FlyBase Allele Report: Scer\GAL4[Hand.PU]

General Information

Symbol

Scer\GAL4^Hand.PU

Species

S. cerevisiae

Name

Hand promoter construct of Unknown

FlyBase ID

FBal0303643

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{Hand-GAL4.U}

Also Known As

Hand-Gal4, Hand^4.2-Gal4, handC-Gal4, HandGal4, Hand4.2-Gal4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{Hand-GAL4.U}

Cytology

Description

GAL4 expression is driven by Hand regulatory sequences.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

Hand

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal axis specification | embryonic stage, with hop^Tum.UAS

(Lai et al., 2023)

abnormal cell polarity | embryonic stage, with CAP^RNAi.UAS

(Dondi et al., 2021)

abnormal cell polarity | embryonic stage, with Vinc^GD10928

(Dondi et al., 2021)

abnormal gravitaxis | adult stage, with Sirt1^EP2300

(Wen et al., 2019)

abnormal gravitaxis | adult stage, with Sirt1^RNAi.UAS.cUa

(Wen et al., 2019)

abnormal mating behavior, with for^HMS04486

(Miao et al., 2025)

abnormal mating behavior, with Pdfr^HMJ02073

(Miao et al., 2025)

decreased body weight, with Khk^TH02586.N

(Ping et al., 2025)

decreased rate of adult locomotory behavior, with tim^UAS.cYa

(Tang et al., 2024)

increased cell number | embryonic stage, with mys^JF02819

(Dondi et al., 2021)

increased cell number | embryonic stage, with Vinc^GD10928

(Dondi et al., 2021)

increased cell number | embryonic stage, with WASp^GL00607

(Dondi et al., 2021)

increased size | adult stage, with Cls^KK108761

(Smeir et al., 2021)

lethal - all die during pupal stage, with chic^HMS00550

(Kooij et al., 2016)

long lived, with Sirt1^EP2300

(Wen et al., 2019)

majority die during P-stage, with rhea^GD12050

(Bogatan et al., 2015)

partially lethal - majority die, with rhea^GD12050

(Bogatan et al., 2015)

short lived, with rhea^GD12050

(Bogatan et al., 2015)

short lived, with Sirt1^RNAi.UAS.cUa

(Wen et al., 2019)

short lived, with TER94^GD9777

(Viswanathan et al., 2016)

short lived, with TER94^RNAi.UAS.cUa

(Viswanathan et al., 2016)

Phenotype Manifest In

adult abdominal fat mass, with Khk^TH02586.N

(Ping et al., 2025)

adult heart, with Act57B^{A296S.UAS.GFP}

(Viswanathan et al., 2017)

adult heart, with Act57B^A296S.UAS

(Viswanathan et al., 2017)

adult heart, with Act57B^M306L.UAS

(Viswanathan et al., 2020)

adult heart, with Act57B^UAS.cVa

(Viswanathan et al., 2017)

adult heart, with Act57B^UAS.GFP

(Viswanathan et al., 2017)

adult heart, with ATPsynβL^GD11634

(Gill et al., 2015)

adult heart, with CG18809^GD9655

(Gill et al., 2015)

adult heart, with chic^UAS.cJa

(Kooij et al., 2016)

adult heart, with Cls^KK108761

(Smeir et al., 2021)

adult heart, with Khk^TH02586.N

(Ping et al., 2025)

adult heart, with ND-SGDH^GD3876

(Gill et al., 2015)

adult heart, with RyR^JF03381

(Zmojdzian et al., 2026)

adult heart, with Sirt1^EP2300

(Wen et al., 2019)

adult heart, with Sirt1^GD11580

(Wen et al., 2019)

adult heart, with Sirt1^KK109370

(Wen et al., 2019)

adult heart, with Sirt1^RNAi.UAS.cUa

(Wen et al., 2019)

adult heart, with TER94^A229E.UAS

(Viswanathan et al., 2016)

adult heart, with TER94^GD9777

(Viswanathan et al., 2016)

adult heart, with TER94^R152H.UAS

(Viswanathan et al., 2016)

