FlyBase Gene Report: Dmel\Seipin

General Information

Symbol

Dmel\Seipin

Species

D. melanogaster

Name

Seipin

Annotation Symbol

CG9904

Feature Type

protein_coding_gene

FlyBase ID

FBgn0040336

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Seipin (Seipin) encodes a transmembrane protein with roles in ER calcium homeostasis and lipid storage. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

dSeipin, EG:BACR7C10.1

Key Links

Genomic Location

Cytogenetic map

3A7-3A8

Sequence location

X:2,619,799..2,622,140 [+]

Recombination map

1-1

RefSeq locus

NC_004354 REGION:2619799..2622140

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables channel activator activity

inferred from direct assay

(Bi et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (10 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in diacylglycerol metabolic process

inferred from mutant phenotype

(Tian et al., 2011)

involved_in intracellular calcium ion homeostasis

inferred from mutant phenotype

(Bi et al., 2014)

involved_in lipid droplet formation

inferred from mutant phenotype

(Wang et al., 2016)

involved_in phosphatidic acid metabolic process

inferred from mutant phenotype

(Tian et al., 2011)

involved_in positive regulation of axon extension involved in regeneration

inferred from genetic interaction with FLYBASE:Eb1; FB:FBgn0027066

(Rao et al., 2016)

involved_in regulation of lipid biosynthetic process

inferred from mutant phenotype

(Tian et al., 2011)

inferred from genetic interaction with FLYBASE:mdy; FB:FBgn0004797

(Tian et al., 2011)

inferred from genetic interaction with FLYBASE:mino; FB:FBgn0027579

(Tian et al., 2011)

inferred from genetic interaction with FLYBASE:SCAP; FB:FBgn0033052

(Tian et al., 2011)

involved_in regulation of lipid storage

inferred from mutant phenotype

(Tian et al., 2011)

involved_in regulation of triglyceride metabolic process

inferred from mutant phenotype

(Tian et al., 2011)

involved_in response to starvation

inferred from mutant phenotype

(Tian et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in lipid storage

inferred from electronic annotation with InterPro:IPR009617

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from direct assay

(Bi et al., 2014)

located_in endoplasmic reticulum membrane

inferred from direct assay

(Wang et al., 2016)

located_in endoplasmic reticulum

inferred from direct assay

(Tian et al., 2011)

located_in lipid droplet

inferred from direct assay

(Chartschenko et al., 2021)

inferred from direct assay

(Wang et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from biological aspect of ancestor with PANTHER:PTN000476621

(GO Reference Genome Project, 2011-)

located_in endoplasmic reticulum membrane

inferred from experiment

(Tian et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Seipin

Summaries

Gene Snapshot

Seipin (Seipin) encodes a transmembrane protein with roles in ER calcium homeostasis and lipid storage. [Date last reviewed: 2019-03-14]

Protein Function (UniProtKB)

Acts as a tissue-autonomous lipid modulator, preventing ectopic lipid accumulation in salivary gland (a non-adipose tissue) and in promoting lipid storage in fat tissue (PubMed:21533227). Required for the growth and maturation of small nascent lipid droplets (LDs) into larger mature LDs (PubMed:27564575).

(UniProt, Q9V3X4)

Summary (Interactive Fly)

Transmembrane lipid-binding protein - promotes adipose tissue lipid storage via calcium-dependent mitochondrial metabolism

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Seipin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3X4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

6MLU

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Seipin-RA

FBtr0070442

NM_130656

2045

370

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Seipin-PA

FBpp0070426

42.6

370

8.96

Q9V3X4

NP_570012

AAF45798

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Seipin

PDB - An information portal to biological macromolecular structures

6MLU

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9V3X4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Seipin using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Seipin_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.60

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval hindgut

(Tian et al., 2011)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

larval stage

embryonic/larval fat body

(Tian et al., 2011)

embryonic/larval salivary gland

(Tian et al., 2011)

embryonic/larval anterior midgut

(Tian et al., 2011)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval brain

(Tian et al., 2011)

embryonic/larval fat body

(Tian et al., 2011)

embryonic/larval salivary gland

(Tian et al., 2011)

embryonic/larval midgut

(Tian et al., 2011)

larval muscle system

(Tian et al., 2011)

Additional Descriptive Data

Seipin transcripts are detected at the highest levels by qRT-PCR in the larval fat body and at moderate levels in the salivary gland, midgut, and muscle. In situ hybridization reveals strong expression in late embryos in the hindgut as well as expression in larvae in the fat body, salivary gland, and anterior midgut.

