FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Wdr24
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General Information
Symbol
Dmel\Wdr24
Species
D. melanogaster
Name
WD repeat domain 24
Annotation Symbol
CG7609
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027518
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
WD repeat domain 24 (Wdr24) encodes a component of the GATOR2 complex that promotes activation of the Crtc product and anabolic metabolism. It localizes to lysosomes and autolysosomes and regulates lysosome function independent of the activity of the Crtc product. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
99B9-99B10
Sequence location
Recombination map
3-99
RefSeq locus
NT_033777 REGION:29741972..29745092
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from mutant phenotype
(Bar-Peled et al., 2013)
involved_in lysosomal lumen acidification
inferred from mutant phenotype
(Cai et al., 2016)
involved_in positive regulation of cell growth
inferred from mutant phenotype
(Cai et al., 2016)
involved_in positive regulation of macroautophagy
inferred from mutant phenotype
(Cai et al., 2016)
inferred from genetic interaction with FLYBASE:Nprl3; FB:FBgn0036397
(Cai et al., 2016)
involved_in positive regulation of TOR signaling
inferred from mutant phenotype
(Bar-Peled et al., 2013)
involved_in positive regulation of TORC1 signaling
inferred from mutant phenotype
(Cai et al., 2016)
involved_in regulation of autophagy
inferred from mutant phenotype
(Cai et al., 2016)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from biological aspect of ancestor with PANTHER:PTN002920831
(GO Reference Genome Project, 2011-)
involved_in positive regulation of macroautophagy
inferred from biological aspect of ancestor with PANTHER:PTN001872860
(GO Reference Genome Project, 2011-)
involved_in positive regulation of TOR signaling
inferred from electronic annotation with InterPro:IPR037590
(InterPro Project Members, 2004-)
involved_in positive regulation of TORC1 signaling
inferred from biological aspect of ancestor with PANTHER:PTN001872860
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Cai et al., 2016)
located_in lysosome
inferred from direct assay
(Cai et al., 2016)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of GATOR2 complex
traceable author statement
(Cai et al., 2016)
inferred from biological aspect of ancestor with PANTHER:PTN001872860
(GO Reference Genome Project, 2011-)
part_of Seh1-associated complex
inferred from sequence or structural similarity with SGD:S000005498
(Dokudovskaya et al., 2011)
is_active_in vacuolar membrane
inferred from biological aspect of ancestor with PANTHER:PTN001872860
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the WD repeat WDR24 family. (Q9XZ25)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
WD repeat domain 24 (Wdr24) encodes a component of the GATOR2 complex that promotes activation of the Crtc product and anabolic metabolism. It localizes to lysosomes and autolysosomes and regulates lysosome function independent of the activity of the Crtc product. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
GATOR2 COMPLEX -
GATOR2 is a subcomplex of the GATOR or SEA complex. It suppresses the Rag GTPase activating protein activity of the GATOR1 subcomplex, promoting TORC1 activity. (Adapted from FBrf0232362 and PMID:25934700).
Protein Function (UniProtKB)
An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27166823). GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:23723238, PubMed:27166823). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (By similarity). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of components of the GATOR1 complex, leading to GATOR1 inactivation (By similarity). This GATOR2 component is required for activating mTORC1 and promoting cell growth in both germline and somatic cells (PubMed:23723238, PubMed:27166823). In addition to its role in regulation of the mTORC1 complex, functions independently of mTORC1 to promote the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
(UniProt, Q9XZ25)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Wdr24 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9XZ25)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Wdr24-RB
FBtr0085543
NM_143463
2699
776
Wdr24-RC
FBtr0330297
NM_170424
2702
777
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Wdr24-PB
FBpp0084909
87.1
776
7.59
Q9XZ25
NP_651720
AAN14184
Wdr24-PC
FBpp0303329
87.2
777
7.59
Q86BR7
NP_733303
AAF56930
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13. Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with Nup44A/Seh1 (PubMed:27166823). Interacts with mio (PubMed:27166823). Interacts with Nplr3 (PubMed:27166823). The GATOR2 complex associates with unmet in the absence of S-adenosyl-L-methionine; the mio-Wdr24-Nup44A subcomplex is essential and sufficient for this interaction while Wdr59 and Sec13 are dispensable (PubMed:38514639). This association acts as a nutrient sensor to inhibit mTORC1 signaling in the absence of methionine (PubMed:38514639).

