FlyBase Gene Report: Dmel\NLaz

General Information

Symbol

Dmel\NLaz

Species

D. melanogaster

Name

Neural Lazarillo

Annotation Symbol

CG33126

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053126

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

Neural Lazarillo (NLaz) encodes an extracellular lipid binding protein of the Lipocalin family. It is regulated by JNK signaling and negatively regulates the IIS pathway. It contributes to longevity, stress resistance, and behavior. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

22A1-22A1

Sequence location

2L:1,359,837..1,361,821 [-]

Recombination map

2-3

RefSeq locus

NT_033779 REGION:1359837..1361821

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables pigment binding

inferred from electronic annotation with InterPro:IPR003057

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in carbohydrate homeostasis

inferred from mutant phenotype

(Hull-Thompson et al., 2009)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Hull-Thompson et al., 2009)

involved_in insemination

inferred from high throughput expression pattern

(Findlay et al., 2008)

involved_in response to oxidative stress

inferred from mutant phenotype

(Hull-Thompson et al., 2009)

involved_in triglyceride homeostasis

inferred from mutant phenotype

(Hull-Thompson et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in lipid metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000064703

(GO Reference Genome Project, 2011-)

involved_in response to reactive oxygen species

inferred from biological aspect of ancestor with PANTHER:PTN000064703

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

inferred from direct assay

(Sanchez et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000064703

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Summary (Interactive Fly)

Lipocalin family member, a homologue of vertebrate Apolipoprotein D and Retinol Binding Protein 4, required for JNK-mediated stress and starvation tolerance, negatively regulates Insulin signaling, disrupting glucose homeostasis, repressing growth, and extending lifespan

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\NLaz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PBN2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

NLaz-RA

FBtr0077942

NM_175946

917

224

NLaz-RB

FBtr0329947

NM_001272938

917

245

NLaz-RC

FBtr0343844

NM_001298631

1149

224

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

NLaz-PA

FBpp0077607

24.3

224

4.67

FBpp0302979

27.1

245

4.73

FBpp0310390

24.3

224

4.67

Q8SXR1

NP_001285560

AHN54075

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

224 aa isoforms: NLaz-PA, NLaz-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NLaz using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NLaz_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.33

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10 -- 11

cell | subset of visceral trunk mesoderm | anterior | dorsal

(Sanchez et al., 2000)

embryonic stage 12 -- 13

amnioserosa

(Sanchez et al., 2000)

fat body primordium

(Sanchez et al., 2000)

embryonic stage 12 -- 16

larval neuron | subset of larval central nervous system

(Sanchez et al., 2000)

embryonic neuroblast | subset of larval central nervous system

(Sanchez et al., 2000)

embryonic stage 13

midgut primordium

(Sanchez et al., 2000)

embryonic hindgut

(Sanchez et al., 2000)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

embryonic midgut chamber

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 15

larval MP1 neuron

(Sanchez et al., 2000)

larval DA1 motor neuron

(Sanchez et al., 2000)

embryonic stage 16 -- 17

cell | subset of embryonic/larval gut

(Sanchez et al., 2000)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- first instar larval stage

organism

Comment: weak expression

(Sanchez et al., 2000)

pupal stage -- adult stage

organism

Comment: strong expression

(Sanchez et al., 2000)

Additional Descriptive Data

NLaz transcript is expressed in a subset of neurons and neuroblasts in the embryonic CNS from embryonic stages 12-16. At stages 14-15, NLaz transcript is observed in 12-15 cells/hemisegment; this expression is finely temporally regulated. Most NLaz-expressing cells are located ventral to the neuropil. NLaz-expressing neuroblasts are located at the ventral midline, and may be midline precursors. There is no expression in the PNS. Non-neuronally, NLaz transcript is expressed in a group of dorsal anterior visceral mesodermal cells at embryonic stages 10-11. These cells migrate to the amnioserosa at stages 12-13. NLaz is also expressed in groups of non-epithelial sessile cells on the surface of the gut epithelium at embryonic stage 16-17.

(Sanchez et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

amnioserosa

(Sanchez et al., 2000)

larval ventral nerve cord

(Sanchez et al., 2000)

fat body primordium

(Sanchez et al., 2000)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

NLaz protein is secreted from developing axons. NLaz protein is localized to the amnioserosa and to fat body cells. Localization in the embryonic CNS is mainly restricted to the dorsal surface of the brain and ventral nerve cord.