(Tian et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from direct assay

(Bi et al., 2014)

located_in endoplasmic reticulum membrane

inferred from direct assay

(Wang et al., 2016)

located_in endoplasmic reticulum

inferred from direct assay

(Tian et al., 2011)

located_in lipid droplet

inferred from direct assay

(Chartschenko et al., 2021)

inferred from direct assay

(Wang et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Seipin in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Seipin

View exonic expression by tissue for Dmel\Seipin

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040336

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31245/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040336

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040336

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040336

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9904

Flygut - An atlas of the Drosophila adult midgut

FBgn0040336

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Seipin

Transgenic constructs containing regulatory region of Seipin

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 13 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | nutrition conditional

Seipin^null

viable

Seipin^null

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Seipin^GD3208

viable, with Scer\GAL4^Mef2.PR

Seipin^GD3208

viable, with Scer\GAL4^pnr-MD237

Seipin^GD3208

viable, with Scer\GAL4^tin.CΔ4

Seipin^GD3208

Sterility

Allele

fertile

Seipin^null

Other Phenotypes

Allele

abnormal size | larval stage, with Scer\GAL4²²¹

Seipin^KK107525

abnormal wound healing | larval stage, with Scer\GAL4²²¹

Seipin^KK107525

decreased cell size | somatic clone

Seipin^null

Phenotype manifest in

Allele

adult fat body | nutrition conditional

Seipin^null

adult fat body | somatic clone

Seipin^null

axon | larval stage, with Scer\GAL4²²¹

Seipin^KK107525

embryonic/larval fat body | nutrition conditional

Seipin^null

fat body

Seipin^null

fat body, with Scer\GAL4^ppl.PP

Seipin^GD3208

larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4²²¹

Seipin^KK107525

lipid droplet

Seipin^null

lipid droplet, with Scer\GAL4^ppl.PP

Seipin^GD3208

lipid droplet | adult stage, with Scer\GAL4^Mhc.PK

Seipin^RNAi.UAS

lipid droplet | ectopic

Seipin^null

lipid droplet | ectopic, with Scer\GAL4^48Y

Seipin^GD3208

lipid droplet | ectopic, with Scer\GAL4^elav.PU

Seipin^GD3208

lipid droplet | ectopic, with Scer\GAL4^ppl.PP

Seipin^GD3208

lipid droplet | somatic clone

Seipin^null

mesothoracic tergotrochanter muscle cell, with Scer\GAL4^Mhc.PK

Seipin^RNAi.UAS

salivary gland

Seipin^null

salivary gland, with Scer\GAL4^48Y

Seipin^GD3208

salivary gland, with Scer\GAL4^elav.PU

Seipin^GD3208

salivary gland, with Scer\GAL4^ppl.PP

Seipin^GD3208

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\BSCL2

12 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Bscl2

10 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Bscl2

11 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\bscl2

6 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\bscl2l

12 of 14

Yes

Drer\bscl2

11 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\seip-1

7 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP003143

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\AT5G16460

7 of 13

Yes

Atha\AT1G29760

6 of 13

Yes

Atha\AT2G34380

6 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC3A11.04

9 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Seipin. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Seipin^null

model of congenital generalized lipodystrophy

CEA

(Bi et al., 2014, Tian et al., 2011)

Seipin^GD3208

model of congenital generalized lipodystrophy

CEA

(Bi et al., 2014)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

BSCL2; BSCL2 lipid droplet biogenesis associated, seipin

model of autosomal dominant distal hereditary motor neuronopathy 13

IEA

(FlyBase, 2019-)

model of congenital generalized lipodystrophy type 2

IEA

(FlyBase, 2019-)

model of hereditary spastic paraplegia 17

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Seipin^null

model of congenital generalized lipodystrophy

is ameliorated by mdy^QX25

(Tian et al., 2011)

is ameliorated by Pcyt1¹⁶⁹¹⁹

(Tian et al., 2011)

is ameliorated by Cds^EY08412

(Tian et al., 2011)

is exacerbated by mdy^QX25

(Tian et al., 2011)

is exacerbated by Cds¹

(Tian et al., 2011)

is exacerbated by mdy^EY07280

(Tian et al., 2011)

is ameliorated by SCAP^EY06708

(Tian et al., 2011)

is ameliorated by Lpin^GD14004

(Tian et al., 2011)

is exacerbated by mino^EY00734

(Tian et al., 2011)

is exacerbated by Cds^NIG.7962R

(Tian et al., 2011)

is ameliorated by mdy^EY07280

(Tian et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BSCL2; BSCL2 lipid droplet biogenesis associated, seipin

