FlyBase Gene Report: Dmel\Nle

General Information

Symbol

Dmel\Nle

Species

D. melanogaster

Name

Notchless

Annotation Symbol

CG2863

Feature Type

protein_coding_gene

FlyBase ID

FBgn0021874

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Plays a role in regulating Notch activity. (UniProt, Q9VPR4)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
UniProtKB
Interactive Fly

Also Known As

l(2)k13714

Key Links

Genomic Location

Cytogenetic map

21E2-21E2

Sequence location

2L:566,366..568,121 [-]

Recombination map

2-1.5

RefSeq locus

NT_033779 REGION:566366..568121

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables Notch binding

inferred from direct assay

(Royet et al., 1998)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of Notch signaling pathway

inferred from mutant phenotype

(Royet et al., 1998)

inferred from genetic interaction with FLYBASE:dx; FB:FBgn0000524

(Royet et al., 1998)

involved_in positive regulation of Notch signaling pathway

inferred from mutant phenotype

(Royet et al., 1998)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of Notch signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001068308

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleolus

inferred from biological aspect of ancestor with PANTHER:PTN000457354

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY

NEGATIVE REGULATORS OF NOTCH SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the NLE1/RSA4 family. (Q9VPR4)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
NEGATIVE REGULATORS OF NOTCH SIGNALING PATHWAY -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Protein Function (UniProtKB)

Plays a role in regulating Notch activity.

(UniProt, Q9VPR4)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nle for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPR4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nle-RA

FBtr0078075

NM_057946

1584

488

Additional Transcript Data and Comments

Reported size (kB)

1.521 (longest cDNA)

(Royet et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nle-PA

FBpp0077735

53.8

488

6.93

Q9VPR4

NP_477294

AAF51479

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

480 (aa)

(Royet et al., 1998)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Notch (via cytoplasmic domain) (PubMed:9857191). Associates with the pre-60S ribosomal particle (By similarity).

(UniProt, Q9VPR4)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VPR4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nle using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nle_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.55

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anal pad primordium

Comment: reported as anal pad specific anlage

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nle in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nle

View exonic expression by tissue for Dmel\Nle

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0021874

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33234/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0021874

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0021874

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0021874

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2863

Flygut - An atlas of the Drosophila adult midgut

FBgn0021874

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Nle

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nle

Transgenic constructs containing regulatory region of Nle

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(2L)BSC107

(Deal and Cook, 2005.3.10)

Df(2L)Exel8003

(Ryder, 2004.4.26)

Df(2L)Nle^Δ8

(Royet et al., 1998)

Gene not disrupted in

Df(2L)al

(Spradling et al., 1999, Royet et al., 1998, BDGP Project Members, 1994-1999)

Df(2L)ast1

(Royet et al., 1998, BDGP Project Members, 1994-1999)

Df(2L)ast2

(Spradling et al., 1999)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^dpp.blk1

Nle^GD9836

lethal, with Scer\GAL4^en-e16E

Nle^GD9836

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Nle^GD9836

lethal | recessive

Nle^k13714

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

Nle^GD9836

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Nle^GD9836

viable

Nle^k13714

Sterility

Allele

male sterile

Nle^k13714

Other Phenotypes

Allele

some die during second instar larval stage | recessive

Nle^js1

some die during third instar larval stage | recessive

Nle^js1

visible, with Scer\GAL4^pnr-MD237

Nle^GD9836

wild-type

Nle^+t15

Phenotype manifest in

Allele

mesonotum, with Scer\GAL4^pnr-MD237

Nle^GD9836

microchaeta, with Scer\GAL4^ap-md544

Nle^UAS.cRa

trichogen cell, with Scer\GAL4^pnr-MD237

Nle^GD9836

wing hair | increased number, with Scer\GAL4^ap-md544

Nle^GD9836

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (70)

Hsap\NLE1

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (34)

Rnor\Nle1

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (36)

Mmus\Nle1

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (49)

Xtro\nle1

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (35)

Drer\nle1

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (33)

Cele\W07E6.2

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (52)

Agam\AgaP_AGAP002221

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

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1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (58)

Atha\AT5G52820

12 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RUP2

1 of 13

Yes

Atha\SPA1

1 of 13

Yes

Atha\SPA2

1 of 13

Yes

Atha\SPA3

1 of 13

Yes

Atha\SPA4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (23)

Scer\RSA4

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

Schizosaccharomyces pombe (Fission yeast) (13)

Spom\SPCC18.05c

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nle. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (58)

