FlyBase Gene Report: Dmel\Cds

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\Cds

General Information

Symbol

Dmel\Cds

Species

D. melanogaster

Name

CDP-diacylglycerol synthase

Annotation Symbol

CG7962

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010350

Gene Model Status

Stock Availability

20 publicly available

Enzyme Name (EC)

phosphatidate cytidylyltransferase (2.7.7.41)

Gene Summary

CDP-diacylglycerol synthase (Cds) encodes an enzyme for the synthesis of cytidine diphosphate diacylglycerol (CDP-DAG) from phosphatidic acid. CDP-DAG is the precursor of two phospholipids, phosphatidylinositol and phosphatidylglycerol. The product of Cds has roles in cell growth and lipid storage. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

CdsA, CDP diglyceride synthetase, winded, CDP-diacylglycerol synthetase, eye-CDS

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:8,127,762..8,131,675 [+]

Recombination map

3-22

RefSeq locus

NT_037436 REGION:8127762..8131675

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables phosphatidate cytidylyltransferase activity

inferred from direct assay

(Wang and Montell, 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables phosphatidate cytidylyltransferase activity

inferred from electronic annotation with InterPro:IPR016720

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000349519

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Wu et al., 1995)

enables transferase activity, transferring phosphorus-containing groups

inferred from electronic annotation with InterPro:IPR000374

(InterPro Project Members, 2004-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in G protein-coupled opsin signaling pathway

inferred from mutant phenotype

(Zuker, 1996)

involved_in lipid biosynthetic process

inferred from mutant phenotype

(Laurinyecz et al., 2016)

involved_in negative regulation of triglyceride biosynthetic process

inferred from mutant phenotype

(Liu et al., 2014)

involved_in phototransduction

inferred from mutant phenotype

(Wu et al., 1995)

inferred from genetic interaction with FLYBASE:Arr2; FB:FBgn0000121

(Wu et al., 1995)

involved_in positive regulation of phosphatidylinositol biosynthetic process

inferred from mutant phenotype

(Liu et al., 2014)

involved_in regulation of lipid storage

inferred from mutant phenotype

(Tian et al., 2011)

involved_in sperm individualization

inferred from mutant phenotype

(Laurinyecz et al., 2016)

involved_in terminal branching, open tracheal system

inferred from high throughput mutant phenotype

(Ghabrial et al., 2011)

involved_in thermotaxis

inferred from direct assay

(Kwon et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in CDP-diacylglycerol biosynthetic process

non-traceable author statement

(Montell, 1999)

inferred from biological aspect of ancestor with PANTHER:PTN000349519

(GO Reference Genome Project, 2011-)

involved_in lipid droplet formation

inferred from biological aspect of ancestor with PANTHER:PTN000349519

(GO Reference Genome Project, 2011-)

involved_in phototransduction

non-traceable author statement

(Hardie, 2001, Montell, 1999)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from biological aspect of ancestor with PANTHER:PTN000349519

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR000374

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES

Protein Family (UniProt)

Belongs to the CDS family. (P56079)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

phosphatidate cytidylyltransferase activity

a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl- sn-glycerol + diphosphate (2.7.7.41)

RHEA 16229:

Summaries

Gene Snapshot

CDP-diacylglycerol synthase (Cds) encodes an enzyme for the synthesis of cytidine diphosphate diacylglycerol (CDP-DAG) from phosphatidic acid. CDP-DAG is the precursor of two phospholipids, phosphatidylinositol and phosphatidylglycerol. The product of Cds has roles in cell growth and lipid storage. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES -: Cytidylyltransferases catalyse the transfer of a cytidylyl group to an acceptor.

Protein Function (UniProtKB)

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:24603715, PubMed:7816135). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135). In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715). Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715). This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715). Required for spermatid individualization by regulating lipid compositions and lipid-mediated signaling during spermatogenesis (PubMed:26791243).

(UniProt, P56079)

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Cds for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P56079)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0076688

2391

447

FBtr0346546

2609

447

Additional Transcript Data and Comments

Reported size (kB)

2.5 (northern blot)

(Wu et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0076411

51.5

447

7.42

FBpp0312164

51.5

447

7.42

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

447 aa isoforms: Cds-PA, Cds-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

447 (aa); 49 (kD observed)

(Wu et al., 1995)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cds using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.37

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

(Xu et al., 2004)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

photoreceptor cell R1 -- photoreceptor cell R8

(Wu et al., 1995)

(Wu et al., 1995)

(Wu et al., 1995)

Additional Descriptive Data

Cds protein is expressed in fly heads but not bodies. In frozen sections of adult heads, Cds protein is localized to the photoreceptor cell neurons both in the eye and in the ocelli.

(Wu et al., 1995)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{HZ}Cds¹

Stage

Tissue/Position (including subcellular localization)

Reference

photoreceptor cell R1 -- photoreceptor cell R8

(Wu et al., 1995)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cds in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cds

View exonic expression by tissue for Dmel\Cds

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010350

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43950/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010350

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010350

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010350

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7962

Flygut - An atlas of the Drosophila adult midgut

FBgn0010350

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cds

Stages(s) 1-3
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cds

Transgenic constructs containing regulatory region of Cds

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

(Ryder, 2004.4.26)

(Ghabrial et al., 2011)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Cds⁷

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cds^GD2357

Cds¹

viable, with Scer\GAL4^Mef2.PR

Cds^GD2357

viable, with Scer\GAL4^pnr-MD237

Cds^GD2357

viable, with Scer\GAL4^tin.CΔ4

Cds^GD2357

Sterility

Allele

male sterile (with Df(3L)BSC795)

Other Phenotypes

Allele

abnormal neurophysiology

Cds¹

abnormal thermotaxis

Cds¹

abnormal visual behavior

Cds¹

decreased cell size

Cds^GS8005

decreased cell size, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

majority die during larval stage

Cds^GS8005

some die during embryonic stage

Cds^GS8005

Phenotype manifest in

Allele

brain, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

Cds^UM-8246-3

embryonic/larval fat body, with Scer\GAL4^ppl.PP

Cds^NIG.7962R

embryonic/larval fat body, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

embryonic/larval salivary gland

Cds¹

embryonic/larval salivary gland, with Scer\GAL4^ppl.PP

Cds^EY08412

embryonic/larval salivary gland | cell autonomous | somatic clone

Cds^GS8005

eye | somatic clone

eye photoreceptor cell

Cds¹

imaginal disc, with Scer\GAL4^αTub84B.PL

Cds^NIG.7962R

larval tracheal system

lipid droplet | ectopic

Cds¹

lipid droplet | ectopic, with Scer\GAL4^elav.PU

Cds^NIG.7962R

lipid droplet | ectopic, with Scer\GAL4^ppl.PP

Cds^NIG.7962R

major mitochondrial derivative

Cds^CB-0128-3

minor mitochondrial derivative

Cds^CB-0128-3

Cds¹

photoreceptor cell R1

Cds¹

photoreceptor cell R2

Cds¹

photoreceptor cell R3

Cds¹

photoreceptor cell R4

Cds¹

photoreceptor cell R5

Cds¹

photoreceptor cell R6

Cds¹

photoreceptor cell R7

Cds¹

photoreceptor cell R8

Cds¹

photoreceptor neuron

Cds¹

Cds¹

Cds¹

salivary gland, with Scer\GAL4^elav.PU

Cds^NIG.7962R

salivary gland, with Scer\GAL4^ppl.PP

Cds^NIG.7962R

spermatid axoneme

Cds^CB-0128-3

Cds^CB-0128-3

terminal tracheal cell

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

14 of 14

Yes

Yes

13 of 14

No

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

14 of 14

Yes

Yes

13 of 14

No

Yes

Mus musculus (laboratory mouse) (2)

14 of 14

Yes

Yes

13 of 14

No

Yes

Xenopus tropicalis (Western clawed frog) (5)

11 of 13

Yes

Yes

7 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

Danio rerio (Zebrafish) (2)

13 of 14

Yes

Yes

12 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

13 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP007175

12 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (5)

13 of 13

Yes

Yes

12 of 13

No

Yes

12 of 13

No

Yes

4 of 13

No

Yes

4 of 13

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

13 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBC13A2.03

12 of 12

Yes

Yes

Escherichia coli (enterobacterium) (2)

7 of 11

Yes

Yes

5 of 11

No

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cds. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

exacerbates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

exacerbates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

ameliorates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDS1; CDP-diacylglycerol synthase 1

14 of 14

CDS2; CDP-diacylglycerol synthase 2

13 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Liu et al., 2014)

enhanceable

(Raghu et al., 2009)

enhanceable

(Liu et al., 2014)

enhanceable

(Raghu et al., 2009)

suppressible

(Liu et al., 2014)

suppressible

(Laurinyecz et al., 2016, Wang and Montell, 2006)

enhanceable

(Garcia-Murillas et al., 2006)

enhanceable

(Tian et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Raghu et al., 2009)

suppressible

(Xu et al., 2021)

enhanceable

(Raghu et al., 2009)

suppressible

(Xu et al., 2021)

suppressible

(Laviolette et al., 2005)

suppressible

(Liu et al., 2014)

enhanceable

(Yang et al., 2019)

suppressible

(Yang et al., 2019)

enhanceable

(Garcia-Murillas et al., 2006)

enhanceable

(Tian et al., 2011)

suppressible

(Tian et al., 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68739

DroID - A comprehensive database of gene and protein interactions.

FBgn0010350

MIST (genetic) - An integrated Molecular Interaction Database

43950

MIST (protein-protein) - An integrated Molecular Interaction Database

43950

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-22

Cytogenetic map

Sequence location

3L:8,127,762..8,131,675 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66B7-66B7

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Location based on deficiency mapping with Df(3L)pbl-X1.