adult heart, with TER94^R188Q.UAS

(Viswanathan et al., 2016)

adult heart, with tim^GD1267

(Tang et al., 2024)

adult heart, with tim^UAS.cYa

(Tang et al., 2024)

adult heart muscle cell, with rhea^GD12050

(Bogatan et al., 2015)

cardial cell, with mys^KK100518

(Bogatan et al., 2015)

cardial cell, with rhea^GD12050

(Bogatan et al., 2015)

cardial cell | larval stage, with rhea^GD12050

(Bogatan et al., 2015)

embryonic/larval garland cell | third instar larval stage, with Hsap\APOL1^{G0.UAS.Tag:HA}

(Gerstner et al., 2022)

embryonic/larval garland cell | third instar larval stage, with Hsap\APOL1^{G1.UAS.Tag:HA}

(Gerstner et al., 2022)

embryonic/larval garland cell | third instar larval stage, with Hsap\APOL1^{G2.UAS.Tag:HA}

(Gerstner et al., 2022)

embryonic/larval gut | embryonic stage, with hop^Tum.UAS

(Lai et al., 2023)

embryonic/larval heart | larval stage, with rhea^GD12050

(Bogatan et al., 2015)

embryonic/larval heart | third instar larval stage, with rhea^HM05161

(Bogatan et al., 2015)

embryonic/larval heart visceral muscle cell | third instar larval stage, with rhea^HM05161

(Bogatan et al., 2015)

embryonic cardioblast, with CAP^RNAi.UAS

(Dondi et al., 2021)

embryonic cardioblast, with Msp300^HMS00368

(Dondi et al., 2021)

embryonic cardioblast | increased number, with mys^JF02819

(Dondi et al., 2021)

embryonic cardioblast | increased number, with Vinc^GD10928

(Dondi et al., 2021)

embryonic cardioblast | increased number, with WASp^GL00607

(Dondi et al., 2021)

endoplasmic reticulum | third instar larval stage, with Hsap\APOL1^{G0.UAS.Tag:HA}

(Gerstner et al., 2022)

endoplasmic reticulum | third instar larval stage, with Hsap\APOL1^{G1.UAS.Tag:HA}

(Gerstner et al., 2022)

endoplasmic reticulum | third instar larval stage, with Hsap\APOL1^{G2.UAS.Tag:HA}

(Gerstner et al., 2022)

larval cardial cell, with Tmem43^{S333L.UAS.Tag:HA}

(Jürgens et al., 2025)

mitochondrial crista | larval stage, with Tmem43^{S333L.UAS.Tag:HA}

(Jürgens et al., 2025)

mitochondrial outer membrane | larval stage, with Tmem43^{S333L.UAS.Tag:HA}

(Jürgens et al., 2025)

mitochondrion | larval stage, with Tmem43^{S333L.UAS.Tag:HA}

(Jürgens et al., 2025)

myofibril, with mys^KK100518

(Bogatan et al., 2015)

myofibril, with rhea^GD12050

(Bogatan et al., 2015)

nucleus | embryonic stage, with CAP^RNAi.UAS

(Dondi et al., 2021)

wing disc | third instar larval stage, with Hsap\APOL1^{G2.UAS.Tag:HA}

(Gerstner et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

drn^UAS.cLa/Scer\GAL4^Hand.PU rescues drn¹

(Lai et al., 2023)

mthl5^UAS.cPa/Scer\GAL4^Hand.PU rescues Df(3R)mthl5-AD5

(Patel et al., 2016)

Fails to rescue

Scer\GAL4^Hand.PU/Mtx2^UAS.EGFP fails to rescue Mtx2¹/Mtx2^ΔDsRed

(Shou et al., 2026)

Scer\GAL4^Hand.PU/Mtx2^UAS.EGFP fails to rescue Mtx2^EGFP-/Mtx2¹

(Shou et al., 2026)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scer\GAL4^Hand.PU

Name Synonyms

Hand promoter construct of Unknown

Secondary FlyBase IDs

References (41)

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