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FB2026_01
,
released March 12, 2026
C3HC4 type (RING finger) protein - works downstream of insulin receptor/mTOR pathway to regulate temporal control of neuronal differentiation
Please see the JBrowse view of Dmel\unk for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.04
6.5, 4.1, 2.5 (northern blot)
614 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\unk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
The major 2.5kb and 4.1kb unc transcripts are most abundant during the first 5 hrs of embryogenesis. Subsequently, the 2.5kb transcript disappears and the 4.1kb transcript is reduced. The minor 6.5kb species is at the same level throughout embryogenesis. In situ hybridizations show that unk RNA is ubiquitous in most somatic tissues through stage 15 of embryogenesis but becomes restricted to the nervous system in stages 16 and early 17.
The major 2.5kb and 4.1kb unc transcripts are most abundant during the first 5 hrs of embryogenesis. Subsequently, the 2.5kb transcript disappears and the 4.1kb transcript is reduced. The minor 6.5kb species is at the same level throughout embryogenesis. In situ hybridizations show that unk RNA is ubiquitous in most somatic tissues through most of embryogenesis but becomes restricted to the nervous system in stages 16 and early 17.
unk transcripts are ubiquitous and abundant in the embryo.
unk protein is ubiquitously expressed. It is expressed throughout the eye discs but is expressed more strongly posterior to the morphogenetic furrow and is found in cone cells and photoreceptor cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\unk in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
unk plays no role in the regulation of growth.
dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.
unk lies between the location of enhancer trap elements that report hh expression and hh itself.
