FlyBase Gene Report: Dmel\CtsL1

(Fisher et al., 2012)

embryonic stage 4 -- 6

(Fisher et al., 2012)

embryonic stage 7 -- 8

ventral nerve cord primordium

(Fisher et al., 2012)

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

garland cell primordium

(Fisher et al., 2012)

ventral sensory complex anlage

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 13 -- 16

apoptotic amnioserosa

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 13 -- 17

larval glial cell

(Kerr et al., 2014)

embryonic stage 15

embryonic/larval midgut primordium

(Matsumoto et al., 1995)

larval ventral nerve cord

(Matsumoto et al., 1995)

embryonic stage 15 -- 16

embryonic/larval garland cell

(Matsumoto et al., 1995)

embryonic stage 16

gastric caecum

(Matsumoto et al., 1995)

embryonic/larval anterior midgut

(Matsumoto et al., 1995)

embryonic/larval middle midgut

(Matsumoto et al., 1995)

embryonic/larval posterior midgut

(Matsumoto et al., 1995)

third instar larval stage

embryonic/larval anterior midgut

(Matsumoto et al., 1995)

embryonic/larval salivary gland

(Matsumoto et al., 1995)

embryonic/larval garland cell

(Matsumoto et al., 1995)

embryonic/larval plasmatocyte

(Matsumoto et al., 1995)

Additional Descriptive Data

CtsL1 transcript is expressed in most glial cells from embryonic stage 13.

(Kerr et al., 2014)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain cell body glial cell

ommatidium

• cell body

(Kinser and Dolph, 2012)

(Lee et al., 2019)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult head

• membrane

(Aradska et al., 2015)

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

organism

(Rahman et al., 2012)

Additional Descriptive Data

CtsL1 protein is detected in the cell body in ommatidium cells, in 8 distinct puncta. In retinas that are exposed to light, CtsL1 protein colocalises with ninaE in the cell body.

(Kinser and Dolph, 2012)

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in autolysosome

inferred from mutant phenotype

(Xu et al., 2021)

located_in fusome

inferred from direct assay

(Lighthouse et al., 2008)

located_in late endosome

inferred from direct assay

(Xu et al., 2021)

located_in lysosome

inferred from direct assay

(Xu et al., 2021, Kowalewski-Nimmerfall et al., 2014)

Expression Deduced from Reporters

Reporter: P{GawB}CtsL1^NP7036

Stage

Tissue/Position (including subcellular localization)

Reference

adult fruitless aSP4 (male) neuron

(Yu et al., 2010)

neuron | subset of adult ventral nerve cord

(Yu et al., 2010)

Reporter: P{PTT-GC}CtsL1^CC01377

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

air sac primordium

(Dong et al., 2015)

adult stage | female

germarium

• fusome

(Lighthouse et al., 2008)

oogenesis & adult stage | female

female germline cell

(Neumüller et al., 2012)

fusome

(Neumüller et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CtsL1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CtsL1

View exonic expression by tissue for Dmel\CtsL1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013770

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36546/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013770

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013770

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013770

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6692

Flygut - An atlas of the Drosophila adult midgut

FBgn0013770

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 32 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CtsL1

Transgenic constructs containing regulatory region of CtsL1

Aberrations (Deficiencies and Duplications) ( 26 )

Inferred from experimentation ( 26 )

Gene disrupted in

Df(2R)50C-16

(Preston et al., 1996)

Df(2R)50C-21

(Preston et al., 1996)

Df(2R)50C-36

(Preston et al., 1996)

Df(2R)50C-38

(Preston et al., 1996)

Df(2R)50C-40

(Preston et al., 1996)

Df(2R)50C-43

(Preston et al., 1996)

Df(2R)50C-45

(Preston et al., 1996)

Df(2R)50C-49

(Preston et al., 1996)

Df(2R)50C-68

(Preston et al., 1996)

Df(2R)50C-69

(Preston et al., 1996)

Df(2R)50C-71

(Preston et al., 1996)

Df(2R)50C-81

(Preston et al., 1996)

Df(2R)50C-85

(Preston et al., 1996)

Df(2R)50C-89

(Preston et al., 1996)

Df(2R)50C-101

(Preston et al., 1996)

Df(2R)50C-102

(Preston et al., 1996)

Df(2R)50C-107

(Preston et al., 1996)

Df(2R)50C-111

(Preston et al., 1996)

Df(2R)50C-116

(Preston et al., 1996)

Df(2R)50C-128

(Preston et al., 1996)

Df(2R)50C-129

(Preston et al., 1996)

Df(2R)50C-131

(Preston et al., 1996)

Df(2R)50C-132

(Preston et al., 1996)

Df(2R)50C-133

(Preston et al., 1996)