12 of 14

BSCL2 GENE; BSCL2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Seipin

Hsap\BSCL2

(Tian et al., 2011)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Seipin

anti tag coimmunoprecipitation, anti tag western blot, electron microscopy

(Sui et al., 2018, Bi et al., 2014)

Seipin - Ldaf1

split luciferase complementation

(Chartschenko et al., 2021)

Seipin - Lsp1α

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Seipin - Lsp1β

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Seipin - Lsp1γ

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Seipin - SERCA

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(Bi et al., 2014)

Seipin - Tkt

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Seipin - Use1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Seipin - apolpp

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Seipin - insv

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Seipin - regucalcin

anti tag coimmunoprecipitation, peptide massfingerprinting

(Bi et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Seipin

enhanceable

Cds

(Tian et al., 2011)

Seipin

suppressible

Cds

(Tian et al., 2011)

Seipin

suppressible

Lpin

(Tian et al., 2011)

Seipin

suppressible

mdy

(Tian et al., 2011)

Seipin

enhanceable

mdy

(Tian et al., 2011)

Seipin

enhanceable

mino

(Tian et al., 2011)

suppressible

(Bi et al., 2014)

suppressible

(Tian et al., 2011)

suppressible

(Bi et al., 2014)

enhanceable

(Bi et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cds

enhanceable

Seipin

(Tian et al., 2011)

mdy

enhanceable

Seipin

(Tian et al., 2011)

SERCA

enhanceable

Seipin

(Bi et al., 2014)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0040336

MIST (genetic) - An integrated Molecular Interaction Database

31245

MIST (protein-protein) - An integrated Molecular Interaction Database

31245

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-1

Cytogenetic map

3A7-3A8

Sequence location

X:2,619,799..2,622,140 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3A7-3A8

Limits computationally determined from genome sequence between P{EP}egh^EP804 and P{EP}sgg^EP1576

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-1

(FlyBase, 2016)

1-1.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

95024

y¹ TI{CRIMIC.TG4.2}Seipin^{CR70292-TG4.2} w^*/FM7h

37501

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01643}attP40

NIG-Fly

9904R-2

P{NIG.9904R}2

HMJ22700

y¹ v¹; P{TRiP.HMJ22700}attP40/CyO

VDRC

v104326

P{KK107525}VIE-260B

v45478

w¹¹¹⁸; P{GD3208}v45478

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD04409

Other clones

DPiM_SD04409

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0040336

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0040336

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2R+ : A stable cell line overexpressing eGFP-GPAT4 was created. Seipin knock-in and knock-out cell lines were created.
(Song et al., 2022)

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: EG:BACR7C10.1 CG9904

(FlyBase, 1996-)

Additional comments

Source for merge of EG:BACR7C10.1 CG9904 was sequence comparison ( date:000425 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Seipin CG9904

(Tian et al., 2011)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG9904

(National Institute of Genetics Fly Stocks, 2023-, Krahmer et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2011.7.19, Tian et al., 2011, Keleman et al., 2009.8.5)

EG:BACR7C10.1

(Inlow and Restifo, 2004, Benos et al., 2001, Benos, 2000.2.6)

Seipin

(Vesala et al., 2024, Jacquemyn et al., 2021, Gene Disruption Project members, 2018-, Bussmann and Storkebaum, 2017, Rao et al., 2016, Shiao et al., 2015, Bi et al., 2014, Krahmer et al., 2013)

dSeipin

(Ding et al., 2018, Pagac et al., 2016, Bi et al., 2014, Lee et al., 2013)

dmSeipin

(Kolkhof et al., 2017)

seipin

(Toprak, 2026, Song et al., 2022, Wat et al., 2020, Sui et al., 2018)

Name Synonyms

Seipin

(Chartschenko et al., 2021, Hasygar et al., 2021, Toprak et al., 2020)

dSeipin

(Musselman and Kühnlein, 2018, Lee et al., 2013, Tian et al., 2011)

Secondary FlyBase IDs

FBgn0029631

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31245

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3X4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3X4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3X4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040336

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31245/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040336

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040336

FlyMine - An integrated database for Drosophila genomics

FBgn0040336

InterPro - A database of protein families, domains and functional sites

Seipin

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9904

MARRVEL_MODEL - MARRVEL (model organism gene)

31245

PDB - An information portal to biological macromolecular structures

6MLU

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0040336

DroID - A comprehensive database of gene and protein interactions.

FBgn0040336

DRSC - Results frm RNAi screens

FBgn0040336

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Seipin_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040336

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0040336

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9904

Flygut - An atlas of the Drosophila adult midgut

FBgn0040336

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010317

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

31245

MIST (protein-protein) - An integrated Molecular Interaction Database

31245

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

-0.60

Report Sections