Human Disease Model Report: insulin signaling, regulation of fat storage, Drosophila fat body model

General Information

Name

insulin signaling, regulation of fat storage, Drosophila fat body model

FlyBase ID

FBhh0001170

Disease Ontology Term

Parent Disease

OMIM

Overview

The insect fat body is an adipose- and liver-like tissue that stores fat and maintains circulating glucose; it also plays a key role in the humoral immune response. The Drosophila fat body has been used extensively as a tractable system for investigation of regulatory networks impacting insulin signaling, regulation of fat storage, and metabolic homeostasis.

Many studies use a high-sugar diet to induce molecular changes analogous to type 2 diabetes; a high-fat diet has also been used. Manipulation of genes known to play roles in insulin signaling pathways, including InR, foxo, Akt, Akh, EcR, and Hsap\SLC2A4, have been used. A number of genes with newly identified roles in energy homeostasis and lipid storage have been characterized, including fs(1)h, svp, Sdc, gbb, trbl and Naa40. Enzymes required for CoA synthesis; a number of RNA splicing factors, including SF2, Rbp1, and tra2; and genes encoding peptidoglycan recognition proteins involved in the innate immune response have been characterized in this system. Using the Drosophila gene rl, the role of the MAPK/ERK pathway in regulating lipolysis, and the resulting impact on circulating glycerol and glucose levels, has been investigated.

[updated Aug. 2023 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: insulin signaling, regulation of fat storage, Drosophila fat body model

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

External links

Disease synonyms

insulin signaling, regulation of fat storage in Drosophila fat body

Related Diseases

Related human health report(s)

diabetes mellitus, noninsulin-dependent (type 2) (fly models overview)

diabetes mellitus type 2, susceptibility to, AKT-related

high-sugar diet, adipokinetic hormone signaling

insulin pathway effects, BMP/TGFB-related

insulin pathway effects, TRIB-related

insulin resistance syndromes, INSR-related

obesity, susceptibility to, adipokinetic hormone model

obesity, susceptibility to (fly models overview)

Ortholog Information

Human gene(s) in FlyBase

Hsap\SLC2A4

Other mammalian ortholog(s) used

D. melanogaster Gene Information (15)

Dmel\tra2

Gene Snapshot

transformer 2 (tra2) is a sex-determining gene that encodes a pre-mRNA binding protein. It regulates the alternative splicing of several mRNAs including those from key regulators of sexual differentiation, dsx and fru, and Taf1, which encodes a TFIID component. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate to high-scoring ortholog of human TRA2B and TRA2A.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\InR

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

INS-C
RTK

Comments on ortholog(s)

Moderate to high-scoring ortholog of human IGF1R, INSR, and INSRR.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\foxo

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate-scoring ortholog of human FOXO1, FOXO3, FOXO4, and FOXO6.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Akt

Gene Snapshot

Akt kinase (Akt) encodes the core kinase component of the insulin/insulin-like growth factor pathway. It functions downstream of the product of Pi3K92E and is activated by phosphatidylinositol binding and phosphorylation. It regulates cell growth and survival, stress responses and ageing. [Date last reviewed: 2019-03-07]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate- to high-scoring ortholog of human genes AKT2, AKT3, and AKT1 (1 Drosophila to 3 human). Dmel\Akt shares 60-64% identity and 75-77% similarity with these human genes.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Akh

Gene Snapshot

Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body. [Date last reviewed: 2019-03-07]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

NPPH

Comments on ortholog(s)

Dmel\Akh is postulated to play a role analogous to some of the functions of mammalian glucagon.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\EcR

Gene Snapshot

Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. [Date last reviewed: 2019-03-07]

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Component of the receptor for the insect steroid hormone ecdysone.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\fs(1)h

Gene Snapshot

female sterile (1) homeotic (fs(1)h) encodes a Bromodomain and Extra-Terminal domain (BET) family of protein, characterized by the presence of two tandem bromodomains and an extra-terminal (ET) domain. BET proteins can bind acetylated lysine residues in histones and regulate transcription. The proteins encoded by fs(1)h and human BRD2 possess protein kinase activity. [Date last reviewed: 2021-01-21]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

DBDTF-U
A-PK

Comments on ortholog(s)

Moderate-scoring ortholog of human BRD2, BRD3, BRD4, and BRDT.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\svp

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate-scoring ortholog of human NR2F1, NR2F2, and NR2F6.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Sdc

Gene Snapshot

Syndecan (Sdc) encodes a transmembrane heparan sulfate proteoglycan. It binds to the products of sli and robo1 to regulate axon guidance at the CNS midline, and it cooperates with the product of Lar to promote synapse growth at the larval neuromuscular junction. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

GLYP

Comments on ortholog(s)

Low- to moderate-scoring ortholog of human SDC2, SDC1, SDC3, and SDC4.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\gbb

Gene Snapshot

glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. [Date last reviewed: 2018-09-20]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate to high-scoring ortholog of human BMP7, BMP6, BMP5, BMP8B, and BMP8A.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\trbl

Gene Snapshot

tribbles (trbl) encodes the founding member of the Trib family of kinase-like proteins. It contributes to cell growth, cell migration and metabolism. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Low- to moderate-scoring ortholog of human TRIB2, TRIB1, and TRIB3.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\SF2

Gene Snapshot

Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. [Date last reviewed: 2019-09-12]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

SR-C

Comments on ortholog(s)

Moderate to high-scoring ortholog of human SRSF1 and SRSF9.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Rbp1

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

SR-C

Comments on ortholog(s)

Moderate-scoring ortholog of human SRSF3 and SRSF7.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Naa40

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

nucleus

Gene Groups / Pathways

Comments on ortholog(s)

High-scoring ortholog of human NAA40 (1 Drosophila to 1 human).

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\rl

Gene Snapshot

rolled (rl) encodes the mitogen activated protein (MAP) kinase, core component of the RAS/MAPK pathway. It is inactivated by the phosphatases encoded by PTP-ER and Mkp3. It phosphorylates a diverse set of downstream cytoplasmic and nuclear effectors, which impact cell fate decisions in a wide array of tissues. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

High-scoring ortholog of human MAPK1 (ERK2) and MAPK3 (ERK1); multiple related genes in both species.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (580 groups)

tra2

protein-protein

Interacting group

Assay

References

tra2

far western blotting, autoradiography, nucleic acid uv cross-linking assay, two hybrid

(Qi et al., 2007, Amrein et al., 1994)

tra2 - CG12769

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

tra2 - hrg

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

tra2 - SF2

two hybrid, far western blotting, autoradiography

(Amrein et al., 1994)

tra2 - tra

two hybrid, far western blotting, autoradiography, anti tag coimmunoprecipitation

(Amrein et al., 1994, Inoue et al., 1992)

RNA-protein

Interacting group

Assay

References

tra2

far western blotting, autoradiography, nucleic acid uv cross-linking assay, two hybrid

(Qi et al., 2007, Amrein et al., 1994)

tra2 - dsx

nucleic acid uv cross-linking assay, autoradiography

(Amrein et al., 1994, Inoue et al., 1992, Hedley and Maniatis, 1991)

tra2 - hfp

anti tag coimmunoprecipitation, primer specific pcr, quantitative reverse transcription pcr, electrophoretic mobility shift assay, predetermined participant

(Casier et al., 2023, Wang et al., 2013)

tra2 - Marf1

anti tag coimmunoprecipitation, quantitative reverse transcription pcr, nucleotide sequence identification

(Kawaguchi et al., 2020)

tra2 - Rbp1

nucleic acid uv cross-linking assay, autoradiography

(Qi et al., 2007)

InR

protein-protein

Interacting group

Assay

References

InR

enzymatic study, molecular sieving, molecular weight estimation by staining

(Krishnan et al., 2024)

InR - 14-3-3ζ

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - Cdc37

bimolecular fluorescence complementation, fluorescence microscopy, proximity ligation assay

(Huang and Wang, 2018)

InR - CG10916

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Friedman et al., 2011, Friedman et al., 2011)

InR - CG30122

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

InR - cher

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - chico

anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting, two hybrid, fluorescent resonance energy transfer

(Breitkopf et al., 2016, Vinayagam et al., 2016, Almudi et al., 2013, Friedman et al., 2011, Glatter et al., 2011, Pflieger et al., 2008, Kulansky Poltilove et al., 2000)

InR - CNBP

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - ctp

anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting

(Vinayagam et al., 2016, Friedman et al., 2011)

InR - dock

two hybrid, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Li et al., 2014, Wu et al., 2011, Song et al., 2003)

InR - Droj2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - Elp6

anti bait coimmunoprecipitation, peptide massfingerprinting

(Bolukbasi et al., 2012)

InR - glo

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - Gp93

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - Hrb98DE

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

InR - Hsp83

bimolecular fluorescence complementation, fluorescence microscopy, proximity ligation assay, anti tag coimmunoprecipitation, peptide massfingerprinting

(Huang and Wang, 2018, Friedman et al., 2011)

InR - Ilp5

electron microscopy, competition binding

(Viola et al., 2023, Sajid et al., 2011)

InR - Ilp8

pull down, Identification by mass spectrometry

(Garelli et al., 2015)

InR - Lar

enzymatic study, anti bait coimmunoprecipitation, western blot, surface plasmon resonance

(Kaur et al., 2019, Madan et al., 2011)

InR - Lnk

fluorescent resonance energy transfer

(Almudi et al., 2013)

InR - M7BP

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - Pi3K21B

anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting

(Vinayagam et al., 2016, Friedman et al., 2011, Glatter et al., 2011)

InR - Pi3K92E

anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting

(Vinayagam et al., 2016, Friedman et al., 2011)

InR - Ptp61F

pull down, western blot

(Wu et al., 2011)

InR - Ptp99A

enzymatic study, surface plasmon resonance

(Madan et al., 2011)

InR - RpL6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - RpL10

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - RpL15

anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting

(Vinayagam et al., 2016, Friedman et al., 2011)

InR - RpL30

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - RpL36

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

InR - RpLP1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

InR - RpS7

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

InR - RpS13

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

InR - RpS23

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - RpS28b

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - SF2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

InR - sta

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

InR - STUB1

enzymatic study, western blot

(Tawo et al., 2017)

InR - UQCR-C2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RNA-protein

Interacting group

Assay

References

InR - DENR

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Schleich et al., 2014)

InR - Imp

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Sreejith et al., 2022)

InR - lin-28

anti tag coimmunoprecipitation, primer specific pcr, quantitative reverse transcription pcr

(Sreejith et al., 2022, Chen et al., 2015)

RNA-RNA

Interacting group

Assay

References

InR - mir-276a

luminiscence technology

(Lee et al., 2023)

foxo

protein-protein

Interacting group

Assay

References

foxo

anti tag coimmunoprecipitation, anti tag western blot

(Sun et al., 2024)

foxo - 14-3-3ε

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting, Identification by mass spectrometry

(Vinayagam et al., 2016, Glatter et al., 2011, Nielsen et al., 2008)

foxo - 14-3-3ζ

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting, Identification by mass spectrometry

(Vinayagam et al., 2016, Glatter et al., 2011, Nielsen et al., 2008)

foxo - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

foxo - Act5C

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - AGO2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Aldh

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - αCOP

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - α-Spec

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - alt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - ana2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Antp

two hybrid array

(Shokri et al., 2019)

foxo - arm

anti tag coimmunoprecipitation, anti tag western blot, western blot, anti bait coimmunoprecipitation

(Zhang et al., 2016)

foxo - β'COP

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - bif

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Blimp-1

two hybrid array

(Shokri et al., 2019)

foxo - bowl

two hybrid array

(Shokri et al., 2019)

foxo - brm

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - bsf

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - BtbVII

two hybrid array

(Shokri et al., 2019)

foxo - BuGZ

two hybrid array

(Shokri et al., 2019)

foxo - bun

two hybrid array

(Shokri et al., 2019)

foxo - Caf1-55

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - cbt

two hybrid array

(Shokri et al., 2019)

foxo - CCT1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CCT6

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Cdc5

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG1513

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG1620

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG2691

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG3335

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG3817

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG4364

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG4730

two hybrid array

(Shokri et al., 2019)

foxo - CG6418

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG6693

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG6769

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG7564

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG8089

two hybrid array

(Shokri et al., 2019)

foxo - CG9667

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG11180

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG11723

two hybrid array

(Shokri et al., 2019)

foxo - CG11906

two hybrid array

(Shokri et al., 2019)

foxo - CG13096

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG14711

two hybrid array

(Shokri et al., 2019)

foxo - CG15019

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG15336

two hybrid array

(Shokri et al., 2019)

foxo - CG15784

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG17803

two hybrid array

(Shokri et al., 2019)

foxo - CG30122

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG31460

two hybrid array

(Shokri et al., 2019)

foxo - CG31550

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CG31955

two hybrid array

(Shokri et al., 2019)

foxo - CG32772

two hybrid array

(Shokri et al., 2019)

foxo - CG33695

two hybrid array

(Shokri et al., 2019)

foxo - Chc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - cindr

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Claspin

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - cora

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - CrebB

two hybrid array

(Shokri et al., 2019)

foxo - croc

two hybrid array

(Shokri et al., 2019)

foxo - CtBP

two hybrid array

(Shokri et al., 2019)

foxo - Ctf4

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - cyc

two hybrid array

(Shokri et al., 2019)

foxo - da

two hybrid array

(Shokri et al., 2019)

foxo - Dlip3

two hybrid array

(Shokri et al., 2019)

foxo - dmrt11E

two hybrid array

(Shokri et al., 2019)

foxo - Dr

two hybrid array

(Shokri et al., 2019)

foxo - dsx

two hybrid array

(Shokri et al., 2019)

foxo - E2f1

two hybrid array

(Shokri et al., 2019)

foxo - eIF3a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF3b

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF3c

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF3e

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF3f1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF3h

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF3i

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF3k

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - eIF4G1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - erm

two hybrid array

(Shokri et al., 2019)

foxo - exex

two hybrid array

(Shokri et al., 2019)

foxo - ey

coimmunoprecipitation, anti tag western blot

(Okamoto and Nishimura, 2015)

foxo - fd96Cb

two hybrid array

(Shokri et al., 2019)

foxo - Fer2

two hybrid array

(Shokri et al., 2019)

foxo - Fib

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - glo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - H2.0

two hybrid array

(Shokri et al., 2019)

foxo - Hey

two hybrid array

(Shokri et al., 2019)

foxo - HmgD

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - hng2

two hybrid array

(Shokri et al., 2019)

foxo - Hrb98DE

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Hsap\ATXN3

anti tag coimmunoprecipitation, anti tag western blot

(Kwon et al., 2018)

foxo - Hsc70-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - ind

two hybrid array

(Shokri et al., 2019)

foxo - Ipo9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Iswi

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Kdm5

pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2014)

foxo - kis

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - kn

two hybrid array

(Shokri et al., 2019)

foxo - Kr-h1

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Kang et al., 2017)

foxo - kst

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - l(1)G0020

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - larp

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - lds

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Lime

two hybrid array

(Shokri et al., 2019)

foxo - Lrrk

protein kinase assay, autoradiography

(Kanao et al., 2010)

foxo - maf-S

two hybrid array

(Shokri et al., 2019)

foxo - Mi-2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Mink

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - mle

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - MRP

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - msn

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - NAT1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - nonA

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Nop53

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Nop60B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Nup358

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Pak3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - pan

anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2016)

foxo - pav

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - pho

two hybrid array

(Shokri et al., 2019)

foxo - pic

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - pit

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - pll

anti tag coimmunoprecipitation, anti tag western blot, pull down

(Wu et al., 2015)

foxo - Polr1A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Polr1B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Poxm

two hybrid array

(Shokri et al., 2019)

foxo - Poxn

two hybrid array

(Shokri et al., 2019)

foxo - Prp8

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Prp19

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Ptx1

two hybrid array

(Shokri et al., 2019)

foxo - pzg

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - qkr58E-2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - qkr58E-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RAF2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Ref1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Rheb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RhoGEF2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Rm62

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - rn

two hybrid array

(Shokri et al., 2019)

foxo - ro

two hybrid array

(Shokri et al., 2019)

foxo - RpL7A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL10

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL13A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL14

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL15

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL17

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL18

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL18A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL19

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL23

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL23A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL26

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpL35A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpLP1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpLP2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS5a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS6

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS7

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS11

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS14a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS15

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS17

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS19b

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS23

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - RpS26

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Rpt2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Rpt4

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - rump

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - run

two hybrid array

(Shokri et al., 2019)

foxo - Sams

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Sarm

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - schlank

two hybrid array

(Shokri et al., 2019)

foxo - Sf3b2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - sip2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - sle

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - sna

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot, two hybrid array

(Guo et al., 2022, Shokri et al., 2019)

foxo - Spps

two hybrid array

(Shokri et al., 2019)

foxo - sqd

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Sry-β

two hybrid array

(Shokri et al., 2019)

foxo - Su(z)12

two hybrid array

(Shokri et al., 2019)

foxo - sug

two hybrid array

(Shokri et al., 2019)

foxo - Syp

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - TBPH

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - TfIIFβ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - tono

two hybrid array

(Shokri et al., 2019)

foxo - trabl

two hybrid array

(Shokri et al., 2019)

foxo - Trl

two hybrid array

(Shokri et al., 2019)

foxo - tyf

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

foxo - usp

anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot

(Koyama et al., 2014)

foxo - Usp7

anti tag coimmunoprecipitation, anti tag western blot

(Sun et al., 2024)

foxo - vig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - vig2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Vsx2

two hybrid array

(Shokri et al., 2019)

foxo - yki

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, pull down

(Sun et al., 2024)

foxo - yps

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

foxo - Zn72D

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt

protein-protein

Interacting group

Assay

References

Akt - Act57B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Afg3l2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Akap200

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - αCOP

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Arc42

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Arf1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - AsnRS

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Atpα

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - ATPsynβ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - ATPsynγ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - ben

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - βTub60D

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - βTub97EF

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - blw

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - cathD

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CCT1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CCT2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CCT4

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CCT5

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CCT6

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CCT7

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CCT8

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CG1416

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CG2614

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CG5504

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CG9281

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CG15784

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Chc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - clu

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - cpa

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - cpb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - CtsK1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - δCOP

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Desat1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Dref

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Drice

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Droj2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - eEF1α1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - eEF2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - eIF2α

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - eIF2γ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - eIF4A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - eIF4G1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - FASN1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - fax

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - fkh

anti tag coimmunoprecipitation, anti tag western blot

(Bolukbasi et al., 2017)

Akt - GCS2β

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Gfat2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Gmppb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - GstE7

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Hel25E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Hsc70-2

proximity ligation assay, fluorescence microscopy

(Azuma et al., 2021)

Akt - Hsc70-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Hsc70-5

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Hsp60A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - hts

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Ipo9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Kap-α3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Kcmf1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - l(1)G0320

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - l(2)09851

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Ldh

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - lic

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Lon

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Mcad

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - MetRS

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Mkk4

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - mRpL12

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - mts

anti tag coimmunoprecipitation, anti tag western blot

(Gil-Ranedo et al., 2019)

Akt - Nap1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Nfs1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Nph

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - nst

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Ogdh1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Ost1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Ost48

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Pcb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - pch2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - PCNA

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Pdha1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - pic

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Pp2A-29B

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Psa

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Pyk

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rack1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - r-l

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rop

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpL9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpL17

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpL23

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpL31

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpLP1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpn1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpn5

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpn9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpn10

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpn13

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpS7

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpS9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpS14a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpS15Aa

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpS16

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - RpS17

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpt1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpt2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpt4

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpt5

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Rpt6

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Sams

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Scox

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - ScsβA

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - ScsβG

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - SERCA

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Shmt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - slmb

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Wong et al., 2013)

Akt - smid

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Sply

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - sqd

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Srlp

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - SsRβ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Tctp

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - TER94

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Tkt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - trbl

pull down, autoradiography, anti bait coimmunoprecipitation, western blot, two hybrid

(Fischer et al., 2025, Fischer et al., 2017, Das et al., 2014)

Akt - Trmt2a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - tud

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - UQCR-C2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - Vha68-2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - wal

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Akt - wdb

anti bait coimmunoprecipitation, western blot

(Fischer et al., 2015, Vereshchagina et al., 2008)

Akt - yki

enzymatic study, western blot

(Li et al., 2022)

Akt - yps

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RNA-RNA

Interacting group

Assay

References

Akt - mir-263b

luminiscence technology

(Kim et al., 2025)

Akh

RNA-protein

Interacting group

Assay

References

Akh - Atx2

proximity labelling technology, nucleotide sequence identification

(Singh et al., 2021)

protein-protein

Interacting group

Assay

References

Akh - AkhR

biochemical, inferred by author, enzymatic study, Identification by mass spectrometry, luminiscence technology

(Caers et al., 2012, Park et al., 2002, Staubli et al., 2002)

Akh - CCAP-R

enzymatic study, inferred by author

(Park et al., 2002)

Akh - CrzR

enzymatic study, inferred by author

(Park et al., 2002)

EcR

protein-protein

Interacting group

Assay

References

EcR

bimolecular fluorescence complementation, fluorescence microscopy

(Dutko-Gwóźdź et al., 2008)

EcR - 14-3-3ε

fluorescent resonance energy transfer, fluorescence microscopy

(Ng et al., 2017)

EcR - alien

pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Huang et al., 2014, Dressel et al., 1999)

EcR - ari-1

two hybrid, anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, western blot

(Gradilla et al., 2011)

EcR - Art1

anti tag coimmunoprecipitation, western blot

(Kimura et al., 2008)

EcR - Art4

anti tag coimmunoprecipitation, western blot

(Cakouros et al., 2004)

EcR - bon

pull down, anti tag western blot

(Beckstead et al., 2001)

EcR - brm

proximity-dependent biotin identification, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot

(Mazina et al., 2020)

EcR - Cdk8

two hybrid, anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot

(Xie et al., 2015)

EcR - cg

proximity ligation assay

(Hitrik et al., 2016)

EcR - CG10209

two hybrid array

(Shokri et al., 2019)

EcR - Chd64

two hybrid, pull down, autoradiography

(Li et al., 2007)

EcR - Chro

anti bait coimmunoprecipitation, western blot, proximity-dependent biotin identification, Identification by mass spectrometry

(Mazina et al., 2020)

EcR - Cp190

anti bait coimmunoprecipitation, western blot, proximity-dependent biotin identification, Identification by mass spectrometry

(Mazina et al., 2020)

EcR - crc

two hybrid, pull down, autoradiography

(Gauthier et al., 2012)

EcR - CSN4

anti tag coimmunoprecipitation, anti tag western blot

(Huang et al., 2014)

EcR - CSN5

anti tag coimmunoprecipitation, anti tag western blot

(Huang et al., 2014)

EcR - CTCF

anti bait coimmunoprecipitation, western blot

(Pascual-Garcia et al., 2017)

EcR - CycC

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - Dek

pull down, western blot, anti tag coimmunoprecipitation

(Sawatsubashi et al., 2010)

EcR - E(bx)

pull down, autoradiography

(Badenhorst et al., 2005)

EcR - ERR

anti tag coimmunoprecipitation, anti tag western blot

(Kovalenko et al., 2019)

EcR - Fkbp39

two hybrid, pull down, autoradiography

(Li et al., 2007)

EcR - fru

anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2018)

EcR - Hr38

bimolecular fluorescence complementation

(Zoglowek et al., 2012)

EcR - Hsc70-4

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - Jra

pull down, western blot, proximity ligation assay, fluorescence microscopy

(Yoo et al., 2021)

EcR - kay

pull down, western blot

(Yoo et al., 2021)

EcR - Kdm4A

anti tag coimmunoprecipitation, western blot

(Tsurumi et al., 2013)

EcR - kto

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - LKRSDH

pull down, peptide massfingerprinting, autoradiography, anti bait coimmunoprecipitation, western blot

(Cakouros et al., 2008)

EcR - Lpt

anti tag coimmunoprecipitation, western blot, pull down

(Chauhan et al., 2012)

EcR - MBD-like

two hybrid array

(Shokri et al., 2019)

EcR - MED1

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - MED14

two hybrid, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - MED15

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - MED26

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - MED27

anti tag coimmunoprecipitation, western blot

(Homem et al., 2014)

EcR - Met

two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Long et al., 2025, Bitra and Palli, 2009, Li et al., 2007)

EcR - Mgtor

anti bait coimmunoprecipitation, western blot

(Pascual-Garcia et al., 2017)

EcR - Mi-2

pull down, autoradiography, anti bait coimmunoprecipitation, western blot, molecular weight estimation by staining, proximity-dependent biotin identification, Identification by mass spectrometry

(Mazina et al., 2020, Brehm, 2017.5.22, Kreher et al., 2017)

EcR - mor

proximity-dependent biotin identification, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot

(Mazina et al., 2020)

EcR - nej

anti tag coimmunoprecipitation, anti tag western blot

(Kirilly et al., 2011)

EcR - Nelf-A

anti bait coimmunoprecipitation, western blot, proximity-dependent biotin identification, Identification by mass spectrometry

(Mazina et al., 2021, Mazina et al., 2020)

EcR - NELF-B

anti bait coimmunoprecipitation, western blot

(Mazina et al., 2021)

EcR - Nelf-E

anti bait coimmunoprecipitation, western blot

(Mazina et al., 2021)

EcR - Nup98-96

anti bait coimmunoprecipitation, western blot

(Pascual-Garcia et al., 2017)

EcR - Nup358

anti bait coimmunoprecipitation, western blot, proximity-dependent biotin identification, Identification by mass spectrometry

(Mazina et al., 2020)

EcR - osa

proximity-dependent biotin identification, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot

(Mazina et al., 2020)

EcR - Parp1

anti tag coimmunoprecipitation, western blot

(Sawatsubashi et al., 2004)

EcR - Rel

two hybrid array

(Shokri et al., 2019)

EcR - rig

pull down, autoradiography, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015, Gates et al., 2004)

EcR - skd

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

EcR - Smr

anti bait coimmunoprecipitation, Identification by mass spectrometry, two hybrid

(Xie et al., 2015, Wang et al., 2006)

EcR - Spt5

proximity-dependent biotin identification, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot

(Mazina et al., 2020)

EcR - svp

two hybrid

(Zelhof et al., 1995)

EcR - tai

pull down, autoradiography, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015, Bai et al., 2000)

EcR - TP53INP

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, pull down

(Xie et al., 2015, Francis et al., 2010)

EcR - Trf

two hybrid array

(Shokri et al., 2019)

EcR - trr

anti bait coimmunoprecipitation, western blot

(Pascual-Garcia et al., 2017)

EcR - twi

anti tag coimmunoprecipitation, anti tag western blot

(Ruan et al., 2024)

EcR - usp

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, two hybrid, electrophoretic mobility shift assay, autoradiography, Identification by mass spectrometry, pull down, electrophoretic mobility supershift assay, bimolecular fluorescence complementation, fluorescence microscopy, peptide massfingerprinting, experimental knowledge based, x-ray crystallography

