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Citation
Wildonger, J., Sosinsky, A., Honig, B., Mann, R.S. (2005). Lozenge directly activates argos and klumpfuss to regulate programmed cell death.  Genes Dev. 19(9): 1034--1039.
FlyBase ID
FBrf0187601
Publication Type
Research paper
Abstract

We show that reducing the activity of the Drosophila Runx protein Lozenge (Lz) during pupal development causes a decrease in cell death in the eye. We identified Lz-binding sites in introns of argos (aos) and klumpfuss (klu) and demonstrate that these genes are directly activated targets of Lz. Loss of either aos or klu reduces cell death, suggesting that Lz promotes apoptosis at least in part by regulating aos and klu. These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development.

PubMed ID
PubMed Central ID
PMC1091738 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (17)
    Genes (20)
    Sequence Features (3)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (2)
    Transgenic Constructs (8)