FlyBase Gene Report: Dmel\CG44153

General Information

Symbol

Dmel\CG44153

Species

D. melanogaster

Name

Annotation Symbol

CG44153

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265002

Gene Model Status

Current

Stock Availability

127 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

BP1029

Key Links

Genomic Location

Cytogenetic map

31A2-31B1

Sequence location

2L:10,064,121..10,180,256 [-]

Recombination map

2-39

RefSeq locus

NT_033779 REGION:10064121..10180256

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR001879, InterPro:IPR036445

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN005252242

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN005252242

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001879, InterPro:IPR036445

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN005252242

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED CLASS C GPCRs

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

UNCLASSIFIED CLASS C GPCRs -: This group comprises orphan Class C GPCRs that do not classify under other groups in FlyBase.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG44153 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VL42)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG44153-RA

FBtr0335509

NM_001103666

7090

1946

CG44153-RB

FBtr0335510

NM_001273385

7309

1946

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG44153-PA

FBpp0307477

210.3

1946

7.31

FBpp0307478

210.3

1946

7.31

Q9VL42

NP_001260314

AGB92849

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1946 aa isoforms: CG44153-PA, CG44153-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG44153 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG44153_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.60

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG44153 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG44153

View exonic expression by tissue for Dmel\CG44153

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265002

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34341/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265002

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265002

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31714

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 28 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG44153

Transgenic constructs containing regulatory region of CG44153

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)Exel6026

(Ryder, 2004.4.26)

Df(2L)Exel8024

(Ryder, 2004.4.26)

Df(2L)Exel9032

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG44153^GD5370

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (10)

Hsap\CELSR3

1 of 14

Yes

Hsap\CSMD1

1 of 14

Yes

Hsap\DLL4

1 of 14

Yes

Hsap\FAT1

1 of 14

Yes

Hsap\FAT3

1 of 14

Yes

Hsap\FAT4

1 of 14

Yes

Hsap\LRP12

1 of 14

Yes

Hsap\NOTCH2

1 of 14

Yes

Hsap\NOTCH3

1 of 14

Yes

Hsap\SVEP1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\Celsr3

1 of 14

Yes

Rnor\Csmd1

1 of 14

Yes

Rnor\Egflam

1 of 14

Yes

Rnor\Fat1

1 of 14

Yes

Rnor\Fat3

1 of 14

Yes

Rnor\Fat4

1 of 14

Yes

Rnor\Lrp12

1 of 14

Yes

Rnor\Neto1

1 of 14

Yes

Mus musculus (laboratory mouse) (8)

Mmus\Ccdc141

1 of 14

Yes

Mmus\Celsr3

1 of 14

Yes

Mmus\Csmd1

1 of 14

Yes

Mmus\Fat1

1 of 14

Yes

Mmus\Fat3

1 of 14

Yes

Mmus\Fat4

1 of 14

Yes

Mmus\Lrp12

1 of 14

Yes

Mmus\Neto1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\fat1

1 of 13

Yes

Xtro\jag1

1 of 13

Yes

Xtro\lrp12

1 of 13

Yes

Xtro\nlgn4x

1 of 13

Yes

Xtro\notch1

1 of 13

Yes

Xtro\notch2

1 of 13

Yes

Xtro\vcan

1 of 13

Yes

Danio rerio (Zebrafish) (5)

Drer\fat1a

1 of 14

Yes

Drer\fat1b

1 of 14

Yes

Drer\lrp12

1 of 14

Yes

Drer\notch2

1 of 14

Yes

Drer\slit2

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\lin-12

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP009793

6 of 12

Yes

Agam\AgaP_AGAP009797

2 of 12

Yes

Agam\AgaP_AGAP002949

1 of 12

Agam\AgaP_AGAP009796

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG44153. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

bdl

1 of 13

Bsg

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265002

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-39

Cytogenetic map

31A2-31B1

Sequence location

2L:10,064,121..10,180,256 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

31A2-31B1

Limits computationally determined from genome sequence between P{lacW}l(2)k06324^k06324 and P{lacW}me31B^k06607;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-39

(FlyBase, 2016)

2-33.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (127)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

13364

P{VT005105-GAL4}attP2

14994

P{VT005106-GAL4}attP2

14995

P{VT005107-GAL4}attP2

14996

P{VT005108-GAL4}attP2

14997

P{VT005110-GAL4}attP2

15585

P{GMR72G06-GAL4}JK73A

15586

P{GMR72G06-GAL4}JK22C

16330

P{GMR72G03-lexA}JK22C

16353

P{GMR72G06-lexA}JK73A

17369

P{GMR72G03-lexA}JK73A

16165

P{GMR72G04-lexA}attP40

VDRC

v102832

P{KK105207}VIE-260B

More stocks available...

Genomic Clones (83)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265002

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG34048) in release 4.3 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG5833 CG13132

(FlyBase, 1996-)

Source for merge of: CG13134 CG13136 CG34048

(FlyBase Genome Annotators, 2010)

Source for merge of: CG31714 CG42843

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG31714 and CG42843 merged as CG44153 in release 5.47 of the genome annotation. Merge supported by second tier modENCODE RNA-seq junction data (FBrf0217580) and RNA-seq expression data.

(FlyBase Genome Annotators, 2012)

Annotations CG13134, CG13136 and CG34048 merged as CG42843 in release 5.30 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG5833, CG13132 merged as CG31714 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG5833 CG13132 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: CG34048 BP1029

(FlyBase Genome Annotators, 2005)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

BP1029

(Yandell et al., 2005)

CG13132

CG13134

(Lawniczak and Begun, 2004)

CG13136

CG31714

(Wu et al., 2020, Abruzzi et al., 2017, Hosono et al., 2015, Ashwal-Fluss et al., 2014, Ozkan et al., 2013, Page et al., 2012, Rodriguez et al., 2012, Nagoshi et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Holloway et al., 2008)

CG34048

(Ashwal-Fluss et al., 2014)

CG42843

(FlyBase Genome Annotators, 2010)

CG44153

(Chen et al., 2025, Tu et al., 2025, Eiman et al., 2024, Mao et al., 2024, Voutyraki et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Schlichting et al., 2022, Watanabe and Riddle, 2021, Xie et al., 2021, Brunet Avalos et al., 2019, Hall et al., 2019, Highfill et al., 2019, Rao and Deng, 2019.10.23, Teets and Hahn, 2018, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, FlyBase Genome Annotators, 2012)

CG5833

(Halfon et al., 2002)

Name Synonyms

Secondary FlyBase IDs

FBgn0032180
FBgn0032179
FBgn0262032
FBgn0032182
FBgn0054048
FBgn0032186
FBgn0082877

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34341

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VL42

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VL42

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265002

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34341/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265002

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265002

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG44153

MARRVEL_MODEL - MARRVEL (model organism gene)

34341

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265002

DroID - A comprehensive database of gene and protein interactions.

FBgn0265002

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG44153_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265002

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31714

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034482

References (71)

The following external sites may use different assemblies or annotations than FlyBase.

-0.60

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