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

ebi

1 of 13

Elp2

1 of 13

flr

1 of 13

Gβ13F

1 of 13

gro

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

tex

1 of 13

tous

1 of 13

U4-U6-60K

1 of 13

wda

1 of 13

Wdr24

1 of 13

Wdr33

1 of 13

wds

1 of 13

WDY

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NLE1; notchless homolog 1

14 of 14

620924

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Nle - Hsp23

experimental knowledge based

(Guruharsha et al., 2011)

Nle - Ip259

experimental knowledge based

(Guruharsha et al., 2011)

Nle - P32

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Nle

(Royet et al., 1998)

enhanceable

Nle

(Royet et al., 1998)

suppressible

Nle

(Royet et al., 1998)

External Data

Subunit Structure (UniProtKB)

Interacts with Notch (via cytoplasmic domain) (PubMed:9857191). Associates with the pre-60S ribosomal particle (By similarity).

(UniProt, Q9VPR4 )

Linkouts

BioGRID - A database of protein and genetic interactions.

59490

DroID - A comprehensive database of gene and protein interactions.

FBgn0021874

MIST (genetic) - An integrated Molecular Interaction Database

33234

MIST (protein-protein) - An integrated Molecular Interaction Database

33234

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY
NEGATIVE REGULATORS OF NOTCH SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O96995

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-1.5

Cytogenetic map

21E2-21E2

Sequence location

2L:566,366..568,121 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21E2-21E2

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

21C7-21C8

(determined by in situ hybridisation)

(Spradling et al., 1999)

21C7-21C8

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-1.5

(FlyBase, 2016)

2-0.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

11099

y¹ w^67c23; P{lacW}Nle^k13714 Sf3b1^k13714/CyO

97385

w^*; Nle^js1 M{3xP3-RFP.attP}ZH-51D/CyO, P{2xTb¹-RFP}CyO

97386

w^*; Nle^js2 M{3xP3-RFP.attP}ZH-51D/CyO, P{2xTb¹-RFP}CyO

97387

w^*; Nle^js3 M{3xP3-RFP.attP}ZH-51D/CyO, P{2xTb¹-RFP}CyO

Kyoto

126149

w¹¹¹⁸; P{RS5}Nle^5-SZ-3596

111330

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}Nle^k13714 P{neoFRT}40A/CyO y⁺

NIG-Fly

HMJ23844

y¹ v¹; P{TRiP.HMJ23844}attP40/CyO

2LG-0113

y² VhaAC39-1^cho-1 v¹; P{U6-Nle.NIG.sgRNA}attP40/CyO

VDRC

v110728

P{KK102603}VIE-260B

v33574

w¹¹¹⁸; P{GD9836}v33574

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT08344

Other clones

DPiM_AT08344

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0021874

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0021874

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The Nle gene product physically interacts with the N gene product cytoplasmic domain. In direction of increasing cytology: Nle- CG2807+

(Royet et al., 1998)

The Nle gene product modulates N signalling activity.

(Royet et al., 1998)

Loss of function mutations dominantly suppress the wing notching caused by alleles of N. Mutants show no interaction with Ser, Dl, H or sno.

(Royet et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Nle anon-WO0026364

(FlyBase, 1996-)

Additional comments

Source for merge of Nle anon-WO0026364 was sequence comparison ( date:030908 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Nle CG2863

(Guan, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG2863

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Weber et al., 2012, Keleman et al., 2009.8.5)

Nle

(Zhu et al., 2025, Skeath, 2023.1.28, National Institute of Genetics Fly Stocks, 2022-, DeAngelis et al., 2021, Hu et al., 2017.6.13, Weber et al., 2012)

anon-WO0026364

l(2)k13714

(Spradling et al., 1999)

nle

(May and Zwaan, 2017)

Name Synonyms

Notchless

(Shen et al., 2013, Royet et al., 1998)

notchless

(Royet, 1998.10.28)

Secondary FlyBase IDs

FBgn0042663

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33234

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPR4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VPR4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPR4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0021874

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33234/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0021874

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0021874

FlyMine - An integrated database for Drosophila genomics

FBgn0021874

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2863

MARRVEL_MODEL - MARRVEL (model organism gene)

33234

Linkouts

BioGRID - A database of protein and genetic interactions.

59490

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0021874

DroID - A comprehensive database of gene and protein interactions.

FBgn0021874

DRSC - Results frm RNAi screens

FBgn0021874

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nle_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0021874

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0021874

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2863

Flygut - An atlas of the Drosophila adult midgut

FBgn0021874

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0021874

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004394

MIST (genetic) - An integrated Molecular Interaction Database

33234

MIST (protein-protein) - An integrated Molecular Interaction Database

33234

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O96995

References (48)

The following external sites may use different assemblies or annotations than FlyBase.

2.55

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