et al., 2015)

inferred from genetic interaction with FLYBASE:Cul3; FB:FBgn0261268

(Fujiyama-Nakamura et al., 2009)

inferred from physical interaction with FLYBASE:Cul3; FB:FBgn0261268

(Fujiyama-Nakamura et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of Cul3-RING ubiquitin ligase complex

inferred from biological aspect of ancestor with PANTHER:PTN001561260

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN001561260

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\KLHL18 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VGE5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

KLHL18-RA

FBtr0082556

NM_141886

2101

575

KLHL18-RB

FBtr0082557

NM_169446

2199

538

KLHL18-RC

FBtr0335434

NM_001275565

2292

575

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

KLHL18-PA

FBpp0082029

64.9

575

6.51

FBpp0082030

60.4

538

6.61

FBpp0307415

64.9

575

6.51

Q9VGE5

NP_001262494

AGB95876

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

575 aa isoforms: KLHL18-PA, KLHL18-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\KLHL18 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

KLHL18_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.73

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of Cul3-RING ubiquitin ligase complex

inferred from direct assay

(Zhou et al., 2015)

inferred from genetic interaction with FLYBASE:Cul3; FB:FBgn0261268

(Fujiyama-Nakamura et al., 2009)

inferred from physical interaction with FLYBASE:Cul3; FB:FBgn0261268

(Fujiyama-Nakamura et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\KLHL18 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\KLHL18

View exonic expression by tissue for Dmel\KLHL18

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037978

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41458/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037978

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037978

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037978

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3571

Flygut - An atlas of the Drosophila adult midgut

FBgn0037978

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of KLHL18

Transgenic constructs containing regulatory region of KLHL18

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3R)Δ87A5-1

(Patrón et al., 2019)

Df(3R)Exel6162

(Ryder, 2004.4.26)

Df(3R)Exel7312

(Ryder, 2004.4.26)

Df(3R)Exel8155

(Ryder, 2004.4.26)

Gene not disrupted in

Df(3R)Δ87A4-1

(Patrón et al., 2019)

Df(3R)Δ87A4-2

(Patrón et al., 2019)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

KLHL18^GD11014

viable, with Scer\GAL4^Mef2.PR

KLHL18^GD11014

viable, with Scer\GAL4^pnr-MD237

KLHL18^GD11014

viable, with Scer\GAL4^tin.CΔ4

KLHL18^GD11014

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

adult external thorax | dorsal, with Scer\GAL4^pnr-MD237

scutellar bristle, with Scer\GAL4^pnr-MD237

trichogen cell, with Scer\GAL4^pnr-MD237

KLHL18^GD11014

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (73)

Hsap\KLHL18

14 of 14

Yes

Hsap\KLHL12

6 of 14

Yes

6 of 14

6 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Hsap\KLHL28

5 of 14

Yes

Hsap\ENC1

4 of 14

Hsap\IVNS1ABP

4 of 14

Yes

Hsap\KEAP1

4 of 14

Hsap\KLHL7

4 of 14

Yes

Hsap\KLHL8

4 of 14

Yes

Hsap\KLHL26

4 of 14

Hsap\KLHL36

4 of 14

Hsap\KBTBD2

3 of 14

Yes

Hsap\KBTBD3

3 of 14

Yes

Hsap\KBTBD8

3 of 14

Yes

Hsap\KBTBD12

3 of 14

Yes

Hsap\KLHL6

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Hsap\KLHL22

3 of 14

Hsap\KLHL23

3 of 14

Yes

Hsap\KLHL24

3 of 14

Yes

Hsap\KLHL29

3 of 14

Yes

Hsap\KLHL30

3 of 14

Yes

Hsap\KLHL31

3 of 14

Hsap\KLHL34

3 of 14

Hsap\KLHL35

3 of 14

Yes

Hsap\KLHL40

3 of 14

Yes

Hsap\KLHL41

3 of 14

Yes

Hsap\GAN

2 of 14

Yes

Hsap\KBTBD4

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\PHOSPHO2-KLHL23

2 of 14

Yes

Hsap\ABTB1

1 of 14

Yes

Hsap\BACH1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (71)

