FlyBase Gene Report: Dmel\lin

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\lin

General Information

Symbol

Dmel\lin

Species

D. melanogaster

Name

lines

Annotation Symbol

CG11770

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002552

Gene Model Status

Stock Availability

11 publicly available

Gene Summary

lines (lin) encodes a nuclear protein involved in developmental patterning and cell fate specification. The Odd-skipped family protein encoded by bowl binds to and destabilizes the product of lin in the nucleus. Converserly the Odd family protein encoded by drm stabilizes the product of bowl in the nucleus by outcompeting the binding of the product of lin to the product of bowl and localizing the product of lin to the cytoplasm. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:8,914,524..8,918,234 [+]

Recombination map

2-59

RefSeq locus

NT_033778 REGION:8914524..8918234

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9VQS6

(Green et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (10 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in embryonic foregut morphogenesis

inferred from mutant phenotype

(Johansen et al., 2003)

involved_in embryonic hindgut morphogenesis

inferred from mutant phenotype

(Johansen et al., 2003, Iwaki et al., 2001)

involved_in embryonic pattern specification

inferred from mutant phenotype

(Iwaki et al., 2001, Bokor and DiNardo, 1996)

involved_in epidermis development

inferred from mutant phenotype

(Hatini et al., 2000)

involved_in foregut morphogenesis

inferred from mutant phenotype

(Green et al., 2002)

involved_in hindgut morphogenesis

inferred from mutant phenotype

(Green et al., 2002, Iwaki et al., 2001)

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Castelli-Gair, 1998)

involved_in proximal/distal axis specification

inferred from mutant phenotype

(Greenberg and Hatini, 2009)

involved_in spiracle morphogenesis, open tracheal system

inferred from mutant phenotype

(Castelli-Gair, 1998)

involved_in wing disc development

inferred from mutant phenotype

(Nusinow et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Hatini et al., 2000)

located_in nucleus

inferred from direct assay

(Hatini et al., 2000)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the protein lines family. (Q9V4Z9)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

lines (lin) encodes a nuclear protein involved in developmental patterning and cell fate specification. The Odd-skipped family protein encoded by bowl binds to and destabilizes the product of lin in the nucleus. Converserly the Odd family protein encoded by drm stabilizes the product of bowl in the nucleus by outcompeting the binding of the product of lin to the product of bowl and localizing the product of lin to the cytoplasm. [Date last reviewed: 2019-03-14]

Protein Function (UniProtKB)

Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein. Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis. Also required for Abd-B to form an eighth abdominal denticle belt. Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Required to regulate expression of embryonic hindgut patterning genes in order to establish the large intestine and at least some rectum, and to repress small intestine fate. Required for late wingless (wg)-dependent cell fate specification in the dorsal embryonic epidermis. Acts in concert with wg to regulate expression of wg itself and also to regulate wg-target genes. May have a role in ventral epidermal patterning, independent of wg signaling.

(UniProt, Q9V4Z9)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

lin: lines (C. Nusslein-Volhard)

Embryonic lethal; small anterior portion of each segment deleted; A8, spiracles, and anal plates absent. Head abnormal.

Summary (Interactive Fly)

novel segment polarity gene - Lines is crucial for completing Wg signal transduction, acting downstream or in parallel to Armadillo

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\lin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V4Z9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0088651

3654

858

Additional Transcript Data and Comments

Reported size (kB)

3.416 (longest cDNA)

(Hatini et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0087732

96.3

858

4.96

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

858 (aa)

(Hatini et al., 2000)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with drm.

(UniProt, Q9V4Z9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lin using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lin_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.21

Transcript Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

embryonic hindgut

(Iwaki et al., 2001)

embryonic/larval midgut primordium | posterior

(Iwaki et al., 2001)

organism | ubiquitous

(Iwaki et al., 2001)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic epidermis

(Hatini et al., 2000)

(Hatini et al., 2000)

(Hatini et al., 2000)

inclusive hindgut primordium

(Hatini et al., 2000)

Additional Descriptive Data

lin transcript is expressed widely, at low levels in the embryonic epidermis at the time of epidermal patterning and at higher levels in the hindgut and foregut primordia and in the mesoderm.

(Hatini et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

lin protein localization could not be determined with the anti-lin antibody, or with Myc-tagged lin, so localization was studied by overexpressing lin using the GAL4-UAS system. In 10 hr. embryos carrying "UAS-Lin" (lin^UAS.cHa) and the "Ptc-GAL4" driver (Scer\GAL4^ptc-559.1), lin protein localizes to the nucleus in cells anterior to the en domain, but localizes to the cytoplasm posterior to the en domain.

(Hatini et al., 2000)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Hatini et al., 2000)

located_in nucleus

inferred from direct assay

(Hatini et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lin in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lin

View exonic expression by tissue for Dmel\lin

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45325/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002552

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002552

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002552

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11770

Flygut - An atlas of the Drosophila adult midgut

FBgn0002552

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lin

Transgenic constructs containing regulatory region of lin

Aberrations (Deficiencies and Duplications) ( 17 )

Inferred from experimentation ( 17 )

Gene not disrupted in

(Mohr and Boswell, 2002)

(Wen et al., 2024)

(Wen et al., 2024)

(Wen et al., 2024)

(Zheng et al., 2003)

(Mohr and Boswell, 2002)

(Mohr and Boswell, 2002)

(Mohr and Boswell, 2002)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | larval stage | somatic clone

lin^G2

lethal, with Scer\GAL4^byn-Gal4

lin^UAS.cHa

lethal | recessive

lethal - all die before end of larval stage

lethal - all die during embryonic stage | recessive

lin^unspecified

partially lethal - majority die, with Scer\GAL4^pnr-MD237

lin^GD1479

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

lin^GD1479

viable, with Scer\GAL4^Mef2.PR

lin^GD1479

viable, with Scer\GAL4^tin.CΔ4

lin^GD1479

Other Phenotypes

Allele

abnormal size | embryonic stage

lin²

decreased size | adult stage | somatic clone - tissue specific

lin^G2

increased cell death, with Scer\GAL4^{Ubx-lac1-GAL4}

lin^UAS.cHa

increased cell number | embryonic stage

lin²

increased size | adult stage | somatic clone - tissue specific

increased size | larval stage | somatic clone

some die during embryonic stage | recessive

lin^unspecified

some die during larval stage

some die during pupal stage, with Scer\GAL4^pnr-MD237

lin^GD1479

visible, with Scer\GAL4^klu-G410

lin^UAS.cHa

visible, with Scer\GAL4^pnr-MD237

lin^GD1479

visible, with Scer\GAL4^{Ubx-lac1-GAL4}

lin^UAS.cHa

visible | adult stage | somatic clone - tissue specific

visible | pharate adult stage, with Scer\GAL4^dpp.blk1

lin^UAS.cHa

visible | somatic clone

lin^G2

visible | somatic clone, with Scer\GAL4^Act5C.PU

lin^UAS.cHa

Phenotype manifest in

Allele

abdominal segment 8

lin²

adult head capsule, with Scer\GAL4^dpp.blk1

lin^UAS.cHa

adult thorax, with Scer\GAL4^{Ubx-lac1-GAL4}

lin^UAS.cHa

adult thorax | somatic clone, with Scer\GAL4^Act5C.PU

lin^UAS.cHa

lin^G1

antenna | ectopic, with Scer\GAL4^dpp.blk1

lin^UAS.cHa

antenna | somatic clone

lin^G2

antennal disc, with Scer\GAL4^dpp.blk1

lin^UAS.cHa

arista, with Scer\GAL4^bab1-Agal4-5

lin^GD1479

arista, with Scer\GAL4^bab1-Pgal4-2

lin^GD1479

arista, with Scer\GAL4^dac-p7d23

lin^GD1479

basal cylinder, with Scer\GAL4^bab1-Agal4-5

lin^GD1479

basal cylinder, with Scer\GAL4^bab1-Pgal4-2

lin^GD1479

basal cylinder, with Scer\GAL4^dac-p7d23

lin^GD1479

basal cylinder, with Scer\GAL4^{rn-GAL4-DeltaS}

lin^GD1479

lin^unspecified

denticle | ectopic (with lin²)

