|Citation||van Roessel, P., Elliott, D.A., Robinson, I.M., Prokop, A., Brand, A.H. (2004). Independent regulation of synaptic size and activity by the anaphase-promoting complex. Cell 119(5): 707--718. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Neuronal plasticity relies on tightly regulated control of protein levels at synapses. One mechanism to control protein abundance is the ubiquitin-proteasome degradation system. Recent studies have implicated ubiquitin-mediated protein degradation in synaptic development, function, and plasticity, but little is known about the regulatory mechanisms controlling ubiquitylation in neurons. In contrast, ubiquitylation has long been studied as a central regulator of the eukaryotic cell cycle. A critical mediator of cell-cycle transitions, the anaphase-promoting complex/cyclosome (APC/C), is an E3 ubiquitin ligase. Although the APC/C has been detected in several differentiated cell types, a functional role for the complex in postmitotic cells has been elusive. We describe a novel postmitotic role for the APC/C at Drosophila neuromuscular synapses: independent regulation of synaptic growth and synaptic transmission. In neurons, the APC/C controls synaptic size via a downstream effector Liprin-alpha; in muscles, the APC/C regulates synaptic transmission, controlling the concentration of a postsynaptic glutamate receptor.|
|Review||Limits to Growth.
Anonymous, 2004, Science 306(5705): 2164 [FBrf0188457]
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|Language of Publication||English|
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