FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Rbf2
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General Information
Symbol
Dmel\Rbf2
Species
D. melanogaster
Name
Retinoblastoma-family protein 2
Annotation Symbol
CG5083
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038390
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Retinoblastoma-family protein 2 (Rbf2) encodes a transcriptional repressor belonging to the retinoblastoma family. It is mainly known for its role in repressing cell-cycle genes, but can also attenuate expression of other housekeeping genes, as-well as cell type specific enhancers. [Date last reviewed: 2023-09-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
89A8-89A8
Sequence location
Recombination map
3-58
RefSeq locus
NT_033777 REGION:15965446..15968138
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables transcription cis-regulatory region binding
inferred from direct assay
(Ullah et al., 2007)
enables transcription corepressor activity
inferred from physical interaction with FLYBASE:E2f2; FB:FBgn0024371
(Stevaux et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000348425
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in negative regulation of G1/S transition of mitotic cell cycle
inferred from direct assay
(Stevaux et al., 2002)
involved_in negative regulation of transcription by RNA polymerase II
inferred from genetic interaction with FLYBASE:Rbf; FB:FBgn0015799
(Lewis et al., 2004)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000348425
(GO Reference Genome Project, 2011-)
involved_in negative regulation of G1/S transition of mitotic cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000348425
(GO Reference Genome Project, 2011-)
involved_in regulation of cell cycle
inferred from electronic annotation with InterPro:IPR002719, InterPro:IPR002720, InterPro:IPR028309
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from electronic annotation with InterPro:IPR028309
(InterPro Project Members, 2004-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
part_of DRM complex
inferred from direct assay
(Beall et al., 2007)
part_of Myb complex
inferred from direct assay
(Korenjak et al., 2004, Lewis et al., 2004)
part_of Rb-E2F complex
inferred from direct assay
(Stevaux et al., 2002)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in chromatin
inferred from biological aspect of ancestor with PANTHER:PTN000348425
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from electronic annotation with InterPro:IPR002719, InterPro:IPR002720
(InterPro Project Members, 2004-)
part_of transcription regulator complex
inferred from biological aspect of ancestor with PANTHER:PTN000348425
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Retinoblastoma-family protein 2 (Rbf2) encodes a transcriptional repressor belonging to the retinoblastoma family. It is mainly known for its role in repressing cell-cycle genes, but can also attenuate expression of other housekeeping genes, as-well as cell type specific enhancers. [Date last reviewed: 2023-09-07]
Gene Group (FlyBase)
DREAM TRANSCRIPTIONAL REPRESSOR COMPLEX, RBF2 VARIANT -
The DREAM complex is a MuvB-type transcriptional repressor complex containing multiple site-specific DNA-binding proteins, including E2f2 and Rbf2. (Adapted from PMID:35468940 and FBrf0258562.)
DREAM TRANSCRIPTIONAL REPRESSOR COMPLEX, RBF VARIANT -
The DREAM complex is a MuvB-type transcriptional repressor complex containing multiple site-specific DNA-binding proteins, including E2f2 and Rbf. (Adapted from PMID:35468940 and FBrf0258562.)
Summary (Interactive Fly)

cell cycle and developmental regulator - functions in concert with E2F2 to repress the expression of differentiation markers in ovaries and embryos where RBF2 is highly expressed

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rbf2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VF04)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.53

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rbf2-RA
FBtr0083213
NM_079648
2693
783
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rbf2-PA
FBpp0082667
89.8
783
8.05
Q9VF04
NP_524372
AAF55258
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rbf2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.24