Rnor\Klhl18

13 of 14

Yes

Rnor\Klhl12

6 of 14

Yes

6 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Rnor\Klhl28

5 of 14

Yes

Rnor\Enc1

4 of 14

Rnor\Ivns1abp

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Rnor\Klhl8

4 of 14

Yes

Rnor\Klhl26

4 of 14

Rnor\Klhl36

4 of 14

Rnor\Kbtbd2

3 of 14

Yes

Rnor\Kbtbd8

3 of 14

Yes

Rnor\Klhl1

3 of 14

Rnor\Klhl6

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Rnor\Klhl22

3 of 14

Rnor\Klhl23

3 of 14

Yes

Rnor\Klhl24

3 of 14

Yes

Rnor\Klhl29

3 of 14

Yes

Rnor\Klhl30

3 of 14

Yes

Rnor\Klhl31

3 of 14

Rnor\Klhl34

3 of 14

Rnor\Klhl35

3 of 14

Yes

Rnor\Klhl38

3 of 14

Yes

Rnor\Klhl40

3 of 14

Yes

Rnor\Klhl41

3 of 14

Yes

Rnor\Gan

2 of 14

Rnor\Kbtbd3

2 of 14

Rnor\Kbtbd12

2 of 14

Yes

Rnor\Klhdc8b

2 of 14

Yes

Rnor\Klhl13

2 of 14

Rnor\Klhl32

2 of 14

Rnor\Abtb1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Klhdc8a

1 of 14

Rnor\Klhl11

1 of 14

Yes

Rnor\Klhl33

1 of 14

Rnor\Klhl42

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (82)

Mmus\Klhl18

14 of 14

Yes

Mmus\Klhl12

6 of 14

Yes

6 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Mmus\Klhl28

5 of 14

Yes

Mmus\Enc1

4 of 14

Mmus\Ivns1abp

4 of 14

Yes

Mmus\Keap1

4 of 14

Mmus\Klhl3

4 of 14

Mmus\Klhl7

4 of 14

Yes

Mmus\Klhl8

4 of 14

Yes

Mmus\Klhl26

4 of 14

Mmus\Klhl36

4 of 14

Mmus\Kbtbd2

3 of 14

Yes

Mmus\Kbtbd8

3 of 14

Yes

Mmus\Kbtbd12

3 of 14

Yes

Mmus\Klhl6

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Mmus\Klhl23

3 of 14

Yes

Mmus\Klhl24

3 of 14

Yes

Mmus\Klhl29

3 of 14

Yes

Mmus\Klhl30

3 of 14

Yes

Mmus\Klhl31

3 of 14

Mmus\Klhl34

3 of 14

Mmus\Klhl35

3 of 14

Yes

Mmus\Klhl40

3 of 14

Yes

Mmus\Klhl41

3 of 14

Yes

Mmus\Kbtbd3

2 of 14

Mmus\Klhdc8b

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Klhdc7b

1 of 14

Yes

Mmus\Klhdc8a

1 of 14

Mmus\Klhl11

1 of 14

Yes

Mmus\Klhl33

1 of 14

Mmus\Klhl42

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (68)

Xtro\klhl18

7 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

Yes

Xtro\klhl28

4 of 13

Yes

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Yes

Xtro\klhl8

3 of 13

Yes

Xtro\klhl12

3 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Yes

Xtro\ivns1abp

2 of 13

Yes

Xtro\kbtbd2

2 of 13

Yes

Xtro\kbtbd3

2 of 13

Yes

Xtro\kbtbd8

2 of 13

Yes

Xtro\kbtbd12

2 of 13

Yes

Xtro\keap1

2 of 13

Xtro\klhl6

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\klhl24

2 of 13

Yes

Xtro\klhl29

2 of 13

Yes

Xtro\klhl31

2 of 13

Xtro\klhl34

2 of 13

Xtro\klhl38

2 of 13

Yes

Xtro\klhl40

2 of 13

Yes

Xtro\LOC100496285

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ccdc14

1 of 13

Yes

Xtro\csde1

1 of 13

Xtro\fbrs

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\klhdc8a

1 of 13

Yes

Xtro\klhdc8b

1 of 13

Yes

Xtro\klhl10

1 of 13

Xtro\klhl15

1 of 13

Xtro\klhl30

1 of 13

Yes

Xtro\klhl32

1 of 13

Xtro\klhl41

1 of 13

Yes

Xtro\LOC100489128

1 of 13

Yes

Xtro\LOC116406879

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (85)

