Human Disease Model Report: obesity, susceptibility to (postulated), Wnt signaling pathway

General Information

Name

obesity, susceptibility to (postulated), Wnt signaling pathway

FlyBase ID

FBhh0001102

Disease Ontology Term

obesity

Parent Disease

obesity, susceptibility to (fly models overview)

OMIM

Overview

The Drosophila wg gene was identified in an RNAi-based screen to identify muscle-secreted proteins that, when inhibited, cause an obese phenotype. The flies exhibit increased abdominal fat body mass, enlarged lipid droplets in fat body cells, and an increase in total triglyceride amounts. Consistent with the results from wg knockdown experiments, wg overexpression in muscle decreases fat accumulation. A second gene in the Wnt signaling pathway, arm, was assessed in the same assays, with comparable results.

See the FlyBase report for the Wnt-TCF Signaling Pathway Core Components (FBgg0000890).

UAS constructs of the human genes Hsap\WNT1 (an ortholog of wg) and Hsap\CTNNB1 (an ortholog of arm) have been introduced into flies, but have not been characterized.

The fly ortholog of MED13 (Dmel\skd), which is not a secreted protein, also exhibits obesity-related phenotypes when knocked down in muscle; see the human disease model 'obesity, susceptibility to (postulated), MED13-related' (FBhh0000506). Genetic experiments have been performed to assess epistatic relationships between wg and skd for the obesity-related phenotypes. These data support the conclusion that muscle-secreted wg protein acts as a downstream effector of skd function in muscle to suppress fat deposition in the fat body.

[updated Apr. 2020 by FlyBase; FBrf0222196]

Disease Summary Information

Parent Disease Summary: obesity, susceptibility to (fly models overview)

Symptoms and phenotype

Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).

(FlyBase Curators, 2013-)

The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).

(FlyBase Curators, 2013-)

Specific Disease Summary: obesity, susceptibility to (postulated), Wnt signaling pathway

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes (FBgg0000890).

(FlyBase Curators, 2013-)

External links

Disease synonyms

Related Diseases

Related human health report(s)

obesity, susceptibility to (fly models overview)

obesity, susceptibility to (postulated), MED13-related

Related Specific Diseases

OMIM phenotypic series

Disease

Associated Human gene(s)

Drosophila model

Human transgene in Drosophila

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (2)

Dmel\arm

Gene Snapshot

armadillo (arm) encodes the Drosophila homolog of beta-catenin. It plays separable roles in cell adhesion and Wingless signaling. It links classic cadherin cell adhesion receptors to alpha-catenin and the actin cytoskeleton, and it acts as the key regulated effector of Wingless signaling, working with TCF/LEF proteins as a transcriptional co-activator. [Date last reviewed: 2019-03-07]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate- to high-scoring ortholog of human CTNNB1 and JUP (1 Drosophila to 2 human). Dmel\arm shares 63-67% identity and 76-77% similarity with the human genes.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\wg

Gene Snapshot

wingless (wg) is a segment polarity gene that encodes a ligand of the Wnt/Wg signaling pathway. Its post-translational modification (addition of palmitoleate by the product of por) is essential for signaling activity. It contributes to segment polarity, tissue growth and patterning, neuromuscular junction morphogenesis, gut homeostasis and long term memory formation. [Date last reviewed: 2019-03-21]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

WNT
WNT-TCFC

Comments on ortholog(s)

High-scoring ortholog of human WNT1 (1 Drosophila to 1 human, best and reverse best hits); multiple orthologs and paralogs in both species. Dmel\wg shares 44% identity and 55% similarity with the human gene.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (80 groups)

arm

RNA-RNA

Interacting group

Assay

References

arm - mir-92a

western blot

(Pancratov et al., 2013)

arm - mir-92b

western blot

(Pancratov et al., 2013)

arm - mir-310

western blot, luminiscence technology

(Pancratov et al., 2013)

arm - mir-311

luminiscence technology, western blot

(Pancratov et al., 2013)

arm - mir-312

luminiscence technology, western blot

(Pancratov et al., 2013)

arm - mir-313

luminiscence technology, western blot

(Pancratov et al., 2013)

protein-protein

Interacting group

Assay

References

arm - α-Cat

anti bait coimmunoprecipitation, western blot, two hybrid, anti tag coimmunoprecipitation, pull down, far western blotting, experimental knowledge based

(Escobar et al., 2015, Houssin et al., 2015, Desai et al., 2013, Guruharsha et al., 2011, Sawyer et al., 2009, Geisbrecht and Montell, 2002, Cox et al., 1999, Orsulic and Peifer, 1996, Pai et al., 1996, Oda et al., 1994, Oda et al., 1993, Peifer, 1993)

arm - aop

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Olson et al., 2011)

arm - Apc

pull down, autoradiography, coimmunoprecipitation, western blot

(Hamada and Bienz, 2004, Hayashi et al., 1997)

arm - Apc2

anti bait coimmunoprecipitation, western blot, two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Croy et al., 2016, Yamulla et al., 2014, Kunttas-Tatli et al., 2012, Buttrick et al., 2008, Hamada and Bienz, 2004, McCartney et al., 1999, Yu et al., 1999)

arm - Axn

pull down, autoradiography, two hybrid

(Kremer et al., 2010, Tolwinski et al., 2003, Hamada et al., 1999)

arm - baz

two hybrid, anti bait coimmunoprecipitation, western blot, pull down, autoradiography

(Wei et al., 2005)

arm - br

proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, anti tag western blot

(Xu et al., 2018)

arm - CadN

anti bait coimmunoprecipitation, western blot

(Loureiro and Peifer, 1998, Iwai et al., 1997)

arm - Caf1-55

pull down, western blot

(Song et al., 2009)

arm - Cdk8

pull down, western blot

(Park et al., 2003)

arm - CkIα

protein kinase assay, autoradiography, enzymatic study, western blot

(Matsubayashi et al., 2004, Yanagawa et al., 2002)

arm - Cul4

anti bait coimmunoprecipitation, western blot

(Tripathi et al., 2007)

arm - dsh

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Vuong et al., 2014)

arm - Dsor1

proximity ligation assay, fluorescence microscopy

(Hall and Verheyen, 2015)

arm - dx

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Sharma et al., 2024)

arm - ebd1

pull down, anti tag western blot, anti tag coimmunoprecipitation

(Benchabane et al., 2011)

arm - Egfr

anti bait coimmunoprecipitation, western blot

(Dumstrei et al., 2002)

arm - Exo70

two hybrid

(Langevin et al., 2005)

arm - foxo

anti tag coimmunoprecipitation, anti tag western blot, western blot, anti bait coimmunoprecipitation

(Zhang et al., 2016)

arm - Hipk

anti tag coimmunoprecipitation, anti tag western blot, protein kinase assay, autoradiography

(Lee et al., 2009)

arm - hyx

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography

(Mosimann et al., 2006)

arm - Inx2

anti tag coimmunoprecipitation, autoradiography, anti bait coimmunoprecipitation, western blot

(Bauer et al., 2004)

arm - Iswi

pull down, autoradiography, western blot

(Song et al., 2009)

arm - jar

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, pull down

(Geisbrecht and Montell, 2002)

arm - Klp64D

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, pull down

(Vuong et al., 2020, Vuong et al., 2014)

arm - lgs

two hybrid, pull down, autoradiography

(Staedeli and Basler, 2005, Hoffmans and Basler, 2004, Townsley et al., 2004, Kramps et al., 2002)

arm - lqfR

anti tag coimmunoprecipitation, western blot

(Lee and Fischer, 2012)

arm - Mad

anti tag coimmunoprecipitation, anti tag western blot

(Eivers et al., 2011)

arm - mbt

enzymatic study, autoradiography

(Walther et al., 2016)

arm - MED17

pull down, western blot

(Park et al., 2003)

arm - MED21

pull down, western blot

(Park et al., 2003)

arm - MED31

pull down, western blot

(Park et al., 2003)

arm - mib2

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Trivedi et al., 2022)

arm - Myo31DF

pull down, autoradiography, anti tag coimmunoprecipitation, western blot, two hybrid

(Petzoldt et al., 2012, Speder et al., 2006)

arm - N

anti bait coimmunoprecipitation, western blot

(Koca et al., 2022, Hayward et al., 2005)

arm - nej

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, autoradiography, anti bait coimmunoprecipitation

(Li et al., 2007)

arm - NitFhit

pull down, molecular weight estimation by staining, anti tag coimmunoprecipitation, anti tag western blot