lin^G2

denticle | ectopic (with lin^G2)

lin²

denticle belt & abdominal segment 8

lin^G1

denticle row 1 (with lin²)

lin^G2

denticle row 1 (with lin^G2)

lin²

denticle row 2 (with lin²)

lin^G2

denticle row 2 (with lin^G2)

lin²

denticle row 2 | ectopic, with Scer\GAL4^ptc-559.1, lin^G2/lin²

lin^UAS.cHa

denticle row 2 | ectopic (with lin²), with Scer\GAL4^ptc-559.1, lin^UAS.cHa

lin^G2

denticle row 2 | ectopic (with lin^G2), with Scer\GAL4^ptc-559.1, lin^UAS.cHa

lin²

denticle row 3 (with lin²)

lin^G2

denticle row 3 (with lin^G2)

lin²

denticle row 3 | ectopic, with Scer\GAL4^ptc-559.1, lin^G2/lin²

lin^UAS.cHa

denticle row 3 | ectopic (with lin²), with Scer\GAL4^ptc-559.1, lin^UAS.cHa

lin^G2

denticle row 3 | ectopic (with lin^G2), with Scer\GAL4^ptc-559.1, lin^UAS.cHa

lin²

denticle row 4 (with lin²)

lin^G2

denticle row 4 (with lin^G2)

lin²

disc epithelium proper & dorsal mesothoracic disc | somatic clone

lin^unspecified

dorsal denticle, with Scer\GAL4^ptc-559.1

lin^UAS.cHa

dorsal denticle | ectopic (with lin²)

lin^G2

dorsal denticle | ectopic (with lin^G2)

lin²

dorsal fine hair

lin²

dorsal fine hair | ectopic, with Scer\GAL4^ptc-559.1

lin^UAS.cHa

dorsal thick hair

lin²

dorsal thick hair, with Scer\GAL4^ptc-559.1

lin^UAS.cHa

embryonic/larval hindgut | embryonic stage

lin²

embryonic/larval posterior spiracle

embryonic/larval spiracle primordium

lin^unspecified

embryonic abdominal segment 8

lin^unspecified

embryonic dorsal epidermis

lin^unspecified

embryonic dorsal epidermis, with Scer\GAL4^ptc-559.1

lin^UAS.cHa

embryonic epidermis | dorsal

lin^unspecified

embryonic epidermis | dorsal, with Scer\GAL4^ptc-559.1

lin^UAS.cHa

embryonic foregut

lin^unspecified

lin^unspecified

embryonic hindgut

embryonic hindgut, with Scer\GAL4^byn-Gal4

lin^UAS.cHa

embryonic large intestine

lin^unspecified

embryonic Malpighian tubule

lin²

embryonic proventriculus

lin^unspecified

embryonic segment | anterior

lin^unspecified

eye | somatic clone

lin^13B

eye | somatic clone - tissue specific

eye disc | larval stage | somatic clone

lin^A25

eye disc | somatic clone, with Scer\GAL4^Act5C.PP

lin^UAS.cHa

lin^unspecified

hindgut proper primordium

lin^G1

keyhole structure

lin^unspecified

larval somatic muscle cell | dorsal

lin²

mesonotum, with Scer\GAL4^pnr-MD237

lin^GD1479

lin^G1

peripodial epithelium & dorsal mesothoracic disc, with Scer\GAL4^ptc-559.1

lin^UAS.cHa

peripodial epithelium & dorsal mesothoracic disc, with Scer\GAL4^{Ubx-lac1-GAL4}

lin^UAS.cHa

peripodial epithelium & dorsal mesothoracic disc | somatic clone, with Scer\GAL4^Act5C.PU

