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FB2026_01
,
released March 12, 2026
dec-1, defective chorion 1, fs(1)384, dec1, fs(1)1501
Please see the JBrowse view of Dmel\dec for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
Gene model reviewed during 5.42
Gene model reviewed during 5.41
Gene model reviewed during 5.56
Multiphase exon postulated: exon reading frame differs in alternative transcripts.
5.7, 3.7 (northern blot)
5.8, 4.0 (northern blot)
None of the polypeptides share 100% sequence identity.
1589, 1123, 950 (aa); 177, 125, 106 (kD predicted)
One of a couple of products generated by alternative splicing.
In D. melanogaster four variant dec-1 protein
forms have been found, differing by 2-3kD each. The variation is due to
deletions of 1,2, or 3 units of a 5-time repeated sequence (78bp long).
Multiple dec-1 proteins are made from alternatively spliced transcripts. The distribution of the various dec-1 protein products was studied in dec-1 mutants. Evidence suggests that the 106kD product and its derivatives are not sufficient for the formation of a functional eggshell. Other products such as the 125kD and 177kD products are required.
Multiple dec-1 proteins are made from alternatively spliced transcripts. dec-1 protein product diversity is also accomplished by protein processing. The 950aa dec-1 product is processed at a site determined in this study, to yield an 80kD C-terminal product (s80) and a 26kD N-terminal product. The 80kD product is further processed to give rise to a 60kD peptide (s60). The distribution of the various dec-1 protein products was studied in dec-1 mutants. Evidence suggests that the 106kD product and its derivatives are not sufficient for the formation of a functional eggshell. Other products such as the 125kD and 177kD products are required.
Proteolytic cleavage of isoform FC106 generates 2 further products, S80 and S60.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dec using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\dec in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The fc177 cleaved derivative of dec-1 is necessary to prevent ectopic aggregation of the endochorion during eggshell assembly.
The diverse distributions of the various dec-1 derivatives suggest that they are functionally distinct and likely to play different roles in the assembly and stabilisation of the mature eggshell.
A follicular cell marker system that yields a visible phenotype within the mature egg shell allows direct comparison of a clone and its effect on the dorsal ventral pattern of the embryos.
dec-1 encodes multiple products that are post-translationally cleaved and that are necessary for proper egg shell assembly.
Mature egg shell shows lack of organization within the endochorion and accumulation of electron dense material in the vitelline membrane of stage-14 egg chambers. No abnormalities detected in stage-10 oocytes.
Mutations in dec-1 disrupt chorion gene amplification.
Three protein products of gene detected; the primary translation product of 130kD found in stage-10 follicles; this appears to be quickly processed into an 85kD product, which is in turn processed into a 67kD protein in stage 13 and 14 egg shells.
Three protein products of gene detected; these products measured as 92, 82 and 76kD, respectively. All three proteins absent in dec-1 mutants, and they vary coordinately in molecular weight in natural variant alleles.
Source for identity of: dec-1 CG2175
Source for identity of: dec dec-1
Changed from 'dec-1' to 'dec' to prevent the symbol being auto-converted into a date when used in spreadsheet programs (see PMID:15214961, PMID: 27552985).