Drer\klhl18

13 of 14

Yes

6 of 14

6 of 14

5 of 14

5 of 14

5 of 14

Yes

Drer\LOC108178999

5 of 14

Yes

Drer\enc1

4 of 14

Drer\enc3

4 of 14

Drer\ivns1abpa

4 of 14

Yes

Drer\ivns1abpb

4 of 14

Yes

Drer\keap1b

4 of 14

Drer\klhl3

4 of 14

Drer\klhl25

4 of 14

Yes

Drer\klhl26

4 of 14

Drer\klhl28

4 of 14

Yes

Drer\klhl36

4 of 14

Drer\si:ch211-256e16.3

4 of 14

Yes

Drer\enc2

3 of 14

Yes

Drer\kbtbd2

3 of 14

Yes

Drer\kbtbd8

3 of 14

Yes

Drer\kbtbd12

3 of 14

Yes

Drer\klhl2

3 of 14

Drer\klhl4

3 of 14

Drer\klhl6

3 of 14

Yes

Drer\klhl7

3 of 14

Yes

Drer\klhl8

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\klhl22

3 of 14

Drer\klhl24a

3 of 14

Yes

Drer\klhl29

3 of 14

Yes

Drer\klhl30

3 of 14

Yes

Drer\klhl38a

3 of 14

Yes

Drer\klhl40a

3 of 14

Yes

Drer\klhl40b

3 of 14

Yes

Drer\klhl41a

3 of 14

Yes

Drer\klhl41b

3 of 14

Yes

Drer\klhl43

3 of 14

Drer\LOC100334314

3 of 14

Yes

Drer\klhdc8b

2 of 14

Yes

Drer\klhl10b.1

2 of 14

Drer\klhl14

2 of 14

Drer\klhl23

2 of 14

Yes

Drer\klhl24b

2 of 14

Yes

Drer\klhl31

2 of 14

Drer\klhl32

2 of 14

Drer\klhl35

2 of 14

Yes

Drer\si:dkey-260j18.2

2 of 14

Yes

Drer\si:rp71-68n21.9

2 of 14

Drer\abtb1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\kbtbd13a

1 of 14

Yes

Drer\kbtbd13b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC101886608

1 of 14

Yes

Drer\si:ch73-29c22.1

1 of 14

Drer\si:ch211-63p21.8

1 of 14

Drer\spop

1 of 14

Drer\spopla

1 of 14

Drer\spoplb

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (52)

Cele\kel-3

13 of 14

Yes

Cele\kel-20

6 of 14

Cele\C53A5.9

4 of 14

Yes

Cele\ivns-1

4 of 14

Yes

Cele\kel-1

4 of 14

Cele\kel-8

4 of 14

Yes

Cele\C53A5.6

3 of 14

Yes

Cele\C53A5.11

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Cele\bath-2

1 of 14

Yes

Cele\bath-3

1 of 14

Cele\bath-4

1 of 14

Yes

Cele\bath-5

1 of 14

Yes

Cele\bath-7

1 of 14

Yes

Cele\bath-9

1 of 14

Yes

Cele\bath-13

1 of 14

Cele\bath-15

1 of 14

Yes

Cele\bath-21

1 of 14

Cele\bath-23

1 of 14

Cele\bath-24

1 of 14

Yes

Cele\bath-25

1 of 14

Cele\bath-31

1 of 14

Yes

Cele\bath-33

1 of 14

Yes

Cele\bath-35

1 of 14

Yes

Cele\bath-36

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\btb-2

1 of 14

Yes

Cele\btb-7

1 of 14

Yes

Cele\btb-16

1 of 14

Yes

Cele\btb-17

1 of 14

Yes

Cele\btb-20

1 of 14

Yes

Cele\C15H9.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (29)

Agam\AgaP_AGAP011142

12 of 12

Yes

5 of 12

5 of 12

5 of 12

4 of 12

4 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (159)

