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FB2026_01
,
released March 12, 2026
This report includes links to reviews and general information on fly models of susceptibility to obesity. Obesity is an excessive accumulation of body fat, usually defined as 20% or more over an individual's ideal body weight. The development of obesity is recognized as having both genetic and environmental components. Flies have also been used to model diet-induced development of obesity, including epigenetic effects of parental diet; see reports for 'high-fat diet, obesity' (FBhh0000495) and 'high-sugar diet, obesity' (FBhh0000494).
References describing biology of this Drosophila system, methods and assays: Trinh and Boulianne, 2013 (FBrf0220929); Smith, et al., 2014 (FBrf0226963); Ugur, et al., 2016 (FBrf0231139); Brookheart and Duncan, 2016 (FBrf0233008, FBrf0233415); Li and Tennessen, 2017 (FBrf0236417); Musselman and Kuhnlein, 2018 (FBrf0238315); Galikova and Klepsatel, 2018 (FBrf0239311); Chatterjee and Perrimon, 2021 (FBrf0249260).
Reports for models of susceptibility to obesity in flies are listed in the "Related Diseases" section, below, and in the FlyBase Human Disease Model Report Index (http://flybase.org/lists/FBhh/).
[updated Aug. 2021 by FlyBase; FBrf0222196]
[OBESITY](https://omim.org/entry/601665)
Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).
The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).
An average figure from relevant research estimates that obesity is about 40% genetic and 60% due to environmental factors. (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).
The "thrifty gene hypothesis" (Neel, 1962; pubmed:13937884), originally postulated in reference to populations with a high incidence of diabetes mellitus type 2, has also been invoked to explain genetic susceptibility to obesity.
Adipose tissue is the major site for storage of excess energy in the form of triglycerides; it also has endocrine functions, secreting multiple adipokines involved in energy homeostasis and inflammation (reviewed in Jung and Choi, 2014; pubmed:24733068).