(Sanchez et al., 2000)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

inferred from direct assay

(Sanchez et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\NLaz in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\NLaz

View exonic expression by tissue for Dmel\NLaz

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053126

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33324/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053126

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053126

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053126

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33126

Flygut - An atlas of the Drosophila adult midgut

FBgn0053126

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\NLaz

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of NLaz

Transgenic constructs containing regulatory region of NLaz

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

NLaz^GD12709

viable, with Scer\GAL4^Mef2.PR

NLaz^GD12709

viable, with Scer\GAL4^pnr-MD237

NLaz^GD12709

viable, with Scer\GAL4^tin.CΔ4

NLaz^GD12709

Other Phenotypes

Allele

abnormal courtship behavior

NLaz^NW5

abnormal courtship behavior | male

NLaz^NW5

abnormal developmental rate, with Scer\GAL4^P0206

NLaz^UAS.cBa

abnormal developmental rate, with Scer\GAL4^rn.PU

NLaz^UAS.cBa

abnormal oxidative stress response, with Scer\GAL4^da.PU

abnormal oxidative stress response | progressive, with Scer\GAL4^da.PU

NLaz^UAS.cRa

abnormal starvation stress response

NLaz^NW5

abnormal stress response

NLaz^NW5

abnormal stress response, with Scer\GAL4^ppl.PP

NLaz^UAS.cHTa

chemical resistant, with Scer\GAL4^da.PU

NLaz^N165S.UAS

chemical resistant | progressive, with Scer\GAL4^da.PU

NLaz^UAS.cRa

chemical sensitive

NLaz^NW5

chemical sensitive, with Scer\GAL4^da.PU

NLaz^L130R.UAS

long lived, with Scer\GAL4^da.PU

NLaz^UAS.cHTa

short lived

NLaz^NW5

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\APOD

13 of 14

Yes

Hsap\RBP4

2 of 14

Yes

Hsap\PTGDS

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Apod

13 of 14

Yes

Rnor\Rbp4

2 of 14

Yes

Mus musculus (laboratory mouse) (3)

Mmus\Apod

12 of 14

Yes

Mmus\Rbp4

2 of 14

Yes

Mmus\Lcn5

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\rbp4l

2 of 13

Yes

Xtro\rbp4

2 of 13

Yes

Danio rerio (Zebrafish) (6)

Drer\apodb

13 of 14

Yes

Drer\apoda.2

12 of 14

Yes

Drer\apoda.1

11 of 14

Yes

Drer\rbp4

2 of 14

Yes

Drer\rbp4l

2 of 14

Yes

Drer\ambp

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\lpr-4

2 of 14

Yes

Cele\lpr-1

1 of 14

Yes

Cele\lpr-3

1 of 14

Yes

Cele\lpr-5

1 of 14

Yes

Cele\lpr-6

1 of 14

Yes

Cele\lpr-7

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP009281

12 of 12

Yes

Agam\AgaP_AGAP013229

7 of 12

Yes

Agam\AgaP_AGAP013318

7 of 12

Yes

Agam\AgaP_AGAP002593

6 of 12

Yes

Agam\AgaP_AGAP013451

6 of 12

Yes

Agam\AgaP_AGAP002592

5 of 12

Yes

Agam\AgaP_AGAP002594

4 of 12

Yes

Agam\AgaP_AGAP009282

4 of 12

Yes

Agam\AgaP_AGAP005223

3 of 12

Agam\AgaP_AGAP011478

3 of 12

Yes

Agam\AgaP_AGAP000790

2 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\TIL

8 of 13

Yes

Atha\CHL

3 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (1)

Ecol\blc

10 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:NLaz. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

6 of 13

4 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

NLaz^UAS.cHTa

ameliorates spinocerebellar ataxia 1

modeled by Hsap\ATXN1^82Q.UAS

(Del Caño-Espinel et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

APOD; apolipoprotein D

13 of 14

107740

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hep

suppressible

NLaz

(Hull-Thompson et al., 2009)

suppressible

(Liu et al., 2017)

suppressible

(Liu et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59572

DroID - A comprehensive database of gene and protein interactions.

