FlyBase Gene Report: Dmel\ATP8A

General Information

Symbol

Dmel\ATP8A

Species

D. melanogaster

Name

ATPase 8A

Annotation Symbol

CG42321

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259221

Gene Model Status

Current

Stock Availability

15 publicly available

Enzyme Name (EC)

P-type phospholipid transporter (7.6.2.1)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

50A5-50A8

Sequence location

2R:13,414,978..13,439,051 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13414978..13439051

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR006539

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR001757

(InterPro Project Members, 2004-)

enables ATPase-coupled intramembrane lipid transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000000024

(Tanaka et al., 2011)

inferred from electronic annotation with InterPro:IPR006539

(InterPro Project Members, 2004-)

enables magnesium ion binding

inferred from electronic annotation with InterPro:IPR006539

(InterPro Project Members, 2004-)

enables nucleotide binding

inferred from electronic annotation with InterPro:IPR023299

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in phospholipid translocation

inferred from sequence or structural similarity with SGD:S000000024

(Tanaka et al., 2011)

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(GO Reference Genome Project, 2011-)

involved_in phospholipid transport

inferred from electronic annotation with InterPro:IPR006539

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(Tanaka et al., 2011)

inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR006539

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(GO Reference Genome Project, 2011-)

is_active_in trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN008394225

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PHOSPHOLIPID TRANSPORTING ATPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATPase-coupled intramembrane lipid transporter activity

ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2 (7.6.2.1)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Group (FlyBase)

PHOSPHOLIPID TRANSPORTING ATPASES -: The phospholipid transporting type IV P-ATPases are flippases that translocate phospholipids against concentration gradient from one side of a membrane to the other. This lipid shuttling forms new membrane structures, in particular vesicles. (Adapted from PMID:18439418 and PMID:26240149).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ATP8A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry B7YZF8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ATP8A-RE

FBtr0299754

NM_137029

4365

1150

ATP8A-RG

FBtr0299755

NM_001144177

5273

1324

ATP8A-RH

FBtr0299757

NM_001144179

5566

1350

ATP8A-RI

FBtr0299756

NM_001144178

4974

1216

ATP8A-RJ

FBtr0299758

NM_001144180

4655

1095

ATP8A-RK

FBtr0299759

NM_165984

4658

1176

ATP8A-RL

FBtr0299760

NM_001144181

4552

1091

ATP8A-RM

FBtr0299761

NM_001144182

4261

1150

ATP8A-RN

FBtr0299762

NM_170625

4553

1275

ATP8A-RO

FBtr0299763

NM_001144183

4787

1275

ATP8A-RP

FBtr0299764

NM_170624

5080

1301

ATP8A-RQ

FBtr0299765

NM_001144184

5460

1265

ATP8A-RR

FBtr0303100

NM_001201990

4930

1082

ATP8A-RS

FBtr0306698

NM_001259361

3980

1127

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ATP8A-PE

FBpp0289032

130.9

1150

6.09

FBpp0289033

149.6

1324

6.76

FBpp0289035

152.4

1350

7.04

FBpp0289034

137.5

1216

7.26

FBpp0289036

124.7

1095

6.17

FBpp0289037

133.7

1176

6.51

FBpp0289038

124.3

1091

6.11

FBpp0289039

130.9

1150

6.09

FBpp0289040

144.1

1275

7.18

FBpp0289041

144.1

1275

7.18

FBpp0289042

146.9

1301

7.53

FBpp0289043

143.0

1265

6.80

FBpp0292219

123.3

1082

6.26

FBpp0297637

128.2

1127

5.82

A0A0B4K7Y0

NP_001246290

AFH08044

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1150 aa isoforms: ATP8A-PE, ATP8A-PM

1275 aa isoforms: ATP8A-PN, ATP8A-PO

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ATP8A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.56

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

hindgut proper primordium

Comment: reported as hindgut proper anlage

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

hindgut proper primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic large intestine

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ATP8A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ATP8A

View exonic expression by tissue for Dmel\ATP8A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259221

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36488/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259221

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259221

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259221

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17034

Flygut - An atlas of the Drosophila adult midgut

FBgn0259221

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ATP8A

Transgenic constructs containing regulatory region of ATP8A

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(2R)cnn^25cn1

(Zhang and Megraw, 2007)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

ATP8A^GD9980

viable

ATP8A^{MI06777-GFSTF.1}

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

ATP8A^GD3507

viable, with Scer\GAL4^tin.CΔ4

ATP8A^GD3507

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

ATP8A^GD9980

Phenotype manifest in

Allele

larval multidendritic class IV neuron | larval stage, with Spyo\Cas9^ppk.PS

ATP8A^sgRNA.U6

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

Hsap\ATP8A1

13 of 14

Yes

Hsap\ATP8A2

12 of 14

Yes

7 of 14

7 of 14

6 of 14

6 of 14

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Atp8a1

12 of 14

Yes

Rnor\Atp8a2

11 of 14

Yes

7 of 14

6 of 14

6 of 14

6 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Mus musculus (laboratory mouse) (16)

Mmus\Atp8a1

13 of 14

Yes

Mmus\Atp8a2

11 of 14

Yes

7 of 14

7 of 14

7 of 14

6 of 14

6 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (19)

Xtro\atp8a1

8 of 13

Yes

Xtro\atp8a2

7 of 13

Yes

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (17)

Drer\atp8a2

12 of 14

Yes

7 of 14

7 of 14

7 of 14

6 of 14

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Drer\si:dkey-211e20.10

2 of 14

Drer\atp11b

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\tat-1

13 of 14

Yes

6 of 14

5 of 14

4 of 14

3 of 14

3 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP011483

12 of 12

Yes

6 of 12

5 of 12

3 of 12

3 of 12

Arabidopsis thaliana (thale-cress) (12)

Atha\ACA.l

12 of 13

Yes

Atha\AT1G17500

12 of 13

Yes

Atha\AT1G26130

12 of 13

Yes

Atha\AT1G54280

12 of 13

Yes

Atha\AT1G68710

12 of 13

Yes

Atha\AT1G72700

12 of 13

Yes

Atha\AT3G13900

12 of 13

Yes

Atha\AT3G25610

12 of 13

Yes

Atha\AT3G27870

12 of 13

Yes

Atha\ALA3

10 of 13

Yes

Atha\ALA1

6 of 13

Atha\ALA2

5 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\DRS2

12 of 13

Yes

Scer\DNF1

4 of 13

Scer\DNF2

4 of 13

Scer\DNF3

4 of 13

Yes

Scer\NEO1

2 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\SPBC887.12

11 of 12

Yes

Spom\SPAC4F10.16c

4 of 12

Spom\SPAC24B11.12c

4 of 12

Spom\SPAC821.13c

4 of 12

Yes

Spom\SPAC6C3.06c

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ATP8A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

9 of 13

6 of 13

6 of 13

5 of 13

4 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ATP8A2; ATPase phospholipid transporting 8A2

model of cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

ATP8A^KG03082

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

ATP8A^KG05950

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATP8A1; ATPase phospholipid transporting 8A1

13 of 14

609542

ATP8A2; ATPase phospholipid transporting 8A2

12 of 14

605870

CEREBELLAR ATAXIA, IMPAIRED INTELLECTUAL DEVELOPMENT, AND DYSEQUILIBRIUM SYNDROME 4; CAMRQ4

cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4

ATP8B2; ATPase phospholipid transporting 8B2

7 of 14

605867

ATP8B4; ATPase phospholipid transporting 8B4 (putative)

7 of 14

609123

ATP8B1; ATPase phospholipid transporting 8B1

6 of 14

602397

ATP8B3; ATPase phospholipid transporting 8B3

6 of 14

605866

ATP10A; ATPase phospholipid transporting 10A (putative)

5 of 14

605855

ATP10B; ATPase phospholipid transporting 10B (putative)

5 of 14

619791

ATP10D; ATPase phospholipid transporting 10D (putative)

5 of 14

619815

ATP11A; ATPase phospholipid transporting 11A

4 of 14

605868

ATP11B; ATPase phospholipid transporting 11B (putative)

4 of 14

605869

ATP11C; ATPase phospholipid transporting 11C (ATP11C blood group)

4 of 14

300516

HEMOLYTIC ANEMIA, CONGENITAL, X-LINKED; HACXL

X-linked congenital hemolytic anemia

ATP9A; ATPase phospholipid transporting 9A

3 of 14

609126

NEURODEVELOPMENTAL DISORDER WITH POOR GROWTH AND BEHAVIORAL ABNORMALITIES; NEDGBA

neurodevelopmental disorder with poor growth and behavioral abnormalities

ATP9B; ATPase phospholipid transporting 9B

3 of 14

614446

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Nmnat

suppressible

ATP8A

(Ji et al., 2022)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0259221

MIST (protein-protein) - An integrated Molecular Interaction Database

36488

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Efferocytosis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

50A5-50A8

Sequence location

2R:13,414,978..13,439,051 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50A5-50A8

Limits computationally determined from genome sequence between P{EP}Dp^EP358 and P{lacW}drk^k13809&P{EP}mip120^EP606

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-72.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

95238

w^*; P{UAS-ATP8A.FLAG.HA}attP2

22098

w¹¹¹⁸; P{EPg}ATP8A^HP26676

25463

w¹¹¹⁸; Mi{ET1}ATP8A^MB05800

34250

y¹ w^*; Mi{MIC}ATP8A^MI01815

42175

y¹ w^*; Mi{MIC}ATP8A^MI06777

44824

y¹ w^*; Mi{MIC}ATP8A^MI08838

28558

y¹ v¹; P{TRiP.HM05044}attP2/TM3, Sb¹

60563

y¹ w^67c23; Mi{PT-GFSTF.2}ATP8A^{MI08838-GFSTF.2}

61761

y¹ w^67c23; Mi{PT-GFSTF.1}ATP8A^{MI01815-GFSTF.1}

63180

y¹ w^67c23; Mi{PT-GFSTF.1}ATP8A^{MI06777-GFSTF.1}

VDRC

v107000

P{KK101296}VIE-260B

v8136

w¹¹¹⁸; P{GD3507}v8136

More stocks available...

Genomic Clones (32)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (45)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP15278

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0259221

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259221

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG30061) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG17034 CG30061

(FlyBase Genome Annotators, 2008)

Source for merge of: CG17034 anon-WO0153538.54

(FlyBase, 1996-)

Additional comments

Annotations CG17034 and CG30061 merged as CG42321 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Source for merge of CG17034 anon-WO0153538.54 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: ATP8A CG42321

(Sapar et al., 2018)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

ATP8A

(Chen et al., 2025, Knop et al., 2025, Ji et al., 2023, Ji et al., 2022, Kumar et al., 2021, Shiomi et al., 2021, FlyBase Genome Annotators, 2019-, Gene Disruption Project members, 2018-, Sapar et al., 2018)

Atp8a

(Pavlidaki et al., 2022)

CG17034

(Schertel et al., 2013, Gan et al., 2010, Keleman et al., 2009.8.5, Zhang and Megraw, 2007)

CG30061

CG42321

(Lassetter et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Kumar et al., 2021, Shiomi et al., 2021, Harbison et al., 2019, Al-Ramahi et al., 2018, Sapar et al., 2018, Aradska et al., 2015, Gene Disruption Project members, 2015-, Vichas et al., 2015, Ma et al., 2012, Abruzzi et al., 2011, Perkins et al., 2009, FlyBase Genome Annotators, 2008)

DmCG42321

(Tanaka et al., 2011)

anon-WO0153538.54

Name Synonyms

ATPase 8A

CG17034

CG30061

Secondary FlyBase IDs

FBgn0033837
FBgn0045898
FBgn0050061

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 109 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36488

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

B7YZF8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

B7YZF8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259221

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36488/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259221

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259221

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42321

MARRVEL_MODEL - MARRVEL (model organism gene)

36488

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0259221

DroID - A comprehensive database of gene and protein interactions.

FBgn0259221

DRSC - Results frm RNAi screens

FBgn0259221

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259221

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0259221

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17034

Flygut - An atlas of the Drosophila adult midgut

FBgn0259221

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0259221

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007810

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Efferocytosis

MIST (protein-protein) - An integrated Molecular Interaction Database

36488

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (62)

The following external sites may use different assemblies or annotations than FlyBase.

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