(Mittag et al., 2016)

arm - Oseg1

anti tag coimmunoprecipitation, western blot

(Vuong et al., 2018)

arm - p120ctn

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Myster et al., 2003)

arm - pan

pull down, autoradiography, two hybrid, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Gonsalves et al., 2011, Staedeli and Basler, 2005, Kramps et al., 2002, Von Ohlen and Hooper, 1999, Yu et al., 1999, Levanon et al., 1998, Brunner et al., 1997, van de Wetering et al., 1997)

arm - pygo

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Thompson, 2004, Belenkaya et al., 2002)

arm - rempA

pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Vuong and Mlodzik, 2024, Vuong et al., 2018)

arm - sdk

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Uechi and Kuranaga, 2019)

arm - Sec10

two hybrid, anti tag coimmunoprecipitation, western blot, pull down, autoradiography

(Langevin et al., 2005)

arm - sgg

enzymatic study, western blot, protein kinase assay, autoradiography, anti tag coimmunoprecipitation

(White et al., 2018, Matsubayashi et al., 2004, Yanagawa et al., 2002)

arm - shg

anti bait coimmunoprecipitation, molecular weight estimation by staining, anti tag coimmunoprecipitation, western blot, two hybrid, fluorescent resonance energy transfer, fluorescence microscopy, pull down, autoradiography

(Röper et al., 2018, Chen et al., 2017, Houssin et al., 2015, Hamada-Kawaguchi et al., 2014, Huang et al., 2011, Bahri et al., 2010, Sawyer et al., 2009, Liu et al., 2008, Stevens et al., 2008, Takahashi et al., 2005, Myster et al., 2003, Dumstrei et al., 2002, Cox et al., 1999, Loureiro and Peifer, 1998, Iwai et al., 1997, Orsulic and Peifer, 1996, Pai et al., 1996, Oda et al., 1994)

arm - slmb

anti tag coimmunoprecipitation, western blot

(White et al., 2018)

arm - Src42A

anti bait coimmunoprecipitation, western blot, pull down

(Takahashi et al., 2005)

arm - ssp

pull down, western blot, anti tag coimmunoprecipitation, two hybrid

(Taniue et al., 2010)

arm - Traf4

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography

(Mathew et al., 2011)

arm - tsh

anti bait coimmunoprecipitation, western blot, pull down, autoradiography

(Gallet et al., 1998)

arm - Ubx

two hybrid

(Hsiao et al., 2014)

RNA-RNA

Interacting group

Assay

References

wg - mir-8

luminiscence technology

(Nesler et al., 2013)

RNA-protein

Interacting group

Assay

References

wg - egl

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Vazquez-Pianzola et al., 2017)

protein-protein

Interacting group

Assay

References

wg - apolpp

anti bait coimmunoprecipitation, western blot

(Panakova et al., 2005)

wg - arr

affinity technology, fluorescence microscopy, inferred by author

(Piddini et al., 2005)

wg - bai

anti tag coimmunoprecipitation, western blot

(Li et al., 2015)

wg - CHOp24

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Li et al., 2015, Port et al., 2011)

wg - Cow

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation

(Chang and Sun, 2014)

wg - dally

anti tag coimmunoprecipitation, western blot

(Kleinschmit et al., 2013)

wg - dlp

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, coimmunoprecipitation

(McGough et al., 2020, Waghmare et al., 2020, Yan et al., 2009)

wg - fz

affinity technology, fluorescence microscopy, inferred by author, enzyme linked immunosorbent assay, proximity ligation assay

(Portela et al., 2019, Mulligan et al., 2012, Wu and Nusse, 2002, Bhanot et al., 1996)

wg - fz2

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, fluorescent resonance energy transfer, fluorescence microscopy, affinity technology, enzyme linked immunosorbent assay, inferred by author, cross-linking study

(Hemalatha et al., 2016, Mulligan et al., 2012, Tang et al., 2012, Yan et al., 2009, Piddini et al., 2005, Wu and Nusse, 2002, Wesley, 1999, Bhanot et al., 1996)

wg - fz3

affinity technology, enzyme linked immunosorbent assay, inferred by author

(Wu and Nusse, 2002)

wg - N

anti bait coimmunoprecipitation, cross-linking study, western blot

(Wesley, 1999)

wg - Notum

pull down, western blot

(McGough et al., 2020)

wg - opm

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Buechling et al., 2011)

wg - peg

anti tag coimmunoprecipitation, western blot

(Magny et al., 2021)

wg - por

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation

(Herr and Basler, 2012, Tanaka et al., 2002)

wg - Ror

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

wg - sona

enzymatic study, western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, anti tag western blot

