FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ilp3
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General Information
Symbol
Dmel\Ilp3
Species
D. melanogaster
Name
Insulin-like peptide 3
Annotation Symbol
CG14167
Feature Type
protein_coding_gene
FlyBase ID
FBgn0044050
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dilp3, DILP-3, Ilp-3, Dilp 3, Ilp

Key Links
Genomic Location
Cytogenetic map
67C8-67C8
Sequence location
Recombination map
3-31
RefSeq locus
NT_037436 REGION:9801298..9802120
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables hormone activity
inferred from electronic annotation with InterPro:IPR016179, InterPro:IPR022352
(InterPro Project Members, 2004-)
enables insulin receptor binding
inferred from sequence or structural similarity with UniProtKB:P01308
(Brogiolo et al., 2001)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in female mating behavior
inferred from mutant phenotype
(Wigby et al., 2011)
involved_in insulin receptor signaling pathway
inferred from mutant phenotype
(Kim and Neufeld, 2015)
involved_in locomotor rhythm
inferred from mutant phenotype
(Metaxakis et al., 2014)
involved_in negative regulation of entry into reproductive diapause
inferred from mutant phenotype
(Schiesari et al., 2016)
involved_in response to carbohydrate
inferred from expression pattern
(Kim and Neufeld, 2015)
involved_in sleep
inferred from mutant phenotype
(Metaxakis et al., 2014)
NOT involved_in circadian rhythm
inferred from mutant phenotype
(Metaxakis et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in insulin receptor signaling pathway
inferred from sequence or structural similarity with UniProtKB:Q9VT51
(Brogiolo et al., 2001)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Kim and Neufeld, 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in extracellular region
inferred from electronic annotation with InterPro:IPR016179
(InterPro Project Members, 2004-)
located_in extracellular space
inferred from sequence or structural similarity with UniProtKB:P01308
(Brogiolo et al., 2001)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the insulin family. (Q9VT52)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
NEUROPEPTIDES -
Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).
INSULIN-LIKE PEPTIDES -
The insulin superfamily consists of peptides such as vertebrate insulins, mammalian relaxin and insulin-like growth factors, and invertebrate insulin-like peptides (ILP). They are synthesized as pre-propeptides and processed to yield two peptides, A and B, linked by disulfide bonds. ILPs have been identified throughout invertebrate species. In D.mel, ILPs may function as peptide hormones and/or neuropeptides. They have been linked to the regulation of growth and development. (Adapted from FBrf0189697 and FBrf0152330).
Pathway (FlyBase)
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Protein Function (UniProtKB)
Possible ligand of InR/insulin-like receptor.
(UniProt, Q9VT52)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ilp3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VT52)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ilp3-RA
FBtr0076373
NM_140103
751
120
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ilp3-PA
FBpp0076102
13.7
120
8.70
Q9VT52
NP_648360
AAF50203
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

(UniProt, Q9VT52)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ilp3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.71

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval brain | anterior | medial | restricted
(Brogiolo et al., 2001)
late third instar larval stage
insulin secreting cell of pars intercerebralis of larval pars intercerebralis
(Ikeya et al., 2002)
adult stage
insulin secreting cell of pars intercerebralis
(Broughton et al., 2005)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
first instar larval stage
larval insulin secreting cell of pars intercerebralis
(Okamoto and Nishimura, 2015)
second instar larval stage
larval insulin secreting cell of pars intercerebralis
(Okamoto and Nishimura, 2015)
third instar larval stage
larval insulin secreting cell of pars intercerebralis
(Okamoto and Nishimura, 2015)
prepupal stage P3 -- pharate adult stage P15
organism
(Slaidina et al., 2009)
adult stage | male
organism
(Slaidina et al., 2009)
adult stage | female
organism
(Slaidina et al., 2009)
Additional Descriptive Data

Expression of Ilp3 is low in first and second instar larvae and increases sharply during the third instar larval stage.

(Okamoto and Nishimura, 2015)

Ilp3 is expressed in a bilaterally symmetrical cluster of 5 to 7 neurosecretory cells in the pars intercerebralis. It is co-expressed with Ilp2 and Ilp5.

(Broughton et al., 2005)

Transcript is expressed in two clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) from the second through third larval instars.