(UniProt, Q9XZ25)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Wdr24 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Cai et al., 2016)
located_in lysosome
inferred from direct assay
(Cai et al., 2016)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Wdr24 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Wdr24
Transgenic constructs containing regulatory region of Wdr24
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (49)
Hsap\WDR24
14 of 14
Yes
Yes
Hsap\WDR59
2 of 14
No
No
Hsap\ATG16L1
1 of 14
No
No
Hsap\BTRC
1 of 14
No
No
1  
Hsap\CIAO1
1 of 14
No
No
Hsap\COP1
1 of 14
No
Yes
Hsap\CORO1B
1 of 14
No
No
Hsap\CORO1C
1 of 14
No
No
Hsap\CSTF1
1 of 14
No
No
Hsap\DAW1
1 of 14
No
No
Hsap\DCAF7
1 of 14
No
No
1  
Hsap\DDB2
1 of 14
No
Yes
Hsap\DNAI1
1 of 14
No
No
Hsap\DNAI2
1 of 14
No
No
Hsap\DNAI3
1 of 14
No
No
Hsap\DNAI4
1 of 14
No
No
Hsap\DPH7
1 of 14
No
No
Hsap\DYNC1I1
1 of 14
No
No
2  
Hsap\DYNC1I2
1 of 14
No
No
2  
Hsap\DYNC2I2
1 of 14
No
No
Hsap\EML4
1 of 14
No
No
Hsap\GNB4
1 of 14
No
No
Hsap\GRWD1
1 of 14
No
No
Hsap\NLE1
1 of 14
No
No
Hsap\NUP43
1 of 14
No
No
Hsap\PAFAH1B1
1 of 14
No
No
1  
Hsap\PEX7
1 of 14
No
No
Hsap\POC1A
1 of 14
No
No
1  
Hsap\POC1B
1 of 14
No
No
1  
Hsap\PRPF4
1 of 14
No
No
Hsap\PWP1
1 of 14
No
No
1  
Hsap\RBBP4
1 of 14
No
No
2  
Hsap\RBBP7
1 of 14
No
No
4  
Hsap\SEC31A
1 of 14
No
No
Hsap\SEC31B
1 of 14
No
No
Hsap\SNRNP40
1 of 14
No
No
Hsap\TAF5
1 of 14
No
No
Hsap\TAF5L
1 of 14
No
No
Hsap\TBL1X
1 of 14
No
No
1  
Hsap\TBL1Y
1 of 14
No
No
1  
Hsap\TBL3
1 of 14
No
No
Hsap\THOC3
1 of 14
No
No
Hsap\WDR1
1 of 14
No
No
Hsap\WDR5
1 of 14
No
No
11  
Hsap\WDR12
1 of 14
No
No
Hsap\WDR17
1 of 14
No
No
Hsap\WDR77
1 of 14
No
No
Hsap\WDR83
1 of 14
No
No
Hsap\WDR89
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (40)
Rnor\Wdr24
14 of 14
Yes
Yes
Rnor\Wdr59
2 of 14
No
No
Rnor\Apaf1
1 of 14
No
No
Rnor\Atg16l1
1 of 14
No
No
Rnor\Btrc
1 of 14
No
No
Rnor\Ciao1
1 of 14
No
No
Rnor\Copa
1 of 14
No
No
Rnor\Cstf1
1 of 14
No
No
Rnor\Dcaf7
1 of 14
No
No
Rnor\Ddb2
1 of 14
No
Yes
Rnor\Dnai1
1 of 14
No
No
Rnor\Dnai2
1 of 14
No
No
Rnor\Dnai3
1 of 14
No
No
Rnor\Dnai4
1 of 14
No
No
Rnor\Dph7
1 of 14
No
No
Rnor\Dync1i1
1 of 14
No
No
Rnor\Dync1i2
1 of 14
No
No
Rnor\Dync2i2
1 of 14
No
No
Rnor\Eipr1
1 of 14
No
No
Rnor\Nedd1
1 of 14
No
No
Rnor\Nle1
1 of 14
No
No
Rnor\Nup43
1 of 14
No
No
Rnor\Pafah1b1
1 of 14
No
No
Rnor\Pex7
1 of 14
No
No
Rnor\Poc1a
1 of 14
No
No
Rnor\Poc1b
1 of 14
No
No
Rnor\Prpf4
1 of 14
No
No
Rnor\Pwp1
1 of 14
No
No
Rnor\Rbbp4
1 of 14
No
No
Rnor\RGD1563620
1 of 14
No
No
Rnor\Sec31a
1 of 14
No
No
Rnor\Taf5l
1 of 14
No
No
Rnor\Taf5
1 of 14
No
No
Rnor\Thoc3
1 of 14
No
No
Rnor\Wdr1
1 of 14
No
No
Rnor\Wdr5
1 of 14
No
No
Rnor\Wdr17
1 of 14
No
No
Rnor\Wdr77
1 of 14
No
No
Rnor\Wdr83
1 of 14
No
No
Rnor\Wdr89
1 of 14
No
No
Mus musculus (laboratory mouse) (36)
Mmus\Wdr24
14 of 14
Yes
Yes
Mmus\Atg16l1
1 of 14
No
No
Mmus\Btrc
1 of 14
No
No
Mmus\Ciao1
1 of 14
No
No
Mmus\Copa
1 of 14
No
No
Mmus\Coro1b
1 of 14
No
No
Mmus\Cstf1
1 of 14
No
No
Mmus\Dcaf7
1 of 14
No
No
Mmus\Ddb2
1 of 14
No
Yes
Mmus\Dnai1
1 of 14
No
No
Mmus\Dnai2
1 of 14
No
No
Mmus\Dnai3
1 of 14
No
No
Mmus\Dnai4
1 of 14
No
No
Mmus\Dph7
1 of 14
No
No
Mmus\Dync1i1
1 of 14
No
No
Mmus\Dync1i2
1 of 14
No
No
Mmus\Dync2i2
1 of 14
No
No
Mmus\Eipr1
1 of 14
No
No
Mmus\Nle1
1 of 14
No
No
Mmus\Nup43
1 of 14
No
No
Mmus\Pafah1b1
1 of 14
No
No
Mmus\Pex7
1 of 14
No
No
Mmus\Poc1a
1 of 14
No
No
Mmus\Prpf4
1 of 14
No
No
Mmus\Pwp1
1 of 14
No
No
Mmus\Rbbp4
1 of 14
No
No
Mmus\Sec31a
1 of 14
No
No
Mmus\Taf5l
1 of 14
No
No
Mmus\Thoc3
1 of 14
No
No
Mmus\Wdr1
1 of 14
No
No
Mmus\Wdr5b
1 of 14
No
No
Mmus\Wdr5
1 of 14
No
No
Mmus\Wdr59
1 of 14
No
No
Mmus\Wdr77
1 of 14
No
No
Mmus\Wdr83
1 of 14
No
No
Mmus\Wdr89
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (28)
Xtro\wdr24
7 of 13
Yes
Yes
Xtro\wdr59
2 of 13
No
No
Xtro\apaf1
1 of 13
No
No
Xtro\atg16l1
1 of 13
No
No
Xtro\copa
1 of 13
No
No
Xtro\coro1c
1 of 13
No
No
Xtro\coro7
1 of 13
No
No
Xtro\cstf1
1 of 13
No
No
Xtro\dcaf7
1 of 13
No
No
Xtro\ddb2
1 of 13
No
Yes
Xtro\dnai4
1 of 13
No
No
Xtro\dtl
1 of 13
No
No
Xtro\dync2i2
1 of 13
No
No
Xtro\eipr1
1 of 13
No
No
Xtro\grwd1
1 of 13
No
No
Xtro\katnb1
1 of 13
No
No
Xtro\nup43
1 of 13
No
No
Xtro\pafah1b1
1 of 13
No
No
Xtro\pwp1
1 of 13
No
No
Xtro\rbbp4
1 of 13
No
No
Xtro\rbbp7
1 of 13
No
No
Xtro\sec31a
1 of 13
No
No
Xtro\slc39a2
1 of 13
No
No
Xtro\snrnp40
1 of 13
No
No
Xtro\taf5l
1 of 13
No
No
Xtro\wdr5
1 of 13
No
No
Xtro\wdr77
1 of 13
No
No
Xtro\wdsub1
1 of 13
No
Yes
Danio rerio (Zebrafish) (40)
Drer\wdr24
14 of 14
Yes
Yes
Drer\wdr59
2 of 14
No
No
Drer\copa
1 of 14
No
No
Drer\cstf1
