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Citation
Sustar, A., Schubiger, G. (2005). A transient cell cycle shift in Drosophila imaginal disc cells precedes multipotency.  Cell 120(3): 383--393.
FlyBase ID
FBrf0183774
Publication Type
Research paper
Abstract

When Drosophila imaginal discs regenerate, specific groups of cells can switch disc identity so that, for example, cells determined for leg identity switch to wing. Such switches in cell determination are known as transdetermination. We have developed a system by which individual cells are marked and monitored in vivo as they transdetermine so that their proliferation, cell sizes, and differentiation are accurately traced. Here, we document that when cells transdetermine, they do not convert to a younger cell cycle. Instead, cell cycle changes precede transdetermination and are different from those observed at any time in normal development. We propose that it is not a younger but a unique cell cycle progression and a big cell size that conditions the cells for developmental plasticity.

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Related Publication(s)
Note

Regeneration and transdetermination: new tricks from old cells.
Johnston, 2005, Cell 120(3): 288--290 [FBrf0183773]

Developmental biology: Youth gone by.
Khamsi, 2005, Nature 433(7027): 702 [FBrf0188391]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference