FlyBase Allele Report: Dmel\lwr[05486]

(Pardi et al., 2011, Sánchez et al., 2010, Watts et al., 2003, Apionishev et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone

(Watts et al., 2003)

decreased occurrence of cell division | somatic clone

(Watts et al., 2003)

lethal | recessive

(Bhaskar et al., 2002, Apionishev et al., 2001, Spradling et al., 1999, Apionishev and Rasooly, 1997)

Phenotype Manifest In

adult head (with lwr^unspecified)

(Epps and Tanda, 1998)

embryonic epidermis

(Epps and Tanda, 1998)

eye (with lwr^unspecified)

(Epps and Tanda, 1998)

leg (with lwr^unspecified)

(Epps and Tanda, 1998)

neuroblast | somatic clone

(Watts et al., 2003)

wing (with lwr^unspecified)

(Epps and Tanda, 1998)

Detailed Description

Statement

Reference

No defects are seen in axon pruning during metamorphosis, though a severe proliferation defect is seen when somatic clones are made in the neuroblast.

(Watts et al., 2003)

Embryos transheterozygous for lwr⁰⁵⁴⁸⁶ and lwr⁰²⁸⁵⁸ show cuticle patterns resembling those of lwr¹¹⁸ homozygotes and of lwr⁰⁵⁴⁸⁶/lwr¹¹⁸ transheterozygotes: a phenotype intermediate between the bcd and the hb mutant phenotypes. bcd protein is retained in the cytoplasm of lwr⁰⁵⁴⁸⁶/lwr⁰²⁸⁵⁸ transheterozygotes and lwr⁰⁵⁴⁸⁶ homozygotes.

(Epps and Tanda, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

lwr⁰⁵⁴⁸⁶/lwr[+] is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Suppressor of

Statement

Reference

lwr⁰⁵⁴⁸⁶ is a suppressor of abnormal meiotic cell cycle | female phenotype of Axs^D

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of abnormal meiotic cell cycle | female phenotype of mei-218⁶

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of abnormal meiotic cell cycle | dominant | female phenotype of nod^DTW

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of abnormal meiotic cell cycle | female phenotype of ncd^D/ncd¹

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of abnormal meiotic cell cycle | female phenotype of nod²/nod^a

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶ is a suppressor of abnormal meiotic cell cycle | female phenotype of mei-218¹, nod^DTW

(Apionishev et al., 2001)

Other

Statement

Reference

Df(2L)32FP-5/+, lwr⁰⁵⁴⁸⁶ has visible | dominant phenotype

(Sánchez et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

lwr⁰⁵⁴⁸⁶/lwr[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

lwr⁰⁵⁴⁸⁶/Sumo⁰⁴⁴⁹³ is an enhancer of wing margin phenotype of ct⁶, mod(mdg4)^ul

(Capelson and Corces, 2006)

NOT Enhancer of

Statement

Reference

lwr⁰⁵⁴⁸⁶/lwr[+] is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, p53^UAS.Ex

(Pardi et al., 2011)

lwr⁰⁵⁴⁸⁶, Sumo^k06307, smt3[+], lwr[+] is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, p53^UAS.Ex

(Pardi et al., 2011)

lwr⁰⁵⁴⁸⁶ is a non-enhancer of wing vein | ectopic phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

Suppressor of

Statement

Reference

lwr⁰⁵⁴⁸⁶/Sumo⁰⁴⁴⁹³ is a suppressor of adult cuticle phenotype of ct⁶, mod(mdg4)^ul

(Capelson and Corces, 2006)

lwr⁰⁵⁴⁸⁶/Sumo⁰⁴⁴⁹³ is a suppressor of adult cuticle phenotype of mod(mdg4)^ul, y²

(Capelson and Corces, 2006)

lwr⁰⁵⁴⁸⁶/Sumo⁰⁴⁴⁹³ is a suppressor of wing margin phenotype of ct⁶, mod(mdg4)^ul

(Capelson and Corces, 2006)

lwr⁰⁵⁴⁸⁶ is a suppressor of meiosis & nuclear chromosome | female phenotype of Axs^D

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of meiosis & nuclear chromosome | female phenotype of mei-218⁶

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of meiosis & nuclear chromosome | female phenotype of nod^DTW

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of meiosis & nuclear chromosome | female phenotype of ncd^D/ncd¹

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶/lwr[+] is a suppressor of meiosis & nuclear chromosome | female phenotype of nod²/nod^a

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶ is a suppressor of meiosis & nuclear chromosome | female phenotype of mei-218¹, nod^DTW

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶ is a suppressor of oocyte & spindle phenotype of mei-218¹, nod^DTW

(Apionishev et al., 2001)

lwr⁰⁵⁴⁸⁶ is a suppressor of phenotype of nod^DTW

(Apionishev and Rasooly, 1997)

NOT Suppressor of

Statement

Reference

lwr⁰⁵⁴⁸⁶/lwr[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, p53^UAS.Ex

(Pardi et al., 2011)

lwr⁰⁵⁴⁸⁶, Sumo^k06307, smt3[+], lwr[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, p53^UAS.Ex

(Pardi et al., 2011)

lwr⁰⁵⁴⁸⁶ is a non-suppressor of wing vein | ectopic phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

Other

Statement

Reference

Df(2L)32FP-5/+, lwr⁰⁵⁴⁸⁶ has wing phenotype

(Sánchez et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A loss of heterozygosity assay, using mwh¹ as a marker, reveals that a lwr⁰⁵⁴⁸⁶ heterozygous background increases the number of mwh¹ clones after irradiation with 250 rad of X-rays, in p53^5A-1-4 mutants.