1 of 14
No
No
Drer\dcaf7
1 of 14
No
No
Drer\dnai1.1
1 of 14
No
No
Drer\dnai1.2
1 of 14
No
No
Drer\dnai2a
1 of 14
No
No
Drer\dnai2b
1 of 14
No
No
Drer\dnai3
1 of 14
No
No
Drer\dnai4
1 of 14
No
No
Drer\dph7
1 of 14
No
No
Drer\dtl
1 of 14
No
No
Drer\dync1i1
1 of 14
No
No
Drer\dync1i2a
1 of 14
No
No
Drer\dync1i2b
1 of 14
No
No
Drer\dync2i2
1 of 14
No
No
Drer\grwd1
1 of 14
No
No
Drer\nedd1
1 of 14
No
No
Drer\nup43
1 of 14
No
No
Drer\pafah1b1a
1 of 14
No
No
Drer\pafah1b1b
1 of 14
No
No
Drer\pex7
1 of 14
No
No
Drer\poc1a
1 of 14
No
No
Drer\poc1b
1 of 14
No
No
Drer\prpf4
1 of 14
No
No
Drer\prpf19
1 of 14
No
No
Drer\pwp1
1 of 14
No
No
Drer\rbb4l
1 of 14
No
No
Drer\rbbp4
1 of 14
No
No
Drer\sec13
1 of 14
No
No
Drer\sec31a
1 of 14
No
No
Drer\sec31b
1 of 14
No
No
Drer\tbl1x
1 of 14
No
No
Drer\tbl3
1 of 14
No
No
Drer\thoc3
1 of 14
No
No
Drer\wdr5
1 of 14
No
No
Drer\wdr17
1 of 14
No
No
Drer\wdr83
1 of 14
No
No
Drer\wdr89
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\Y32H12A.8
7 of 14
Yes
Yes
Cele\copb-2
1 of 14
No
No
Cele\dyci-1
1 of 14
No
No
Cele\F55F8.3
1 of 14
No
No
Cele\JC8.2
1 of 14
No
No
Cele\lin-53
1 of 14
No
No
Cele\rba-1
1 of 14
No
No
Cele\sel-10
1 of 14
No
No
Cele\snrp-40.1
1 of 14
No
No
Cele\snrp-40.2
1 of 14
No
No
Cele\swan-1
1 of 14
No
No
Cele\swan-2
1 of 14
No
No
Cele\wdr-12
1 of 14
No
No
Cele\Y43F4B.9
1 of 14
No
No
Cele\Y54H5A.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (30)
Agam\AgaP_AGAP001159
12 of 12
Yes
Yes
Agam\AgaP_AGAP000319
1 of 12
No
No
Agam\AgaP_AGAP000320
1 of 12
No
No
Agam\AgaP_AGAP000480
1 of 12
No
No
Agam\AgaP_AGAP000678
1 of 12
No
No
Agam\AgaP_AGAP001944
1 of 12
No
No
Agam\AgaP_AGAP002019
1 of 12
No
No
Agam\AgaP_AGAP002776
1 of 12
No
No
Agam\AgaP_AGAP002839
1 of 12
No
No
Agam\AgaP_AGAP003228
1 of 12
No
No
Agam\AgaP_AGAP004374
1 of 12
No
No
Agam\AgaP_AGAP004768
1 of 12
No
No
Agam\AgaP_AGAP005524
1 of 12
No
No
Agam\AgaP_AGAP006036
1 of 12
No
No
Agam\AgaP_AGAP006264
1 of 12
No
No
Agam\AgaP_AGAP007125
1 of 12
No
No
Agam\AgaP_AGAP007525
1 of 12
No
No
Agam\AgaP_AGAP007626
1 of 12
No
No
Agam\AgaP_AGAP008331
1 of 12
No
No
Agam\AgaP_AGAP008689
1 of 12
No
No
Agam\AgaP_AGAP009506
1 of 12
No
No
Agam\AgaP_AGAP009782
1 of 12
No
No
Agam\AgaP_AGAP011539
1 of 12
No
No
Agam\AgaP_AGAP011540
1 of 12
No
No
Agam\AgaP_AGAP011551
1 of 12
No
No
Agam\AgaP_AGAP011849
1 of 12
No
No
Agam\AgaP_AGAP012029
1 of 12
No
No
Agam\AgaP_AGAP012731
1 of 12
No
No
Agam\AgaP_AGAP013233
1 of 12
No
No
Agam\WDR12_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (43)
Atha\AT1G11160
1 of 13
Yes
No
Atha\AT1G15470
1 of 13
Yes
No
Atha\AT1G18830
1 of 13
Yes
No
Atha\AT1G52730
1 of 13
Yes
No
Atha\AT2G01330
1 of 13
Yes
No
Atha\AT2G19540
1 of 13
Yes
No
Atha\AT2G43770
1 of 13
Yes
No
Atha\AT2G47790
1 of 13
Yes
No
Atha\AT3G15610
1 of 13
Yes
No
Atha\AT3G16650
1 of 13
Yes
No
Atha\AT3G63460
1 of 13
Yes
No
Atha\AT4G00070
1 of 13
Yes
Yes
Atha\AT4G04940
1 of 13
Yes
No
Atha\AT4G18900
1 of 13
Yes
No
Atha\AT4G18905
1 of 13
Yes
No
Atha\AT4G30840
1 of 13
Yes
No
Atha\AT4G34280
1 of 13
Yes
Yes
Atha\AT4G35370
1 of 13
Yes
No
Atha\AT5G08390
1 of 13
Yes
No
Atha\AT5G23430
1 of 13
Yes
No
Atha\AT5G43920
1 of 13
Yes
No
Atha\AT5G63010
1 of 13
Yes
No
Atha\ATAN11
1 of 13
Yes
No
Atha\COP1
1 of 13
Yes
No
Atha\DWA3
1 of 13
Yes
No
Atha\FVE
1 of 13
Yes
No
Atha\FY
1 of 13
Yes
No
Atha\FZR3
1 of 13
Yes
No
Atha\HOS15
1 of 13
Yes
No
Atha\LST8-2
1 of 13
Yes
No
Atha\LWD2
1 of 13
Yes
No
Atha\MSI1
1 of 13
Yes
No
Atha\MSI2
1 of 13
Yes
No
Atha\MSI3
1 of 13
Yes
No
Atha\NFC5
1 of 13
Yes
No
Atha\PEX7
1 of 13
Yes
No
Atha\PRL1
1 of 13
Yes
No
Atha\RAPTOR2
1 of 13
Yes
No
Atha\SMU1
1 of 13
Yes
No
Atha\SPA2
1 of 13
Yes
Yes
Atha\SPA3
1 of 13
Yes
Yes
Atha\TEX1
1 of 13
Yes
No
Atha\TTG1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (16)
Scer\RTC1
9 of 13
Yes
Yes
Scer\CDH1
1 of 13
No
No
Scer\HAT2
1 of 13
No
No
Scer\LST8
1 of 13
No
No
Scer\MSI1
1 of 13
No
No
Scer\MTC5
1 of 13
No
No
Scer\PEX7
1 of 13
No
No
Scer\PRP4
1 of 13
No
No
Scer\PWP1
1 of 13
No
No
Scer\RPN14
1 of 13
No
No
Scer\RRB1
1 of 13
No
No
Scer\RRT2
1 of 13
No
No
Scer\SEC31
1 of 13
No
No
Scer\TAF5
1 of 13
No
No
Scer\YNL035C
1 of 13
No
No
Scer\YPL247C
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (15)
Spom\SPAC4F8.11
11 of 12
Yes
Yes
Spom\caf4
1 of 12
No
Yes
Spom\cpc2
1 of 12
No
No
Spom\dic1
1 of 12
No
No
Spom\mis16
1 of 12
No
No
Spom\pex7
1 of 12
No
No
Spom\pfs2
1 of 12
No
No
Spom\pof1
1 of 12
No
No
Spom\pop3
1 of 12
No
No
Spom\prw1
1 of 12
No
No
Spom\SPAC11E3.05
1 of 12
No
No
Spom\SPBC17D11.08
1 of 12
No
No
Spom\SPBC1711.16
1 of 12
No
No
Spom\SPCC18.15
1 of 12
No
No
Spom\utp13