Atha\AFR

3 of 13

Yes

Atha\AT1G16250

3 of 13

Yes

Atha\AT1G27420

3 of 13

Yes

Atha\AT1G30090

3 of 13

Yes

Atha\AT1G55270

3 of 13

Yes

Atha\AT1G67480

3 of 13

Yes

Atha\AT2G29820

3 of 13

Yes

Atha\AT2G30600

3 of 13

Yes

Atha\AT3G63220

3 of 13

Yes

Atha\AT5G26960

3 of 13

Yes

Atha\AT5G60570

3 of 13

Yes

Atha\SKIP6

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\LRB3

2 of 13

Yes

Atha\NSP5

2 of 13

Atha\POB1

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G48190

1 of 13

Yes

Atha\AT1G52000

1 of 13

Yes

Atha\AT1G52100

1 of 13

Yes

Atha\AT1G52110

1 of 13

Atha\AT1G52120

1 of 13

Yes

Atha\AT1G52130

1 of 13

Yes

Atha\AT1G55760

1 of 13

Atha\AT1G57570

1 of 13

Yes

Atha\AT1G60095

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G05330

1 of 13

Atha\AT2G14288

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G03010

1 of 13

Atha\AT5G28520

1 of 13

Atha\AT5G35940

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\BT5

1 of 13

Yes

Atha\ESP

1 of 13

Atha\JAL22

1 of 13

Atha\JAL23

1 of 13

Yes

Atha\JAL34

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:KLHL18. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (22)

CG9426

10 of 13

CG17754

10 of 13

dbo

10 of 13

CG15097

9 of 13

Keap1

9 of 13

kel

9 of 13

8 of 13

4 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

hiw

1 of 13

lute

1 of 13

rdx

1 of 13

Tango10

1 of 13

Trl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

KLHL7; kelch like family member 7

model of cold-induced sweating syndrome 3

IEA

(FlyBase, 2019-)

model of retinitis pigmentosa 42

IEA

(FlyBase, 2019-)

IVNS1ABP; influenza virus NS1A binding protein

model of immunodeficiency 70

IEA

(FlyBase, 2019-)

KLHL41; kelch like family member 41

model of nemaline myopathy 9

IEA

(FlyBase, 2019-)

KLHL40; kelch like family member 40

model of nemaline myopathy 8

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KLHL18; kelch like family member 18

14 of 14

619926

KLHL12; kelch like family member 12

6 of 14

614522

KLHL17; kelch like family member 17

6 of 14

619262

KLHL20; kelch like family member 20

6 of 14

617679

NEURODEVELOPMENTAL DISORDER WITH EARLY-ONSET SEIZURES, FACIAL DYSMORPHISM, AND BEHAVIORAL ABNORMALITIES; NEDSZFB

IPP; intracisternal A particle-promoted polypeptide

5 of 14

147485

KLHL1; kelch like family member 1

5 of 14

605332

KLHL2; kelch like family member 2

5 of 14

605774

KLHL3; kelch like family member 3

5 of 14

605775

PSEUDOHYPOALDOSTERONISM, TYPE IID; PHA2D

KLHL4; kelch like family member 4

5 of 14

300348

KLHL5; kelch like family member 5

5 of 14

608064

KLHL25; kelch like family member 25

5 of 14

619893

KLHL28; kelch like family member 28

5 of 14

ENC1; ectodermal-neural cortex 1

4 of 14

605173

IVNS1ABP; influenza virus NS1A binding protein

4 of 14

609209

IMMUNODEFICIENCY 70; IMD70

immunodeficiency 70

KEAP1; kelch like ECH associated protein 1

4 of 14

606016

KLHL7; kelch like family member 7

4 of 14

611119

KLHL8; kelch like family member 8

4 of 14

611967

KLHL26; kelch like family member 26

4 of 14

KLHL36; kelch like family member 36

4 of 14

KBTBD2; kelch repeat and BTB domain containing 2

3 of 14

619393

KBTBD3; kelch repeat and BTB domain containing 3

3 of 14

KBTBD8; kelch repeat and BTB domain containing 8

3 of 14

616607

KBTBD12; kelch repeat and BTB domain containing 12

3 of 14

KLHL6; kelch like family member 6

3 of 14

614214

KLHL9; kelch like family member 9

3 of 14

611201

KLHL10; kelch like family member 10

3 of 14

608778

SPERMATOGENIC FAILURE 11; SPGF11

spermatogenic failure 11

KLHL14; kelch like family member 14

3 of 14

613772

KLHL15; kelch like family member 15

3 of 14

300980

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED 103; XLID103

non-syndromic X-linked intellectual disability 103

KLHL21; kelch like family member 21

3 of 14

616262

KLHL22; kelch like family member 22

3 of 14

618020

KLHL23; kelch like family member 23

3 of 14

KLHL24; kelch like family member 24

3 of 14

611295

KLHL29; kelch like family member 29

3 of 14

KLHL30; kelch like family member 30

3 of 14

KLHL31; kelch like family member 31

3 of 14

610749

KLHL34; kelch like family member 34

3 of 14

KLHL35; kelch like family member 35

3 of 14

KLHL40; kelch like family member 40

3 of 14

615340

NEMALINE MYOPATHY 8; NEM8

nemaline myopathy 8

KLHL41; kelch like family member 41

3 of 14

607701

NEMALINE MYOPATHY 9; NEM9

nemaline myopathy 9

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

KLHL18

anti tag coimmunoprecipitation, anti tag western blot

(Zhou et al., 2015)