Df(2R)Exel7129

(Ryder, 2004.4.26)

Df(2R)mam⁰⁴⁶¹⁵

(Preston et al., 1996)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CtsL1^GD5803

viable, with Scer\GAL4^Mef2.PR

CtsL1^GD5803

viable, with Scer\GAL4^pnr-MD237

CtsL1^GD5803

viable, with Scer\GAL4^tin.CΔ4

CtsL1^GD5803

Sterility

Allele

female sterile | recessive

fertile

CtsL1^Wee-P118

male fertile

CtsL1^unspecified

Other Phenotypes

Allele

abnormal body color | recessive

CtsL1^unspecified

abnormal cell number | embryonic stage, with Scer\GAL4^{VP16.nanos.UTR}

CtsL1^HMS02336

chemical resistant | adult stage, with Scer\GAL4^NP2222

CtsL1^GD5803

chemical resistant | adult stage, with Scer\GAL4^repo

CtsL1^GD5803

chemical sensitive | adult stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

chemical sensitive | adult stage, with Scer\GAL4^NP2222

chemical sensitive | adult stage, with Scer\GAL4^repo

chemical sensitive | adult stage | RU486 conditional, with Scer\GAL4^GSG7293-1

decreased cell death | oogenesis stage S13, with Scer\GAL4^GR1

CtsL1^HMS00725

increased cell death, with Avic\GFP^{RNAi.UAS.V22.1}, Scer\GAL4^{VP16.nanos.UTR}

CtsL1^CC01377

non-suppressor of variegation | dominant, with In(1)w^m4

CtsL1^llcnbw38

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

CtsL1^llcnbw38

visible | recessive

Phenotype manifest in

Allele

adult abdominal segment 1

CtsL1^unspecified

adult abdominal segment 2

CtsL1^unspecified

adult abdominal segment 3

CtsL1^unspecified

adult abdominal segment 4

CtsL1^unspecified

adult abdominal segment 5

CtsL1^unspecified

air sac primordium | third instar larval stage, with Scer\GAL4^btl.PS

CtsL1^RNAi.UAS.cUa

dorsal appendage | oogenesis stage S14, with Scer\GAL4^GR1

CtsL1^HMS00725

egg

CtsL1^unspecified

female germline cell, with Avic\GFP^{RNAi.UAS.V22.1}, Scer\GAL4^{VP16.nanos.UTR}

CtsL1^CC01377

female germline cell, with Avic\GFP^{RNAi.UAS.V22.2}, Scer\GAL4^{VP16.nanos.UTR}

CtsL1^CC01377

filopodium | third instar larval stage, with Scer\GAL4^btl.PS

CtsL1^RNAi.UAS.cUa

nurse cell | oogenesis stage S13, with Scer\GAL4^GR1

CtsL1^HMS00725

nurse cell | oogenesis stage S14 | increased number, with Scer\GAL4^GR1

CtsL1^HMS00725

primordial germ cell | embryonic stage, with Scer\GAL4^{VP16.nanos.UTR}

CtsL1^HMS02336

wing

CtsL1^unspecified

wing blade, with Scer\GAL4^nub.PU

CtsL1^RNAi.UAS.cUa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

Hsap\CTSL

12 of 14

Yes

Hsap\CTSV

12 of 14

Yes

Hsap\CTSK

8 of 14

Yes

Hsap\CTSS

8 of 14

Yes

Hsap\CTSH

6 of 14

Yes

Hsap\CTSF

4 of 14

Hsap\CTSB

3 of 14

Hsap\CTSC

3 of 14

Yes

Hsap\CTSO

3 of 14

Yes

Hsap\CTSZ

3 of 14

Yes

Hsap\CTSL3P

2 of 14

Yes

Hsap\CTSW

2 of 14

Hsap\TINAG

1 of 14

Hsap\TINAGL1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (29)

Rnor\Ctsl

13 of 14

Yes

Rnor\Ctsll3

12 of 14

Yes

Rnor\RGD1308751

12 of 14

Yes

Rnor\Cts8

10 of 14

Yes

Rnor\Ctsr

10 of 14

Yes

Rnor\Testin

10 of 14

Yes

Rnor\Ctsj

9 of 14

Yes

Rnor\Ctsm

9 of 14

Yes

Rnor\MGC114246

9 of 14

Yes

Rnor\RGD1564827

9 of 14

Yes

Rnor\Cts7

8 of 14

Yes

Rnor\Ctsk

8 of 14

Yes

Rnor\Ctsql2

8 of 14

Yes

Rnor\Ctsq

8 of 14

Yes

Rnor\Ctss

7 of 14

Yes

Rnor\LOC100364523

7 of 14

Yes

Rnor\RGD1564657

7 of 14

Yes

Rnor\Ctsh

6 of 14

Yes

Rnor\Ctsf

4 of 14

Rnor\Ctsb

3 of 14

Rnor\Ctsc

3 of 14

Yes

Rnor\Ctsz

3 of 14

Yes

Rnor\Ctla2a

2 of 14

Rnor\Ctsw

2 of 14

Rnor\Tpbpa

2 of 14

Yes

Rnor\Cts8l1

1 of 14

Yes

Rnor\Ctso

1 of 14

Yes

Rnor\Tinagl1

1 of 14

Rnor\Tinag

1 of 14

Mus musculus (laboratory mouse) (26)