lin^UAS.cHa

photoreceptor neuron | somatic clone

lin^13B

prescutum, with Scer\GAL4^klu-G410

lin^UAS.cHa

prothoracic tarsal segment, with Scer\GAL4^bab1-Agal4-5

lin^GD1479

prothoracic tarsal segment, with Scer\GAL4^bab1-Pgal4-2

lin^GD1479

prothoracic tarsal segment, with Scer\GAL4^dac-p7d23

lin^GD1479

prothoracic tarsal segment, with Scer\GAL4^Dll-md23

lin^GD1479

prothoracic tarsal segment, with Scer\GAL4^{rn-GAL4-DeltaS}

lin^GD1479

prothoracic tarsal segment | cell autonomous | somatic clone

lin^G2

sex comb, with Scer\GAL4^bab1-Agal4-5

lin^GD1479

sex comb, with Scer\GAL4^bab1-Pgal4-2

lin^GD1479

sex comb, with Scer\GAL4^dac-p7d23

lin^GD1479

sex comb, with Scer\GAL4^Dll-md23

lin^GD1479

sex comb, with Scer\GAL4^{rn-GAL4-DeltaS}

lin^GD1479

third segment of antenna, with Scer\GAL4^dac-p7d23

lin^GD1479

third segment of antenna, with Scer\GAL4^{rn-GAL4-DeltaS}

lin^GD1479

ventral denticle belt

lin^G1

ventral denticle belt (with lin²)

lin^G2

ventral denticle belt (with lin^G2)

lin²

wing disc | larval stage | somatic clone

wing hinge primordium | somatic clone

lin^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

4 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

3 of 14

Yes

Yes

Mus musculus (laboratory mouse) (1)

4 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (1)

2 of 13

Yes

Yes

Danio rerio (Zebrafish) (1)

4 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP010757

11 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (1)

2 of 13

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:lin. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

LINS1; lines homolog 1

model of autosomal recessive intellectual developmental disorder 27

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

LINS1; lines homolog 1

4 of 14

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 27; MRT27

autosomal recessive intellectual developmental disorder 27

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot, coimmunoprecipitation

(Wen et al., 2024, Del Signore et al., 2012, Hatini et al., 2005)

coimmunoprecipitation, anti tag western blot

(Del Signore et al., 2012)

anti tag coimmunoprecipitation, anti tag western blot

(Wen et al., 2024)

coimmunoprecipitation, anti tag western blot

(Del Signore et al., 2012)

coimmunoprecipitation, anti tag western blot

(Del Signore et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Wen et al., 2024)

suppressible

(Wen et al., 2024)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Castelli-Gair, 1998)

External Data

Subunit Structure (UniProtKB)

Interacts with drm.

(UniProt, Q9V4Z9 )

Linkouts

BioGRID - A database of protein and genetic interactions.

69592

DroID - A comprehensive database of gene and protein interactions.

FBgn0002552

MIST (protein-protein) - An integrated Molecular Interaction Database

45325

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-59

Cytogenetic map

Sequence location

2R:8,914,524..8,918,234 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44F6-44F7

Limits computationally determined from genome sequence between P{lacW}Dmn^k16109&P{lacW}Gγ1^k08017 and P{lacW}babo^k16912

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

44F-44F

(Hatini, 2000.5.25)

Experimentally Determined Recombination Data

Location

2-59

(FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)