(Ghabrial et al., 2011)

66B-66B

(determined by in situ hybridisation)

(Wu et al., 1995)

Experimentally Determined Recombination Data

Location

3-22

(FlyBase, 2016)

3-19.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

39088

w¹¹¹⁸; P{GMR54G09-GAL4}attP2

53506

w¹¹¹⁸; P{GMR54G09-lexA}attP40

70033

w¹¹¹⁸; P{R54G09-p65.AD}attP40

28075

y¹ v¹; P{TRiP.JF02912}attP2

58118

y¹ v¹; P{TRiP.HMJ22055}attP40

94367

w^*; TI{CRIMIC.TG4.0}Cds^{CR60271-TG4.0}

112133

y^* w^*; P{GawB}Cds^NP0318

7962R-1

7962R-2

HMJ22055

y¹ v¹; P{TRiP.HMJ22055}attP40/CyO

v103415

P{KK100637}VIE-260B

v5121

w¹¹¹⁸; P{GD2357}v5121

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (89)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH66092

Other clones

FI18858

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010350

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010350

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wu et al., 1995)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

CdsA diverts phosphatidic acid from triacylglycerol synthesis to phosphatidylinositol synthesis and coordinates cell growth and fat storage.

(Liu et al., 2014)

May be required for tracheal terminal cell growth and branching.

(Ghabrial et al., 2005)

A step in the resynthesis of phosphatidylinositol-4,5-biphosphate, PtdInsP₂ (needed for signal transduction), is performed by CDP-DAG synthase. CdsA encodes CDP-DAG synthase, an enzyme that activates phosphatidic acid by converting it to CDP-DAG.

(Hurley, 1995)

CdsA protein is required for the regeneration of the signalling molecule phosphatidylinositol-4,5-biphosphate (PtdInsP₂) from phosphatidic acid. A photoreceptor cell isoform of CdsA is a key regulator of phototransduction.

(Wu et al., 1995)

Relationship to Other Genes

Source for database merge of

Source for merge of: CdsA CG7962

(Whitfield, 2000.10.30)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: CdsA winded

(Ghabrial, 2005.3.2)

Source for identity of: Cds CdsA

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CDS

(Le et al., 2024, Liu et al., 2014, Hurley, 1995)

CG7962

(Wang et al., 2019, Liu et al., 2018, Cockcroft and Raghu, 2016, Laurinyecz et al., 2016, Hosono et al., 2015, Banerjee et al., 2012, Bridon et al., 2012, Cammarato et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Laviolette et al., 2005)

Cds

(Sebastian et al., 2022, Olson et al., 2019, Yan et al., 2019, Gene Disruption Project members, 2018-, Suratekar et al., 2018, Cockcroft and Raghu, 2016)

CdsA

(Agrawal et al., 2021, Jacomin et al., 2021, Xu et al., 2021, Yang et al., 2019, Yan et al., 2017, Laurinyecz et al., 2016, Liu et al., 2014, Bridon et al., 2012, Mizrak et al., 2012, Senthilan et al., 2012, Tian et al., 2011, Ranade et al., 2008, Landry et al., 2007, Girardot et al., 2006, Wijnen et al., 2006, Laviolette et al., 2005)

cdsA

(Liu et al., 2018, Ghabrial, 2005.3.2)

eye-CDS

(Acharya et al., 1998, Hurley, 1995)

eye-cds

(Wu et al., 1995)

Name Synonyms

CDP diglyceride synthetase

(Cammarato et al., 2011, Khanna et al., 2010)

CDP-DAG synthase

(Huang et al., 2010, Montell, 1999)

CDP-diacylglycerol synthase

(Wang and Montell, 2006)

CDP-diacylglycerol synthetase

(Liu et al., 2014, Wu et al., 1995)

CDS-diacylglycerol synthase

(Kwon et al., 2008)

cytidine diphosphate (CDP)-DAG synthase

(Raghu et al., 2009)

diacyl-glycerol-synthetase

(Banerjee et al., 2012)

winded

(Ghabrial et al., 2011, Ghabrial et al., 2005)

Secondary FlyBase IDs

FBgn0035841

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43950

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P56079

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P56079

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JC55

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P56079

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010350

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43950/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010350

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010350

FlyMine - An integrated database for Drosophila genomics

FBgn0010350

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7962

MARRVEL_MODEL - MARRVEL (model organism gene)

43950

Linkouts

BioGRID - A database of protein and genetic interactions.

68739

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010350

DroID - A comprehensive database of gene and protein interactions.

FBgn0010350

DRSC - Results frm RNAi screens

FBgn0010350

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010350

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010350

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7962

Flygut - An atlas of the Drosophila adult midgut

FBgn0010350

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010350

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014743

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

43950

MIST (protein-protein) - An integrated Molecular Interaction Database

43950

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (93)