(Won et al., 2019, Kim et al., 2016)

wg - Swim

inferred by author, affinity technology, fluorescence microscopy, enzyme linked immunosorbent assay, affinity chromatography technology, molecular sieving, peptide massfingerprinting

(Mulligan et al., 2012)

wg - wdp

anti tag coimmunoprecipitation, western blot

(Koh et al., 2023)

wg - wls

anti bait coimmunoprecipitation, anti tag western blot

(Herr and Basler, 2012, Tang et al., 2012)

Alleles Reported to Model Human Disease (Disease Ontology) (26 alleles)

arm

Models Based on Experimental Evidence ( 6 )

Allele

Disease

Evidence

References

arm^{S10.UAS.Tag:MYC}

model of neuropathy

CEA

(Hale et al., 2022)

arm^{S2.UAS.Tag:MYC}

model of neuropathy

CEA

(Hale et al., 2022)

arm^UAS.Exel

model of carcinoma

CEA

(Zhang et al., 2019)

arm^HMS01414

model of obesity

CEA

(Lee et al., 2014)

arm^{H47R.UAS.Tag:HA}

model of cancer

CEA

(White et al., 2018)

arm^{H47A.UAS.Tag:HA}

DOES NOT model cancer

CEA

(White et al., 2018)

Modifiers Based on Experimental Evidence ( 11 )

Allele

Disease

Interaction

References

arm¹

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

arm²

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

arm³

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

arm⁴

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

arm⁸

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q200.FL.UAS

(Greco et al., 2022)

arm^G0192

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

arm^G0234

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

arm^{S10.UAS.Tag:MYC}

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

ameliorates intellectual disability

modeled by Hsap\HUWE1^UAS.cVa

(Vandewalle et al., 2013)

exacerbates cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

arm^UAS.Exel

model of carcinoma

is exacerbated by Ras85D^V12.UAS

(Zhang et al., 2019)

exacerbates Huntington's disease

modeled by Hsap\HTT^Q200.FL.UAS

(Greco et al., 2022)

arm^GD1372

ameliorates carcinoma

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Zhang et al., 2019)

arm^KK102545

ameliorates chromosome 16p11.2 deletion syndrome, 593-kb

modeled by CG10465^KK105756

(Iyer et al., 2018)

modeled by rl^KK115768

(Iyer et al., 2018)

modeled by Pp4-19C^GD9561

(Iyer et al., 2018)

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

wg^HMS00794

model of obesity

CEA

(Lee et al., 2014)

wg^HMS00844

model of obesity

CEA

(Lee et al., 2014)

Modifiers Based on Experimental Evidence ( 10 )

Allele

Disease

Interaction

References

wg¹

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

wg^{UAS.cHa.Tag:HA}

ameliorates neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures

modeled by Hsap\IRF2BPL^UAS.cBa

(Marcogliese et al., 2022)

ameliorates obesity

modeled by skd^HMS01305

(Lee et al., 2014)

exacerbates intestinal cancer

modeled by Rab11^KK108297

(Nie et al., 2019)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{1-42.UAS.CRY2(PHR),mCherry}

(Kaur et al., 2022)

wg^Sp-1

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

wg^l-12

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

wg^l-17

exacerbates amyotrophic lateral sclerosis type 2

modeled by Als2^Δ1

(Kim et al., 2021)

wg^GD5007

ameliorates cancer

modeled by Egfr^UAS.cBa, psq^KK111691

(Herranz et al., 2014)

modeled by Csk^Q156Stop, Ras85D^V12.UAS

(Hirabayashi et al., 2013)

modeled by BacA\p35^UAS.cHa, rod^GD8768

(Muzzopappa et al., 2017)

modeled by BacA\p35^UAS.cHa, mud^HMS01458

(Muzzopappa et al., 2017)

modeled by Ras85D^V12.UAS, mud^HMS01458

(Muzzopappa et al., 2017)

ameliorates carcinoma

modeled by scrib^GD11666

(Zhang et al., 2019)

