FlyBase Allele Report: Dmel\emc[1]

somatic clones of emc¹ cells in the ovarian follicle cells look morphologically normal during most of oogenesis. However, the resulting egg chamber often have dorsal appendage defects. These defects take a variety of forms, from split-ends through varying degress of fusion, to almost complete loss. Follicle cell imprints on the shells of these eggs show that at least some main body follicle cells are abnormally large and/or misshapen.

(Papadia et al., 2005)

Homozygous follicle cell clones can result in fused egg chambers containing 32 germline nuclei. These egg chambers contain 2 oocyte nuclei suggesting that they probably result from fusion of two distinct cysts. These fused egg chambers have polar cells only at the termini of the fused cysts.

(Adam and Montell, 2004)

emc¹/Df(3L)emc-E12 cells do not form normal size clones in the wing. Homozygous clones in the wing show ectopic veins in specific positions and only occasionally cause the differentiation of thicker veins.

(Baonza et al., 2000)

emc¹/emc¹¹ flies have slightly smaller wings than normal, although the wing vein pattern is normal. emc¹ clones in rho^ve-1 vn¹ wings differentiate as veins in positions possibly corresponding to those of wild-type veins. Vein differentiation in these clones frequently fails in distal regions of veins. emc¹ clones in bs² wings differentiate as vein everywhere in the wing blade covering intervein regions as vein. The ectopic wing vein phenotype of px⁷² wings is exaggerated in regions occupied by emc¹ homozygous clones. The borders of the emc¹ clones respect not only normal veins as restriction borders, but also tend not to cross ectopic veins. Clones in the wing intervein regions that are doubly mutant for Gap1^B1 and emc¹ largely differentiate as veins. Clones in the wing intervein regions that are doubly mutant for rho^Wk and emc¹ largely differentiate as veins.

(Baonza and Garcia-Bellido, 1999)

emc¹ h²² and emc¹ h⁴¹ clones display differentiated photoreceptors that arise in a more anterior position that in adjacent wild type tissue, the morphogenetic furrow has been shifted anteriorly.

(Brown et al., 1995)

Extra neuron mutant.

(Sturtevant and Bier, 1995)

emc¹/Df(3L)emc-E12 clones in the wing show defects in cell proliferation but overall wing size is not affected due to compensation by growth of surrounding non-mutant cells. Clones are very elongated and preferentially appear along the veins and wing margin. Clones can differentiate veins but exhibit an emc phenotype. Homozygous clones in the wing also exhibit proliferation defects causing a reduction in wing size. Clones can shift the position of veins and fuse veins but reducing the intervein region. Homozygous and hemizygous clones in the notum, leg and haltere cause similar defects, shortening of segments and deletion of structures.

(de Celis et al., 1995)

Variations in chaetae number and size: ectopic macrochaetae and mesochaetae appear as a second and third posterior row, microchaetae smaller than wild type differentiate posteriorly to the macrochaetae.

(Mari-Beffa et al., 1991)

Extra chaetae form in characteristic patterns.

(de Celis et al., 1991)

very strong, although not amorphic phenotype.

(Garrell and Modolell, 1990)

The density of chaetae in emc¹/emc² flies with different doses of sc⁺ show a saturation effect on the notum, wing and tergite. The spatial distribution of the chaetae results from cell interactions probably by a mechanism of lateral inhibition.

(del Prado and Garcia-Bellido, 1984)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

emc¹ has visible | somatic clone phenotype, enhanceable by Delta^M1/Dl[+]

(Baonza et al., 2000)

emc¹ has visible | somatic clone phenotype, enhanceable by N[+]/N^55e11

(Baonza et al., 2000)

emc¹ has visible | somatic clone phenotype, enhanceable by N^l1N-ts1/N[+]

(Baonza et al., 2000)

NOT Enhanced by

Statement

Reference

emc¹ has visible | somatic clone phenotype, non-enhanceable by N[+]/N^Ax-M3

(Baonza et al., 2000)

NOT suppressed by

Statement

Reference

emc¹ has visible | somatic clone phenotype, non-suppressible by N[+]/N^Ax-M3

(Baonza et al., 2000)

