BcDNA:GH08860 , l(2)k08903, jf5, trehalose synthase, trehalose-6-phosphate synthase
Gene model reviewed during 5.44
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tps1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tps1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The TPS (trehalose-6-phosphate synthase) and TPP (trehalose-6-phosphate phosphatase) domains of Tps1 are both required for trehalose synthesis in vivo.
In vitro experiments showed that trehalose reduced protein aggregation caused by anoxia.
Upon induction of Tps1, trehalose increased and this was associated with increased tolerance to anoxia.
Overexpression of Tps1 results in increased tolerance to anoxia and an increase in trehalose levels.
Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.