EcR - Usp7

pull down, autoradiography

(van der Knaap et al., 2010)

EcR - Utx

pull down, autoradiography, anti tag coimmunoprecipitation, western blot

(Denton et al., 2013)

EcR - yki

coimmunoprecipitation, western blot

(Zhang et al., 2015)

RNA-protein

Interacting group

Assay

References

EcR - B52

systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing, electrophoretic mobility shift assay, autoradiography

(Kim et al., 2003)

RNA-RNA

Interacting group

Assay

References

EcR - mir-14

fluorescence technology, western blot, luminiscence technology, necessary binding region, immunohistochemistry

(Varghese and Cohen, 2007)

EcR - mir-34

immunohistochemistry

(Lai et al., 2016)

fs(1)h

protein-protein

Interacting group

Assay

References

fs(1)h - ash1

anti tag coimmunoprecipitation, anti tag western blot, ion exchange chromatography, peptide massfingerprinting

(Kockmann et al., 2013)

fs(1)h - BEAF-32

anti bait coimmunoprecipitation, western blot

(Kellner et al., 2013)

fs(1)h - CBP

anti bait coimmunoprecipitation, western blot

(Bi et al., 2022)

fs(1)h - cnc

anti tag coimmunoprecipitation, western blot

(Chatterjee et al., 2016)

fs(1)h - Cp190

anti bait coimmunoprecipitation, western blot, pull down

(Kellner et al., 2013)

fs(1)h - CtBP

anti bait coimmunoprecipitation, western blot

(Bi et al., 2022)

fs(1)h - east

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

fs(1)h - His3

pull down, anti tag western blot

(Kockmann et al., 2013)

fs(1)h - His4

pull down, anti tag western blot

(Kockmann et al., 2013)

fs(1)h - mod(mdg4)

anti bait coimmunoprecipitation, western blot, pull down

(Kellner et al., 2013)

fs(1)h - Pc

tandem affinity purification, Identification by mass spectrometry, pull down, peptide massfingerprinting, anti tag coimmunoprecipitation, anti tag western blot, western blot

(Lv et al., 2018, Kang et al., 2015, Strübbe et al., 2011)

fs(1)h - PIP4K

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

fs(1)h - Polr2A

anti bait coimmunoprecipitation, western blot

(Bi et al., 2022)

fs(1)h - Psc

anti tag coimmunoprecipitation, western blot, molecular weight estimation by staining, cross-linking study, tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2017)

fs(1)h - Sce

pull down, western blot, anti tag coimmunoprecipitation

(Lv et al., 2018)

fs(1)h - su(Hw)

pull down, western blot, anti bait coimmunoprecipitation

(Kellner et al., 2013)

fs(1)h - Su(z)2

cross-linking study, tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2017)

fs(1)h - Trl

pull down, western blot, anti bait coimmunoprecipitation

(Kellner et al., 2013)

fs(1)h - Utx

anti bait coimmunoprecipitation, western blot

(Bi et al., 2022)

svp

protein-protein

Interacting group

Assay

References

svp - abd-A

bimolecular fluorescence complementation, fluorescence microscopy, anti tag coimmunoprecipitation, anti tag western blot

(Bischof et al., 2018, Baëza et al., 2015)

svp - Abd-B

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

svp - alien

pull down, autoradiography

(Dressel et al., 1999)

svp - Antp

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

svp - AOX1

two hybrid

(Hu et al., 2017.6.13)

svp - bon

pull down, anti tag western blot

(Beckstead et al., 2001)

svp - CG4820

two hybrid array

(Shokri et al., 2019)

svp - CG5011

two hybrid

(Hu et al., 2017.6.13)

svp - CG13501

two hybrid

(Hu et al., 2017.6.13)

svp - CG14711

two hybrid array

(Shokri et al., 2019)

svp - CG15336

two hybrid array

(Shokri et al., 2019)

svp - CG15478

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, two hybrid

(Hu et al., 2017.6.13, Rhee et al., 2014)

svp - CG31612

two hybrid array

(Shokri et al., 2019)

svp - CG32846

two hybrid

(Hu et al., 2017.6.13)

svp - CG45071

two hybrid array

(Shokri et al., 2019)

svp - comr

two hybrid array

(Shokri et al., 2019)

svp - Coop

two hybrid array

(Shokri et al., 2019)

svp - Cph

two hybrid array

(Shokri et al., 2019)

svp - CrebB

two hybrid array

(Shokri et al., 2019)

svp - CycK

two hybrid

(Hu et al., 2017.6.13)

svp - disco

two hybrid

(Hu et al., 2017.6.13)

svp - drm

two hybrid array

(Shokri et al., 2019)

svp - EcR

two hybrid

(Zelhof et al., 1995)

svp - Ets21C

two hybrid array

(Shokri et al., 2019)

svp - Gug

two hybrid, pull down, autoradiography

(Wang et al., 2006)

svp - H2.0

two hybrid

(Hu et al., 2017.6.13)

svp - HLH54F

two hybrid array

(Shokri et al., 2019)

svp - hng2

two hybrid array

(Shokri et al., 2019)

svp - Lime

two hybrid array

(Shokri et al., 2019)

svp - odd

two hybrid array

(Shokri et al., 2019)

svp - PolE4

two hybrid array

(Shokri et al., 2019)

svp - Poxm

two hybrid

(Hu et al., 2017.6.13)

svp - Pph13

two hybrid array

(Shokri et al., 2019)

svp - Rab8

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

svp - rig

pull down, autoradiography

(Gates et al., 2004)

svp - soul

two hybrid array

(Shokri et al., 2019)

svp - Sp1

two hybrid array

(Shokri et al., 2019)

svp - su(sable)

two hybrid

(Hu et al., 2017.6.13)

svp - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

svp - Vta1

two hybrid

(Hu et al., 2017.6.13)

svp - zfh2

two hybrid array

(Shokri et al., 2019)

Sdc

protein-protein

Interacting group

Assay

References

Sdc - Lar

pull down, enzyme linked immunosorbent assay, affinity technology, inferred by author, tag visualisation

(Johnson et al., 2006, Fox and Zinn, 2005)

Sdc - Mtpβ

experimental knowledge based

(Guruharsha et al., 2011)

Sdc - robo1

anti bait coimmunoprecipitation, western blot

(Johnson et al., 2004)

Sdc - Sidpn

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Sdc - sli

anti bait coimmunoprecipitation, western blot

(Johnson et al., 2004)

RNA-protein

Interacting group

Assay

References

Sdc - B52

systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing, electrophoretic mobility shift assay, autoradiography

(Kim et al., 2003)

Sdc - Imp

anti tag coimmunoprecipitation, reverse transcription pcr

(Roy and Link, 2025)

gbb

protein-protein

Interacting group

Assay

References

gbb

chromatography technology, western blot, coimmunoprecipitation, comigration in non denaturing gel electrophoresis

(Anderson and Wharton, 2017)

gbb - cmpy

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, two hybrid

(James et al., 2014, James and Broihier, 2011)

gbb - ctrip

anti tag coimmunoprecipitation, anti tag western blot

(Hossain et al., 2023)

gbb - cv

anti tag coimmunoprecipitation, anti tag western blot

(Shimmi et al., 2005)

gbb - cv-2

anti tag coimmunoprecipitation, anti tag western blot

(Serpe et al., 2008)

gbb - cv-d

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2012)

gbb - dpp

anti tag coimmunoprecipitation, anti tag western blot, comigration in non denaturing gel electrophoresis, western blot

(Anderson and Wharton, 2017, Tian and Jiang, 2014, Serpe et al., 2005)

gbb - GstO1

anti tag coimmunoprecipitation, western blot

(Hossain et al., 2023)

gbb - Hsap\FURIN

enzymatic study, western blot

(Anderson and Wharton, 2017)

gbb - nord

anti tag coimmunoprecipitation, anti tag western blot

(Yang et al., 2022)

gbb - sax

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Akiyama et al., 2012, Le and Wharton, 2012, Haerry, 2010)

gbb - sog

anti tag coimmunoprecipitation, anti tag western blot

(Shimmi et al., 2005)

gbb - stj

proximity ligation assay, fluorescence microscopy

(Hoover et al., 2019)

gbb - tkv

anti tag coimmunoprecipitation, anti tag western blot

(Haerry, 2010)

gbb - tsg

anti tag coimmunoprecipitation, anti tag western blot

(Shimmi et al., 2005)

trbl

RNA-RNA

Interacting group

Assay

References

trbl - mir-ban

fluorescence technology

(Gerlach et al., 2019)

protein-protein

Interacting group

Assay

References

trbl

two hybrid

(Fischer et al., 2025, Masoner et al., 2013)

trbl - Akt

pull down, autoradiography, anti bait coimmunoprecipitation, western blot, two hybrid

(Fischer et al., 2025, Fischer et al., 2017, Das et al., 2014)

trbl - CG12708

two hybrid

(Hu et al., 2017.6.13)

trbl - slbo

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Fischer et al., 2025, Fischer et al., 2017, Masoner et al., 2013, Rorth et al., 2000)

SF2

protein-protein

Interacting group

Assay

References

SF2 - glo

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Bansal et al., 2020)

SF2 - InR

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

SF2 - kel

proximity-dependent biotin identification, Identification by mass spectrometry

(Mannix et al., 2019)

SF2 - osk

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Hurd et al., 2016)

SF2 - qkr58E-3

pull down, autoradiography

(Robard et al., 2006)

SF2 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

SF2 - stau

anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Bansal et al., 2020)

SF2 - tra

far western blotting, autoradiography, two hybrid

(Amrein et al., 1994)

SF2 - tra2

two hybrid, far western blotting, autoradiography

(Amrein et al., 1994)

SF2 - Ubx

anti tag coimmunoprecipitation, anti tag western blot, proximity-dependent biotin identification, Identification by mass spectrometry

(Carnesecchi et al., 2020)

Rbp1

protein-protein

Interacting group

Assay

References

Rbp1 - Doa

enzymatic study, autoradiography

(Wan et al., 2008)

Rbp1 - x16

two hybrid, pull down, western blot

(Wan et al., 2008)

RNA-protein

Interacting group

Assay

References

Rbp1 - tra2

nucleic acid uv cross-linking assay, autoradiography

(Qi et al., 2007)

Naa40

protein-protein

Interacting group

Assay

References

Naa40 - Pebp1

experimental knowledge based

(Guruharsha et al., 2011)

protein-protein

Interacting group

Assay

References

rl - aop

pull down, autoradiography, enzymatic study

(Baker et al., 2001)

rl - Cdk2

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Friedman et al., 2011, Friedman et al., 2011)

rl - CG9391

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

rl - cic

anti tag coimmunoprecipitation, western blot, comigration in non denaturing gel electrophoresis, anti tag western blot, cross-linking study, Identification by mass spectrometry, two hybrid, pull down, autoradiography

(Paul et al., 2020, Futran et al., 2015, Astigarraga et al., 2007)

rl - corto

anti bait coimmunoprecipitation, western blot, pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Mouchel-Vielh et al., 2011)

rl - Dsor1

anti tag coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy

(Hall and Verheyen, 2015, Tipping et al., 2010)

rl - Gαq

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

rl - Gp93

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

rl - hid

two hybrid

(Hu et al., 2017.6.13)

rl - hng1

two hybrid

(Hu et al., 2017.6.13)

rl - Hsp60A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

rl - Imp

anti tag coimmunoprecipitation, anti tag western blot

(Graeve et al., 2024)

rl - Jra

enzymatic study, autoradiography

(Ciapponi et al., 2001)

rl - kay

enzymatic study, autoradiography

(Ciapponi et al., 2001)

rl - krz

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Tipping et al., 2010)

rl - Lamtor3

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography

(Mouchel-Vielh et al., 2011, Mouchel-Vielh et al., 2008)

rl - Lk6

anti tag coimmunoprecipitation, anti tag western blot

(Parra-Palau et al., 2005)

rl - Lpin

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

rl - msk

anti bait coimmunoprecipitation, western blot

(Lorenzen et al., 2001)

rl - pnt

enzymatic study, autoradiography

(Qiao et al., 2006)

rl - poe

anti tag coimmunoprecipitation, anti tag western blot

(Xie et al., 2021)

rl - Ppm1

anti tag coimmunoprecipitation, anti tag western blot

(Friedman and Perrimon, 2006)

rl - Rack1

anti tag coimmunoprecipitation, anti tag western blot

(Xie et al., 2021)

rl - Raf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

rl - Svil

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

rl - tay

pull down, autoradiography, anti tag coimmunoprecipitation, western blot

(Molnar and de Celis, 2013)

RNA-protein

Interacting group

Assay

References

rl - pum

rna three hybrid

(Kim et al., 2012)

Alleles Reported to Model Human Disease (Disease Ontology) (99 alleles)

tra2

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

tra2^KK108747

ameliorates cancer

modeled by Pten^KK109278

(Parniewska and Stocker, 2020)

Hsap\SLC2A4

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Hsap\SLC2A4^{UAS.Tag:HA,GFP}

model of acquired metabolic disease

CEA

(Crivat et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

InR

Models Based on Experimental Evidence ( 13 )

Allele

Disease

Evidence

References

InR⁰⁵⁵⁴⁵

model of diabetes mellitus

CEA

(Banzai and Nishimura, 2023)

CEC with InR^Y902C

(Banzai and Nishimura, 2023)

model of type 2 diabetes mellitus

CEA with InR^3T5

(Murillo-Maldonado et al., 2011)

InR^93Dj-4

model of diabetic neuropathy

CEA with InR^E19

(Wang et al., 2023)

InR^A1325D.UAS

model of glucose metabolism disease

CEA

(Musselman et al., 2018)

model of carcinoma

CEA with Csk^Q156Stop, Ras85D^V12.UAS

(Hirabayashi and Cagan, 2015)

InR^E19

model of diabetic neuropathy

CEA with InR^93Dj-4

(Wang et al., 2023)

model of type 2 diabetes mellitus

CEA with InR^3T5

(Murillo-Maldonado et al., 2011)

model of glucose metabolism disease

CEA with InR^3T5

(Álvarez-Rendón and Riesgo-Escovar, 2023, Álvarez-Rendón and Riesgo-Escovar, 2020)

InR^K1409A.UAS

model of sleep disorder

CEA

(Metaxakis et al., 2014)

model of type 2 diabetes mellitus

CEA

(Cao et al., 2022)

InR^UAS.Exel

model of cancer

CEA

(Khaket et al., 2024)

InR^GD104

model of glucose metabolism disease

CEA

(Musselman et al., 2018)

InR^JF01482

model of diabetic neuropathy

CEA

(Wang et al., 2023)

InR^3T5

model of type 2 diabetes mellitus

CEA with InR^E19

(Murillo-Maldonado et al., 2011)

CEA with InR⁰⁵⁵⁴⁵

(Murillo-Maldonado et al., 2011)

model of glucose metabolism disease

CEA with InR^E19

(Álvarez-Rendón and Riesgo-Escovar, 2023, Álvarez-Rendón and Riesgo-Escovar, 2020)

InR^UAS.cUa

model of cervical cancer

CEA with HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa

(Padash Barmchi et al., 2016)

model of high grade glioma

CEA

(Witte et al., 2009)

InR^CA.UAS.cUa

model of alcohol dependence

CEA

(Acevedo et al., 2015)

InR^{lexAop.HMS03166}

model of type 2 diabetes mellitus

CEA

(Tsao et al., 2023)

InR^Y902C

model of diabetes mellitus

CEA

(Banzai and Nishimura, 2023)

CEC with InR⁰⁵⁵⁴⁵

(Banzai and Nishimura, 2023)

Modifiers Based on Experimental Evidence ( 16 )

Allele

Disease

Interaction

References

InR⁰⁵⁵⁴⁵

ameliorates fragile X syndrome

modeled by Fmr1³

(Monyak et al., 2017)

InR³³⁹

ameliorates germ cell cancer

modeled by bam^Δ86

(Zhao et al., 2018)

InR^A1325D.UAS

exacerbates central nervous system cancer

modeled by N^ΔE.UAS

(Voutyraki et al., 2023)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^PO-100.UAS

(Atilano et al., 2021)

modeled by Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

exacerbates cancer

modeled by Csk^Q156Stop, Ras85D^V12.UAS

(Hirabayashi et al., 2013)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Pragati and Sarkar, 2024)

ameliorates cancer

modeled by Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

InR^E19

exacerbates viral infectious disease

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

exacerbates infectious mononucleosis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

exacerbates Epstein-Barr virus hepatitis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

InR^K1409A.UAS

ameliorates central nervous system cancer

modeled by N^ΔE.UAS

(Voutyraki et al., 2023)

ameliorates cancer

modeled by Ras85D^V12.GMR

(Okada et al., 2023)

modeled by scrib¹

(Sanaki et al., 2020)

ameliorates colorectal cancer

modeled by SH3PX1^JF02730

(Zhang et al., 2019)

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^PO-100.UAS

(Atilano et al., 2021)

modeled by Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Martin et al., 2021)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Pragati and Sarkar, 2025, Pragati and Sarkar, 2024)

InR^K414P.UAS

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Pragati and Sarkar, 2025, Pragati and Sarkar, 2024)

InR^UAS.Exel

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Raj and Sarkar, 2019)

modeled by Hsap\HTT^{Q138.UAS.mRFP1}

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

ameliorates syndrome

modeled by NSD^EY01950

(Quintero-Rivera et al., 2021)

exacerbates cancer

modeled by scrib¹

(Sanaki et al., 2020)

model of cancer

is ameliorated by SARS-CoV-2\nsp1^UAS.cZa

(Khaket et al., 2024)

InR^del.UAS

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Vita et al., 2021)

InR^JF01183

ameliorates cancer

modeled by Ras85D^V12.GMR

(Okada et al., 2023)

InR^JF01482

ameliorates cancer

modeled by Ras85D^V12.GMR

(Okada et al., 2023)

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^H50Q.UAS

(Rai and Kumar, 2025)

InR^GL00139

ameliorates cancer

modeled by Ras85D^V12.GMR

(Okada et al., 2023)