Enhancer of

Statement

Reference

emc¹/emc¹¹ is an enhancer of visible | dominant phenotype of amos^Tft

(Villa-Cuesta et al., 2003)

emc¹/emc¹¹ is an enhancer of visible | recessive phenotype of Egfr^E3

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of visible | recessive phenotype of bs²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc[+] is an enhancer of visible | recessive phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of visible | recessive phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc[+] is an enhancer of visible | recessive phenotype of net¹

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of visible phenotype of rho^Stg/rho^Wk

(Baonza and Garcia-Bellido, 1999)

Suppressor of

Statement

Reference

emc¹/emc¹¹ is a suppressor of visible phenotype of Egfr^f37/Egfr^t1

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is a suppressor of visible phenotype of vn^ddd-3/vn¹

(Baonza and Garcia-Bellido, 1999)

Other

Statement

Reference

bs⁰³²⁶⁷, emc¹/emc¹¹ has visible phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹, net¹ has visible phenotype

(Baonza and Garcia-Bellido, 1999)

bs⁰³²⁶⁷, emc¹/emc¹¹ has visible | dominant phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹, net¹ has visible | dominant phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹, rho^hs.PSt has visible phenotype

(Milan et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

emc¹ has wing vein | somatic clone phenotype, enhanceable by Delta^M1/Dl[+]

(Baonza et al., 2000)

emc¹ has wing vein | somatic clone phenotype, enhanceable by N[+]/N^55e11

(Baonza et al., 2000)

emc¹ has wing vein | somatic clone phenotype, enhanceable by N^l1N-ts1/N[+]

(Baonza et al., 2000)

emc¹ has phenotype, enhanceable by bs⁰³²⁶⁷

(Roch et al., 1998)

NOT Enhanced by

Statement

Reference

emc¹ has wing vein | somatic clone phenotype, non-enhanceable by N[+]/N^Ax-M3

(Baonza et al., 2000)

NOT suppressed by

Statement

Reference

emc¹ has macrochaeta | ectopic | somatic clone phenotype, non-suppressible by N^Mcd1

(Ramain et al., 2001)

emc¹/Df(3L)emc-E12 has phenotype, non-suppressible | somatic clone by N^Ax-M3/N^Ax-M3

(Baonza et al., 2000)

emc¹/Df(3L)emc-E12 has wing | somatic clone phenotype, non-suppressible by N^Ax-M3/N^Ax-M3

(Baonza et al., 2000)

emc¹ has wing vein | somatic clone phenotype, non-suppressible by N[+]/N^Ax-M3

(Baonza et al., 2000)

Enhancer of

Statement

Reference

emc¹/emc¹¹ is an enhancer of macrochaeta | ectopic phenotype of amos^Tft

(Villa-Cuesta et al., 2003)

emc¹/emc¹¹ is an enhancer of wing vein phenotype of Egfr^E3

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of wing vein | ectopic phenotype of bs²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc[+] is an enhancer of wing vein | ectopic phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of wing vein | ectopic phenotype of px⁷²

(Baonza and Garcia-Bellido, 1999)

emc¹/emc[+] is an enhancer of wing vein | ectopic phenotype of net¹

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is an enhancer of wing vein | ectopic phenotype of rho^Stg/rho^Wk

(Baonza and Garcia-Bellido, 1999)

Suppressor of

Statement

Reference

emc¹/emc¹¹ is a suppressor of wing vein L4 phenotype of Egfr^f37/Egfr^t1

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is a suppressor of wing vein L4 phenotype of vn^ddd-3/vn¹

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹ is a suppressor | partially of phenotype of sc^260-14

(Mari-Beffa et al., 1991)

emc¹/emc¹¹ is a suppressor of phenotype of ac³

(Mari-Beffa et al., 1991)

emc¹/emc¹¹ is a suppressor | partially of phenotype of sc⁴

(Mari-Beffa et al., 1991)

Other

Statement

Reference

emc¹/Df(3L)emc-E12, N^55e11 has wing phenotype

(Baonza et al., 2000)

emc¹/Df(3L)emc-E12, N^55e11 has wing | somatic clone phenotype

(Baonza et al., 2000)

emc¹/emc¹¹, px⁷² has wing vein phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹/emc¹¹, net¹ has wing vein | ectopic phenotype