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of DRM complex
inferred from direct assay
(Beall et al., 2007)
part_of Myb complex
inferred from direct assay
(Korenjak et al., 2004, Lewis et al., 2004)
part_of Rb-E2F complex
inferred from direct assay
(Stevaux et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rbf2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rbf2
Transgenic constructs containing regulatory region of Rbf2
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(3R)16C3a
(Stevaux et al., 2005)
Df(3R)16C3b
(Stevaux et al., 2005)
Df(3R)Exel7327
(Ryder, 2004.4.26)
Inferred from location ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\RBL1
7 of 14
Yes
No
Hsap\RBL2
7 of 14
Yes
No
Hsap\RB1
5 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Rbl1
7 of 14
Yes
No
Rnor\Rbl2
7 of 14
Yes
No
Rnor\Rb1
5 of 14
No
No
Mus musculus (laboratory mouse) (3)
Mmus\Rbl1
7 of 14
Yes
No
Mmus\Rbl2
7 of 14
Yes
No
Mmus\Rb1
5 of 14
No
No
1  
Xenopus tropicalis (Western clawed frog) (3)
Xtro\rbl1
3 of 13
Yes
No
Xtro\rbl2
3 of 13
Yes
No
Xtro\rb1
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\rbl1
7 of 14
Yes
No
Drer\rbl2
7 of 14
Yes
No
Drer\rb1
5 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\lin-35
10 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006477
7 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (1)
Atha\RBR1
8 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rbf2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Rbf
10 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RBL1; RB transcriptional corepressor like 1
7 of 14
116957
      RBL2; RB transcriptional corepressor like 2
      7 of 14
      180203
      RB1; RB transcriptional corepressor 1
      5 of 14
      614041
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Rbf2 - Caf1-55
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot
      (Korenjak et al., 2004, Taylor-Harding et al., 2004)
      Rbf2 - Dp
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
      (Korenjak et al., 2004, Taylor-Harding et al., 2004)
      Rbf2 - E(z)
      anti bait coimmunoprecipitation, anti tag western blot
      (Lee et al., 2010)
      Rbf2 - E2f2
      anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot
      (Korenjak et al., 2004, Taylor-Harding et al., 2004)
      Rbf2 - Ets21C
      two hybrid array
      (Shokri et al., 2019)
      Rbf2 - HDAC1
      anti tag coimmunoprecipitation, western blot
      (Taylor-Harding et al., 2004)
      Rbf2 - Hr78
      two hybrid array
      (Shokri et al., 2019)
      Rbf2 - Myb
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot
      (Korenjak et al., 2004, Lewis et al., 2004)
      Rbf2 - chinmo
      two hybrid array
      (Shokri et al., 2019)
      Rbf2 - lin-52
      anti tag coimmunoprecipitation, western blot
      (Lewis et al., 2012)
      Rbf2 - mip120
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
      (Korenjak et al., 2004, Lewis et al., 2004)
      Rbf2 - mip130
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
      (Korenjak et al., 2004, Lewis et al., 2004)
      Rbf2 - mip40
      anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot
      (Beall et al., 2007, Korenjak et al., 2004)
      Summary of Genetic Interactions
      Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-58
      Cytogenetic map
      89A8-89A8
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      89A8-89A8
      Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      89B1-89B4
      (Stevaux, 1999.10.15)
      Experimentally Determined Recombination Data
      Location

      3-58

      (FlyBase, 2016)

      3-57.8

      (Comeron et al., 2012)

      3-

      (Stevaux and Dyson, 2000)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (15)
      Genomic Clones (17)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (41)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Rbf2 and E2f2 appear to act synergistically to antagonise Rbf-mediated activation, and may co-operate to block S phase progression.

            (Stevaux et al., 2002)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: Rbf2 CG5083

            (FlyBase, 1996-)
            Additional comments

            The Rbf2 gene may have been derived from the Rbf gene by retroposition.

            (Pan and Zhang, 2009)

            Source for merge of Rbf2 CG5083 was sequence comparison ( date:000407 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (7)
            Reported As
            Symbol Synonym
            CG5083
            (McEachern et al., 2014, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Beall et al., 2007)
            RB
            (Korenjak et al., 2012)
            RBF2
            (Korenjak et al., 2012, Lewis et al., 2012, Longworth et al., 2012, Lee et al., 2010, Ambrus et al., 2009, Wen et al., 2008, Georlette et al., 2007, Tountas and Fortini, 2007, Korenjak and Brehm, 2005, Lipsick, 2004, Taylor-Harding et al., 2004, Lee and Orr-Weaver, 2003, Stevaux, 2002.3.12, Stevaux et al., 2002, Douglas et al., 2000, Harbour and Dean, 2000)
            RBf2
            (Wei et al., 2015)
            Rbf2
            (Hoareau et al., 2024, Huang et al., 2024, Raicu et al., 2024, Raicu et al., 2024, Trujillo et al., 2024, Ding et al., 2022, Payankaulam et al., 2022, Bilder et al., 2021, Mouawad et al., 2020, Prasad and Arnosti, 2020.5.5, Mouawad et al., 2019, Shokri et al., 2019, Transgenic RNAi Project members, 2017-, Sarov et al., 2016, Doggett et al., 2015, Schertel et al., 2015, Spratford and Kumar, 2015, dos Santos, 2014, Japanese National Institute of Genetics, 2012.5.21, Zhai et al., 2012, Gordon and Du, 2011, Toku et al., 2011, Ahlander et al., 2008, Wei et al., 2008, Beall et al., 2007, Buckley et al., 2007, Tadros et al., 2007, Ullah et al., 2007, Buckley et al., 2006, Keller et al., 2005, Stevaux et al., 2005)
            rbf2
            (Korenjak et al., 2012, Wen et al., 2008, Buttitta et al., 2007, Ullah et al., 2007, Foglietti et al., 2006, Dimova et al., 2003, Stevaux and Dyson, 2000, Stevaux, 1999.10.20)
            Name Synonyms
            Retinoblastoma-family protein 2
            (Stevaux and Dyson, 2000)
            Secondary FlyBase IDs
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 45 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (89)