KLHL18 - Cul3

anti tag coimmunoprecipitation, cosedimentation through density gradient, Identification by mass spectrometry, anti tag western blot

(Fujiyama-Nakamura et al., 2009)

KLHL18 - Gpkow

anti tag coimmunoprecipitation, anti tag western blot, cosedimentation through density gradient, Identification by mass spectrometry

(Fujiyama-Nakamura et al., 2009)

KLHL18 - Ppil4

anti tag coimmunoprecipitation, anti tag western blot, cosedimentation through density gradient, Identification by mass spectrometry

(Fujiyama-Nakamura et al., 2009)

KLHL18 - l(2)37Cb

anti tag coimmunoprecipitation, anti tag western blot, cosedimentation through density gradient, Identification by mass spectrometry

(Fujiyama-Nakamura et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

KLHL18

enhanceable

Cul3

(Fujiyama-Nakamura et al., 2009)

KLHL18

enhanceable

Gpkow

(Fujiyama-Nakamura et al., 2009)

KLHL18

enhanceable

l(2)37Cb

(Fujiyama-Nakamura et al., 2009)

KLHL18

enhanceable

Ppil4

(Fujiyama-Nakamura et al., 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66575

DroID - A comprehensive database of gene and protein interactions.

FBgn0037978

MIST (protein-protein) - An integrated Molecular Interaction Database

41458

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

87A4-87A5

Sequence location

3R:12,007,476..12,010,434 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87A4-87A5

Limits computationally determined from genome sequence between P{EP}Lk6^EP886 and P{PZ}svp⁰⁷⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-49.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38352

y¹ v¹; P{TRiP.HMS01820}attP40

Kyoto

206359

y¹ w^67c23; P{GSV6}KLHL18^GS15802/TM3, Sb¹ Ser¹

NIG-Fly

3571R-1

P{NIG.3571R}1

3571R-4

P{NIG.3571R}4

HMS01820

y¹ v¹; P{TRiP.HMS01820}attP40

VDRC

v43777

w¹¹¹⁸; P{GD11014}v43777

v43778

w¹¹¹⁸; P{GD11014}v43778/CyO

Genomic Clones (29)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (193)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH14381

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037978

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037978

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : A stable S2 cell line expressing Tag:FLAG-tagged KLHL18 was generated.
(Fujiyama-Nakamura et al., 2009)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila EST AA536537.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG3571 anon-WO0118547.179

(FlyBase, 1996-)

Additional comments

Source for merge of CG3571 anon-WO0118547.179 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: KLHL18 CG3571

(Fujiyama-Nakamura et al., 2009)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG3571

(Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Fujiyama-Nakamura et al., 2009, Liebl and Featherstone, 2008, Cao et al., 2007)

KLHL18

(Sutton et al., 2024, Luck et al., 2014, Ida et al., 2013)

anon-WO0118547.179

dKLHL18

(Zhou et al., 2015, Fujiyama-Nakamura et al., 2009)

Name Synonyms

Kelch like family member 18

Secondary FlyBase IDs

FBgn0062189

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41458

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VGE5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VGE5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037978

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41458/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037978

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037978

FlyMine - An integrated database for Drosophila genomics

FBgn0037978

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3571

MARRVEL_MODEL - MARRVEL (model organism gene)

41458

Linkouts

BioGRID - A database of protein and genetic interactions.

66575

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037978

DroID - A comprehensive database of gene and protein interactions.

FBgn0037978

DRSC - Results frm RNAi screens

FBgn0037978

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

KLHL18_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037978

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037978

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3571

Flygut - An atlas of the Drosophila adult midgut

FBgn0037978

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006676

MIST (protein-protein) - An integrated Molecular Interaction Database

41458

References (36)

The following external sites may use different assemblies or annotations than FlyBase.

2.73

Report Sections