(Baonza and Garcia-Bellido, 1999)

bs⁰³²⁶⁷, emc¹/emc¹¹ has wing vein | ectopic phenotype

(Baonza and Garcia-Bellido, 1999)

emc¹, rho^hs.PSt has wing vein | ectopic phenotype

(Milan et al., 1997)

emc¹, rho^hs.PSt has wing vein phenotype

(Milan et al., 1997)

emc¹, hry²² has eye disc morphogenetic furrow phenotype

(Zelhof et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The average number of ectopic macrochaetae per heminotum in amos^Tft/+ flies is increased to 35 +/- 6 if they are also carrying emc¹/emc¹¹.

(Villa-Cuesta et al., 2003)

Ectopic macrochaetae are seen in N^Mcd1 emc¹ double mutant clones (as is seen in emc¹ single mutant clones).

(Ramain et al., 2001)

Clones of N^55e11/N^55e11; emc¹/Df(3L)emc-E12 cells in the wing have extremely poor viability. The failure of emc¹/Df(3L)emc-E12 cells to form normal size clones in the wing is not rescued if the flies are also homozygous for N^Ax-M3. The width of wing veins formed by clones of homozygous emc¹ cells is increased if the flies are also heterozygous for N^55e11 or Dl^M1 but is unaffected if the flies are heterozygous for N^Ax-M3. Homozygous emc¹ clones induced in a N^l1N-ts1/+ background result in thickening of the wing veins when pupal development takes place at 29^oC (the restrictive temperature for the N^l1N-ts1 allele).

(Baonza et al., 2000)

emc¹/emc¹¹ suppresses the loss of wing vein L4 seen in vn¹/vn^ddd-3 or Egfr^t1/Egfr^f37 flies. The interactions between emc¹/emc¹¹ and rho^ve-1/rho^ve-1 or rho^ve-1/rho⁹ are additive. The ectopic wing vein phenotype of Egfr^E3/+ flies is slightly enhanced by emc¹/emc¹¹. The ectopic wing vein phenotype of rho^Stg/rho^Wk flies is slightly enhanced by emc¹/emc¹¹. The extra wing vein phenotype of px⁷² homozygotes is enhanced by emc¹/+ or emc¹/emc¹¹. The extra wing vein phenotype of net¹ homozygotes is enhanced by emc¹/+. net¹/+ ; emc¹/emc¹¹ flies show an extra wing vein phenotype. The extra wing vein phenotype of bs² homozygotes is enhanced by emc¹/emc¹¹. bs⁰³²⁶⁷/+ ; emc¹/emc¹¹ flies show an extra wing vein phenotype.

(Baonza and Garcia-Bellido, 1999)

Homozygous emc¹ clones carrying rho^hs.PSt differentiate extra veins and thicker veins. Clones located in both surfaces of the wing have a stronger phenotype than those located in only one surface.

(Milan et al., 1997)

emc¹ h²² double homozygous clones in the eye imaginal disc that intersect the morphogenetic furrow from the posterior, have an anteriorly shifted morphogenetic furrow.

(Zelhof et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

emc^G4.1

(Saito et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5532

w^*; emc¹ P{neoFRT}80B/TM6B, Tb¹

Kyoto

108282

w^*; emc¹ P{neoFRT}80B/TM6B, Tb¹

Notes on Origin

Discoverer

Ripoll.

Comments

Phenotypes of emc alleles can be ordered, going from weakest to strongest: emc¹ < emc¹/Df(3L)emc-E12 < emc⁹ = emc^ip15 = emc⁹/emc^ip15 < emc⁹/Df(3L)emc-E12 = emc^ip15/Df(3L)emc-E12 < Df(3L)emc-E12/Df(3L)emc-E12.

(Cubas et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

emc¹

(Akiba et al., 2024, Li and Baker, 2019, Tanaka-Matakatsu et al., 2014, Foronda et al., 2012, Popova et al., 2011, Salzer et al., 2010, Christensen et al., 2008.4.15, Christensen et al., 2008.10.20, Papadia et al., 2005, Saito et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (34)

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