FB2026_03 , released September 17, 2026
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Lu, Y., Day, F.R., Gustafsson, S., Buchkovich, M.L., Na, J., Bataille, V., Cousminer, D.L., Dastani, Z., Drong, A.W., Esko, T., Evans, D.M., Falchi, M., Feitosa, M.F., Ferreira, T., Hedman, Å.K., Haring, R., Hysi, P.G., Iles, M.M., Justice, A.E., Kanoni, S., Lagou, V., Li, R., Li, X., Locke, A., Lu, C., Mägi, R., Perry, J.R., Pers, T.H., Qi, Q., Sanna, M., Schmidt, E.M., Scott, W.R., Shungin, D., Teumer, A., Vinkhuyzen, A.A., Walker, R.W., Westra, H.J., Zhang, M., Zhang, W., Zhao, J.H., Zhu, Z., Afzal, U., Ahluwalia, T.S., Bakker, S.J., Bellis, C., Bonnefond, A., Borodulin, K., Buchman, A.S., Cederholm, T., Choh, A.C., Choi, H.J., Curran, J.E., de Groot, L.C., De Jager, P.L., Dhonukshe-Rutten, R.A., Enneman, A.W., Eury, E., Evans, D.S., Forsen, T., Friedrich, N., Fumeron, F., Garcia, M.E., Gärtner, S., Han, B.G., Havulinna, A.S., Hayward, C., Hernandez, D., Hillege, H., Ittermann, T., Kent, J.W., Kolcic, I., Laatikainen, T., Lahti, J., Mateo Leach, I., Lee, C.G., Lee, J.Y., Liu, T., Liu, Y., Lobbens, S., Loh, M., Lyytikäinen, L.P., Medina-Gomez, C., Michaëlsson, K., Nalls, M.A., Nielson, C.M., Oozageer, L., Pascoe, L., Paternoster, L., Polašek, O., Ripatti, S., Sarzynski, M.A., Shin, C.S., Narančić, N.S., Spira, D., Srikanth, P., Steinhagen-Thiessen, E., Sung, Y.J., Swart, K.M., Taittonen, L., Tanaka, T., Tikkanen, E., van der Velde, N., van Schoor, N.M., Verweij, N., Wright, A.F., Yu, L., Zmuda, J.M., Eklund, N., Forrester, T., Grarup, N., Jackson, A.U., Kristiansson, K., Kuulasmaa, T., Kuusisto, J., Lichtner, P., Luan, J., Mahajan, A., Männistö, S., Palmer, C.D., Ried, J.S., Scott, R.A., Stancáková, A., Wagner, P.J., Demirkan, A., Döring, A., Gudnason, V., Kiel, D.P., Kühnel, B., Mangino, M., Mcknight, B., Menni, C., O'Connell, J.R., Oostra, B.A., Shuldiner, A.R., Song, K., Vandenput, L., van Duijn, C.M., Vollenweider, P., White, C.C., Boehnke, M., Boettcher, Y., Cooper, R.S., Forouhi, N.G., Gieger, C., Grallert, H., Hingorani, A., Jørgensen, T., Jousilahti, P., Kivimaki, M., Kumari, M., Laakso, M., Langenberg, C., Linneberg, A., Luke, A., Mckenzie, C.A., Palotie, A., Pedersen, O., Peters, A., Strauch, K., Tayo, B.O., Wareham, N.J., Bennett, D.A., Bertram, L., Blangero, J., Blüher, M., Bouchard, C., Campbell, H., Cho, N.H., Cummings, S.R., Czerwinski, S.A., Demuth, I., Eckardt, R., Eriksson, J.G., Ferrucci, L., Franco, O.H., Froguel, P., Gansevoort, R.T., Hansen, T., Harris, T.B., Hastie, N., Heliövaara, M., Hofman, A., Jordan, J.M., Jula, A., Kähönen, M., Kajantie, E., Knekt, P.B., Koskinen, S., Kovacs, P., Lehtimäki, T., Lind, L., Liu, Y., Orwoll, E.S., Osmond, C., Perola, M., Pérusse, L., Raitakari, O.T., Rankinen, T., Rao, D.C., Rice, T.K., Rivadeneira, F., Rudan, I., Salomaa, V., Sørensen, T.I., Stumvoll, M., Tönjes, A., Towne, B., Tranah, G.J., Tremblay, A., Uitterlinden, A.G., van der Harst, P., Vartiainen, E., Viikari, J.S., Vitart, V., Vohl, M.C., Völzke, H., Walker, M., Wallaschofski, H., Wild, S., Wilson, J.F., Yengo, L., Bishop, D.T., Borecki, I.B., Chambers, J.C., Cupples, L.A., Dehghan, A., Deloukas, P., Fatemifar, G., Fox, C., Furey, T.S., Franke, L., Han, J., Hunter, D.J., Karjalainen, J., Karpe, F., Kaplan, R.C., Kooner, J.S., McCarthy, M.I., Murabito, J.M., Morris, A.P., Bishop, J.A., North, K.E., Ohlsson, C., Ong, K.K., Prokopenko, I., Richards, J.B., Schadt, E.E., Spector, T.D., Widén, E., Willer, C.J., Yang, J., Ingelsson, E., Mohlke, K.L., Hirschhorn, J.N., Pospisilik, J.A., Zillikens, M.C., Lindgren, C., Kilpeläinen, T.O., Loos, R.J. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.  Nat. Commun. 7(): 10495.
FlyBase ID
FBrf0232660
Publication Type
Research paper
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
PubMed ID
PubMed Central ID
PMC4740398 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference