FlyBase Allele Report: Dmel\Abl[UAS.cFa]

Third instar larvae expressing Abl^UAS.cFa under the control of Scer\GAL4^elav-C155 display synaptic undergrowth with fewer mature and satellite boutons at the NMJ than controls.

(Kim et al., 2019)

Scer\GAL4^GMR.PU Abl^Scer\UAS.cFa eyes are larger than wild type.

(Tchankouo-Nguetcheu et al., 2014)

Expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF does not affect eye development at 25[o]C, but when the temperature is increased to 29.5[o]C, increasing the expression level of Abl^Scer\UAS.cFa, retinal development is disrupted. The retina in these mutants increases in size (as evidenced by the outward bulging of the retina).

Expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4¹⁴⁰⁷ results in ISNb axons occasionally failing to innervate their target muscles and instead following ISN, leading to a 'bypass' phenotype.

(Lowery et al., 2010)

Expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU results in a rough eye phenotype.

(Ku et al., 2009)

Overexpression of Abl^Scer\UAS.cFa alone results in minimal phenotypic perturbation.

(Xiong et al., 2009)

Overexpression of Abl^Scer\UAS.cFa, under the control of Scer\GAL4^P2.4.Pdf, induces a small increase in axonal outgrowth of the sLNv.

(Leyssen et al., 2005)

Embryos expressing Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu show axons ectopically crossing the midline. In addition, ISNb axons in these embryos show an " ISNb bypass" phenotype, often failing to enter their ventral target domain (muscles 7/6, 13 and 12). Once they have passed their targets, the misguided ISNb axons often make contacts with muscle 12 ("reach-back" phenotype).

(Lee et al., 2004)

Abl^Scer\UAS.cFa animals exhibit a ISNb bypass phenotype.

(Crowner et al., 2003)

Flies expressing Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF have a mild rough eye phenotype. Expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 results in a low level of guidance errors in the ISNb.

(Wills et al., 2002)

Expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^hs.PB results in multilayering of the follicle epithelium. Expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^T155 has little effect on follicle cells.

(Baum and Perrimon, 2001)

When Abl^Scer\UAS.cFa is expressed under the control if Scer\GAL4^elav.PLu or Scer\GAL4^sca-537.4, the bundles of longitudinal connectives of the medial pathway ectopically crosses the midline, in a dose dependant manner.

(Bashaw et al., 2000)

Embryos expressing Abl^Scer\UAS.cFa under the control of Scer\GAL4³¹ have no visible defects in the central nervous system. Flies expressing Abl^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev are viable and fertile and have a mild rough eye phenotype; ommatidia are often fused and mechanosensory bristles are occasionally misplaced. Ommatidia are irregular in shape and size and show an altered trapezoid orientation of photoreceptor cells. The arrangement of the ommatidia is disrupted. Most, but not all, ommatidia contain the correct number of photoreceptor cells.

(Fogerty et al., 1999)

ISNb axons often show a bypass phenotype in embryos expressing Abl^Scer\UAS.cFa under the control of Scer\GAL4¹⁴⁰⁷ or Scer\GAL4^elav.PLu.

(Wills et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, enhanceable by Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^UAS.cFa has abnormal size phenotype, enhanceable by Ptp61F[+]/Ptp61F^4-10

(Tchankouo-Nguetcheu et al., 2014)

Abl^UAS.cFa, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Ptp61F^RNAi.UAS.WIZ, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^UAS.cFa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, enhanceable by chb^EP3403

(Lee et al., 2004)

Abl^UAS.cFa, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, enhanceable by robo1^UAS.cKa

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by robo2^UAS.cSa

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by robo3^UAS.cSa

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by robo1^ΔCC2.UAS

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by robo1^ΔCC3.UAS

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, enhanceable by robo1^ΔCC3.UAS

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by robo1^UAS.cKa

(Wills et al., 2002)

Suppressed by

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^elav-C155 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Abi⁵/Abi[+]

(Kim et al., 2019)

Abl^UAS.cFa, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^insc-Mz1407/msps^d03376

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has abnormal size | heat sensitive phenotype, suppressible | partially by msps^P, Scer\GAL4^GMR.PF

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has abnormal size | heat sensitive phenotype, suppressible by msps^d03376, Scer\GAL4^GMR.PF

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Ptp61F^m.UAS, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^UAS.cFa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible | partially by chb⁴/chb⁴

(Lee et al., 2004)

NOT suppressed by

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy phenotype, non-suppressible by bsk^DN.UAS

(Leyssen et al., 2005)

Enhancer of

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of abnormal size | adult stage phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hem^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^UAS.cFa is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^elav.PLu, chb^EP3403

(Lee et al., 2004)

Abl^UAS.cFa is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, robo1^ΔCC3.UAS

(Wills et al., 2002)

Abl^UAS.cFa is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, robo1^UAS.cKa

(Wills et al., 2002)

Suppressor of

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^GMR.PF is a suppressor of abnormal size | heat sensitive phenotype of Scer\GAL4^GMR.PF, msps^d03376

(Lowery et al., 2010)

Scer\GAL4^elav.PU/Abl^UAS.cFa is a suppressor | partially of abnormal neuroanatomy | maternal effect | embryonic stage phenotype of Dab²/Dab¹

(Song et al., 2010)

Scer\GAL4³¹/Abl^UAS.cFa is a suppressor | partially of lethal phenotype of Abl¹/Df(3L)st-j7, Nrt^M2

(Fogerty et al., 1999)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Abl^UAS.cFa is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Abi⁵/Df(3R)su(Hw)7

(Kim et al., 2019)

Other

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^dpp.blk1, eya^WT.UAS has lethal phenotype

(Xiong et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^UAS.cFa has eye phenotype, enhanceable by Ptp61F[+]/Ptp61F^4-10

(Tchankouo-Nguetcheu et al., 2014)

Abl^UAS.cFa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Ptp61F^RNAi.UAS.WIZ, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^UAS.cFa, Scer\GAL4^elav.PLu has larval intersegmental nerve phenotype, enhanceable by chb^EP3403

(Lee et al., 2004)

Abl^UAS.cFa, Scer\GAL4^elav.PLu has larval neuron phenotype, enhanceable by chb^EP3403

(Lee et al., 2004)

Abl^UAS.cFa, Scer\GAL4^elav-C155 has larval intersegmental nerve phenotype, enhanceable by robo1^UAS.cKa

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by robo2^UAS.cSa

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by robo3^UAS.cSa

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by robo1^ΔCC2.UAS

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by robo1^ΔCC3.UAS

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by robo1^UAS.cKa

(Wills et al., 2002)

Abl^UAS.cFa, Scer\GAL4^elav-C155 has larval intersegmental nerve phenotype, enhanceable by robo1^ΔCC3.UAS

(Wills et al., 2002)

Suppressed by

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^elav-C155 has NMJ bouton | larval stage | decreased number phenotype, suppressible by PDZ-GEF[+]/PDZ-GEF⁶

(Kim et al., 2024)

Abl^UAS.cFa, Scer\GAL4^elav-C155 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Abi⁵/Abi[+]

(Kim et al., 2019)

Abl^UAS.cFa, Scer\GAL4^elav-C155 has NMJ bouton | third instar larval stage phenotype, suppressible by Abi⁵/Abi[+]

(Kim et al., 2019)

Abl^UAS.cFa, Scer\GAL4^insc-Mz1407 has larval intersegmental nerve branch ISNb of A1-7 phenotype, suppressible by Scer\GAL4^insc-Mz1407/msps^d03376

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has eye | heat sensitive phenotype, suppressible | partially by msps^P, Scer\GAL4^GMR.PF

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has retina | heat sensitive phenotype, suppressible | partially by msps^P, Scer\GAL4^GMR.PF

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has eye | heat sensitive phenotype, suppressible by msps^d03376, Scer\GAL4^GMR.PF

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PF has retina | heat sensitive phenotype, suppressible by msps^d03376, Scer\GAL4^GMR.PF

(Lowery et al., 2010)

Abl^UAS.cFa, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ptp61F^m.UAS, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^UAS.cFa, Scer\GAL4^elav.PLu has larval intersegmental nerve phenotype, suppressible | partially by chb⁴/chb⁴

(Lee et al., 2004)

Abl^UAS.cFa, Scer\GAL4^unspecified has larval intersegmental nerve phenotype, suppressible by N^UAS.cBa

(Crowner et al., 2003)

Abl^UAS.cFa, Lar^UAS.cKa has larval intersegmental nerve phenotype, suppressible | partially by Scer\GAL4^elav.PLu

(Wills et al., 1999)

NOT suppressed by

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^P2.4.Pdf has ventral adult lateral neuron & axon phenotype, non-suppressible by bsk^DN.UAS

(Leyssen et al., 2005)

Enhancer of

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Abl^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hem^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^GMR.PU

(Ku et al., 2009)

Abl^UAS.cFa is an enhancer of larval neuron phenotype of Scer\GAL4^elav.PLu, chb^EP3403

(Lee et al., 2004)

Scer\GAL4^unspecified/Abl^UAS.cFa is an enhancer of larval intersegmental nerve | heat sensitive phenotype of N^l1N-ts1

(Crowner et al., 2003)

Abl^UAS.cFa is an enhancer of larval intersegmental nerve phenotype of Scer\GAL4^elav-C155, robo1^ΔCC3.UAS

(Wills et al., 2002)

Abl^UAS.cFa is an enhancer of larval intersegmental nerve phenotype of Scer\GAL4^elav-C155, robo1^UAS.cKa

(Wills et al., 2002)

NOT Enhancer of

Statement

Reference

Scer\GAL4^elav-C155/Abl^UAS.cFa is a non-enhancer of NMJ bouton | larval stage | increased number phenotype of Df(2L)BSC5/PDZ-GEF⁶

(Kim et al., 2024)

Suppressor of

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^GMR.PF is a suppressor of retina | heat sensitive phenotype of Scer\GAL4^GMR.PF, msps^d03376

(Lowery et al., 2010)

Scer\GAL4^elav.PU/Abl^UAS.cFa is a suppressor | partially of larval intersegmental nerve branch ISNb of A1-7 | maternal effect phenotype of Dab²/Dab¹

(Song et al., 2010)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Abl^UAS.cFa is a non-suppressor of NMJ bouton | increased number | larval stage phenotype of Df(2L)BSC5/PDZ-GEF⁶

(Kim et al., 2024)

Scer\GAL4^elav-C155/Abl^UAS.cFa is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Abi⁵/Df(3R)su(Hw)7

(Kim et al., 2019)

Scer\GAL4^elav-C155/Abl^UAS.cFa is a non-suppressor of NMJ bouton | third instar larval stage phenotype of Abi⁵/Df(3R)su(Hw)7

(Kim et al., 2019)

Scer\GAL4^elav.PU/Abl^UAS.cFa is a non-suppressor of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of trio⁸/trio^123.4

(Kannan et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 characteristic for trio⁸/trio^123.4 mutant embryos is not suppressed by Scer\GAL4^elav.PU-driven expression of Abl^Scer\UAS.cFa in the mutant background.

(Kannan et al., 2017)

Co-expression of msps^d03376 under the control of Scer\GAL4¹⁴⁰⁷ suppressed the ISNb bypass phenotype seen upon expression of Abl^Scer\UAS.cFa.

Co-expression of msps^P with Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF partially suppresses the Abl^Scer\UAS.cFa retinal size increase.

Co-expression of msps^d03376 and Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF neutralizes the opposing effects on retinal size, resulting in an eye that is nearly normal in size, albeit still abnormal in lens pattern.

Co-expression of Abl^Scer\UAS.cFa enhances the chb^{Scer\UAS.T:Avic\GFP} mutant eye phenotype when both transgenes are expressed under the control of Scer\GAL4^GMR.PF.

(Lowery et al., 2010)

The penetrance of the ISNb stall phenotype seen in embryos lacking both maternal and zygotic Dab function (derived from Dab¹/Dab² females and having Dab¹ as the paternally derived copy of Dab) is decreased by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU to 29%.

(Song et al., 2010)

The rough eye phenotype caused by expression of Hem^{Scer\UAS.T:Myr-Src64B} under the control of Scer\GAL4^GMR.PU is enhanced by co-expression of Abl^Scer\UAS.cFa.

The rough eye phenotype caused by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU is enhanced by co-expression of Ptp61F^{dsRNA.Scer\UAS.WIZ} and is suppressed co-expression of Ptp61F^m.Scer\UAS.

(Ku et al., 2009)

Scer\GAL4^dpp.blk1-mediated co-expression of eya^WT.Scer\UAS and Abl^Scer\UAS.cFa leads to synthetic lethality.

(Xiong et al., 2009)

Expression of bsk^DN.Scer\UAS, has no effect on Scer\GAL4^P2.4.Pdf>Abl^Scer\UAS.cFa-induced axonal arborization of the sLNv.

(Leyssen et al., 2005)

Co-expression of chb^EP3403 and Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu in embryos results in an increased frequency of axons ectopically crossing the midline compared to embryos expressing either chb^EP3403 or Abl^Scer\UAS.cFa singly under the control of Scer\GAL4^elav.PLu. Co-expression of chb^EP3403 enhances the expressivity of the ISNb axons phenotype caused by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu, although the effect is subtle. The ISNb bypass phenotype caused by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu is reduced by chb⁴/chb⁴.

(Lee et al., 2004)

Co-expression of robo^Scer\UAS.cKa, robo^{ΔCC2.Scer\UAS} or robo^{ΔCC3.Scer\UAS} enhances the rough eye phenotype caused by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF. Co-expression of lea^Scer\UAS.cSa enhances the rough eye phenotype caused by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF. Co-expression of robo3^Scer\UAS.cSa enhances the rough eye phenotype caused by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF. Co-expression of Abl^Scer\UAS.cFa and robo^Scer\UAS.cKa under the control of Scer\GAL4^elav-C155 dramatically increases the frequency of the ISNb bypass phenotype seen when each is expressed alone under the control of Scer\GAL4^elav-C155. Co-expression of Abl^Scer\UAS.cFa and robo^{ΔCC3.Scer\UAS} under the control of Scer\GAL4^elav-C155 dramatically increases the frequency of the ISNb bypass phenotype seen when each is expressed alone under the control of Scer\GAL4^elav-C155.

(Wills et al., 2002)

Expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^T155 in capt¹⁰ mosaic egg chambers alters both the level and distribution of actin filaments in the capt¹⁰ mutant cells. In a few egg chambers, the epithelial morphology is profoundly disrupted.

(Baum and Perrimon, 2001)

The ISNb bypass phenotype of embryos expressing Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu is partially suppressed by Lar^Scer\UAS.cKa.

(Wills et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/Abl^UAS.cFa rescues Abl⁴/Df(3L)st-j7

(Lin et al., 2009)

Scer\GAL4^elav-C155/Abl^UAS.cFa rescues Abl¹

(Wills et al., 2002)

Scer\GAL4^insc-Mz1407/Abl^UAS.cFa rescues Abl^unspecified

(Wills et al., 2002)

Partially rescues

Scer\GAL4³¹/Abl^UAS.cFa partially rescues Abl¹/Df(3L)st-j7

(Fogerty et al., 1999)

Fails to rescue

Scer\GAL4^how-24B/Abl^UAS.cFa fails to rescue Abl⁴/Df(3L)st-j7

(Lin et al., 2009)

Comments

The increased bouton number per muscle area that is seen at the larval neuromuscular junction of Abl⁴/Df(3L)st-j7 animals is rescued by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 but is not rescued by expression of Abl^Scer\UAS.cFa under the control of Scer\GAL4^how-24B.

(Lin et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

28993

w^*; P{UAS-Abl.F}2

8596

w^*; wg^Sp-1/CyO; P{UAS-Abl.F}3

8567

w^*; P{UAS-Abl.F}2/CyO; TM2/TM6B, Tb¹