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Zhang et al., 2019)

modeled by egr^UAS.cIa

(Zhang et al., 2019)

modeled by puc^GD1515

(Zhang et al., 2019)

wg^KK108857

ameliorates retinitis pigmentosa 4

modeled by ninaE^P37H.UAS

(Park et al., 2023)

wg^JF01257

ameliorates cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Lee et al., 2021)

modeled by N^DN.UAS.cUa, Ras85D^V12.cUa.UAS

(Lee et al., 2021)

modeled by N^DN.UAS.cUa

(Lee et al., 2021)

wg^HMS00794

ameliorates cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Lee et al., 2021)

wg^RNAi.UAS.cUa

ameliorates carcinoma

modeled by Csk^Q156Stop, Ras85D^V12.UAS

(Hirabayashi and Cagan, 2015)

modeled by Csk^Q156Stop, InR^A1325D.UAS, Ras85D^V12.UAS

(Hirabayashi and Cagan, 2015)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

arm^{H47R.UAS.Tag:HA}

P{UAS-arm.H47R.HA}

arm^{H47A.UAS.Tag:HA}

P{UAS-arm.H47A.HA}

arm^{S10.UAS.Tag:MYC}

P{UAS-arm.S10}

P{UAS-arm.S10}C, y¹ w¹¹¹⁸

arm^{S2.UAS.Tag:MYC}

P{UAS-arm.S2}

y¹ w¹¹¹⁸; P{UAS-arm.S2}A1

arm^UAS.Exel

P{UAS-arm.Exel}

y¹ w¹¹¹⁸; P{UAS-arm.Exel}2

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

w¹¹¹⁸; P{GD1372}v7767

y¹ v¹; P{TRiP.JF01251}attP2/TM3, Ser¹

arm^JF01252

P{TRiP.JF01252}

y¹ v¹; P{TRiP.JF01252}attP2

arm^HMS01414

P{TRiP.HMS01414}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01414}attP2

wg^HMS06086

P{TRiP.HMS06086}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS06086}attP40

w¹¹¹⁸; P{GD5007}v13351

y¹ v¹; P{TRiP.JF01257}attP2

wg^JF01480

P{TRiP.JF01480}

y¹ v¹; P{TRiP.JF01480}attP2

wg^HMS00794

P{TRiP.HMS00794}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00794}attP2

wg^HMS00844

P{TRiP.HMS00844}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00844}attP2

wg^NIG.4889R

P{NIG.4889R}

P{NIG.4889R}3

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

arm^25B

loss of function allele

PM hybrid dysgenesis

arm⁸

PM hybrid dysgenesis

arm⁸ P{FRT(w^hs)}101/FM7a

arm^G0234

P-element activity

arm^G0192

P-element activity

P{lacW}arm^G0192 w^67c23/FM7c

arm^2a9

amorphic allele - genetic evidence

X ray

arm¹

ethyl methanesulfonate

y¹ arm¹/FM7c

arm²

amorphic allele - genetic evidence

ethyl methanesulfonate

arm² P{FRT(w^hs)}101/FM7a

arm⁴

loss of function allele

ethyl methanesulfonate

y¹ arm⁴ w^*/FM7c, P{ftz-lacC}YH1

arm³

amorphic allele - genetic evidence

ethyl methanesulfonate

y¹ arm³ P{neoFRT}19A/FM7a

arm^LM134

loss of function allele

arm^F1α

loss of function allele

wg^en11

amorphic allele - genetic evidence

Delta2-3 transposase

Df(2L)JS17, dpp^d-ho/CyO, P{en1}wg^en11

wg^PY40

loss of function allele

P-element activity

wg^{UAS.cHa.Tag:HA}

FLPase

w^*; P{UAS-wg.H.T:HA1}6C

wg^S107

amorphic allele - genetic evidence

wg^Sp-m2

loss of function allele

ethyl methanesulfonate

wg^l-17

loss of function allele

X ray

wg^l-17 Adc^b-1 pr¹/CyO

wg^Sp-rv1

loss of function allele

ethyl methanesulfonate

wg^Sp-1

loss of function allele

ethyl methanesulfonate

dpy^ovh wg^Sp-1 cn¹ bw¹ / In(2L)Cy, Duox^Cy dpy^lv1 cn¹ bw¹

wg^CE7

amorphic allele - genetic evidence

wg^l-12

ethyl methanesulfonate

wg^l-12 ck¹³ pr¹ cn¹ / CyO

wg¹

ethyl methanesulfonate

ap^ts78j wg¹/SM5

wg^l-15

amorphic allele - genetic evidence

X ray

CyO, Duox^Cy dpy^lv1 pr¹ cn² / wg^l-15 Adc^b-1 pr¹

wg^l-8

amorphic allele - genetic evidence

ethyl methanesulfonate

wg^l-8 cn¹ bw¹ speck¹/CyO

wg^KO

loss of function allele

cre recombinase

References (3)

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