The rough eye phenotype found at 29[o]C in flies expressing p53^Scer\UAS.Ex under the control of Scer\GAL4^GMR.PF is not affected by a lwr⁰⁵⁴⁸⁶ heterozygous background nor in a lwr⁰⁵⁴⁸⁶-smt3^k06307 transheterozygous background.

(Pardi et al., 2011)

lwr⁰⁵⁴⁸⁶/Df(2L)32FP-5 double heterozygotes show a reduction in wing size (by 10%) compared to wild type.

(Sánchez et al., 2010)

The transheterozygote lwr⁰⁵⁴⁸⁶/smt3⁰⁴⁴⁹³ suppresses the mod(mdg4)^ul suppression of the ct⁶ jagged wing phenotype, leading to a more jagged and discontinuous wing phenotype. The phenotype is also particularly pronounced in females, although it is detectable in both sexes.

The transheterozygote lwr⁰⁵⁴⁸⁶/smt3⁰⁴⁴⁹³ suppresses the mod(mdg4)^ul suppression of the y² cuticle phenotype, leading to a lighter coloration of the abdomen (due to a reduction in y expression).These phenotypic changes occur in approximately 30% of the mutant flies, with the remaining 70% displaying a continuum of less-pronounced effect. The phenotype is also particularly pronounced in females, although it is detectable in both sexes.

(Capelson and Corces, 2006)

lwr⁰⁵⁴⁸⁶ dominantly suppresses the nondisjunction phenotype of nod^DTW/+ females. nod^a/FM7a nod² female nondisjunction is dominantly suppressed by lwr⁰⁵⁴⁸⁶. 4th, but not X chromosome disjunction is suppressed in mei-218⁶ females if they also carry lwr⁰⁵⁴⁸⁶/+. 4th, but not X chromosome disjunction is suppressed in Axs^D females if they also carry lwr⁰⁵⁴⁸⁶. ncd¹/ncd^D female X and 4th chromosome nondisjunction is dominantly suppressed by lwr⁰⁵⁴⁸⁶. nod^DTW mei-218¹ double homozygous females show 60% X chromosome nondisjunction and 63% 4th chromosome nondisjunction. Oocyte spindles are often frayed or oddly shaped, or multiple spindles are present. These defects are suppressed by lwr⁰⁵⁴⁸⁶/+.

(Apionishev et al., 2001)

A lwr⁰⁵⁴⁸⁶ mutant background does not affect the extent of ectopic wing veins or eye roughening seen in Scer\GAL4^GMR.PF Cbl^Dv.Scer\UAS mutants.

(Robertson et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

lwr^semi710

(Apionishev et al., 2001)

lwr⁰²⁸⁵⁸

(Apionishev et al., 2001)

lwr⁰²⁸⁵⁸

(BDGP Project Members, 1994-1999)

Partially complements

lwr^unspecified

(Epps and Tanda, 1998)

lwr⁰²⁸⁵⁸

(Epps and Tanda, 1998)

lwr⁰²⁸⁵⁸

(Epps and Tanda, 1998)

Fails to complement

lwr⁵

(Apionishev et al., 2001)

lwr^01519a

(BDGP Project Members, 1994-1999)

Rescued by

lwr⁰⁵⁴⁸⁶ is rescued by lwr^+t2.4

(Casso et al., 2005)

Comments

Percent hatchability of embryos produced from a cross between lwr⁰⁵⁴⁸⁶ and lwr⁰²⁸⁵⁸ is 75%, whereas hatchability from a cross between ush² and lwr⁰²⁸⁵⁸ is 90%.

(Epps and Tanda, 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11410

P{PZ}lwr⁰⁵⁴⁸⁶ cn¹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Excision of the P{PZ} element can revert the mutant phenotype.

(Apionishev et al., 2001)

Complements: ex⁰¹²⁷⁰. Complements: ds⁰⁵¹⁴². Complements: Gsc⁰⁵³⁴¹. Complements: α-Adaptin⁰⁶⁶⁹⁴. Complements: S^k06101. Complements: l(2)k08915^k08915. Complements: l(2)k09610^k09610. Complements: Nle^k13714.

(BDGP Project Members, 1994-1999)

Most excisions of the P{PZ} element are homozygous viable and no longer suppress nod^DTW. Lethal excision alleles remain suppressors.

(Apionishev and Rasooly, 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

l(2)05486

(Bhaskar et al., 2002, Apionishev et al., 2001, Spradling et al., 1999, Epps and Tanda, 1998, Epps and Tanda, 1998)

l(2)05486⁰⁵⁴⁸⁶

lesswright^r05486

(Simonsen et al., 2007)

lwr⁰⁵⁴⁸⁶

(Gao et al., 2024, Tay and Pek, 2019, Robertson et al., 2000)

lwr⁵⁴⁸⁶

(Capelson and Corces, 2006, Apionishev et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (19)

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