(Ikeya et al., 2002)

The transcript is exclusively detected in seven cells in each brain hemisphere in an anterior-medial postion

(Brogiolo et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ilp3 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ilp3
Transgenic constructs containing regulatory region of Ilp3
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\IGF1
1 of 14
Yes
No
Hsap\IGF2
1 of 14
Yes
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Igf1
1 of 14
Yes
No
Rnor\Igf2
1 of 14
Yes
No
Rnor\Ins1
1 of 14
Yes
No
Mus musculus (laboratory mouse) (3)
Mmus\Igf1
1 of 14
Yes
No
Mmus\Igf2
1 of 14
Yes
No
Mmus\Ins1
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\igf1
1 of 13
Yes
Yes
Xtro\igf2
1 of 13
Yes
No
Xtro\igf3
1 of 13
Yes
Yes
Xtro\ins
1 of 13
Yes
Yes
Danio rerio (Zebrafish) (7)
Drer\ins
3 of 14
Yes
No
Drer\igf2a
2 of 14
No
No
Drer\igf1
1 of 14
No
No
Drer\igf2b
1 of 14
No
No
Drer\igf3
1 of 14
No
No
Drer\insb
1 of 14
No
No
Drer\LOC100534937
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ins-1
2 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP010603
5 of 12
Yes
Yes
Agam\AgaP_AGAP010605
5 of 12
Yes
Yes
Agam\AgaP_AGAP010600
4 of 12
No
Yes
Agam\AgaP_AGAP010601
3 of 12
No
Yes
Agam\AgaP_AGAP010602
2 of 12
No
No
Agam\AgaP_AGAP010604
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ilp3. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
Ilp1
6 of 13
Ilp5
5 of 13
Ilp2
3 of 13
Ilp4
3 of 13
Ilp6
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
LKRSDH
suppressible
Ilp3
(Lv et al., 2024)
LKRSDH
suppressible
Ilp3|Ilp5
(Lv et al., 2024)
Ras85D
suppressible
Ilp3
(Okada et al., 2023)
Ras85D
suppressible
Ilp2|Ilp3|Ilp5
(Okada et al., 2023)
External Data
Subunit Structure (UniProtKB)
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
(UniProt, Q9VT52 )
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-31
Cytogenetic map
67C8-67C8
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
67C8-67C8
Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

3-31

(FlyBase, 2016)

3-24.1

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (8)
Genomic Clones (20)
cDNA Clones (2)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Ryu et al., 2019, Buhler et al., 2018, Hasygar and Hietakangas, 2014, Broughton et al., 2010, Veenstra et al., 2008)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Ilp3 CG14167

          (Brogiolo et al., 2001)
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (35)
          Reported As
          Symbol Synonym
          CG14167
          (El Fissi et al., 2024, Mao et al., 2024, Rovenko et al., 2015, Fukuoh et al., 2014, Lemaitre and Miguel-Aliaga, 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Brogiolo et al., 2001)
          DILP
          (Nijhout, 2003, Nijhout, 2003)
          DILP 3
          (Das and Arur, 2017, Nässel et al., 2015)
          DILP-3
          (Kim et al., 2023, Slankster et al., 2020, Inoue et al., 2018, Nassel, 2002)
          DILP3
          (Nässel, 2025, Montaser et al., 2024, Manoli et al., 2023, Chakrabarty et al., 2022, Meshrif et al., 2022, Nässel and Wu, 2022, Ratnaparkhi and Sudhakaran, 2022, Liguori et al., 2021, Semaniuk et al., 2021, Ahmad et al., 2020, Koyama et al., 2020, Nässel and Zandawala, 2020, Toprak et al., 2020, Nässel et al., 2019, Nie et al., 2019, Jung et al., 2018, Nässel, 2018, Ugrankar et al., 2018, Chen et al., 2016, Nässel and Vanden Broeck, 2016, Zhang et al., 2016, Landayan and Wolf, 2015, Luo et al., 2014, Ferrandon, 2013, Kannan and Fridell, 2013, Miyamoto et al., 2013, Nässel et al., 2013, Musselman et al., 2011, Broughton et al., 2010, Nässel and Winther, 2010, Slaidina et al., 2009, Leevers, 2001)
          DILPs
          (Grenier and Leulier, 2020, Lee et al., 2020)
          Dilp
          (Rhea et al., 2007, Bradley and Leevers, 2003)
          Dilp 3
          (Westfall et al., 2019, Macedo et al., 2017, Claeys et al., 2002)
          Dilp-3
          (Hoshizaki and Gibbs, 2007)
          Dilp1-5
          (Miao et al., 2022)
          Dilp3
          (Liu et al., 2025, Nässel, 2025, Sheng et al., 2025, Chen et al., 2024, Kübler et al., 2024, McPherson et al., 2024, Yoon et al., 2024, Krejčová et al., 2023, Meng et al., 2023, Neophytou et al., 2023, Okada et al., 2023, Tuo et al., 2023, Ding et al., 2022, Eickelberg et al., 2022, He et al., 2022, Neophytou and Pitsouli, 2022, Wang et al., 2022, Zhou et al., 2022, Han et al., 2021, He et al., 2021, Kannangara et al., 2021, Nässel, 2021, Wu et al., 2021, Colombani and Andersen, 2020, Jasper, 2020, Ozakman et al., 2020, Tang et al., 2020, Texada et al., 2020, Wang et al., 2020, Ryu et al., 2019, Texada et al., 2019, Buhler et al., 2018, Liu and Jin, 2017, Liu and Jin, 2017, Droujinine and Perrimon, 2016, Zheng et al., 2016, Kwon et al., 2015, Rovenko et al., 2015, Suh et al., 2015, Amcheslavsky et al., 2014, Kux and Pitsouli, 2014, Andersen et al., 2013, Gimenez et al., 2013, Kwak et al., 2013, Nässel et al., 2013, Okamoto et al., 2013, Shim et al., 2013, Hong et al., 2012, Kapan et al., 2012, Birse et al., 2011, Wang et al., 2009, Lee et al., 2008)
          ILP3
          (Kakizawa et al., 2024, Pragati and Sarkar, 2024, Chowański et al., 2021, Schoberleitner et al., 2021, Polan et al., 2020, Zhou et al., 2020, Ahmad et al., 2018, Warren et al., 2017, Barber et al., 2016)
          ILPs
          (Zhao and Karpac, 2020)
          IlP3
          (Lee et al., 2021)
          Ilp
          (Maistrenko et al., 2016, Edgar, 2006)
          Ilp-3
          (Hersperger et al., 2024, Pospisilik et al., 2010, Veenstra et al., 2008)
          Ilp3
          (Gruys et al., 2025, Gumeni et al., 2023, Lovegrove et al., 2023, Sanz et al., 2023, Chen et al., 2022, Deshpande et al., 2022, Dvořáček et al., 2022, Laskowski et al., 2022, Alvarez-Ochoa et al., 2021, Barber et al., 2021, Ceder et al., 2021, Destalminil-Letourneau et al., 2021, de Tredern et al., 2021, Fabian et al., 2021, Keith et al., 2021, Parra-Peralbo et al., 2021, Funk et al., 2020, Kierdorf et al., 2020, Yu et al., 2020, Brunet Avalos et al., 2019, Castillo-Quan et al., 2019, Lin et al., 2019, Mele and Johnson, 2019, Mirth et al., 2019, Croset et al., 2018, Doupé et al., 2018, Gáliková and Klepsatel, 2018, Rossi and Fernandes, 2018, Gáliková et al., 2017, Tain et al., 2017, Wang et al., 2017, Bahrampour and Thor, 2016, Cao et al., 2016, Crocker et al., 2016, Watanabe and Sakai, 2016, Wiemerslage et al., 2016, Williams et al., 2016, Alfa et al., 2015, Cagin et al., 2015, Chen et al., 2015, Lee et al., 2015, Ma et al., 2015, Williams et al., 2015, Woodcock et al., 2015, Metaxakis et al., 2014, Park et al., 2014, Lemaitre and Miguel-Aliaga, 2013, Marianes and Spradling, 2013, Sopko and Perrimon, 2013, Walker et al., 2013, Papatheodorou et al., 2012, Thomas et al., 2012, Sousa-Nunes et al., 2011, Kühnlein, 2010, Veenstra et al., 2008, InterPro Project Members, 2004-)
          dILP-3
          (Biglou et al., 2021, Ecker et al., 2017, Teleman and Cohen, 2006)
          dILP3
          (Jang et al., 2024, Li et al., 2023, Morón-Oset et al., 2023, Chatterjee and Perrimon, 2021, Eddison, 2021, McDonald et al., 2021, Oliveira et al., 2021, Ding et al., 2020, Megha and Hasan, 2020, Álvarez-Rendón et al., 2018, Koyama and Mirth, 2018, Staats et al., 2018, Brookheart et al., 2017, Mattila and Hietakangas, 2017, Brookheart and Duncan, 2016, Li et al., 2016, Das and Dobens, 2015, Ghosh et al., 2014, Hasygar and Hietakangas, 2014, Schriner et al., 2014, Cheetham and Brand, 2013, Garcia et al., 2013, Mirth and Shingleton, 2012, Wang et al., 2011, Teleman et al., 2008)
          dILp3
          (Jiang et al., 2016)
          dIlp3
          (De Groef et al., 2024, Funk et al., 2020, Bonfini et al., 2016, Boyd et al., 2011)
          dilp
          (Belawat and Hafen, 2005)
          dilp 3
          (Wang et al., 2022)
          dilp-3
          (Wu and Brown, 2006, Hwangbo et al., 2004)
          dilp3
          (Azmin et al., 2025, Nan et al., 2025, Park et al., 2025, Huang et al., 2024, Lee and Min, 2024, Meng et al., 2024, Bobrovskikh and Gruntenko, 2023, Gupta et al., 2023, Gupta et al., 2023, Lee et al., 2023, Li et al., 2023, Rodrigues et al., 2023, Bourouliti and Skoulakis, 2022, Wang et al., 2022, Winant et al., 2022, Yan et al., 2022, Atilano et al., 2021, Clements et al., 2021, De Groef et al., 2021, Ganguly et al., 2021, Kim et al., 2021, Liao et al., 2021, Meschi and Delanoue, 2021, Millington et al., 2021, Nakitto et al., 2021, Pathak and Varghese, 2021, Prince et al., 2021, Semaniuk et al., 2021, Takechi et al., 2021, Yang et al., 2021, Yoshinari et al., 2021, Miller et al., 2020, Strilbytska et al., 2020, Strilbytska et al., 2020, Sudhakar et al., 2020, Wilson et al., 2020, Castillo-Quan et al., 2019, Katsube et al., 2019, Trinh et al., 2019, Zheng et al., 2019, Lin et al., 2018, Lowenstein and Velazquez-Ulloa, 2018, Semaniuk et al., 2018, Westfall et al., 2018, Andreenkova et al., 2017, Gervais and Bardin, 2017, Liao et al., 2017, Tiku et al., 2017, Xu et al., 2017, Zandveld et al., 2017, Hallier et al., 2016, Kubrak et al., 2016, Kučerová et al., 2016, Liu et al., 2016, Schiesari et al., 2016, Wang et al., 2016, Hentze et al., 2015, Ismail et al., 2015, Kawasaki et al., 2015, Kohyama-Koganeya et al., 2015, Li and Gong, 2015, Matsuda et al., 2015, Pasco et al., 2015, Sano et al., 2015, Yan et al., 2015, Gündner et al., 2014, Ostojic et al., 2014, Piper et al., 2014, Hur et al., 2013, Kannan and Fridell, 2013, Parisi et al., 2013, Yamamoto et al., 2013, Bai et al., 2012, Marella et al., 2012, Yu et al., 2012, Alic et al., 2011, Alic et al., 2011, Guirao-Rico and Aguadé, 2011, Sheldon et al., 2011, Slack et al., 2011, Wigby et al., 2011, De Luca et al., 2010, Grönke et al., 2010, Haselton et al., 2010, Sekine et al., 2010, Slack et al., 2010, Varghese et al., 2010, Fridell et al., 2009, Hull-Thompson et al., 2009, Humphrey et al., 2009, Karpac et al., 2009, Kent et al., 2009, Okamoto et al., 2009, Zhang et al., 2009, Broughton et al., 2008, Buch et al., 2008, Clements et al., 2008, Flatt et al., 2008, Wang et al., 2008, Giannakou et al., 2007, Libert, 2007, Mattaliano et al., 2007, Broughton et al., 2005, Buch et al., 2005, Flatt et al., 2005, Melcher and Pankratz, 2005, Wu et al., 2005, Tatar et al., 2003, Ikeya and Hafen, 2002, Ikeya et al., 2002, Rulifson et al., 2002, Brogiolo et al., 2001)
          dipl3
          (Kakanj et al., 2016)
          dlp
          (Mira and Morante, 2020)
          dlp3
          (Liao et al., 2020)
          ilp3
          (Zhang et al., 2021, Newell et al., 2020, Dhiman et al., 2019, Liu et al., 2018, Musashe et al., 2016, Yurgel et al., 2015, Erion and Sehgal, 2013, Song et al., 2010, Veenstra, 2009, Kim et al., 2008, Min et al., 2008, Wang et al., 2008)
          Name Synonyms
          Drosophila insulin-like peptide 3
          (Oldham and Hafen, 2003)
          Insulin-like peptide
          (Maistrenko et al., 2016)
          Insulin-like peptide 3
          (Shafer, 2025)
          insulin-like peptide
          (Flatt et al., 2005)
          insulin-like peptide 3
          (Rovenko et al., 2015, Amcheslavsky et al., 2014, Zhan et al., 2013, Veenstra, 2009, Brogiolo et al., 2001)
          insulin/insulin-like growth factor
          (Quigley and Amdam, 2021)
          Secondary FlyBase IDs
          • FBgn0036047
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 34 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          References (451)