Mmus\Ctsl

13 of 14

Yes

Mmus\BC051665

12 of 14

Yes

Mmus\Ctsll3

12 of 14

Yes

Mmus\4930486L24Rik

10 of 14

Yes

Mmus\Cts8

10 of 14

Yes

Mmus\Cts6

9 of 14

Yes

Mmus\Ctsj

8 of 14

Yes

Mmus\Ctsk

8 of 14

Yes

Mmus\Ctsm

8 of 14

Yes

Mmus\Ctsr

8 of 14

Yes

Mmus\Ctss

8 of 14

Yes

Mmus\Cts7

7 of 14

Yes

Mmus\Ctsq

7 of 14

Yes

Mmus\Cts3

6 of 14

Yes

Mmus\Ctsh

6 of 14

Yes

Mmus\Ctsf

4 of 14

Mmus\Ctsb

3 of 14

Mmus\Ctsc

3 of 14

Yes

Mmus\Ctso

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Tinagl1

1 of 14

Mmus\Tinag

1 of 14

Mmus\Tpbpb

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (28)

Xtro\ctsv

8 of 13

Yes

Xtro\ctss

6 of 13

Yes

Xtro\LOC594890

6 of 13

Yes

Xtro\LOC105948322

6 of 13

Yes

Xtro\psmb11

6 of 13

Yes

Xtro\XB986811

5 of 13

Yes

Xtro\ctsh

4 of 13

Yes

Xtro\ctsl

4 of 13

Yes

Xtro\LOC100124852

4 of 13

Yes

Xtro\LOC448216

3 of 13

Yes

Xtro\ctsc

2 of 13

Yes

Xtro\LOC100496172

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ctss.2

1 of 13

Yes

Xtro\ctsw

1 of 13

Xtro\ctsz

1 of 13

Yes

Xtro\cyp4f2

1 of 13

Yes

Xtro\LOC100492634

1 of 13

Yes

Xtro\LOC100494325

1 of 13

Yes

Xtro\LOC100498084

1 of 13

Yes

Xtro\LOC105945585

1 of 13

Yes

Xtro\rapgef2

1 of 13

Xtro\srgap2

1 of 13

Yes

Xtro\tspan1

1 of 13

Xtro\XB5914295

1 of 13

Yes

Danio rerio (Zebrafish) (36)

Drer\ctsla

11 of 14

Yes

Drer\ctslb

11 of 14

Yes

Drer\ctsll

11 of 14

Yes

Drer\si:dkey-239j18.3

11 of 14

Yes

Drer\si:dkey-269i1.4

11 of 14

Yes

Drer\zgc:174153

11 of 14

Yes

Drer\zgc:174154

11 of 14

Yes

Drer\si:dkey-239j18.2

10 of 14

Yes

Drer\zgc:174855

10 of 14

Yes

Drer\cts12

8 of 14

Yes

Drer\ctsk

8 of 14

Yes

Drer\ctsl.1

8 of 14

Yes

Drer\ctss2.1

8 of 14

Yes

Drer\ctss2.2

8 of 14

Yes

Drer\ctss1

7 of 14

Yes

Drer\ctsh

6 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\si:dkey-26g8.5

3 of 14

Yes

Drer\si:dkey-228a15.1

3 of 14

Drer\zgc:103438

3 of 14

Drer\ctsbb

2 of 14

Drer\ctsc

2 of 14

Yes

Drer\LOC100332358

2 of 14

Drer\LOC100333521

2 of 14

Yes

Drer\MGC174155

2 of 14

Yes

Drer\si:dkey-26g8.4

2 of 14

Yes

Drer\wu:fa26c03

2 of 14

Yes

Drer\zgc:123103

2 of 14

Drer\LOC100536033

1 of 14

Yes

Drer\si:dkey-183k8.2

1 of 14

Drer\si:dkey-267n13.1

1 of 14

Drer\tinagl1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\cpl-1

12 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\F15D4.4

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP011828

12 of 12

Yes

4 of 12

4 of 12

3 of 12

3 of 12

Yes

Agam\AgaP_AGAP003875

3 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

Yes

Agam\AgaP_AGAP002879

2 of 12

Agam\AgaP_AGAP007684

1 of 12

Arabidopsis thaliana (thale-cress) (38)