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Wdr24. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (37)
Wdr59
3 of 13
Caf1-55
2 of 13
l(2)09851
2 of 13
Pex7
2 of 13
can
1 of 13
CG1571
1 of 13
CG6724
1 of 13
CG9313
1 of 13
CG9945
1 of 13
CG10859
1 of 13
CG10931
1 of 13
CG12134
1 of 13
Dic61B
1 of 13
Dnai2
1 of 13
Dph7
1 of 13
kat80
1 of 13
mmm
1 of 13
nclb
1 of 13
Nle
1 of 13
Nup43
1 of 13
Nup44A
1 of 13
pod1
1 of 13
Sdic1
1 of 13
Sdic2
1 of 13
Sdic3
1 of 13
Sdic4
1 of 13
SdicA
1 of 13
SdicB
1 of 13
SdicC
1 of 13
Sec31
1 of 13
Ski8
1 of 13
sw
1 of 13
tous
1 of 13
wap
1 of 13
Wdr33
1 of 13
Wdr37
1 of 13
wds
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    WDR24; WD repeat domain 24
    14 of 14
    620307
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Wdr24
        suppressible
        Nprl2
        (Cai et al., 2016)
        Wdr24
        suppressible
        Nprl3
        (Cai et al., 2016)
        Wdr24
        suppressible
        RagA-B
        (Yang et al., 2020)
        Wdr24
        suppressible
        Tsc1
        (Cai et al., 2016)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13. Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with Nup44A/Seh1 (PubMed:27166823). Interacts with mio (PubMed:27166823). Interacts with Nplr3 (PubMed:27166823). The GATOR2 complex associates with unmet in the absence of S-adenosyl-L-methionine; the mio-Wdr24-Nup44A subcomplex is essential and sufficient for this interaction while Wdr59 and Sec13 are dispensable (PubMed:38514639). This association acts as a nutrient sensor to inhibit mTORC1 signaling in the absence of methionine (PubMed:38514639).
        (UniProt, Q9XZ25 )
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-99
        Cytogenetic map
        99B9-99B10
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        99B9-99B10
        Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-99

        (FlyBase, 2016)

        3-96.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (11)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (31)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: Wdr24 CG7609

            (Cai et al., 2016)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (10)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 40 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            References (41)