FBgn0053126

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-3

Cytogenetic map

22A1-22A1

Sequence location

2L:1,359,837..1,361,821 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

22A1-22A1

Limits computationally determined from genome sequence between P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619 and P{lacW}RFeSP^k11704

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-3

(FlyBase, 2016)

2-2.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

603625

w^*; NLaz^NW5

600343

y¹ w^*; M{UAS-NLaz.R}ZH-86Fb

18673

w¹¹¹⁸; PBac{WH}NLaz^f03602/CyO

76608

y¹ w^*; PBac{UAS-NLaz.B}VK00033

600608

y¹ w^*; M{UAS-NLaz.Y47A}ZH-86Fb

600606

y¹ w^*; M{UAS-NLaz.N165S}ZH-86Fb

600607

y¹ w^*; M{UAS-NLaz.L130R}ZH-86Fb

600610

w^*; NLaz^NW5 GLaz^Δ2/CyO

NIG-Fly

16933R-3

P{NIG.16933R}3

16933R-1

P{NIG.16933R}1/TM3, P{ActGFP}JMR2, Ser¹

VDRC

v101321

P{KK107553}VIE-260B

v35558

w¹¹¹⁸; P{GD12709}v35558

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (219)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE67583

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0053126

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

AT09888

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0053126

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Sanchez et al., 2000)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: NLaz BcDNA:RE67583

(FlyBase, 1996-)

Additional comments

Source for identity of NLaz CG16933 was sequence comparison ( date:000721 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Source for merge of NLaz BcDNA:RE67583 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: NLaz CG16933

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BcDNA:RE67583

CG16933

(Spellman and Rubin, 2002)

CG33126

(National Institute of Genetics Fly Stocks, 2022-, Ibaraki et al., 2021, Hosono et al., 2015, Keleman et al., 2009.8.5)

CT33980

(Ceriani et al., 2002)

DNLaz

(Sanchez et al., 2000)

NLaz

(Banu et al., 2025, Londoño-Nieto et al., 2025, Ganfornina, 2024.4.29, Goodman et al., 2024, Kubrak et al., 2024, Fyfe-Desmarais et al., 2023, Li et al., 2023, Ramesh et al., 2023, Salgado-Canales et al., 2023, Deolankar et al., 2022, Cattenoz et al., 2021, Chatterjee and Perrimon, 2021, Joy et al., 2021, Liguori et al., 2021, Meschi and Delanoue, 2021, Xie et al., 2021, Cho et al., 2020, Parkhitko et al., 2020, Rust et al., 2020, Bhattacharjee et al., 2019, Hopkins et al., 2019, Hudry et al., 2019, Villanueva et al., 2019, Gene Disruption Project members, 2018-, Mattila and Hietakangas, 2017, Friedrich et al., 2016, Kubrak et al., 2016, Del Caño-Espinel et al., 2015, Bischof and FlyORF project members, 2014.6.20, Owusu-Ansah and Perrimon, 2014, Ruiz et al., 2014, Hyun, 2013, Wang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mirth and Shingleton, 2012, Pezzulo et al., 2012, Ruiz et al., 2012, Jungreis et al., 2011, Kühnlein, 2010, Maynard et al., 2010, Hull-Thompson et al., 2009, Morozova et al., 2006, Spellman and Rubin, 2002)

Nlaz

(Avila et al., 2024, Zhang et al., 2023, Ibaraki et al., 2021, Lourido et al., 2021, Li et al., 2020, Liu et al., 2017, Kubrak et al., 2016, Sieber and Spradling, 2015, Rynes et al., 2012, Biteau et al., 2011, Allen and Spradling, 2008)

nlaz

(Pathak and Varghese, 2021)

Name Synonyms

Neural Lazarillo

(Mattila and Hietakangas, 2017, Friedrich et al., 2016, Kubrak et al., 2016, Mirth and Shingleton, 2012, Kühnlein, 2010, Hull-Thompson et al., 2009)

neural Lazarillo

(Maynard et al., 2010, Sanchez et al., 2000)

Secondary FlyBase IDs

FBgn0031336
FBgn0063669

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33324

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PBN2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PBN2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053126

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33324/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053126

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053126

FlyMine - An integrated database for Drosophila genomics

FBgn0053126

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33126

MARRVEL_MODEL - MARRVEL (model organism gene)

33324

Linkouts

BioGRID - A database of protein and genetic interactions.

59572

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0053126

DroID - A comprehensive database of gene and protein interactions.

FBgn0053126

DRSC - Results frm RNAi screens

FBgn0053126

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NLaz_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053126

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0053126

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33126

Flygut - An atlas of the Drosophila adult midgut

FBgn0053126

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010813

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (101)

The following external sites may use different assemblies or annotations than FlyBase.

2.33

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