Atha\AT3G19390

13 of 13

Yes

Atha\AT3G19400

12 of 13

Yes

Atha\RD21A

12 of 13

Yes

Atha\RD21B

12 of 13

Yes

Atha\AT3G43960

11 of 13

Yes

Atha\CEP1

11 of 13

Yes

Atha\CEP2

11 of 13

Yes

Atha\CEP3

11 of 13

Yes

Atha\SAG12

11 of 13

Yes

Atha\XCP1

11 of 13

Yes

Atha\XCP2

11 of 13

Yes

Atha\AT1G06260

10 of 13

Yes

Atha\AT4G11310

10 of 13

Yes

Atha\CP1

10 of 13

Yes

Atha\XBCP3

10 of 13

Yes

Atha\AT2G27420

9 of 13

Yes

Atha\AT3G49340

9 of 13

Yes

Atha\AT4G11320

9 of 13

Yes

Atha\AT4G23520

9 of 13

Yes

Atha\AT2G34080

7 of 13

Yes

Atha\AT1G29080

6 of 13

Yes

Atha\AT1G29090

6 of 13

Yes

Atha\AT1G29110

5 of 13

Yes

Atha\ALP

4 of 13

Yes

Atha\AT2G21430

4 of 13

Atha\AT2G22160

4 of 13

Yes

Atha\AT3G45310

4 of 13

Yes

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

Yes

Atha\AT4G01610

3 of 13

Atha\AT5G17080

2 of 13

Yes

Atha\AT5G17140

2 of 13

Yes

Atha\AT5G05050

1 of 13

Yes

Atha\AT5G17130

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CtsL1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (15)

6 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

cer

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Cys

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

alcohol, response to, cathepsin-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

CtsL1^HMS00725

model of alcohol use disorder

CEA

(Lee et al., 2019)

CtsL1^KK107765

model of alcohol use disorder

CEA

(Lee et al., 2019)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

CTSK; cathepsin K

model of pycnodysostosis

IEA

(FlyBase, 2019-)

CTSC; cathepsin C

model of aggressive periodontitis

IEA

(FlyBase, 2019-)

model of Papillon-Lefevre disease

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

CtsL1^HMS00725

model of alcohol use disorder

is ameliorated by Dpse\GA25021^UAS.cLa

(Lee et al., 2019)

CtsL1^EY05806

exacerbates retinal degeneration

modeled by norpA^EE5

(Kinser and Dolph, 2012)

CtsL1^llcnbw38

ameliorates retinal degeneration

modeled by norpA^EE5

(Kinser and Dolph, 2012)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

12 of 14

12 of 14

8 of 14

PYCNODYSOSTOSIS

pycnodysostosis

8 of 14

6 of 14

4 of 14

CEROID LIPOFUSCINOSIS, NEURONAL, 13 (KUFS TYPE); CLN13

neuronal ceroid lipofuscinosis 13

CTSB; cathepsin B

3 of 14

116810

KERATOLYTIC WINTER ERYTHEMA; KWE

3 of 14

3 of 14

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CtsL1 - Arf1

(Guruharsha et al., 2011)

CtsL1 - CG5854

(Guruharsha et al., 2011)

CtsL1 - Cnx99A

(Guruharsha et al., 2011)

CtsL1 - CtsF

(Guruharsha et al., 2011)

CtsL1 - Droj2

(Guruharsha et al., 2011)

CtsL1 - Gfat2

(Guruharsha et al., 2011)

CtsL1 - Gp93

(Guruharsha et al., 2011)

CtsL1 - Hel25E

(Guruharsha et al., 2011)

CtsL1 - Mcad

(Guruharsha et al., 2011)

CtsL1 - Nfs1

(Guruharsha et al., 2011)

CtsL1 - Ost1

(Guruharsha et al., 2011)

CtsL1 - Pcb

(Guruharsha et al., 2011)

CtsL1 - Rab5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011)

CtsL1 - Raf

(Friedman et al., 2011)

CtsL1 - RpS10b

(Guruharsha et al., 2011)

CtsL1 - SERCA

(Guruharsha et al., 2011)

CtsL1 - ScsβA

(Guruharsha et al., 2011)

CtsL1 - ScsβG

(Guruharsha et al., 2011)

CtsL1 - SsRβ

(Guruharsha et al., 2011)

CtsL1 - Tapδ

(Guruharsha et al., 2011)

CtsL1 - cathD

enzymatic study, fluorescence technology

(Guruharsha et al., 2011)

CtsL1 - cer

(Tseng et al., 2012)

CtsL1 - mEFTu1