2-58.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

7074

w^*; P{UAS-lin.H}8

606306

w^*; P{UAS-lin.Myc.W}2

7087

w^*; lin^G2/CyO

50603

y¹ v¹; P{TRiP.HMC02375}attP2

40939

y¹ v¹; P{TRiP.HMS02187}attP40

606304

P{hsFLP}1, w^*; P{neoFRT}42D lin^A25/CyO

3099

cn¹ lin² bw¹ speck¹/CyO

106840

cn¹ lin² bw¹ speck¹/CyO

HMC02375

y¹ v¹; P{TRiP.HMC02375}attP2

2RG-1046

y² VhaAC39-1^cho-1 v¹; P{U6-lin.NIG.sgRNA}attP40/CyO

v16801

w¹¹¹⁸; P{GD1479}v16801

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (26)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD43682

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002552

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002552

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hatini et al., 2000)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

lin and bowl act as a binary switch to specify disc proper and peripodial epithelium fates respectively during early development of the wing primordium.

(Nusinow et al., 2008)

lin is required for patterning of the hindgut.

(Iwaki et al., 2001)

lin is essential for wg-dependent patterning in the embryonic dorsal epidermis.

(Hatini et al., 2000)

Genetic evidence demonstrates that lin is required for the function of the Abd-B protein, but not for the function of other Hox genes. In mutant embryos Abd-B protein expression is normal but incapable of promoting its normal functions: formation of the posterior spiracle and specification of the eighth abdominal denticle belt.

(Castelli-Gair, 1998)

wg and hh signaling account for all cell types across the dorsal epidermis, where lin regulates the late expression of wg. lin function is antagonized by hh.

(Bokor and DiNardo, 1996)

lin is able to suppress some aspects of the late wg phenotype and later the identity of some hh-dependent cell types.

(Bokor et al., 1995)

The role of lin in the regulation of run mRNA expression in the early embryo has been investigated.

(Klingler and Gergen, 1993)

wg and en expression patterns are studied in all known segment polarity mutants to investigate the requirement of other segment polarity genes in mediating the maintenance of wg and en.

(van den Heuvel et al., 1993)

Zygotically active locus involved in the terminal developmental program in the embryo.

(Strecker et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: lin CG11770

(FlyBase, 1996-)

Additional comments

Source for merge of lin CG11770 was sequence comparison ( date:000622 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG11770

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Ni et al., 2010.12.1, Kim et al., 2004)

Lin

(Zoller and Schulz, 2012, Johansen et al., 2001)

lin

(Wen et al., 2024, Xie et al., 2021, Kittelmann et al., 2018, Aleksic et al., 2013, Zoller and Schulz, 2012, Zhai et al., 2010, Benítez et al., 2009, Mulinari and Häcker, 2009, Zhai et al., 2009, Brás-Pereira and Casares, 2008, Junion et al., 2007, Tao et al., 2007)

Name Synonyms

lines

(Bourbon et al., 2022, Wieschaus and Nüsslein-Volhard, 2016, Del Signore et al., 2012, Whitworth et al., 2012, Zoller and Schulz, 2012, Grusche et al., 2011, Zhai et al., 2010, Benítez et al., 2009, Greenberg and Hatini, 2009, Mulinari and Häcker, 2009, Zhai et al., 2009, Brás-Pereira and Casares, 2008, DiNardo et al., 2008, Nusinow et al., 2008, Hatini and Nusinow, 2007, Tao et al., 2007, Bras-Pereira et al., 2006, Waldrop et al., 2006)

Secondary FlyBase IDs

FBgn0033346

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

45325

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V4Z9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V4Z9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q2XY68

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V4Z9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45325/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002552

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002552

FlyMine - An integrated database for Drosophila genomics

FBgn0002552

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11770

MARRVEL_MODEL - MARRVEL (model organism gene)

45325

Linkouts

BioGRID - A database of protein and genetic interactions.

69592

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0002552

DroID - A comprehensive database of gene and protein interactions.

FBgn0002552

DRSC - Results frm RNAi screens

FBgn0002552

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lin_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002552

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0002552

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11770

Flygut - An atlas of the Drosophila adult midgut

FBgn0002552

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011514

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

45325

References (106)