InR^NIG.18402R

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Sharma et al., 2025)

InR^UAS.cUa

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^H50Q.UAS

(Rai and Kumar, 2025)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Sharma et al., 2025)

InR^UAS.ECFP

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Raj and Sarkar, 2019)

InR^HMS03166

ameliorates lung adenocarcinoma

modeled by Hsap\KIF5B::Hsap\RET^UAS.cDa

(Das and Cagan, 2017)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Pragati and Sarkar, 2025, Pragati and Sarkar, 2024)

modeled by Hsap\MAPT^V337M.UAS

(Pragati and Sarkar, 2024)

modeled by Hsap\MAPT^R406W.UAS

(Pragati and Sarkar, 2024)

InR^RNAi.UAS.cUa

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Raj and Sarkar, 2019)

foxo

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

foxo^HMS00793

model of Parkinson's disease

CEA

(Tas et al., 2018)

foxo^Δ94

model of Parkinson's disease

CEA

(Tas et al., 2018)

foxo^HMS00422

model of Parkinson's disease

CEA

(Tas et al., 2018)

foxo^GD4348

model of Parkinson's disease

CEA

(Tas et al., 2018)

Modifiers Based on Experimental Evidence ( 12 )

Allele

Disease

Interaction

References

foxo^UAS.cUa

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Martin et al., 2021)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Cheng et al., 2021)

foxo²¹

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Hong et al., 2012)

ameliorates lower respiratory tract disease

modeled by PGRP-LC^x.UAS

(Wagner et al., 2021)

foxo²⁵

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Hong et al., 2012)

foxo^UAS.cFa

ameliorates Parkinson's disease

modeled by park²⁵

(Tain et al., 2009)

modeled by Fer2^MB09480

(Tas et al., 2018)

foxo^UAS.cPa

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q70.cc0.UAS.Tag:HA,Tag:MYC}

(Kwon et al., 2018)

foxo^TM.UAS

ameliorates cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Lee et al., 2021)

ameliorates brain glioma

modeled by btl::Egfr^λ.UAS, Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

(Read et al., 2009)

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Martin et al., 2021)

foxo^UASp.GFP

ameliorates congenital muscular dystrophy due to LMNA mutation

modeled by LamC^G489V.UAS

(Chandran et al., 2019)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Sharma et al., 2025)

foxo^KK108485

exacerbates congenital muscular dystrophy due to LMNA mutation

modeled by LamC^G489V.UAS

(Chandran et al., 2019)

foxo^Δ94

model of Parkinson's disease

is ameliorated by Fer2^UAS.Tag:FLAG

(Tas et al., 2018)

foxo^JF02734

ameliorates lower respiratory tract disease

modeled by PGRP-LC^x.UAS

(Wagner et al., 2021)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Sharma et al., 2025)

foxo^UAS.cKd

ameliorates Parkinson's disease

modeled by Pink1^B9

(Koh et al., 2012)

foxo^{G.UAS.Tag:FLAG}

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q70.cc0.UAS.Tag:HA,Tag:MYC}

(Kwon et al., 2018)

modeled by Hsap\ATXN3^{tr.Q76.UAS.Tag:HA,Tag:MYC}

(Kwon et al., 2018)

Akt

Models Based on Experimental Evidence ( 6 )

Allele

Disease

Evidence

References

Akt¹

model of type 2 diabetes mellitus

CEA with Akt³

(Murillo-Maldonado et al., 2011)

Akt³

model of type 2 diabetes mellitus

CEA with Akt¹

(Murillo-Maldonado et al., 2011)

Akt^EY10012

model of Parkinson's disease

CEA

(Inamdar et al., 2014)

Akt^UAS.Exel

model of alcohol use disorder

CEA

(Eddison et al., 2011)

Akt⁰⁴²²⁶

model of Parkinson's disease

CEA

(Inamdar et al., 2014)

Akt^{ΔPH.UAS.Tag:Myr(Unk)}

model of carcinoma

CEA

(Bhattacharya et al., 2024)

Modifiers Based on Experimental Evidence ( 16 )

Allele

Disease

Interaction

References

Akt^HMS00007

ameliorates cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Lee et al., 2021)

exacerbates frontotemporal dementia

modeled by Hsap\CHMP2B^Intron5.UAS

(West et al., 2018)

Akt^HM04007

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cBa}

(Na et al., 2023)

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Sharma et al., 2025)

Akt^GD1361

ameliorates brain glioma

modeled by btl::Egfr^λ.UAS, Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

(Read et al., 2009)

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

Akt¹

ameliorates carcinoma

modeled by Ras85D^V12.UAS, scrib¹

(Igaki et al., 2006)

Akt³

exacerbates frontotemporal dementia

modeled by Hsap\CHMP2B^Intron5.UAS

(West et al., 2018)

Akt^EY10012

ameliorates alcohol use disorder

modeled by aru^8.128

(Eddison et al., 2011)

Akt^UAS.Exel

ameliorates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Liévens et al., 2008)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-PR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Sharma et al., 2025)

ameliorates cancer

modeled by Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Akt^UAS.Tag:HA

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Chen et al., 2003)

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Akt^{T342D.S505D.GMR}

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

Akt⁰⁴²²⁶

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Chen et al., 2003)

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

exacerbates frontotemporal dementia

modeled by Hsap\CHMP2B^Intron5.UAS

(West et al., 2018)

ameliorates cancer

modeled by Csk^Q156Stop, Ras85D^V12.UAS

(Hirabayashi et al., 2013)

ameliorates carcinoma

modeled by Csk^Q156Stop, InR^A1325D.UAS, Ras85D^V12.UAS

(Hirabayashi and Cagan, 2015)

Akt^KK100495

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

ameliorates high grade glioma

modeled by Wdr62^UAS.Tag:HA

(Shohayeb et al., 2020)

Akt^{UAS.Tag:Myr(Unk)}

ameliorates glucose metabolism disease

modeled by Tl^10b.UAS.cUa

(Roth et al., 2018)

Akt^{T342D.UAS.Tag:HA}

ameliorates glucose metabolism disease

modeled by Tl^10b.UAS.cUa

(Roth et al., 2018)

Akt^{ΔPH.UAS.Tag:Myr(Unk)}

exacerbates frontotemporal dementia

modeled by Hsap\CHMP2B^Intron5.UAS

(West et al., 2018)

ameliorates intestinal cancer

modeled by yki^{3SA.lexAop.sfGFP}

(Saavedra et al., 2023)

ameliorates cancer

modeled by yki^{3SA.lexAop.Tag:Myr(Unk),GFP}

(Chen et al., 2022)

ameliorates type 2 diabetes mellitus

modeled by Uch^KO

(Lee et al., 2024)

Akt^HMS06047

ameliorates carcinoma

modeled by yki^HMS00041

(Bhattacharya et al., 2024)

Akt^RNAi.UAS.cUa

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Cheng et al., 2021)

EcR

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 7 )

Allele

Disease

Interaction

References

EcR^B1.UAS

ameliorates brain cancer

modeled by brat^KK113206

(Jiang et al., 2018)

EcR^{B2-ΔC655.F645A.UAS}

exacerbates cancer

modeled by ph-d⁵⁰⁵, ph-p⁵⁰⁵

(Jiang et al., 2018)

EcR^KG04522

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

EcR^Q50st

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

EcR^RNAi.A.UAS

exacerbates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

EcR^NIG.1765R

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

EcR^DN.UAS.cUa

ameliorates carcinoma

modeled by Ras85D^V12.UAS, dlg1^GD4689

(Santabárbara-Ruiz and Léopold, 2021)

fs(1)h

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

fs(1)h^rnc

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

svp

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

svp^KK108498

model of type 2 diabetes mellitus

CEA

(Musselman et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

svp¹

ameliorates central nervous system cancer

modeled by N^UAS.icd

(Zacharioudaki et al., 2016)

gbb

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

gbb^UAS.cKa

model of fibrodysplasia ossificans progressiva

CEA with sax^{K262H.UAS.Tag:FLAG}

(Le et al., 2018)

model of obesity

CEA

(Hong et al., 2016)

model of diabetes mellitus

CEA

(Hong et al., 2016)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

gbb¹

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q138.UAS.mRFP1}

(Akbergenova and Littleton, 2017)

gbb²

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q138.UAS.mRFP1}

(Akbergenova and Littleton, 2017)

gbb^UAS.cKa

ameliorates amyotrophic lateral sclerosis type 1

modeled by Sod1^G85R

(Held et al., 2019)

model of obesity

is ameliorated by trbl^RNAi.UAS.cUa

(Hong et al., 2016)

model of diabetes mellitus

is ameliorated by trbl^RNAi.UAS.cUa

(Hong et al., 2016)

trbl

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

trbl^KK108667

model of glucose metabolism disease

CEA

(Popovic et al., 2023)

trbl^{R141Q.UAS.Tag:FLAG}

model of glucose metabolism disease

CEA

(Popovic et al., 2023, Fischer et al., 2017)

trbl^UAS.Tag:HA

model of glucose metabolism disease

CEA

(Popovic et al., 2023)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

trbl^UAS.cMa

ameliorates cancer

modeled by BacA\p35^UAS.cHa, Bub3^GD9924

(Muzzopappa et al., 2017)

modeled by Ras85D^V12.UAS, dlg1^GD4689

(Muzzopappa et al., 2017)

trbl^RNAi.UAS.cUa

ameliorates obesity

modeled by gbb^UAS.cKa

(Hong et al., 2016)

ameliorates diabetes mellitus

modeled by gbb^UAS.cKa

(Hong et al., 2016)

SF2

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 8 )

Allele

Disease

Interaction

References

SF2^GD12097

ameliorates amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^36.UAS

(Hautbergue et al., 2017)

DOES NOT ameliorate amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^PO-36.UAS

(Hautbergue et al., 2017)

modeled by Zzzz\poly-PR^PO-36.UAS

(Hautbergue et al., 2017)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^36.UAS

(Castelli et al., 2021, Ortega et al., 2020)

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.TDPBR

(Pons et al., 2017)

ameliorates cancer

modeled by Pten^KK109278

(Parniewska and Stocker, 2020)

SF2^HM05199

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Malik et al., 2021, Linsalata et al., 2019)

ameliorates cancer

modeled by Pten^KK109278

(Parniewska and Stocker, 2020)

SF2^HMS00358

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Malik et al., 2021, Linsalata et al., 2019)

ameliorates amyotrophic lateral sclerosis type 10

modeled by TBPH^N493D.UAS

(Kankel et al., 2020)

modeled by Hsap\TARDBP^{M.UAS.Tag:FLAG}

(Azpurua et al., 2021)

ameliorates cancer

modeled by Pten^KK109278

(Parniewska and Stocker, 2020)

SF2^UAS.GFP

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.TDPBR

(Pons et al., 2017)

SF2^gRNA.pCFD3-1

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M.UAS.Tag:FLAG}

(Azpurua et al., 2021)

SF2^gRNA.pCFD3-2

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M.UAS.Tag:FLAG}

(Azpurua et al., 2021)

SF2^RNAi.UAS.cUa

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cUa

(Krupp et al., 2023)

SF2^UAS.Tag:HA

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Malik et al., 2021)

Rbp1

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Rbp1^GD9289

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.TDPBR

(Pons et al., 2017)

Models Based on Experimental Evidence ( 8 )

Allele

Disease

Evidence

References

rl¹

model of chromosome 16p11.2 deletion syndrome, 593-kb

CEA

(Park et al., 2017)

rl^RNAi.UAS.cUa

model of chromosome 16p11.2 deletion syndrome, 593-kb

CEA

(Park et al., 2017)

rl^KK115768

model of chromosome 16p11.2 deletion syndrome, 593-kb

CEA

(Yusuff et al., 2020, Iyer et al., 2018)

rl^{E335K.UAS.cTa}

DOES NOT model cancer

CEA

(Taylor et al., 2019)

rl^{D334N.UAS.cTa}

model of cancer

CEA

(Taylor et al., 2019)

rl^R80S.UAS

model of cancer

CEA with scrib¹

(Kushnir et al., 2020)

rl^{D334N.UAS.cKa}

model of cancer

CEA with scrib¹

(Kushnir et al., 2020)

rl^{R80S.D334N.UAS}

model of cancer

CEA with scrib¹

(Kushnir et al., 2020)

Modifiers Based on Experimental Evidence ( 12 )

Allele

Disease

Interaction

References

rl^JF01080

ameliorates mitochondrial DNA depletion syndrome 15

modeled by TFAM^UAS.cCa

(Duncan et al., 2018)

rl¹

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Park et al., 2013)

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2006)

ameliorates Billuart-type X-linked syndromic intellectual developmental disorder

modeled by Graf¹

(Kim et al., 2021)

ameliorates Noonan syndrome

modeled by csw⁵

(Leahy et al., 2024)

rl¹⁰

ameliorates Billuart-type X-linked syndromic intellectual developmental disorder

modeled by Graf¹

(Kim et al., 2021)

rl^Sem

exacerbates carcinoma

modeled by Ras85D^V12.UAS

(Karim and Rubin, 1998)

rl^Sem.C.UAS

DOES NOT ameliorate neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Liévens et al., 2008)

rl^Sem.S.UAS

exacerbates hematologic cancer

modeled by mxc¹

(Kurihara et al., 2020)

rl^GD4697

ameliorates carcinoma

modeled by Ras85D^V12.UAS

(Murcia et al., 2019)

modeled by Ras85D^V12.UAS, scrib^KK101128

(Murcia et al., 2019)

rl^HMS00173

ameliorates prostate cancer

modeled by Ras85D^V12.UAS

(Rambur et al., 2020)

ameliorates mitochondrial DNA depletion syndrome 15

modeled by TFAM^UAS.cCa

(Duncan et al., 2018)

ameliorates hematologic cancer

modeled by mxc¹

(Kurihara et al., 2020)

rl^GD12910

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{695.UAS.Tag:MYC}

(Huichalaf et al., 2019)

rl^RNAi.UAS.cUa

ameliorates cardiomyopathy

modeled by Hsap\RAF1^gof.UAS

(Yu et al., 2013)

rl^KK115768

model of chromosome 16p11.2 deletion syndrome, 593-kb

is ameliorated by COX6AL^KK101601

(Iyer et al., 2018)

is ameliorated by arm^KK102545

(Iyer et al., 2018)

exacerbates brain cancer

modeled by Ras85D^V12.cUa.UAS, scrib⁶⁷³

(Manzanero-Ortiz et al., 2021)

rl^UAS.Tag:FLAG

ameliorates neurodegenerative disease

modeled by Zzzz\CAG^{63Q.GMR.Tag:HA}

(Xie et al., 2021)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Xie et al., 2021)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Hsap\SLC2A4^UAS.GFP

P{UAS-hSLC2A4.GFP}

Hsap\SLC2A4^{UAS.Tag:HA,GFP}

P{UAS-hSLC2A4.HA.GFP}

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

gbb^UAS.cKa

P{UAS-gbb.K}

trbl^{R141Q.UAS.Tag:FLAG}

P{UAS-FLAG-trbl.R141Q}

foxo^{G.UAS.Tag:FLAG}

P{UAS-foxo.G.FLAG}

foxo^UAS.cPa

P{UAS-foxo.P}

y¹ w^*; P{UAS-foxo.P}2

y¹ w^*; P{UAS-foxo.F}3

foxo^UASp.GFP

P{UASp-foxo.GFP}

w¹¹¹⁸; P{UASp-foxo.GFP}3

Akt^{T342D.UAS.Tag:HA}

P{UAS-Akt.T342D.HA}

Akt^{ΔPH.UAS.Tag:Myr(Unk)}

P{UAS-myr-Akt.DeltaPH}

w^*; P{UAS-myr-Akt.ΔPH}3/TM3, Sb¹

Akt^UAS.Tag:HA

P{UAS-Akt.HA}

Akt^{T342D.S505D.GMR}

P{GMR-Akt.T342D.S505D}

P{GMR-Akt.T342D.S505D}1, y¹ w¹¹¹⁸

Akt^UAS.Exel

P{UAS-Akt.Exel}

y¹ w¹¹¹⁸; P{UAS-Akt.Exel}2

Akt^{UAS.Tag:Myr(Unk)}

EcR^{B2-ΔC655.F645A.UAS}

P{UAS-EcR.B2.F645A}

w^*; P{UAS-EcR.B2.F645A}TP1

y¹ w^*; P{UAS-rl^Sem.S}2

SF2^gRNA.pCFD3-1

P{U6:3-SF2.gRNA.pCFD3-1}

SF2^gRNA.pCFD3-2

P{U6:3-SF2.gRNA.pCFD3-2}

y¹ w¹¹¹⁸; P{UAS-InR.del}2

InR^UAS.Exel

P{UAS-InR.Exel}

y¹ w¹¹¹⁸; P{UAS-InR.Exel}2

InR^K414P.UAS

P{UAS-InR.K414P}

y¹ w¹¹¹⁸; P{UAS-InR.K414P}2

InR^K1409A.UAS

P{UAS-InR.K1409A}

P{UAS-InR.K1409A}1, y¹ w¹¹¹⁸

InR^A1325D.UAS

P{UAS-InR.A1325D}

y¹ w¹¹¹⁸; P{UAS-InR.A1325D}2

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

fs(1)h^GD4452

P{GD4452}

w¹¹¹⁸; P{GD4452}v51227

y¹ sc^* v¹ sev²¹; P{TRiP.GL00006}attP2

y¹ v¹; P{TRiP.HMS02257}attP40/CyO

fs(1)h^HMS02340

P{TRiP.HMS02340}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02340}attP40

fs(1)h^HMS02723

P{TRiP.HMS02723}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02723}attP40/CyO

w¹¹¹⁸; P{GD4545}v13322

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03265}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01243}attP2

