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Reference
Citation
Buechling, T., Chaudhary, V., Spirohn, K., Weiss, M., Boutros, M. (2011). p24 proteins are required for secretion of Wnt ligands.  EMBO Rep. 12(12): 1265--1272.
FlyBase ID
FBrf0216831
Publication Type
Research paper
Abstract

During development and disease, the exocytosis of signalling molecules, such as Wnt ligands, is essential to orchestrate cellular programs in multicellular organisms. However, it remains a largely unresolved question whether signalling molecules follow specialized transport routes through the exocytic pathway. Here we identify several Drosophila p24 proteins that are required for Wnt signalling. We demonstrate that one of these p24 proteins, namely Opossum, shuttles in the early secretory pathway, and that the Drosophila Wnt proteins are retained in the absence of p24 proteins. Our results indicate that Wnt secretion relies on a specialized anterograde secretion route with p24 proteins functioning as conserved cargo receptors.

PubMed ID
PubMed Central ID
PMC3245698 (PMC) (EuropePMC)
Related Publication(s)
Note

Wnts need a p(assport)24 to leave the ER.
Palmer et al., 2011, EMBO Rep. 12(12): 1207--1208 [FBrf0217809]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference
    Alleles (12)
    Gene Groups (1)
    Genes (22)
    Physical Interactions (2)
    Cell Lines (2)
    Natural transposons (1)
    Experimental Tools (2)
    Transgenic Constructs (10)