w¹¹¹⁸ P{GD3838}v11352

Akh^JF02357

P{TRiP.JF02357}

y¹ v¹; P{TRiP.JF02357}attP2/TM3, Sb¹

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00477}attP2

w¹¹¹⁸; P{GD11640}v22113

y¹ sc^* v¹ sev²¹; P{TRiP.GL01337}attP2

y¹ v¹; P{TRiP.HMJ02089}attP40

trbl^HMC04159

P{TRiP.HMC04159}

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04159}attP2

y¹ v¹; P{TRiP.HMS04999}attP40

svp^GD1546

P{GD1546}

w¹¹¹⁸; P{GD1546}v37087

y¹ v¹; P{TRiP.JF03105}attP2

svp^RNAi.UAS

P{UAS-svp.RNAi}

w^*; P{UAS-svp.RNAi}attP16

foxo^RNAi.UAS

P{UAS-foxo.RNAi}

y¹ w^*; P{UAS-foxo.RNAi}3

y¹ v¹; P{TRiP.JF02019}attP2

y¹ v¹; P{TRiP.JF02734}attP2

foxo^HMS00422

P{TRiP.HMS00422}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00422}attP2

foxo^HMS00793

P{TRiP.HMS00793}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00793}attP2

foxo^GD4348

P{GD4348}

w¹¹¹⁸; P{GD4348}v30557

Akt^HMS06047

P{TRiP.HMS06047}

y¹ v¹; P{TRiP.HMS06047}attP40/CyO

Akt^{lexAop.HMS00007}

P{lexAop-HMS00007}

Akt^{RNAi.13xlexAop.cZa}

P{13xlexAop-Akt.RNAi.Z}

w¹¹¹⁸; P{GD1361}v2902

y¹ v¹; P{TRiP.HM04007}attP2

Akt^HMS00007

P{TRiP.HMS00007}

y¹ v¹; P{TRiP.HMS00007}attP2

y¹ v¹; P{TRiP.HMJ21422}attP40/CyO

y¹ v¹; P{TRiP.HMJ24031}attP40/CyO

w¹¹¹⁸; P{hs-EcR.RNAi.L}11

EcR^{RNAi.B1.UAS.cSa}

P{UAS-EcR.RNAi.S}

EcR^RNAi.A.UAS

P{UAS-EcR.A.RNAi}

w¹¹¹⁸; P{UAS-EcR.A.RNAi}91/TM3, P{ActGFP}JMR2, Ser¹

EcR^RNAi.B1.UAS

P{UAS-EcR.B1.RNAi}

w¹¹¹⁸; P{UAS-EcR.B1.RNAi}168

EcR^GD1428

P{GD1428}

w¹¹¹⁸; P{GD1428}v37058

EcR^JF02538

P{TRiP.JF02538}

y¹ v¹; P{TRiP.JF02538}attP2

w¹¹¹⁸; P{UAS-EcR.RNAi.C}97

y¹ v¹; P{TRiP.HMC03114}attP2/TM3, Sb¹

EcR^HMJ22371

P{TRiP.HMJ22371}

y¹ v¹; P{TRiP.HMJ22371}attP40/CyO

w^*; P{UAS-tra2.RNAi}61X; P{UAS-tra2.RNAi}82A-3

y¹ v¹; P{TRiP.JF02852}attP2

tra2^HMS04334

P{TRiP.HMS04334}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS04334}attP40

w¹¹¹⁸; P{GD4697}v43123

rl^JF01080

P{TRiP.JF01080}

y¹ v¹; P{TRiP.JF01080}attP2

rl^JF01366

P{TRiP.JF01366}

y¹ v¹; P{TRiP.JF01366}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.GL00215}attP2

rl^HMS00173

P{TRiP.HMS00173}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00173}attP2

rl^GD12910

P{GD12910}

w¹¹¹⁸; P{GD12910}v35641

w¹¹¹⁸; P{GD9289}v21083/TM3

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03902}attP40

w¹¹¹⁸; P{GD12097}v27775/TM3

SF2^HM05199

P{TRiP.HM05199}

y¹ v¹; P{TRiP.HM05199}attP2

SF2^HMS00358

P{TRiP.HMS00358}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00358}attP2

SF2^NIG.6987R

P{NIG.6987R}

P{NIG.6987R}2

InR^{lexAop.HMS03166}

w¹¹¹⁸; P{GD104}v991/TM3

y¹ v¹; P{TRiP.JF01183}attP2

InR^JF01482

P{TRiP.JF01482}

y¹ v¹; P{TRiP.JF01482}attP2

InR^GL00139

P{TRiP.GL00139}

y¹ sc^* v¹ sev²¹; P{TRiP.GL00139}attP2

y¹ v¹; P{TRiP.HMS03166}attP40/CyO

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

fs(1)h^rnc

ethyl methanesulfonate

C(1;YL)1, y¹ fs(1)h^rnc/FM7c

fs(1)h¹¹¹²

amorphic allele - molecular evidence

ethyl methanesulfonate

gbb²

amorphic allele - genetic evidence

gbb¹

loss of function allele

bw¹ gbb¹/SM6a

Akh^AP

amorphic allele - molecular evidence

CRISPR/Cas9

Akh^SAP

amorphic allele - molecular evidence

CRISPR/Cas9

trbl^EP1119

loss of function allele

P-element activity

w¹¹¹⁸; P{EP}trbl^EP1119/TM6B, Tb¹

trbl^GFP

loss of function allele

CRISPR/Cas9

trbl^3-54

loss of function allele

svp¹

amorphic allele - genetic evidence

ethyl methanesulfonate

svp¹/TM3, Sb¹ Ser¹

svp^sd-22

amorphic allele - genetic evidence

ethyl methanesulfonate

svp^sd-27

amorphic allele - genetic evidence

ethyl methanesulfonate

foxo^c431

loss of function allele

CRISPR/Cas9

foxo²¹

loss of function allele

P-element activity

y¹ w^*; foxo²¹/TM6B, Tb¹

foxo²⁵

loss of function allele

P-element activity

y¹ w^*; foxo²⁵/TM6B, Tb¹

foxo^Δ94

P-element activity

w¹¹¹⁸; foxo^Δ94/TM6B, Tb¹

Akt^EY10012

P-element activity

y¹ w^67c23; P{EPgy2}Akt^EY10012/TM3, Sb¹ Ser¹

Akt¹

loss of function allele

Akt³

Akt⁰⁴²²⁶

P-element activity

ry⁵⁰⁶ P{PZ}Akt⁰⁴²²⁶/TM3, ry^RK Sb¹ Ser¹

EcR^KG04522

P-element activity

EcR^{MI05320-FlpStop.D}

loss of function allele

phiC31 integrase

EcR^M554fs

amorphic allele - genetic evidence

EcR^M554fs/SM6b

EcR^V559fs

loss of function allele

ethyl methanesulfonate

y¹ w¹; EcR^V559fs/CyO, y⁺

EcR^C300Y

loss of function allele

EcR¹¹²

amorphic allele - genetic evidence

Delta2-3 transposase

y¹ w^*; P{lacW}EcR¹¹²/CyO, y⁺

EcR³¹

amorphic allele - genetic evidence

Delta2-3 transposase

y¹ w¹; EcR³¹/CyO, y⁺

EcR⁹⁹

amorphic allele - genetic evidence

Delta2-3 transposase

EcR^10-2

loss of function allele

EcR^Q50st

amorphic allele - genetic evidence

ethyl methanesulfonate

EcR^Q50st/SM6b

tra2^Gal4

loss of function allele

phiC31 integrase

tra2¹

loss of function allele

spontaneous

y¹/Dp(1;Y)y⁺; tra2¹/SM1

tra2^A36

amorphic allele - genetic evidence

tra2^B

loss of function allele

ethyl methanesulfonate

Dp(1;Y)Bar^S; cn¹ tra2^B bw¹/CyO

tra2^PM6

amorphic allele - molecular evidence

tra2^A15

amorphic allele - genetic evidence

rl^2M1

amorphic allele - genetic evidence

ethyl methanesulfonate

rl^ES7

loss of function allele

rl⁹

amorphic allele - genetic evidence

ethyl methanesulfonate

rl^la8

amorphic allele - genetic evidence

ethyl methanesulfonate

rl^Sem

ethyl methanesulfonate

rl^Sem/CyO/Dp(?;2)bw^D, S¹ wg^Sp-1 Ms(2)M¹ bw^D

rl^x-3-30

loss of function allele

rl¹

loss of function allele

spontaneous

rl¹

rl^4H6

amorphic allele - genetic evidence

ethyl methanesulfonate

rl^2L1

amorphic allele - genetic evidence

ethyl methanesulfonate

rl^R29

amorphic allele - genetic evidence

X ray

rl¹⁰

ethyl methanesulfonate

rl^R26

amorphic allele - genetic evidence

X ray

rl^E-80

loss of function allele

ethyl methanesulfonate

InR⁰⁵⁵⁴⁵

P-element activity

ry⁵⁰⁶ P{PZ}InR⁰⁵⁵⁴⁵/TM3, ry^RK Sb¹ Ser¹

InR^null(HR)

loss of function allele

ends-out gene targeting

InR^Y902C

spontaneous

InR^93Dj-4

gamma ray

In(3R)GC25, InR^93Dj-4/TM3, Sb¹

InR^E19

ethyl methanesulfonate

InR^E19/TM2

InR³³⁹

w^*; P{neoFRT}82B InR³³⁹/TM3, Sb¹ Ser¹

InR^3T5

References (21)

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